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Aliases for ZNF230 Gene

Aliases for ZNF230 Gene

  • Zinc Finger Protein 230 2 3 5
  • Zinc Finger Protein FDZF2 3 4
  • FDZF2 3 4

External Ids for ZNF230 Gene

Previous GeneCards Identifiers for ZNF230 Gene

  • GC19P045152
  • GC19P044898
  • GC19P049183
  • GC19P049198
  • GC19P049181
  • GC19P044270
  • GC19P044507

Summaries for ZNF230 Gene

GeneCards Summary for ZNF230 Gene

ZNF230 (Zinc Finger Protein 230) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000267022.

UniProtKB/Swiss-Prot for ZNF230 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF230 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF230 Gene

Genomics for ZNF230 Gene

GeneHancer (GH) Regulatory Elements for ZNF230 Gene

Promoters and enhancers for ZNF230 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I044002 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 581.5 +0.3 255 2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF213 ZNF207 ZNF230 LOC101928063 GC19P044003 ZNF45 ZNF155 ZNF180 ZNF224 ZNF234 XRCC1 LOC100505715
GH19I044006 Promoter 0.5 EPDnew 550.8 +2.5 2546 0.1 ZNF230 ZNF155 ZNF284 ZNF45 GC19P044003 LOC105372414
GH19I043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 70 -223.0 -223023 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF224 ZNF284 ZNF227 ZNF283 ZNF223 ZNF576
GH19I044259 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 60.7 +257.1 257107 1.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ZBTB7B ZNF233 ZNF45 ZNF180 ZNF225 ZNF224 ZNF284 ZNF227 ZNF234 ZNF235 CLASRP
GH19I044844 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 38.9 +845.1 845089 7.3 YBX1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 MCM3 SP3 ZNF610 NECTIN2 GC19P044850 ZNF180 ZNF45 ZNF225 CLASRP ZNF224 ZNF234 ZNF284 FBXO46
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF230 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF230 Gene

Genomic Locations for ZNF230 Gene
11,002 bases
Plus strand

Genomic View for ZNF230 Gene

Genes around ZNF230 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF230 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF230 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF230 Gene

Proteins for ZNF230 Gene

  • Protein details for ZNF230 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 230
    Protein Accession:
    Secondary Accessions:
    • O15322
    • Q504X7
    • Q86W84
    • Q9P1U6

    Protein attributes for ZNF230 Gene

    474 amino acids
    Molecular mass:
    54542 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF230 Gene

Post-translational modifications for ZNF230 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF230 Gene

No data available for DME Specific Peptides for ZNF230 Gene

Domains & Families for ZNF230 Gene

Gene Families for ZNF230 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF230 Gene

Suggested Antigen Peptide Sequences for ZNF230 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF230: view

Function for ZNF230 Gene

Molecular function for ZNF230 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF230 Gene

Gene Ontology (GO) - Molecular Function for ZNF230 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF230: view
genes like me logo Genes that share phenotypes with ZNF230: view

Animal Model Products

CRISPR Products

miRNA for ZNF230 Gene

miRTarBase miRNAs that target ZNF230

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF230 Gene

Localization for ZNF230 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF230 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF230 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF230 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF230: view

Pathways & Interactions for ZNF230 Gene

SuperPathways for ZNF230 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF230: view

Pathways by source for ZNF230 Gene

2 Reactome pathways for ZNF230 Gene

Gene Ontology (GO) - Biological Process for ZNF230 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF230: view

No data available for SIGNOR curated interactions for ZNF230 Gene

Drugs & Compounds for ZNF230 Gene

No Compound Related Data Available

Transcripts for ZNF230 Gene

Unigene Clusters for ZNF230 Gene

Zinc finger protein 230:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF230 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP3: -

Relevant External Links for ZNF230 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF230 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF230 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF230 Gene

This gene is overexpressed in Whole Blood (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF230 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF230 Gene:


SOURCE GeneReport for Unigene cluster for ZNF230 Gene:


Evidence on tissue expression from TISSUES for ZNF230 Gene

  • Liver(4.1)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with ZNF230: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF230 Gene

Orthologs for ZNF230 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF230 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF230 33 34
  • 99.37 (n)
Species where no ortholog for ZNF230 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF230 Gene

Gene Tree for ZNF230 (if available)
Gene Tree for ZNF230 (if available)

Paralogs for ZNF230 Gene

(459) SIMAP similar genes for ZNF230 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF230: view

Variants for ZNF230 Gene

Sequence variations from dbSNP and Humsavar for ZNF230 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000433956 -- 44,013,469(+) A/G 3_prime_UTR_variant
rs1000472517 -- 44,014,359(+) C/T downstream_transcript_variant
rs1001121915 -- 44,001,387(+) G/A upstream_transcript_variant
rs1001291632 -- 44,009,742(+) A/G intron_variant
rs1001301143 -- 44,002,462(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF230 Gene

Variant ID Type Subtype PubMed ID
nsv469650 CNV gain 16826518
nsv819782 CNV loss 19587683
nsv961225 CNV duplication 23825009

Variation tolerance for ZNF230 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.86; 67.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF230 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF230 Gene

Disorders for ZNF230 Gene

Additional Disease Information for ZNF230

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF230 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF230 Gene

Publications for ZNF230 Gene

  1. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 44 58
  4. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood HD … Lan Q (Respiratory medicine 2009) 3 44 58
  5. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PMID: 19684603) Treviño LR … Relling MV (Nature genetics 2009) 3 44 58

Products for ZNF230 Gene

Sources for ZNF230 Gene

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