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Aliases for ZNF234 Gene

Aliases for ZNF234 Gene

  • Zinc Finger Protein 234 2 3 3 5
  • Zinc Finger Protein HZF4 3 4
  • Zinc Finger Protein 269 3 4
  • ZNF269 3 4
  • Zinc Finger Protein 234, Partial Sequence 3
  • C2-H2 Type Zinc Finger Protein 3
  • Homo Sapiens Zinc Finger 234 3
  • Zinc Finger Protein 4 3
  • HZF4 3

External Ids for ZNF234 Gene

Previous HGNC Symbols for ZNF234 Gene

  • ZNF269

Previous GeneCards Identifiers for ZNF234 Gene

  • GC19P045291
  • GC19P045037
  • GC19P049321
  • GC19P049337
  • GC19P044645
  • GC19P041077

Summaries for ZNF234 Gene

GeneCards Summary for ZNF234 Gene

ZNF234 (Zinc Finger Protein 234) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF226.

UniProtKB/Swiss-Prot for ZNF234 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF234 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF234 Gene

Genomics for ZNF234 Gene

GeneHancer (GH) Regulatory Elements for ZNF234 Gene

Promoters and enhancers for ZNF234 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J044140 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 684.3 +0.3 269 2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF143 KLF13 SP3 ZNF234 GC19M044140 ZNF225 ZNF45 ZNF576 ZNF227 ZNF235 ZNF283 ZNF226 LOC100505715
GH19J043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 114.7 -361.6 -361628 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF284 ZNF224 ZNF227 ZNF223 ZNF235 ZNF283
GH19J044844 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 82.1 +706.5 706484 7.3 YBX1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 MCM3 SP3 ZNF610 NECTIN2 GC19P044850 ZNF180 ZNF45 ZNF225 CLASRP ZNF224 ZNF234 ZNF284 FBXO46
GH19J043901 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 110.3 -239.7 -239729 1.6 ARID4B ZNF2 YY1 ZNF766 ZNF416 ZNF143 ZNF548 KLF13 SP3 MXD4 ZNF221 ZNF404 LOC100505715 ENSG00000267191 ZNF45 ZNF180 ZNF225 ZNF224 ZNF227 ZNF284
GH19J044740 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 69.8 +608.5 608487 19.4 YBX1 FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 SP3 BCL3 ZNF45 ZNF180 ZNF155 ZNF224 ZNF284 CLASRP ZNF225 ZNF234 FBXO46
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF234 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF234 gene promoter:
  • LCR-F1
  • C/EBPbeta
  • C/EBPalpha

Genomic Locations for ZNF234 Gene

Genomic Locations for ZNF234 Gene
chr19:44,141,530-44,160,309
(GRCh38/hg38)
Size:
18,780 bases
Orientation:
Plus strand
chr19:44,645,710-44,664,462
(GRCh37/hg19)
Size:
18,753 bases
Orientation:
Plus strand

Genomic View for ZNF234 Gene

Genes around ZNF234 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF234 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF234 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF234 Gene

Proteins for ZNF234 Gene

  • Protein details for ZNF234 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14588-ZN234_HUMAN
    Recommended name:
    Zinc finger protein 234
    Protein Accession:
    Q14588
    Secondary Accessions:
    • A8K1C8
    • Q96IR4
    • Q9NS45
    • Q9NYT7

    Protein attributes for ZNF234 Gene

    Size:
    700 amino acids
    Molecular mass:
    80560 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF234 Gene

Post-translational modifications for ZNF234 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF234 Gene

Domains & Families for ZNF234 Gene

Gene Families for ZNF234 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF234 Gene

Suggested Antigen Peptide Sequences for ZNF234 Gene

Graphical View of Domain Structure for InterPro Entry

Q14588

UniProtKB/Swiss-Prot:

ZN234_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF234: view

Function for ZNF234 Gene

Molecular function for ZNF234 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF234 Gene

Gene Ontology (GO) - Molecular Function for ZNF234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF234: view
genes like me logo Genes that share phenotypes with ZNF234: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF234 Gene

Localization for ZNF234 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF234 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF234 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF234: view

Pathways & Interactions for ZNF234 Gene

SuperPathways for ZNF234 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF234: view

Pathways by source for ZNF234 Gene

2 Reactome pathways for ZNF234 Gene

Gene Ontology (GO) - Biological Process for ZNF234 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF234: view

No data available for SIGNOR curated interactions for ZNF234 Gene

Drugs & Compounds for ZNF234 Gene

No Compound Related Data Available

Transcripts for ZNF234 Gene

Unigene Clusters for ZNF234 Gene

Zinc finger protein 234:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF234 Gene

No ASD Table

Relevant External Links for ZNF234 Gene

GeneLoc Exon Structure for
ZNF234
ECgene alternative splicing isoforms for
ZNF234

Expression for ZNF234 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF234 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF234 Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF234 Gene



Protein tissue co-expression partners for ZNF234 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF234 Gene:

ZNF234

SOURCE GeneReport for Unigene cluster for ZNF234 Gene:

Hs.235992

Evidence on tissue expression from TISSUES for ZNF234 Gene

  • Eye(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZNF234: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF234 Gene

Orthologs for ZNF234 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF234 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF234 34 33
  • 99.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF234 33
  • 86.84 (n)
dog
(Canis familiaris)
Mammalia ZNF234 34 33
  • 83.07 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9215 35
  • 43 (a)
CG5245 35
  • 42 (a)
CG6689 35
  • 36 (a)
CG17568 35
  • 36 (a)
CG2120 35
  • 36 (a)
EG:95B7.7 35
  • 35 (a)
CG7963 35
  • 34 (a)
CG6254 35
  • 33 (a)
CG17803 35
  • 33 (a)
CG10147 35
  • 32 (a)
CG7386 35
  • 31 (a)
CG8301 35
  • 29 (a)
CG10669 35
  • 25 (a)
Species where no ortholog for ZNF234 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF234 Gene

ENSEMBL:
Gene Tree for ZNF234 (if available)
TreeFam:
Gene Tree for ZNF234 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF234: view image

Paralogs for ZNF234 Gene

(580) SIMAP similar genes for ZNF234 Gene using alignment to 4 proteins:

  • ZN234_HUMAN
  • K7ELL2_HUMAN
  • Q86WM2_HUMAN
  • Q86WM3_HUMAN
genes like me logo Genes that share paralogs with ZNF234: view

Variants for ZNF234 Gene

Sequence variations from dbSNP and Humsavar for ZNF234 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000282031 -- 44,153,031(+) C/A intron_variant
rs1000418865 -- 44,153,283(+) G/A intron_variant
rs1000711097 -- 44,160,360(+) A/G downstream_transcript_variant
rs1000738174 -- 44,140,507(+) C/T upstream_transcript_variant
rs1000803414 -- 44,150,867(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF234 Gene

Variant ID Type Subtype PubMed ID
esv2718617 CNV deletion 23290073
nsv1134795 CNV deletion 24896259
nsv833840 CNV gain 17160897
nsv961227 CNV duplication 23825009
esv2718616 CNV deletion 23290073
dgv526e201 CNV deletion 23290073

Variation tolerance for ZNF234 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.63; 86.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF234 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF234

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF234 Gene

Disorders for ZNF234 Gene

Additional Disease Information for ZNF234

No disorders were found for ZNF234 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF234 Gene

Publications for ZNF234 Gene

  1. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4 58
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp JJ … Guthrie C (Nature structural & molecular biology 2015) 3 58
  5. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PMID: 23398456) Bett JS … Hay RT (The Biochemical journal 2013) 3 58

Products for ZNF234 Gene

Sources for ZNF234 Gene