Aliases for ZNF225 Gene

Aliases for ZNF225 Gene

  • Zinc Finger Protein 225 2 3 4 5
  • ZNF225 5

External Ids for ZNF225 Gene

Previous GeneCards Identifiers for ZNF225 Gene

  • GC19P045263
  • GC19P045009
  • GC19P049293
  • GC19P049309
  • GC19P044269
  • GC19P044617

Summaries for ZNF225 Gene

GeneCards Summary for ZNF225 Gene

ZNF225 (Zinc Finger Protein 225) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF224.

UniProtKB/Swiss-Prot Summary for ZNF225 Gene

Gene Wiki entry for ZNF225 Gene

Additional gene information for ZNF225 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF225 Gene

Genomics for ZNF225 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF225 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF225 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF225

Genomic Locations for ZNF225 Gene

Genomic Locations for ZNF225 Gene
chr19:44,111,426-44,134,822
(GRCh38/hg38)
Size:
23,397 bases
Orientation:
Plus strand
chr19:44,616,334-44,637,255
(GRCh37/hg19)
Size:
20,922 bases
Orientation:
Plus strand

Genomic View for ZNF225 Gene

Genes around ZNF225 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF225 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF225 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF225 Gene

Proteins for ZNF225 Gene

  • Protein details for ZNF225 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK10-ZN225_HUMAN
    Recommended name:
    Zinc finger protein 225
    Protein Accession:
    Q9UK10
    Secondary Accessions:
    • A8K8S2
    • Q53F12
    • Q9NS46
    • Q9UID8

    Protein attributes for ZNF225 Gene

    Size:
    706 amino acids
    Molecular mass:
    82471 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF225 Gene

Post-translational modifications for ZNF225 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF225 Gene

Domains & Families for ZNF225 Gene

Gene Families for ZNF225 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF225 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF225 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 225 (ZN225_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UK10

UniProtKB/Swiss-Prot:

ZN225_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF225: view

Function for ZNF225 Gene

Molecular function for ZNF225 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF225 Gene

Gene Ontology (GO) - Molecular Function for ZNF225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF225: view
genes like me logo Genes that share phenotypes with ZNF225: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF225

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF225 Gene

Localization for ZNF225 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF225 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF225 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF225: view

Pathways & Interactions for ZNF225 Gene

genes like me logo Genes that share pathways with ZNF225: view

Pathways by source for ZNF225 Gene

2 Reactome pathways for ZNF225 Gene
1 KEGG pathway for ZNF225 Gene

Interacting Proteins for ZNF225 Gene

Gene Ontology (GO) - Biological Process for ZNF225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF225: view

No data available for SIGNOR curated interactions for ZNF225 Gene

Drugs & Compounds for ZNF225 Gene

No Compound Related Data Available

Transcripts for ZNF225 Gene

mRNA/cDNA for ZNF225 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF225

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF225 Gene

No ASD Table

Relevant External Links for ZNF225 Gene

GeneLoc Exon Structure for
ZNF225

Expression for ZNF225 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF225 Gene

Protein differential expression in normal tissues from HIPED for ZNF225 Gene

This gene is overexpressed in NK cells (32.9) and Monocytes (30.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF225 Gene



Protein tissue co-expression partners for ZNF225 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF225

SOURCE GeneReport for Unigene cluster for ZNF225 Gene:

Hs.279567
genes like me logo Genes that share expression patterns with ZNF225: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF225 Gene

Orthologs for ZNF225 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF225 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF225 30 31
  • 99.48 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Kr 32
  • 48 (a)
CG17568 32
  • 35 (a)
EG:95B7.7 32
  • 33 (a)
CG10669 32
  • 28 (a)
Species where no ortholog for ZNF225 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF225 Gene

ENSEMBL:
Gene Tree for ZNF225 (if available)
TreeFam:
Gene Tree for ZNF225 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF225: view image

Paralogs for ZNF225 Gene

Paralogs for ZNF225 Gene

(471) SIMAP similar genes for ZNF225 Gene using alignment to 4 proteins:

  • ZN225_HUMAN
  • K7ENA2_HUMAN
  • K7ENC8_HUMAN
  • K7ERU6_HUMAN
genes like me logo Genes that share paralogs with ZNF225: view

Variants for ZNF225 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF225 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs16978738 - p.Thr679Ser
rs34863330 - p.Gln50Arg

Additional dbSNP identifiers (rs#s) for ZNF225 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF225 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV gain 17160897
nsv963059 CNV duplication 23825009

Variation tolerance for ZNF225 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF225 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF225

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF225 Gene

Disorders for ZNF225 Gene

No disorders were found for ZNF225 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF225 Gene

Publications for ZNF225 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  5. USP45 and Spindly are part of the same complex implicated in cell migration. (PMID: 30258100) Conte C … Perez-Oliva AB (Scientific reports 2018) 3

Products for ZNF225 Gene

Sources for ZNF225 Gene