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Aliases for ZNF225 Gene

Aliases for ZNF225 Gene

  • Zinc Finger Protein 225 2 3 5

External Ids for ZNF225 Gene

Previous GeneCards Identifiers for ZNF225 Gene

  • GC19P045263
  • GC19P045009
  • GC19P049293
  • GC19P049309
  • GC19P044269
  • GC19P044617

Summaries for ZNF225 Gene

GeneCards Summary for ZNF225 Gene

ZNF225 (Zinc Finger Protein 225) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF224.

UniProtKB/Swiss-Prot for ZNF225 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF225 Gene

Additional gene information for ZNF225 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF225 Gene

Genomics for ZNF225 Gene

GeneHancer (GH) Regulatory Elements for ZNF225 Gene

Promoters and enhancers for ZNF225 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I044111 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 686.9 +0.9 925 2.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF225 LOC100379224 ZNF45 ZNF180 ZNF227 ZNF283 ZNF576 ZNF112 ZNF224 ZNF226
GH19I043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 207.1 -332.2 -332174 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF224 ZNF284 ZNF227 ZNF283 ZNF223 ZNF576
GH19I044164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 169.4 +53.2 53174 1.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF226 ZNF45 ZNF180 ZNF225 ZNF155 ZNF224 ZNF227 ZNF284 ZNF234 ZNF112
GH19I043901 Promoter/Enhancer 1.5 Ensembl ENCODE 199.5 -210.3 -210275 1.6 ARID4B ZNF2 YY1 ZNF766 ZNF302 ZNF416 ZNF143 ZNF548 KLF13 SP3 ZNF404 LOC100505715 ENSG00000267191 ZNF45 ZNF180 ZNF225 ZNF224 ZNF227 ZNF284 ZNF234
GH19I044206 Promoter/Enhancer 1.6 Ensembl ENCODE 182.6 +95.7 95658 1.7 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF302 ZNF227 ZNF45 ZNF180 ZNF225 ZNF224 ZNF283 ZNF223 ZNF226 ZNF235 ZNF112
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF225 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF225 Gene

Genomic Locations for ZNF225 Gene
22,741 bases
Plus strand

Genomic View for ZNF225 Gene

Genes around ZNF225 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF225 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF225 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF225 Gene

Proteins for ZNF225 Gene

  • Protein details for ZNF225 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 225
    Protein Accession:
    Secondary Accessions:
    • A8K8S2
    • Q53F12
    • Q9NS46
    • Q9UID8

    Protein attributes for ZNF225 Gene

    706 amino acids
    Molecular mass:
    82471 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF225 Gene

Post-translational modifications for ZNF225 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF225 Gene

Domains & Families for ZNF225 Gene

Gene Families for ZNF225 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF225 Gene

Suggested Antigen Peptide Sequences for ZNF225 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF225: view

Function for ZNF225 Gene

Molecular function for ZNF225 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF225 Gene

Gene Ontology (GO) - Molecular Function for ZNF225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF225: view
genes like me logo Genes that share phenotypes with ZNF225: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF225 Gene

Localization for ZNF225 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF225 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF225 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF225: view

Pathways & Interactions for ZNF225 Gene

SuperPathways for ZNF225 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF225: view

Pathways by source for ZNF225 Gene

2 Reactome pathways for ZNF225 Gene

Interacting Proteins for ZNF225 Gene

Gene Ontology (GO) - Biological Process for ZNF225 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF225: view

No data available for SIGNOR curated interactions for ZNF225 Gene

Drugs & Compounds for ZNF225 Gene

No Compound Related Data Available

Transcripts for ZNF225 Gene

Unigene Clusters for ZNF225 Gene

Zinc finger protein 225:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF225 Gene

No ASD Table

Relevant External Links for ZNF225 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF225 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF225 Gene

Protein differential expression in normal tissues from HIPED for ZNF225 Gene

This gene is overexpressed in NK cells (32.9) and Monocytes (30.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF225 Gene

Protein tissue co-expression partners for ZNF225 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF225 Gene:


SOURCE GeneReport for Unigene cluster for ZNF225 Gene:

genes like me logo Genes that share expression patterns with ZNF225: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF225 Gene

Orthologs for ZNF225 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF225 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF225 33 34
  • 99.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta Kr 35
  • 48 (a)
CG17568 35
  • 35 (a)
EG:95B7.7 35
  • 33 (a)
CG10669 35
  • 28 (a)
Species where no ortholog for ZNF225 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF225 Gene

Gene Tree for ZNF225 (if available)
Gene Tree for ZNF225 (if available)

Paralogs for ZNF225 Gene

(471) SIMAP similar genes for ZNF225 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF225: view

Variants for ZNF225 Gene

Sequence variations from dbSNP and Humsavar for ZNF225 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000207677 -- 44,116,618(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000287461 -- 44,132,359(+) G/A coding_sequence_variant, missense_variant
rs1000318100 -- 44,115,598(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000559090 -- 44,121,071(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000639168 -- 44,113,805(+) TTCTTT/TT genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF225 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV gain 17160897
nsv963059 CNV duplication 23825009

Variation tolerance for ZNF225 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF225 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF225 Gene

Disorders for ZNF225 Gene

Additional Disease Information for ZNF225

No disorders were found for ZNF225 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF225 Gene

Publications for ZNF225 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF225 Gene

Sources for ZNF225 Gene

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