Aliases for ZNF233 Gene

Aliases for ZNF233 Gene

  • Zinc Finger Protein 233 2 3 4 5
  • FLJ38032 2
  • ZNF233 5

External Ids for ZNF233 Gene

Previous GeneCards Identifiers for ZNF233 Gene

  • GC19U900205
  • GC19P049446
  • GC19P044754
  • GC19P041196

Summaries for ZNF233 Gene

GeneCards Summary for ZNF233 Gene

ZNF233 (Zinc Finger Protein 233) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF214.

UniProtKB/Swiss-Prot Summary for ZNF233 Gene

Additional gene information for ZNF233 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF233 Gene

Genomics for ZNF233 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF233 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF233 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF233

Top Transcription factor binding sites by QIAGEN in the ZNF233 gene promoter:
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6
  • TBP

Genomic Locations for ZNF233 Gene

Genomic Locations for ZNF233 Gene
chr19:44,259,742-44,278,534
(GRCh38/hg38)
Size:
18,793 bases
Orientation:
Plus strand
chr19:44,754,318-44,779,470
(GRCh37/hg19)
Size:
25,153 bases
Orientation:
Plus strand

Genomic View for ZNF233 Gene

Genes around ZNF233 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF233 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF233 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF233 Gene

Proteins for ZNF233 Gene

  • Protein details for ZNF233 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NK53-ZN233_HUMAN
    Recommended name:
    Zinc finger protein 233
    Protein Accession:
    A6NK53
    Secondary Accessions:
    • B2RN78
    • B2RN79
    • Q86WL8

    Protein attributes for ZNF233 Gene

    Size:
    670 amino acids
    Molecular mass:
    76861 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF233 Gene

Post-translational modifications for ZNF233 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF233 Gene

Domains & Families for ZNF233 Gene

Gene Families for ZNF233 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF233 Gene

Suggested Antigen Peptide Sequences for ZNF233 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 233 (ZN233_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NK53

UniProtKB/Swiss-Prot:

ZN233_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF233: view

Function for ZNF233 Gene

Molecular function for ZNF233 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF233 Gene

Gene Ontology (GO) - Molecular Function for ZNF233 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF233: view
genes like me logo Genes that share phenotypes with ZNF233: view

Animal Model Products

CRISPR Products

miRNA for ZNF233 Gene

miRTarBase miRNAs that target ZNF233

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF233

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF233 Gene

Localization for ZNF233 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF233 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF233 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF233 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF233: view

Pathways & Interactions for ZNF233 Gene

genes like me logo Genes that share pathways with ZNF233: view

Pathways by source for ZNF233 Gene

2 Reactome pathways for ZNF233 Gene
1 KEGG pathway for ZNF233 Gene

Interacting Proteins for ZNF233 Gene

Gene Ontology (GO) - Biological Process for ZNF233 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF233: view

No data available for SIGNOR curated interactions for ZNF233 Gene

Drugs & Compounds for ZNF233 Gene

No Compound Related Data Available

Transcripts for ZNF233 Gene

mRNA/cDNA for ZNF233 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF233

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF233 Gene

No ASD Table

Relevant External Links for ZNF233 Gene

GeneLoc Exon Structure for
ZNF233

Expression for ZNF233 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF233 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for ZNF233 Gene

This gene is overexpressed in Plasma (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF233 Gene



Protein tissue co-expression partners for ZNF233 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF233

SOURCE GeneReport for Unigene cluster for ZNF233 Gene:

Hs.466891

Evidence on tissue expression from TISSUES for ZNF233 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF233: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF233 Gene

Orthologs for ZNF233 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF233 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF233 31
  • 74 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 41 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Zfp111 31
  • 41 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 41 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 44 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii zgc:162972 31
  • 35 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG4360 31
  • 23 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea tag-146 31
  • 19 (a)
ManyToMany
C27A12.2 31
  • 16 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
ManyToMany
Species where no ortholog for ZNF233 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ZNF233 Gene

ENSEMBL:
Gene Tree for ZNF233 (if available)
TreeFam:
Gene Tree for ZNF233 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF233: view image

Paralogs for ZNF233 Gene

(499) SIMAP similar genes for ZNF233 Gene using alignment to 6 proteins:

  • ZN233_HUMAN
  • K7EJE5_HUMAN
  • K7EJT0_HUMAN
  • K7EN46_HUMAN
  • K7ER86_HUMAN
  • Q9NS42_HUMAN
genes like me logo Genes that share paralogs with ZNF233: view

Variants for ZNF233 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF233 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs59660444 Benign: not specified 44,274,642(+) CG/C FRAMESHIFT_VARIANT,THREE_PRIME_UTR_VARIANT
rs1233428 - p.Lys531Thr
rs16978899 - p.Ser247Pro

Additional dbSNP identifiers (rs#s) for ZNF233 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF233 Gene

Variant ID Type Subtype PubMed ID
nsv521923 CNV loss 19592680

Variation tolerance for ZNF233 Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.76; 95.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF233 Gene

Human Gene Mutation Database (HGMD)
ZNF233
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF233

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF233 Gene

Disorders for ZNF233 Gene

No disorders were found for ZNF233 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF233 Gene

Publications for ZNF233 Gene

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Knockdown of ZNF233 suppresses hepatocellular carcinoma cell proliferation and tumorigenesis. (PMID: 30179682) Xie W … Wu Y (Gene 2018) 3
  4. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PMID: 21078624) Kahle JJ … Zoghbi HY (Human molecular genetics 2011) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF233 Gene

Sources for ZNF233 Gene