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Aliases for ZNF229 Gene

Aliases for ZNF229 Gene

  • Zinc Finger Protein 229 2 3 3 5

External Ids for ZNF229 Gene

Previous GeneCards Identifiers for ZNF229 Gene

  • GC19M045578
  • GC19M045325
  • GC19M049609
  • GC19M049625
  • GC19M049626
  • GC19U900567
  • GC19M044930
  • GC19M041362

Summaries for ZNF229 Gene

GeneCards Summary for ZNF229 Gene

ZNF229 (Zinc Finger Protein 229) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF112.

UniProtKB/Swiss-Prot for ZNF229 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF229 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF229 Gene

Genomics for ZNF229 Gene

GeneHancer (GH) Regulatory Elements for ZNF229 Gene

Promoters and enhancers for ZNF229 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J044447 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 656.3 +0.5 456 1.7 ATF1 SIN3A ZNF2 YY1 ETS1 ELK1 ZNF143 KLF7 KLF13 SP3 ZNF285 ZNF229 ENSG00000267188 ZNF225 ZNF180 ZNF226 ZNF227 ZNF45 CLASRP ZNF235
GH19J044400 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.2 +47.2 47222 1.4 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ETS1 ZNF143 SP3 ZNF285 ENSG00000267173 ZNF229 ZNF180 GC19P044381 ENSG00000267188
GH19J044245 Enhancer 0.5 FANTOM5 11 +203.2 203162 0.3 ZBTB10 RBAK ZSCAN4 MRPS15P2 ZNF180 ZNF45 ZNF283 ZNF112 ZNF225 ZNF226 ZNF224 ZNF221 ZNF284
GH19J044268 Enhancer 0.5 FANTOM5 10.4 +179.6 179634 0.3 ZNF777 ZNF280D KLF16 ZNF366 IKZF1 GC19P044273 ZNF227 ZNF226 ZNF229 ZNF155 ZNF285 ZNF112 ZNF233 LYPD5 ZNF221
GH19J044111 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 1.8 +335.7 335724 2.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF225 LOC100379224 ZNF45 ZNF180 ZNF227 ZNF283 ZNF576 ZNF224 ZNF226 ZNF223
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF229 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF229 gene promoter:
  • Pax-4a

Genomic Locations for ZNF229 Gene

Genomic Locations for ZNF229 Gene
31,207 bases
Minus strand
31,082 bases
Minus strand

Genomic View for ZNF229 Gene

Genes around ZNF229 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF229 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF229 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF229 Gene

Proteins for ZNF229 Gene

  • Protein details for ZNF229 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 229
    Protein Accession:
    Secondary Accessions:
    • B2RWN3
    • Q59FV2
    • Q86WL9

    Protein attributes for ZNF229 Gene

    825 amino acids
    Molecular mass:
    93707 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG23970.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF229 Gene


neXtProt entry for ZNF229 Gene

Post-translational modifications for ZNF229 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF229 Gene

No data available for DME Specific Peptides for ZNF229 Gene

Domains & Families for ZNF229 Gene

Gene Families for ZNF229 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF229 Gene

Suggested Antigen Peptide Sequences for ZNF229 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF229: view

Function for ZNF229 Gene

Molecular function for ZNF229 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF229 Gene

Gene Ontology (GO) - Molecular Function for ZNF229 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF229: view
genes like me logo Genes that share phenotypes with ZNF229: view

Animal Model Products

miRNA for ZNF229 Gene

miRTarBase miRNAs that target ZNF229

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF229 Gene

Localization for ZNF229 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF229 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF229 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF229 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF229: view

Pathways & Interactions for ZNF229 Gene

SuperPathways for ZNF229 Gene

No Data Available

Interacting Proteins for ZNF229 Gene

Gene Ontology (GO) - Biological Process for ZNF229 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF229: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF229 Gene

Drugs & Compounds for ZNF229 Gene

No Compound Related Data Available

Transcripts for ZNF229 Gene

mRNA/cDNA for ZNF229 Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF229 Gene

Zinc finger protein 229:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF229 Gene

No ASD Table

Relevant External Links for ZNF229 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF229 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF229 Gene

Protein differential expression in normal tissues from HIPED for ZNF229 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF229 Gene

Protein tissue co-expression partners for ZNF229 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF229 Gene:


SOURCE GeneReport for Unigene cluster for ZNF229 Gene:


Evidence on tissue expression from TISSUES for ZNF229 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF229: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF229 Gene

Orthologs for ZNF229 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF229 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF229 33
  • 90.41 (n)
(Canis familiaris)
Mammalia ZNF229 33
  • 80.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10274 35
  • 40 (a)
CG7963 35
  • 32 (a)
Species where no ortholog for ZNF229 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF229 Gene

Gene Tree for ZNF229 (if available)
Gene Tree for ZNF229 (if available)
Evolutionary constrained regions (ECRs) for ZNF229: view image

Paralogs for ZNF229 Gene

(494) SIMAP similar genes for ZNF229 Gene using alignment to 4 proteins:

  • ZN229_HUMAN
  • L8ECE8_HUMAN Pseudogenes for ZNF229 Gene

genes like me logo Genes that share paralogs with ZNF229: view

Variants for ZNF229 Gene

Sequence variations from dbSNP and Humsavar for ZNF229 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000026244 -- 44,427,171(-) T/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1000243940 -- 44,450,390(-) C/A upstream_transcript_variant
rs1000354503 -- 44,444,114(-) C/A/T intron_variant
rs1000462616 -- 44,437,924(-) G/A intron_variant
rs1000514520 -- 44,438,154(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF229 Gene

Variant ID Type Subtype PubMed ID
dgv3605n100 CNV loss 25217958
esv2421963 CNV deletion 20811451
esv2663330 CNV deletion 23128226
esv26773 CNV loss 19812545
esv2758764 CNV loss 17122850
esv2763206 CNV loss 21179565
esv3644482 CNV loss 21293372
esv6503 OTHER inversion 19470904
nsv1061350 CNV loss 25217958
nsv1062330 CNV loss 25217958
nsv1078308 OTHER inversion 25765185
nsv442465 CNV loss 18776908
nsv515911 CNV loss 19592680
nsv579857 CNV loss 21841781
nsv817849 CNV loss 17921354
nsv9734 CNV gain+loss 18304495

Variation tolerance for ZNF229 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.71; 91.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF229 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF229 Gene

Disorders for ZNF229 Gene

Additional Disease Information for ZNF229

No disorders were found for ZNF229 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF229 Gene

Publications for ZNF229 Gene

  1. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. (PMID: 20694014) Thye T … Hill AVS (Nature genetics 2010) 3 44 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for ZNF229 Gene

Sources for ZNF229 Gene

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