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Aliases for ZNF222 Gene

Aliases for ZNF222 Gene

  • Zinc Finger Protein 222 2 3 3 5

External Ids for ZNF222 Gene

Previous GeneCards Identifiers for ZNF222 Gene

  • GC19P045175
  • GC19P044921
  • GC19P049205
  • GC19P049221
  • GC19P044529
  • GC19P040961

Summaries for ZNF222 Gene

GeneCards Summary for ZNF222 Gene

ZNF222 (Zinc Finger Protein 222) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000267022.

UniProtKB/Swiss-Prot for ZNF222 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF222 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF222 Gene

Genomics for ZNF222 Gene

GeneHancer (GH) Regulatory Elements for ZNF222 Gene

Promoters and enhancers for ZNF222 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J044024 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.4 433 2.1 PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 ZNF548 KLF13 SP3 LOC105372414 ENSG00000267022 ZNF222 ZNF225 ZNF223 ZNF45 ZNF180 ZNF155 ZNF230 ZNF227
GH19J043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 44.6 -245.4 -245430 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF284 ZNF224 ZNF227 ZNF223 ZNF235 ZNF283
GH19J043901 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 27.9 -123.5 -123531 1.6 ARID4B ZNF2 YY1 ZNF766 ZNF416 ZNF143 ZNF548 KLF13 SP3 MXD4 ZNF221 ZNF404 LOC100505715 ENSG00000267191 ZNF45 ZNF180 ZNF225 ZNF224 ZNF227 ZNF284
GH19J043798 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 27.6 -226.3 -226315 1.6 ZNF133 SIN3A ZNF2 ZNF121 GLIS2 ZNF416 KLF7 ZNF548 KLF13 SP3 PIR46459 ZNF180 ZNF45 ZNF225 ZNF224 ZNF234 ZNF284 ZNF223 ZNF227 ZNF226
GH19J044111 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 18.8 +87.7 87669 2.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF225 LOC100379224 ZNF45 ZNF180 ZNF227 ZNF283 ZNF576 ZNF224 ZNF226 ZNF223
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF222 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF222 Gene

Genomic Locations for ZNF222 Gene
7,781 bases
Plus strand
7,772 bases
Plus strand

Genomic View for ZNF222 Gene

Genes around ZNF222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF222 Gene

Proteins for ZNF222 Gene

  • Protein details for ZNF222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 222
    Protein Accession:
    Secondary Accessions:
    • G5E9B9
    • Q8N6G7
    • Q9P1U5

    Protein attributes for ZNF222 Gene

    451 amino acids
    Molecular mass:
    52484 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH30261.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF222 Gene


neXtProt entry for ZNF222 Gene

Post-translational modifications for ZNF222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF222 Gene

No data available for DME Specific Peptides for ZNF222 Gene

Domains & Families for ZNF222 Gene

Gene Families for ZNF222 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF222 Gene

Suggested Antigen Peptide Sequences for ZNF222 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF222: view

Function for ZNF222 Gene

Molecular function for ZNF222 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF222 Gene

Gene Ontology (GO) - Molecular Function for ZNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF222: view
genes like me logo Genes that share phenotypes with ZNF222: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF222 Gene

Localization for ZNF222 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF222 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF222 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF222: view

Pathways & Interactions for ZNF222 Gene

SuperPathways for ZNF222 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF222: view

Pathways by source for ZNF222 Gene

2 Reactome pathways for ZNF222 Gene

Interacting Proteins for ZNF222 Gene

Gene Ontology (GO) - Biological Process for ZNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF222: view

No data available for SIGNOR curated interactions for ZNF222 Gene

Drugs & Compounds for ZNF222 Gene

No Compound Related Data Available

Transcripts for ZNF222 Gene

Unigene Clusters for ZNF222 Gene

Zinc finger protein 222:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF222 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for ZNF222 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF222 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF222 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF222 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF222 Gene

Protein tissue co-expression partners for ZNF222 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF222 Gene:


SOURCE GeneReport for Unigene cluster for ZNF222 Gene:


Evidence on tissue expression from TISSUES for ZNF222 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF222: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF222 Gene

Orthologs for ZNF222 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF222 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF222 34 33
  • 99.73 (n)
Species where no ortholog for ZNF222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF222 Gene

Gene Tree for ZNF222 (if available)
Gene Tree for ZNF222 (if available)
Evolutionary constrained regions (ECRs) for ZNF222: view image

Paralogs for ZNF222 Gene

(458) SIMAP similar genes for ZNF222 Gene using alignment to 2 proteins:

  • ZN222_HUMAN
  • K7EN43_HUMAN
genes like me logo Genes that share paralogs with ZNF222: view

Variants for ZNF222 Gene

Sequence variations from dbSNP and Humsavar for ZNF222 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000046543 -- 44,026,003(+) T/G intron_variant
rs1000148116 -- 44,032,740(+) C/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000160503 -- 44,026,397(+) A/G intron_variant
rs1000436516 -- 44,032,375(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1001037153 -- 44,030,882(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF222 Gene

Variant ID Type Subtype PubMed ID
nsv469650 CNV gain 16826518
nsv833840 CNV gain 17160897
nsv961226 CNV duplication 23825009

Variation tolerance for ZNF222 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.13; 87.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF222 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF222 Gene

Disorders for ZNF222 Gene

Additional Disease Information for ZNF222

No disorders were found for ZNF222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF222 Gene

Publications for ZNF222 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4 58
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for ZNF222 Gene

Sources for ZNF222 Gene

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