This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016] See more...

Aliases for ZNF224 Gene

Aliases for ZNF224 Gene

  • Zinc Finger Protein 224 2 3 4 5
  • Zinc Finger Protein 255 2 3 4
  • Zinc Finger Protein 27 2 3 4
  • Bone Marrow Zinc Finger 2 3 4
  • Zinc Finger Protein KOX22 3 4
  • Zinc Finger Protein 233 3 4
  • ZNF255 3 4
  • BMZF-2 3 4
  • ZNF233 3 4
  • ZNF27 3 4
  • BMZF2 3 4
  • KOX22 3 4

External Ids for ZNF224 Gene

Previous HGNC Symbols for ZNF224 Gene

  • ZNF255
  • ZNF27

Previous GeneCards Identifiers for ZNF224 Gene

  • GC19P045244
  • GC19P044990
  • GC19P049232
  • GC19P049290
  • GC19P049182
  • GC19P049278
  • GC19P044598
  • GC19P041030

Summaries for ZNF224 Gene

Entrez Gene Summary for ZNF224 Gene

  • This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016]

GeneCards Summary for ZNF224 Gene

ZNF224 (Zinc Finger Protein 224) is a Protein Coding gene. Diseases associated with ZNF224 include Wilms Tumor 1. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF225.

UniProtKB/Swiss-Prot Summary for ZNF224 Gene

  • May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

Gene Wiki entry for ZNF224 Gene

Additional gene information for ZNF224 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF224 Gene

Genomics for ZNF224 Gene

GeneHancer (GH) Regulatory Elements for ZNF224 Gene

Promoters and enhancers for ZNF224 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF224 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF224

Top Transcription factor binding sites by QIAGEN in the ZNF224 gene promoter:
  • C/EBPalpha

Genomic Locations for ZNF224 Gene

Genomic Locations for ZNF224 Gene
chr19:44,094,329-44,109,886
(GRCh38/hg38)
Size:
15,558 bases
Orientation:
Plus strand
chr19:44,598,482-44,612,479
(GRCh37/hg19)
Size:
13,998 bases
Orientation:
Plus strand

Genomic View for ZNF224 Gene

Genes around ZNF224 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF224 Gene

Proteins for ZNF224 Gene

  • Protein details for ZNF224 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZL3-ZN224_HUMAN
    Recommended name:
    Zinc finger protein 224
    Protein Accession:
    Q9NZL3
    Secondary Accessions:
    • A6NFW9
    • P17033
    • Q86V10
    • Q8IZC8
    • Q9UID9
    • Q9Y2P6

    Protein attributes for ZNF224 Gene

    Size:
    707 amino acids
    Molecular mass:
    82280 Da
    Quaternary structure:
    • Interacts with WT1. Interacts with DEPDC1A.

    Three dimensional structures from OCA and Proteopedia for ZNF224 Gene

neXtProt entry for ZNF224 Gene

Post-translational modifications for ZNF224 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF224 Gene

No data available for DME Specific Peptides for ZNF224 Gene

Domains & Families for ZNF224 Gene

Gene Families for ZNF224 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF224 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF224 Gene

GenScript: Design optimal peptide antigens:
  • ZNF224 protein (Q9BU51_HUMAN)
  • ZNF224 [amino acids 1-78] (Q9HCA8_HUMAN)
  • Zinc finger protein KOX22 (ZN224_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NZL3

UniProtKB/Swiss-Prot:

ZN224_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF224: view

Function for ZNF224 Gene

Molecular function for ZNF224 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

Phenotypes From GWAS Catalog for ZNF224 Gene

Gene Ontology (GO) - Molecular Function for ZNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 12527367
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 20587513
GO:0043565 sequence-specific DNA binding IDA 12527367
genes like me logo Genes that share ontologies with ZNF224: view
genes like me logo Genes that share phenotypes with ZNF224: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF224 Gene

Localization for ZNF224 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF224 Gene

Nucleus. Note=Colocalizes with DEPDC1A at the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF224 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 20587513
GO:0005654 nucleoplasm IDA --
GO:0017053 transcriptional repressor complex IDA 20587513
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with ZNF224: view

Pathways & Interactions for ZNF224 Gene

genes like me logo Genes that share pathways with ZNF224: view

Pathways by source for ZNF224 Gene

2 Reactome pathways for ZNF224 Gene
1 KEGG pathway for ZNF224 Gene

SIGNOR curated interactions for ZNF224 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for ZNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 12527367
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 20587513
genes like me logo Genes that share ontologies with ZNF224: view

Drugs & Compounds for ZNF224 Gene

(1) Drugs for ZNF224 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2822
genes like me logo Genes that share compounds with ZNF224: view

Transcripts for ZNF224 Gene

mRNA/cDNA for ZNF224 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF224 Gene

No ASD Table

Relevant External Links for ZNF224 Gene

GeneLoc Exon Structure for
ZNF224

Expression for ZNF224 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF224 Gene

Protein differential expression in normal tissues from HIPED for ZNF224 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF224 Gene



Protein tissue co-expression partners for ZNF224 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF224

SOURCE GeneReport for Unigene cluster for ZNF224 Gene:

Hs.585869

mRNA Expression by UniProt/SwissProt for ZNF224 Gene:

Q9NZL3-ZN224_HUMAN
Tissue specificity: Ubiquitous. Mainly expressed in fetal tissues.

Evidence on tissue expression from TISSUES for ZNF224 Gene

  • Bone marrow(4)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with ZNF224: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF224 Gene

Orthologs for ZNF224 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF224 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF224 31 30
  • 99.58 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:95B7.7 32
  • 34 (a)
Species where no ortholog for ZNF224 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF224 Gene

ENSEMBL:
Gene Tree for ZNF224 (if available)
TreeFam:
Gene Tree for ZNF224 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF224: view image

Paralogs for ZNF224 Gene

Paralogs for ZNF224 Gene

(535) SIMAP similar genes for ZNF224 Gene using alignment to 6 proteins:

  • ZN224_HUMAN
  • K7EJ30_HUMAN
  • K7EL24_HUMAN
  • K7ENI7_HUMAN
  • Q9BU51_HUMAN
  • Q9HCA8_HUMAN
genes like me logo Genes that share paralogs with ZNF224: view

Variants for ZNF224 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF224 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
708001 Benign: not provided 44,106,817(+) G/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
724433 Benign: not provided 44,108,083(+) G/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
769017 Benign: not provided 44,107,744(+) T/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
769018 Benign: not provided 44,108,260(+) T/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
777498 Benign: not provided 44,100,937(+) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF224 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF224 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV gain 17160897
nsv978828 CNV duplication 23825009

Variation tolerance for ZNF224 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.88; 67.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF224 Gene

Human Gene Mutation Database (HGMD)
ZNF224
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF224

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF224 Gene

Disorders for ZNF224 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF224 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
wilms tumor 1
  • wt1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF224

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF224: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF224 Gene

Publications for ZNF224 Gene

  1. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W … Huang Z (Cellular and molecular life sciences : CMLS 2013) 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. (PMID: 20574532) Shulman JM … De Jager PL (PloS one 2010) 3 41 54
  4. Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells. (PMID: 20587513) Harada Y … Katagiri T (Cancer research 2010) 3 4 54
  5. Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. (PMID: 19118814) Beecham GW … Pericak-Vance MA (American journal of human genetics 2009) 3 41 54

Products for ZNF224 Gene