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Aliases for ZNF226 Gene

Aliases for ZNF226 Gene

  • Zinc Finger Protein 226 2 3 5

External Ids for ZNF226 Gene

Previous GeneCards Identifiers for ZNF226 Gene

  • GC19P045314
  • GC19P045060
  • GC19P049345
  • GC19P049361
  • GC19P049355
  • GC19P044669
  • GC19P041101
  • GC19P044647

Summaries for ZNF226 Gene

GeneCards Summary for ZNF226 Gene

ZNF226 (Zinc Finger Protein 226) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF234.

UniProtKB/Swiss-Prot for ZNF226 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF226 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF226 Gene

Genomics for ZNF226 Gene

GeneHancer (GH) Regulatory Elements for ZNF226 Gene

Promoters and enhancers for ZNF226 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I044164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 620 +0.2 188 1.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF226 ZNF45 ZNF180 ZNF225 ZNF155 ZNF224 ZNF227 ZNF284 ZNF234 ZNF112
GH19I044168 Promoter 0.7 EPDnew 550.8 +4.0 3951 0.1 ZNF362 ZNF530 ZNF226 ZNF284 ZNF155 ZNF180 ZNF45 ZNF224 ZNF225 ZNF227
GH19I043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 100.3 -385.2 -385160 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF224 ZNF284 ZNF227 ZNF283 ZNF223 ZNF576
GH19I044111 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 76.6 -52.1 -52061 2.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF225 LOC100379224 ZNF45 ZNF180 ZNF227 ZNF283 ZNF576 ZNF112 ZNF224 ZNF226
GH19I044206 Promoter/Enhancer 1.6 Ensembl ENCODE 102.8 +42.7 42672 1.7 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF302 ZNF227 ZNF45 ZNF180 ZNF225 ZNF224 ZNF283 ZNF223 ZNF226 ZNF235 ZNF112
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF226 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF226 Gene

Genomic Locations for ZNF226 Gene
13,320 bases
Plus strand

Genomic View for ZNF226 Gene

Genes around ZNF226 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF226 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF226 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF226 Gene

Proteins for ZNF226 Gene

  • Protein details for ZNF226 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 226
    Protein Accession:
    Secondary Accessions:
    • Q8WWE6
    • Q96TE6
    • Q9NS44

    Protein attributes for ZNF226 Gene

    803 amino acids
    Molecular mass:
    91921 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF226 Gene


neXtProt entry for ZNF226 Gene

Post-translational modifications for ZNF226 Gene

  • Ubiquitination at isoforms=253
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF226 Gene

Domains & Families for ZNF226 Gene

Gene Families for ZNF226 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF226 Gene

Suggested Antigen Peptide Sequences for ZNF226 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF226: view

Function for ZNF226 Gene

Molecular function for ZNF226 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF226 Gene

Gene Ontology (GO) - Molecular Function for ZNF226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF226: view
genes like me logo Genes that share phenotypes with ZNF226: view

Animal Models for ZNF226 Gene

MGI Knock Outs for ZNF226:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF226 Gene

Localization for ZNF226 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF226 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF226 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF226: view

Pathways & Interactions for ZNF226 Gene

SuperPathways for ZNF226 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF226: view

Pathways by source for ZNF226 Gene

2 Reactome pathways for ZNF226 Gene

Gene Ontology (GO) - Biological Process for ZNF226 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF226: view

No data available for SIGNOR curated interactions for ZNF226 Gene

Drugs & Compounds for ZNF226 Gene

No Compound Related Data Available

Transcripts for ZNF226 Gene

Unigene Clusters for ZNF226 Gene

Zinc finger protein 226:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF226 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: -
SP8: - - - - - -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - -

Relevant External Links for ZNF226 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF226 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF226 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF226 Gene:


SOURCE GeneReport for Unigene cluster for ZNF226 Gene:


Evidence on tissue expression from TISSUES for ZNF226 Gene

  • Lung(4.2)
  • Muscle(4.2)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ZNF226: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF226 Gene

Orthologs for ZNF226 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF226 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF226 33 34
  • 99.42 (n)
(Canis familiaris)
Mammalia ZNF226 33
  • 86.16 (n)
-- 34
  • 67 (a)
(Mus musculus)
Mammalia Zfp111 33 16
  • 64.07 (n)
Zfp61 34
  • 57 (a)
(Rattus norvegicus)
Mammalia Zfp111 33
  • 62.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5245 33
  • 47.77 (n)
Species where no ortholog for ZNF226 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF226 Gene

Gene Tree for ZNF226 (if available)
Gene Tree for ZNF226 (if available)

Paralogs for ZNF226 Gene

genes like me logo Genes that share paralogs with ZNF226: view

Variants for ZNF226 Gene

Sequence variations from dbSNP and Humsavar for ZNF226 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000012879 -- 44,166,959(+) C/A/T intron_variant
rs1000031956 -- 44,175,687(+) TTT/TT coding_sequence_variant, downstream_transcript_variant, frameshift, genic_downstream_transcript_variant
rs1000082345 -- 44,175,468(+) A/AAAAAAAAAAA 5_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000113218 -- 44,163,870(+) A/G upstream_transcript_variant
rs1000198165 -- 44,167,068(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF226 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV gain 17160897

Variation tolerance for ZNF226 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF226 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF226 Gene

Disorders for ZNF226 Gene

Additional Disease Information for ZNF226

No disorders were found for ZNF226 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF226 Gene

Publications for ZNF226 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4 58
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 58

Products for ZNF226 Gene

Sources for ZNF226 Gene

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