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Aliases for ZNF223 Gene

Aliases for ZNF223 Gene

  • Zinc Finger Protein 223 2 3 3 5
  • Homo Sapiens Zinc Finger Protein 223 3
  • KRAB A Domain 3

External Ids for ZNF223 Gene

Previous GeneCards Identifiers for ZNF223 Gene

  • GC19U990143
  • GC19P044940
  • GC19P049224
  • GC19P049240
  • GC19P049248
  • GC19P044556
  • GC19P040988
  • GC19P044555

Summaries for ZNF223 Gene

Entrez Gene Summary for ZNF223 Gene

  • This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. The function of this protein has yet to be determined. [provided by RefSeq, Mar 2014]

GeneCards Summary for ZNF223 Gene

ZNF223 (Zinc Finger Protein 223) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000267022.

UniProtKB/Swiss-Prot for ZNF223 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF223 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF223 Gene

Genomics for ZNF223 Gene

GeneHancer (GH) Regulatory Elements for ZNF223 Gene

Promoters and enhancers for ZNF223 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J044050 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 684.8 +0.7 692 3.4 PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B SIN3A ZNF2 YY1 CBX5 ZNF213 ZNF223 ZNF45 ZNF180 ZNF225 ZNF155 ZNF284 MRPS15P2 ZNF224 SRRM5 ZNF283
GH19J043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 130.5 -271.5 -271465 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF284 ZNF224 ZNF227 ZNF223 ZNF235 ZNF283
GH19J044206 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 95.1 +156.4 156367 1.7 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 ZNF213 E2F8 ZNF227 ZNF45 ZNF180 ZNF225 ZNF224 ZNF284 ZNF223 ZNF226 ZNF235 ZNF234
GH19J043901 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 78.9 -149.6 -149566 1.6 ARID4B ZNF2 YY1 ZNF766 ZNF416 ZNF143 ZNF548 KLF13 SP3 MXD4 ZNF221 ZNF404 LOC100505715 ENSG00000267191 ZNF45 ZNF180 ZNF225 ZNF224 ZNF227 ZNF284
GH19J044111 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 62 +61.6 61634 2.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF225 LOC100379224 ZNF45 ZNF180 ZNF227 ZNF283 ZNF576 ZNF224 ZNF226 ZNF223
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF223 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF223 gene promoter:
  • NCX

Genomic Locations for ZNF223 Gene

Genomic Locations for ZNF223 Gene
16,628 bases
Plus strand
16,625 bases
Plus strand

Genomic View for ZNF223 Gene

Genes around ZNF223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF223 Gene

Proteins for ZNF223 Gene

  • Protein details for ZNF223 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 223
    Protein Accession:
    Secondary Accessions:
    • Q15736
    • Q8TBJ3
    • Q9HCA9

    Protein attributes for ZNF223 Gene

    482 amino acids
    Molecular mass:
    55763 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB03531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF223 Gene

Post-translational modifications for ZNF223 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF223 Gene

No data available for DME Specific Peptides for ZNF223 Gene

Domains & Families for ZNF223 Gene

Gene Families for ZNF223 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF223 Gene

Suggested Antigen Peptide Sequences for ZNF223 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF223: view

Function for ZNF223 Gene

Molecular function for ZNF223 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF223 Gene

Gene Ontology (GO) - Molecular Function for ZNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10449920
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF223: view
genes like me logo Genes that share phenotypes with ZNF223: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF223 Gene

Localization for ZNF223 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF223 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF223 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF223: view

Pathways & Interactions for ZNF223 Gene

SuperPathways for ZNF223 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF223: view

Pathways by source for ZNF223 Gene

2 Reactome pathways for ZNF223 Gene

Gene Ontology (GO) - Biological Process for ZNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF223: view

No data available for SIGNOR curated interactions for ZNF223 Gene

Drugs & Compounds for ZNF223 Gene

No Compound Related Data Available

Transcripts for ZNF223 Gene

mRNA/cDNA for ZNF223 Gene

Unigene Clusters for ZNF223 Gene

Zinc finger protein 223:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF223 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: -
SP4: - - - -

Relevant External Links for ZNF223 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF223 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF223 Gene

Protein differential expression in normal tissues from HIPED for ZNF223 Gene

This gene is overexpressed in Heart (34.7) and Monocytes (34.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF223 Gene

Protein tissue co-expression partners for ZNF223 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF223 Gene:


SOURCE GeneReport for Unigene cluster for ZNF223 Gene:


Evidence on tissue expression from TISSUES for ZNF223 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF223: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF223 Gene

Orthologs for ZNF223 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF223 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF223 33
  • 99.37 (n)
-- 34
  • 99 (a)
Species where no ortholog for ZNF223 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF223 Gene

Gene Tree for ZNF223 (if available)
Gene Tree for ZNF223 (if available)

Paralogs for ZNF223 Gene

(511) SIMAP similar genes for ZNF223 Gene using alignment to 5 proteins:

  • ZN223_HUMAN
  • K7EQ32_HUMAN
  • K7ER65_HUMAN
genes like me logo Genes that share paralogs with ZNF223: view

Variants for ZNF223 Gene

Sequence variations from dbSNP and Humsavar for ZNF223 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000182776 -- 44,054,388(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000386562 -- 44,064,466(+) A/G intron_variant
rs1000676684 -- 44,064,343(+) A/G intron_variant
rs1000687877 -- 44,051,628(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001011218 -- 44,051,926(+) CC/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF223 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV gain 17160897
nsv963058 CNV duplication 23825009

Variation tolerance for ZNF223 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF223 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF223 Gene

Disorders for ZNF223 Gene

Additional Disease Information for ZNF223

No disorders were found for ZNF223 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF223 Gene

Publications for ZNF223 Gene

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4 58
  2. Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7. (PMID: 8617494) Shannon M … Stubbs L (Genomics 1996) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 58

Products for ZNF223 Gene

Sources for ZNF223 Gene

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