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Aliases for ZNF227 Gene

Aliases for ZNF227 Gene

  • Zinc Finger Protein 227 2 3 3 5

External Ids for ZNF227 Gene

Previous GeneCards Identifiers for ZNF227 Gene

  • GC00U990433
  • GC19U900047
  • GC19P049408
  • GC19P044718
  • GC19P041148

Summaries for ZNF227 Gene

GeneCards Summary for ZNF227 Gene

ZNF227 (Zinc Finger Protein 227) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF112.

UniProtKB/Swiss-Prot for ZNF227 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF227 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF227 Gene

Genomics for ZNF227 Gene

GeneHancer (GH) Regulatory Elements for ZNF227 Gene

Promoters and enhancers for ZNF227 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J044206 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 753.2 +0.2 187 1.7 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 ZNF213 E2F8 ZNF227 ZNF45 ZNF180 ZNF225 ZNF224 ZNF284 ZNF223 ZNF226 ZNF235 ZNF234
GH19J044211 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 693 +5.3 5254 2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF227 ZNF180 ZNF45 ZNF225 ZNF235 ZNF224 ZNF155 ZNF283 ZNF284 ZNF223
GH19J043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 154.2 -427.6 -427645 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF284 ZNF224 ZNF227 ZNF223 ZNF235 ZNF283
GH19J043901 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 130.4 -305.7 -305746 1.6 ARID4B ZNF2 YY1 ZNF766 ZNF416 ZNF143 ZNF548 KLF13 SP3 MXD4 ZNF221 ZNF404 LOC100505715 ENSG00000267191 ZNF45 ZNF180 ZNF225 ZNF224 ZNF227 ZNF284
GH19J044111 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 102.1 -94.5 -94546 2.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF225 LOC100379224 ZNF45 ZNF180 ZNF227 ZNF283 ZNF576 ZNF224 ZNF226 ZNF223
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF227 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF227 gene promoter:
  • STAT1
  • STAT6
  • STAT5B
  • STAT5A
  • STAT4
  • STAT3

Genomic Locations for ZNF227 Gene

Genomic Locations for ZNF227 Gene
29,722 bases
Plus strand
29,722 bases
Plus strand

Genomic View for ZNF227 Gene

Genes around ZNF227 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF227 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF227 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF227 Gene

Proteins for ZNF227 Gene

  • Protein details for ZNF227 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 227
    Protein Accession:
    Secondary Accessions:
    • B3KRU7
    • B7Z5P9

    Protein attributes for ZNF227 Gene

    799 amino acids
    Molecular mass:
    92033 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF227 Gene


neXtProt entry for ZNF227 Gene

Post-translational modifications for ZNF227 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF227 Gene

Domains & Families for ZNF227 Gene

Gene Families for ZNF227 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF227 Gene

Suggested Antigen Peptide Sequences for ZNF227 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF227: view

Function for ZNF227 Gene

Molecular function for ZNF227 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF227 Gene

Gene Ontology (GO) - Molecular Function for ZNF227 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF227: view
genes like me logo Genes that share phenotypes with ZNF227: view

Animal Model Products

miRNA for ZNF227 Gene

miRTarBase miRNAs that target ZNF227

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF227 Gene

Localization for ZNF227 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF227 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF227 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF227 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF227: view

Pathways & Interactions for ZNF227 Gene

SuperPathways for ZNF227 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF227: view

Pathways by source for ZNF227 Gene

2 Reactome pathways for ZNF227 Gene

Gene Ontology (GO) - Biological Process for ZNF227 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF227: view

No data available for SIGNOR curated interactions for ZNF227 Gene

Drugs & Compounds for ZNF227 Gene

No Compound Related Data Available

Transcripts for ZNF227 Gene

Unigene Clusters for ZNF227 Gene

Zinc finger protein 227:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF227 Gene

No ASD Table

Relevant External Links for ZNF227 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF227 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF227 Gene

Protein differential expression in normal tissues from HIPED for ZNF227 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF227 Gene

Protein tissue co-expression partners for ZNF227 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF227 Gene:


SOURCE GeneReport for Unigene cluster for ZNF227 Gene:

genes like me logo Genes that share expression patterns with ZNF227: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF227 Gene

Orthologs for ZNF227 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF227 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF227 34 33
  • 99.58 (n)
(Canis familiaris)
Mammalia ZNF227 33
  • 88.12 (n)
(Bos Taurus)
Mammalia ZNF227 33
  • 80.62 (n)
Species where no ortholog for ZNF227 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF227 Gene

Gene Tree for ZNF227 (if available)
Gene Tree for ZNF227 (if available)
Evolutionary constrained regions (ECRs) for ZNF227: view image

Paralogs for ZNF227 Gene

(525) SIMAP similar genes for ZNF227 Gene using alignment to 9 proteins:

  • ZN227_HUMAN
  • B7Z5P9_HUMAN
  • K7EJ92_HUMAN
  • Q658S5_HUMAN
  • Q86WM4_HUMAN
genes like me logo Genes that share paralogs with ZNF227: view

Variants for ZNF227 Gene

Sequence variations from dbSNP and Humsavar for ZNF227 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000013953 -- 44,215,026(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000079394 -- 44,207,600(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000159028 -- 44,210,429(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000456674 -- 44,216,086(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000591925 -- 44,208,063(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF227 Gene

Variant ID Type Subtype PubMed ID
esv3387904 CNV duplication 20981092
nsv2505 CNV insertion 18451855

Variation tolerance for ZNF227 Gene

Residual Variation Intolerance Score: 16.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF227 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF227 Gene

Disorders for ZNF227 Gene

Additional Disease Information for ZNF227

No disorders were found for ZNF227 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF227 Gene

Publications for ZNF227 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A … Wanker EE (Science signaling 2011) 3 58

Products for ZNF227 Gene

Sources for ZNF227 Gene

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