Aliases for ZNF229 Gene

Aliases for ZNF229 Gene

  • Zinc Finger Protein 229 2 3 4 5
  • ZNF229 5

External Ids for ZNF229 Gene

Previous GeneCards Identifiers for ZNF229 Gene

  • GC19M045578
  • GC19M045325
  • GC19M049609
  • GC19M049625
  • GC19M049626
  • GC19U900567
  • GC19M044930
  • GC19M041362

Summaries for ZNF229 Gene

GeneCards Summary for ZNF229 Gene

ZNF229 (Zinc Finger Protein 229) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF484.

UniProtKB/Swiss-Prot Summary for ZNF229 Gene

Additional gene information for ZNF229 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF229 Gene

Genomics for ZNF229 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF229 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J044447 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 606.2 +0.3 277 2.2 CREB1 ZNF629 SIX5 ZNF692 GABPA ZNF143 POLR2A MTA1 NR2C1 ZNF561 ZNF285 ZNF229 ENSG00000267188 ZNF180 ZNF225 ZNF226 ZNF227 ZNF45 CLASRP ZNF235
GH19J044400 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 11.2 +46.9 46877 2.2 PRDM10 SIX5 IKZF1 ZNF692 ZNF143 RBFOX2 POLR2A PATZ1 NR2C1 IRF2 ZNF285 ENSG00000267173 ZNF229 ZNF180 piR-31534-343 ENSG00000267188
GH19J044268 Enhancer 0.5 FANTOM5 10.4 +179.5 179487 0.3 ZNF777 ZNF366 KLF16 IKZF1 ZNF280D ZNF227 ZNF226 ZNF229 ZNF155 ZNF285 ZNF112 ZNF233 LYPD5 ZNF221 ZNF235
GH19J044245 Enhancer 0.4 FANTOM5 11 +203.0 203015 0.3 ZSCAN4 RBAK ZBTB10 ENSG00000270679 ZNF180 ZNF45 ZNF283 ZNF112 ZNF225 ZNF226 ZNF224 ZNF221 ZNF284
GH19J044111 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 1.8 +335.5 335477 3.8 ZNF221 CREB1 PRDM10 ZNF629 REST TFE3 SIX5 IKZF1 ZNF692 ZNF174 ZNF225 ENSG00000186019 LOC100379224 ZNF45 ZNF227 ZNF180 ZNF226 ZNF283 ZNF223 ZNF576
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF229 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF229

Top Transcription factor binding sites by QIAGEN in the ZNF229 gene promoter:
  • Pax-4a

Genomic Locations for ZNF229 Gene

Genomic Locations for ZNF229 Gene
31,060 bases
Minus strand
31,082 bases
Minus strand

Genomic View for ZNF229 Gene

Genes around ZNF229 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF229 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF229 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF229 Gene

Proteins for ZNF229 Gene

  • Protein details for ZNF229 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 229
    Protein Accession:
    Secondary Accessions:
    • B2RWN3
    • Q59FV2
    • Q86WL9

    Protein attributes for ZNF229 Gene

    825 amino acids
    Molecular mass:
    93707 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG23970.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF229 Gene


neXtProt entry for ZNF229 Gene

Post-translational modifications for ZNF229 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF229 Gene

No data available for DME Specific Peptides for ZNF229 Gene

Domains & Families for ZNF229 Gene

Gene Families for ZNF229 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF229 Gene

  • C2H2-type zinc finger signature
  • KRAB box

Suggested Antigen Peptide Sequences for ZNF229 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 229 (ZN229_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF229: view

Function for ZNF229 Gene

Molecular function for ZNF229 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF229 Gene

Gene Ontology (GO) - Molecular Function for ZNF229 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF229: view
genes like me logo Genes that share phenotypes with ZNF229: view

Animal Model Products

CRISPR Products

miRNA for ZNF229 Gene

miRTarBase miRNAs that target ZNF229

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF229

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF229 Gene

Localization for ZNF229 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF229 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF229 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF229 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF229: view

Pathways & Interactions for ZNF229 Gene

PathCards logo

SuperPathways for ZNF229 Gene

genes like me logo Genes that share pathways with ZNF229: view

Pathways by source for ZNF229 Gene

1 KEGG pathway for ZNF229 Gene

Gene Ontology (GO) - Biological Process for ZNF229 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF229: view

No data available for SIGNOR curated interactions for ZNF229 Gene

Drugs & Compounds for ZNF229 Gene

No Compound Related Data Available

Transcripts for ZNF229 Gene

mRNA/cDNA for ZNF229 Gene

8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF229

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF229 Gene

No ASD Table

Relevant External Links for ZNF229 Gene

GeneLoc Exon Structure for

Expression for ZNF229 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF229 Gene

Protein differential expression in normal tissues from HIPED for ZNF229 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF229 Gene

Protein tissue co-expression partners for ZNF229 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF229

SOURCE GeneReport for Unigene cluster for ZNF229 Gene:


Evidence on tissue expression from TISSUES for ZNF229 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF229: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF229 Gene

Orthologs for ZNF229 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF229 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF229 30
  • 90.41 (n)
(Canis familiaris)
Mammalia ZNF229 30
  • 80.71 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG10274 32
  • 40 (a)
CG7963 32
  • 32 (a)
Species where no ortholog for ZNF229 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF229 Gene

Gene Tree for ZNF229 (if available)
Gene Tree for ZNF229 (if available)
Evolutionary constrained regions (ECRs) for ZNF229: view image

Paralogs for ZNF229 Gene

Paralogs for ZNF229 Gene

(494) SIMAP similar genes for ZNF229 Gene using alignment to 4 proteins:

  • ZN229_HUMAN
  • L8ECE8_HUMAN Pseudogenes for ZNF229 Gene

genes like me logo Genes that share paralogs with ZNF229: view

Variants for ZNF229 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF229 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs199930833 Uncertain Significance: not provided 44,428,886(-) T/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs10409807 - p.Gly804Arg
rs12151338 - p.Arg337Cys
rs1434579 - p.Gly662Arg
rs2571174 - p.Ser156Phe

Additional dbSNP identifiers (rs#s) for ZNF229 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF229 Gene

Variant ID Type Subtype PubMed ID
dgv3605n100 CNV loss 25217958
esv2421963 CNV deletion 20811451
esv2663330 CNV deletion 23128226
esv26773 CNV loss 19812545
esv2758764 CNV loss 17122850
esv2763206 CNV loss 21179565
esv3644482 CNV loss 21293372
esv6503 OTHER inversion 19470904
nsv1061350 CNV loss 25217958
nsv1062330 CNV loss 25217958
nsv1078308 OTHER inversion 25765185
nsv442465 CNV loss 18776908
nsv515911 CNV loss 19592680
nsv579857 CNV loss 21841781
nsv817849 CNV loss 17921354
nsv9734 CNV gain+loss 18304495

Variation tolerance for ZNF229 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.71; 91.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF229 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF229 Gene

Disorders for ZNF229 Gene

Additional Disease Information for ZNF229

No disorders were found for ZNF229 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF229 Gene

Publications for ZNF229 Gene

  1. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. (PMID: 20694014) Thye T … Hill AVS (Nature genetics 2010) 3 41
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3

Products for ZNF229 Gene

Sources for ZNF229 Gene