This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. The function of this protein has yet to be determined. [provided by RefSeq, Mar 2014] See more...

Aliases for ZNF223 Gene

Aliases for ZNF223 Gene

  • Zinc Finger Protein 223 2 3 4 5
  • Homo Sapiens Zinc Finger Protein 223 3
  • KRAB A Domain 3
  • ZNF223 5

External Ids for ZNF223 Gene

Previous GeneCards Identifiers for ZNF223 Gene

  • GC19U990143
  • GC19P044940
  • GC19P049224
  • GC19P049240
  • GC19P049248
  • GC19P044556
  • GC19P040988
  • GC19P044555

Summaries for ZNF223 Gene

Entrez Gene Summary for ZNF223 Gene

  • This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. The function of this protein has yet to be determined. [provided by RefSeq, Mar 2014]

GeneCards Summary for ZNF223 Gene

ZNF223 (Zinc Finger Protein 223) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000267022.

UniProtKB/Swiss-Prot Summary for ZNF223 Gene

Additional gene information for ZNF223 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF223 Gene

Genomics for ZNF223 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF223 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF223 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF223

Top Transcription factor binding sites by QIAGEN in the ZNF223 gene promoter:
  • NCX

Genomic Locations for ZNF223 Gene

Genomic Locations for ZNF223 Gene
chr19:44,051,367-44,069,902
(GRCh38/hg38)
Size:
18,536 bases
Orientation:
Plus strand
chr19:44,555,520-44,572,144
(GRCh37/hg19)
Size:
16,625 bases
Orientation:
Plus strand

Genomic View for ZNF223 Gene

Genes around ZNF223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF223 Gene

Proteins for ZNF223 Gene

  • Protein details for ZNF223 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK11-ZN223_HUMAN
    Recommended name:
    Zinc finger protein 223
    Protein Accession:
    Q9UK11
    Secondary Accessions:
    • Q15736
    • Q8TBJ3
    • Q9HCA9

    Protein attributes for ZNF223 Gene

    Size:
    482 amino acids
    Molecular mass:
    55763 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB03531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ZNF223 Gene

Post-translational modifications for ZNF223 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF223 Gene

No data available for DME Specific Peptides for ZNF223 Gene

Domains & Families for ZNF223 Gene

Gene Families for ZNF223 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF223 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF223 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 223 (ZN223_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UK11

UniProtKB/Swiss-Prot:

ZN223_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF223: view

Function for ZNF223 Gene

Molecular function for ZNF223 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF223 Gene

Gene Ontology (GO) - Molecular Function for ZNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding NAS 10449920
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF223: view
genes like me logo Genes that share phenotypes with ZNF223: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF223

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF223 Gene

Localization for ZNF223 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF223 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF223 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF223: view

Pathways & Interactions for ZNF223 Gene

genes like me logo Genes that share pathways with ZNF223: view

Pathways by source for ZNF223 Gene

2 Reactome pathways for ZNF223 Gene
1 KEGG pathway for ZNF223 Gene

Gene Ontology (GO) - Biological Process for ZNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF223: view

No data available for SIGNOR curated interactions for ZNF223 Gene

Drugs & Compounds for ZNF223 Gene

No Compound Related Data Available

Transcripts for ZNF223 Gene

mRNA/cDNA for ZNF223 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF223

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF223 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: -
SP3:
SP4: - - - -
SP5:

Relevant External Links for ZNF223 Gene

GeneLoc Exon Structure for
ZNF223

Expression for ZNF223 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF223 Gene

Protein differential expression in normal tissues from HIPED for ZNF223 Gene

This gene is overexpressed in Heart (34.7) and Monocytes (34.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF223 Gene



Protein tissue co-expression partners for ZNF223 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF223

SOURCE GeneReport for Unigene cluster for ZNF223 Gene:

Hs.720813

Evidence on tissue expression from TISSUES for ZNF223 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF223: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF223 Gene

Orthologs for ZNF223 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF223 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF223 30
  • 99.37 (n)
-- 31
  • 99 (a)
OneToMany
Species where no ortholog for ZNF223 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF223 Gene

ENSEMBL:
Gene Tree for ZNF223 (if available)
TreeFam:
Gene Tree for ZNF223 (if available)

Paralogs for ZNF223 Gene

(511) SIMAP similar genes for ZNF223 Gene using alignment to 5 proteins:

  • ZN223_HUMAN
  • K7ENM7_HUMAN
  • K7EPW2_HUMAN
  • K7EQ32_HUMAN
  • K7ER65_HUMAN
genes like me logo Genes that share paralogs with ZNF223: view

Variants for ZNF223 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF223 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs4130101 - p.Leu60Ile
rs6509138 - p.Leu138Ile

Additional dbSNP identifiers (rs#s) for ZNF223 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF223 Gene

Variant ID Type Subtype PubMed ID
nsv833840 CNV gain 17160897
nsv963058 CNV duplication 23825009

Variation tolerance for ZNF223 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF223 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF223

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF223 Gene

Disorders for ZNF223 Gene

Additional Disease Information for ZNF223

No disorders were found for ZNF223 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF223 Gene

Publications for ZNF223 Gene

  1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4
  2. Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7. (PMID: 8617494) Shannon M … Stubbs L (Genomics 1996) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ZNF223 Gene

Sources for ZNF223 Gene