Aliases for ZNF224 Gene
External Ids for ZNF224 Gene
Previous HGNC Symbols for ZNF224 Gene
Previous GeneCards Identifiers for ZNF224 Gene
This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016]
GeneCards Summary for ZNF224 Gene
ZNF224 (Zinc Finger Protein 224) is a Protein Coding gene. Diseases associated with ZNF224 include Wilms Tumor 1. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF225.
UniProtKB/Swiss-Prot for ZNF224 Gene
May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.