Aliases for ZNF222 Gene

Aliases for ZNF222 Gene

  • Zinc Finger Protein 222 2 3 4 5
  • ZNF222 5

External Ids for ZNF222 Gene

Previous GeneCards Identifiers for ZNF222 Gene

  • GC19P045175
  • GC19P044921
  • GC19P049205
  • GC19P049221
  • GC19P044529
  • GC19P040961

Summaries for ZNF222 Gene

GeneCards Summary for ZNF222 Gene

ZNF222 (Zinc Finger Protein 222) is a Protein Coding gene. Diseases associated with ZNF222 include Arteriovenous Malformations Of The Brain and Intracranial Berry Aneurysm. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000267022.

UniProtKB/Swiss-Prot Summary for ZNF222 Gene

Additional gene information for ZNF222 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF222 Gene

Genomics for ZNF222 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF222 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF222 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF222

Genomic Locations for ZNF222 Gene

Genomic Locations for ZNF222 Gene
chr19:44,025,324-44,033,110
(GRCh38/hg38)
Size:
7,787 bases
Orientation:
Plus strand
chr19:44,529,494-44,537,265
(GRCh37/hg19)
Size:
7,772 bases
Orientation:
Plus strand

Genomic View for ZNF222 Gene

Genes around ZNF222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF222 Gene

Proteins for ZNF222 Gene

  • Protein details for ZNF222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK12-ZN222_HUMAN
    Recommended name:
    Zinc finger protein 222
    Protein Accession:
    Q9UK12
    Secondary Accessions:
    • G5E9B9
    • Q8N6G7
    • Q9P1U5

    Protein attributes for ZNF222 Gene

    Size:
    451 amino acids
    Molecular mass:
    52484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30261.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF222 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF222 Gene

Post-translational modifications for ZNF222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF222 Gene

No data available for DME Specific Peptides for ZNF222 Gene

Domains & Families for ZNF222 Gene

Gene Families for ZNF222 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF222 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF222 Gene

GenScript: Design optimal peptide antigens:
  • ZNF222 protein (Q8N6G7_HUMAN)
  • Zinc finger protein 222 (ZN222_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UK12

UniProtKB/Swiss-Prot:

ZN222_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF222: view

Function for ZNF222 Gene

Molecular function for ZNF222 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF222 Gene

Gene Ontology (GO) - Molecular Function for ZNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF222: view
genes like me logo Genes that share phenotypes with ZNF222: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF222

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF222 Gene

Localization for ZNF222 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF222 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF222 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF222: view

Pathways & Interactions for ZNF222 Gene

genes like me logo Genes that share pathways with ZNF222: view

Pathways by source for ZNF222 Gene

2 Reactome pathways for ZNF222 Gene
1 KEGG pathway for ZNF222 Gene

Interacting Proteins for ZNF222 Gene

Gene Ontology (GO) - Biological Process for ZNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF222: view

No data available for SIGNOR curated interactions for ZNF222 Gene

Drugs & Compounds for ZNF222 Gene

No Compound Related Data Available

Transcripts for ZNF222 Gene

mRNA/cDNA for ZNF222 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF222

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF222 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1:
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for ZNF222 Gene

GeneLoc Exon Structure for
ZNF222

Expression for ZNF222 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF222 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF222 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF222 Gene



Protein tissue co-expression partners for ZNF222 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF222

SOURCE GeneReport for Unigene cluster for ZNF222 Gene:

Hs.279840

Evidence on tissue expression from TISSUES for ZNF222 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF222: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF222 Gene

Orthologs for ZNF222 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF222 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF222 30 31
  • 99.73 (n)
OneToOne
Species where no ortholog for ZNF222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF222 Gene

ENSEMBL:
Gene Tree for ZNF222 (if available)
TreeFam:
Gene Tree for ZNF222 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF222: view image

Paralogs for ZNF222 Gene

(458) SIMAP similar genes for ZNF222 Gene using alignment to 2 proteins:

  • ZN222_HUMAN
  • K7EN43_HUMAN
genes like me logo Genes that share paralogs with ZNF222: view

Variants for ZNF222 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF222 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs11880330 - p.Lys50Glu
rs59926292 - p.Arg82Gly
rs7258517 - p.Val58Phe
rs8112679 - p.Gly263Asp

Additional dbSNP identifiers (rs#s) for ZNF222 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF222 Gene

Variant ID Type Subtype PubMed ID
nsv469650 CNV gain 16826518
nsv833840 CNV gain 17160897
nsv961226 CNV duplication 23825009

Variation tolerance for ZNF222 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.13; 87.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF222 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF222

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF222 Gene

Disorders for ZNF222 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF222 Gene - From: DISEASES

Disorder Aliases PubMed IDs
arteriovenous malformations of the brain
  • bavm
intracranial berry aneurysm
  • aneurysm, intracranial berry, 1
zellweger syndrome
  • zs
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF222: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF222 Gene

Publications for ZNF222 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for ZNF222 Gene

Sources for ZNF222 Gene