Aliases for ZNF22 Gene

Aliases for ZNF22 Gene

  • Zinc Finger Protein 22 2 3 4 5
  • Zinc Finger Protein Krox-26 3 4
  • Zinc Finger Protein KOX15 3 4
  • KOX15 3 4
  • Zinc Finger Protein 22 (KOX 15) 3
  • Krox-26 Protein 3
  • HKR-T1 3
  • ZNF422 3
  • Zfp422 3
  • KROX26 4

External Ids for ZNF22 Gene

Previous GeneCards Identifiers for ZNF22 Gene

  • GC10P044785
  • GC10P044964
  • GC10P045271
  • GC10P044779
  • GC10P044815
  • GC10P045496
  • GC10P042021

Summaries for ZNF22 Gene

GeneCards Summary for ZNF22 Gene

ZNF22 (Zinc Finger Protein 22) is a Protein Coding gene. Diseases associated with ZNF22 include Tooth Agenesis. An important paralog of this gene is ZNF680.

UniProtKB/Swiss-Prot Summary for ZNF22 Gene

  • Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).

Gene Wiki entry for ZNF22 Gene

Additional gene information for ZNF22 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF22 Gene

Genomics for ZNF22 Gene

GeneHancer (GH) Regulatory Elements for ZNF22 Gene

Promoters and enhancers for ZNF22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF22 gene promoter:
  • ATF-2
  • Bach1
  • c-Rel
  • FOXJ2
  • FOXJ2 (long isoform)
  • HFH-1
  • ITF-2
  • p53
  • RFX1
  • Tal-1beta

Genomic Locations for ZNF22 Gene

Genomic Locations for ZNF22 Gene
4,505 bases
Plus strand
4,855 bases
Plus strand

Genomic View for ZNF22 Gene

Genes around ZNF22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF22 Gene

Proteins for ZNF22 Gene

  • Protein details for ZNF22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 22
    Protein Accession:
    Secondary Accessions:
    • Q5T741
    • Q96FM4

    Protein attributes for ZNF22 Gene

    224 amino acids
    Molecular mass:
    25915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF22 Gene

Post-translational modifications for ZNF22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF22 Gene

Domains & Families for ZNF22 Gene

Gene Families for ZNF22 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF22 Gene


Suggested Antigen Peptide Sequences for ZNF22 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75698, highly similar to Homo sapiens zinc finger protein 22 (KOX 15) (ZNF22), mRNA (Q5T741_HUMAN)
  • Zinc finger protein Krox-26 (ZNF22_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF22: view

Function for ZNF22 Gene

Molecular function for ZNF22 Gene

UniProtKB/Swiss-Prot Function:
Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).
GENATLAS Biochemistry:
zinc finger protein 22 (KOX15) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF22 Gene

Gene Ontology (GO) - Molecular Function for ZNF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding ISS --
GO:0008270 zinc ion binding TAS 1946370
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF22: view
genes like me logo Genes that share phenotypes with ZNF22: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF22 Gene

Localization for ZNF22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF22 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF22 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF22: view

Pathways & Interactions for ZNF22 Gene

PathCards logo

SuperPathways for ZNF22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 14630903
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0042476 odontogenesis NAS 14630903
genes like me logo Genes that share ontologies with ZNF22: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF22 Gene

Drugs & Compounds for ZNF22 Gene

No Compound Related Data Available

Transcripts for ZNF22 Gene

mRNA/cDNA for ZNF22 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(221) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF22 Gene

No ASD Table

Relevant External Links for ZNF22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF22 Gene

Protein differential expression in normal tissues from HIPED for ZNF22 Gene

This gene is overexpressed in NK cells (15.2), Tlymphocyte (14.8), and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF22 Gene

Protein tissue co-expression partners for ZNF22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF22 Gene:


SOURCE GeneReport for Unigene cluster for ZNF22 Gene:


mRNA Expression by UniProt/SwissProt for ZNF22 Gene:

Tissue specificity: In the embryo, expressed in developing craniofacial structures including dental epithelium of maxillary molar tooth organs, tongue epithelium and muscle, and craniofacial bone osteoblasts. In the adult, expressed in mesoderm-derived tissues such as skeletal muscle, heart, kidney and liver. Intermediate expression in spleen, thymus and brain. Low levels in endoderm-derived tissues such as intestine and colon.

Evidence on tissue expression from TISSUES for ZNF22 Gene

  • Nervous system(4.5)
  • Intestine(4.2)
  • Liver(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with ZNF22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF22 Gene

Orthologs for ZNF22 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF22 33 32
  • 99.7 (n)
(Canis familiaris)
Mammalia ZNF22 33 32
  • 90.33 (n)
(Bos Taurus)
Mammalia ZNF22 32
  • 86.31 (n)
(Rattus norvegicus)
Mammalia Zfp422 32
  • 83.41 (n)
(Mus musculus)
Mammalia Zfp422 17 33 32
  • 82.36 (n)
(Monodelphis domestica)
Mammalia ZNF22 33
  • 76 (a)
(Gallus gallus)
Aves ZNF22 33
  • 18 (a)
(Anolis carolinensis)
Reptilia ZNF22 33
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4854 34
  • 45 (a)
Species where no ortholog for ZNF22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF22 Gene

Gene Tree for ZNF22 (if available)
Gene Tree for ZNF22 (if available)
Evolutionary constrained regions (ECRs) for ZNF22: view image

Paralogs for ZNF22 Gene

(517) SIMAP similar genes for ZNF22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF22: view

Variants for ZNF22 Gene

Sequence variations from dbSNP and Humsavar for ZNF22 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
VAR_035566 A breast cancer sample p.His129Leu
rs1000231261 -- 45,002,882(+) T/C intron_variant
rs1000242437 -- 45,000,756(+) C/T upstream_transcript_variant
rs1000523991 -- 44,999,087(+) G/T upstream_transcript_variant
rs1000629693 -- 45,003,292(+) T/C 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF22 Gene

Variant ID Type Subtype PubMed ID
esv3576560 CNV gain 25503493
esv3623079 CNV loss 21293372
esv3623080 CNV gain 21293372
nsv831846 CNV loss 17160897
nsv831848 CNV gain 17160897

Variation tolerance for ZNF22 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF22 Gene

Disorders for ZNF22 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF22 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tooth agenesis
  • familial tooth agenesis
- elite association - COSMIC cancer census association via MalaCards
Search ZNF22 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNF22

genes like me logo Genes that share disorders with ZNF22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF22 Gene

Publications for ZNF22 Gene

  1. The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and maps to the locus for permanent tooth agenesis (He-Zhao deficiency). (PMID: 14630903) Gao Y … Ganss B (Journal of dental research 2003) 3 4 23 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Isolation of a cDNA clone encoding a zinc finger protein highly expressed in T-leukemia lines. (PMID: 1421376) Wu BY … Nabel GJ (Blood 1992) 3 4 56
  4. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P … Dawid IB (Proceedings of the National Academy of Sciences of the United States of America 1991) 3 4 56
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 56

Products for ZNF22 Gene

Sources for ZNF22 Gene