Aliases for ZNF227 Gene

Aliases for ZNF227 Gene

  • Zinc Finger Protein 227 2 3 4 5
  • ZNF227 5

External Ids for ZNF227 Gene

Previous GeneCards Identifiers for ZNF227 Gene

  • GC00U990433
  • GC19U900047
  • GC19P049408
  • GC19P044718
  • GC19P041148

Summaries for ZNF227 Gene

GeneCards Summary for ZNF227 Gene

ZNF227 (Zinc Finger Protein 227) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF235.

UniProtKB/Swiss-Prot Summary for ZNF227 Gene

Additional gene information for ZNF227 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF227 Gene

Genomics for ZNF227 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF227 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF227 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF227

Top Transcription factor binding sites by QIAGEN in the ZNF227 gene promoter:
  • STAT1
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for ZNF227 Gene

Genomic Locations for ZNF227 Gene
chr19:44,207,522-44,237,268
(GRCh38/hg38)
Size:
29,747 bases
Orientation:
Plus strand
chr19:44,711,700-44,741,421
(GRCh37/hg19)
Size:
29,722 bases
Orientation:
Plus strand

Genomic View for ZNF227 Gene

Genes around ZNF227 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF227 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF227 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF227 Gene

Proteins for ZNF227 Gene

  • Protein details for ZNF227 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WZ6-ZN227_HUMAN
    Recommended name:
    Zinc finger protein 227
    Protein Accession:
    Q86WZ6
    Secondary Accessions:
    • B3KRU7
    • B7Z5P9

    Protein attributes for ZNF227 Gene

    Size:
    799 amino acids
    Molecular mass:
    92033 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF227 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF227 Gene

Post-translational modifications for ZNF227 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF227 Gene

Domains & Families for ZNF227 Gene

Gene Families for ZNF227 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF227 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF227 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ78947, highly similar to Zinc finger protein 227 (B7Z5P9_HUMAN)
  • Zinc finger protein ZNF227 (Q86WM4_HUMAN)
  • Zinc finger protein 227 (ZN227_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86WZ6

UniProtKB/Swiss-Prot:

ZN227_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF227: view

Function for ZNF227 Gene

Molecular function for ZNF227 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF227 Gene

Gene Ontology (GO) - Molecular Function for ZNF227 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF227: view
genes like me logo Genes that share phenotypes with ZNF227: view

Animal Model Products

CRISPR Products

miRNA for ZNF227 Gene

miRTarBase miRNAs that target ZNF227

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF227

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF227 Gene

Localization for ZNF227 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF227 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF227 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF227 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF227: view

Pathways & Interactions for ZNF227 Gene

genes like me logo Genes that share pathways with ZNF227: view

Pathways by source for ZNF227 Gene

2 Reactome pathways for ZNF227 Gene
1 KEGG pathway for ZNF227 Gene

Gene Ontology (GO) - Biological Process for ZNF227 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF227: view

No data available for SIGNOR curated interactions for ZNF227 Gene

Drugs & Compounds for ZNF227 Gene

No Compound Related Data Available

Transcripts for ZNF227 Gene

mRNA/cDNA for ZNF227 Gene

9 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF227

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF227 Gene

No ASD Table

Relevant External Links for ZNF227 Gene

GeneLoc Exon Structure for
ZNF227

Expression for ZNF227 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF227 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Thymus (Hematopoietic System)

Protein differential expression in normal tissues from HIPED for ZNF227 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF227 Gene



Protein tissue co-expression partners for ZNF227 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF227

SOURCE GeneReport for Unigene cluster for ZNF227 Gene:

Hs.298089
genes like me logo Genes that share expression patterns with ZNF227: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF227 Gene

Orthologs for ZNF227 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF227 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF227 30 31
  • 99.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF227 30
  • 88.12 (n)
Cow
(Bos Taurus)
Mammalia ZNF227 30
  • 80.62 (n)
Species where no ortholog for ZNF227 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF227 Gene

ENSEMBL:
Gene Tree for ZNF227 (if available)
TreeFam:
Gene Tree for ZNF227 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF227: view image

Paralogs for ZNF227 Gene

Paralogs for ZNF227 Gene

(525) SIMAP similar genes for ZNF227 Gene using alignment to 9 proteins:

  • ZN227_HUMAN
  • B7Z5P9_HUMAN
  • K7EIL7_HUMAN
  • K7EIR9_HUMAN
  • K7EJ92_HUMAN
  • K7ELS1_HUMAN
  • K7EPR2_HUMAN
  • Q658S5_HUMAN
  • Q86WM4_HUMAN
genes like me logo Genes that share paralogs with ZNF227: view

Variants for ZNF227 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF227 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1555794654 Not Provided: not provided 44,236,663(+) A/T NONSENSE

Additional dbSNP identifiers (rs#s) for ZNF227 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF227 Gene

Variant ID Type Subtype PubMed ID
esv3387904 CNV duplication 20981092
nsv2505 CNV insertion 18451855

Variation tolerance for ZNF227 Gene

Residual Variation Intolerance Score: 16.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF227 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF227

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF227 Gene

Disorders for ZNF227 Gene

No disorders were found for ZNF227 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF227 Gene

Publications for ZNF227 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3

Products for ZNF227 Gene

Sources for ZNF227 Gene