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Aliases for ZNF221 Gene

Aliases for ZNF221 Gene

  • Zinc Finger Protein 221 2 3 5

External Ids for ZNF221 Gene

Previous GeneCards Identifiers for ZNF221 Gene

  • GC19P045100
  • GC19P044847
  • GC19P049131
  • GC19P049147
  • GC19P044271
  • GC19P044455

Summaries for ZNF221 Gene

GeneCards Summary for ZNF221 Gene

ZNF221 (Zinc Finger Protein 221) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF224.

UniProtKB/Swiss-Prot for ZNF221 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF221 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF221 Gene

Genomics for ZNF221 Gene

GeneHancer (GH) Regulatory Elements for ZNF221 Gene

Promoters and enhancers for ZNF221 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I043950 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 572.1 +0.3 262 1.8 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF213 ZNF302 ZNF221 ZNF45 ZNF180 ZNF155 ZNF225 ZNF224 XRCC1 ZNF284 ZNF112 ZNF227
GH19I043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 97.1 -171.3 -171321 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF224 ZNF284 ZNF227 ZNF283 ZNF223 ZNF576
GH19I043667 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 57.9 -282.0 -281953 4.2 HDGF PKNOX1 SMAD1 ARNT SIN3A FEZF1 ZNF2 POLR2B ZNF213 E2F8 PLAUR ZNF45 ZNF180 ZNF225 ZNF224 ZNF155 ZNF284 ZNF234 ZNF283 ZNF235
GH19I043901 Promoter/Enhancer 1.5 Ensembl ENCODE 88.7 -49.4 -49422 1.6 ARID4B ZNF2 YY1 ZNF766 ZNF302 ZNF416 ZNF143 ZNF548 KLF13 SP3 ZNF404 LOC100505715 ENSG00000267191 ZNF45 ZNF180 ZNF225 ZNF224 ZNF227 ZNF284 ZNF234
GH19I044259 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 64.2 +308.8 308809 1.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ZBTB7B ZNF233 ZNF45 ZNF180 ZNF225 ZNF224 ZNF284 ZNF227 ZNF234 ZNF235 CLASRP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF221 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF221 Gene

Genomic Locations for ZNF221 Gene
16,487 bases
Plus strand

Genomic View for ZNF221 Gene

Genes around ZNF221 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF221 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF221 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF221 Gene

Proteins for ZNF221 Gene

  • Protein details for ZNF221 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 221
    Protein Accession:
    Secondary Accessions:
    • B2RAI6
    • Q2M2H2
    • Q9P1U8

    Protein attributes for ZNF221 Gene

    617 amino acids
    Molecular mass:
    71170 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF221 Gene

Post-translational modifications for ZNF221 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF221 Gene

Domains & Families for ZNF221 Gene

Gene Families for ZNF221 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF221 Gene

Suggested Antigen Peptide Sequences for ZNF221 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF221: view

Function for ZNF221 Gene

Molecular function for ZNF221 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF221 Gene

Gene Ontology (GO) - Molecular Function for ZNF221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF221: view

Phenotypes for ZNF221 Gene

genes like me logo Genes that share phenotypes with ZNF221: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF221 Gene

Localization for ZNF221 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF221 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF221 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF221: view

Pathways & Interactions for ZNF221 Gene

SuperPathways for ZNF221 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF221: view

Pathways by source for ZNF221 Gene

2 Reactome pathways for ZNF221 Gene

Interacting Proteins for ZNF221 Gene

Gene Ontology (GO) - Biological Process for ZNF221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF221: view

No data available for SIGNOR curated interactions for ZNF221 Gene

Drugs & Compounds for ZNF221 Gene

No Compound Related Data Available

Transcripts for ZNF221 Gene

mRNA/cDNA for ZNF221 Gene

Unigene Clusters for ZNF221 Gene

Zinc finger protein 221:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF221 Gene

No ASD Table

Relevant External Links for ZNF221 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF221 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF221 Gene

Protein differential expression in normal tissues from HIPED for ZNF221 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF221 Gene

Protein tissue co-expression partners for ZNF221 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF221 Gene:


SOURCE GeneReport for Unigene cluster for ZNF221 Gene:


Evidence on tissue expression from TISSUES for ZNF221 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF221: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF221 Gene

Orthologs for ZNF221 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF221 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF221 33 34
  • 98.38 (n)
(Danio rerio)
Actinopterygii -- 33
Species where no ortholog for ZNF221 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF221 Gene

Gene Tree for ZNF221 (if available)
Gene Tree for ZNF221 (if available)

Paralogs for ZNF221 Gene

(499) SIMAP similar genes for ZNF221 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF221: view

Variants for ZNF221 Gene

Sequence variations from dbSNP and Humsavar for ZNF221 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000377306 -- 43,967,411(+) A/G 3_prime_UTR_variant
rs1000509019 -- 43,956,824(+) TGT/T intron_variant
rs1000530153 -- 43,968,547(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000533808 -- 43,961,224(+) G/T intron_variant
rs1000964383 -- 43,968,865(+) C/A 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF221 Gene

Variant ID Type Subtype PubMed ID
nsv1134794 CNV deletion 24896259
nsv469650 CNV gain 16826518
nsv579854 CNV loss 21841781
nsv960849 CNV duplication 23825009

Variation tolerance for ZNF221 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF221 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF221 Gene

Disorders for ZNF221 Gene

Additional Disease Information for ZNF221

No disorders were found for ZNF221 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF221 Gene

Publications for ZNF221 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for ZNF221 Gene

Sources for ZNF221 Gene

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