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Aliases for ZNF217 Gene

Aliases for ZNF217 Gene

  • Zinc Finger Protein 217 2 3 5
  • ZABC1 3 4

External Ids for ZNF217 Gene

Previous GeneCards Identifiers for ZNF217 Gene

  • GC20M051912
  • GC20M052822
  • GC20M052869
  • GC20M051617
  • GC20M052183
  • GC20M048929

Summaries for ZNF217 Gene

GeneCards Summary for ZNF217 Gene

ZNF217 (Zinc Finger Protein 217) is a Protein Coding gene. Diseases associated with ZNF217 include Ovarian Serous Cystadenocarcinoma and Ovarian Cystadenocarcinoma. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is ZNF516.

UniProtKB/Swiss-Prot for ZNF217 Gene

  • Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at Ser-473.

Gene Wiki entry for ZNF217 Gene

Additional gene information for ZNF217 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF217 Gene

Genomics for ZNF217 Gene

GeneHancer (GH) Regulatory Elements for ZNF217 Gene

Promoters and enhancers for ZNF217 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I053578 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 562 +20.0 20010 23 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ZNF217 ENSG00000236352 LOC101927770 TSHZ2 GC20M053551 LOC105372672
GH20I053607 Enhancer 1.5 Ensembl ENCODE dbSUPER 550.8 -1.1 -1057 6.5 HDGF PKNOX1 FOXA2 SMAD1 ARNT SIN3A FEZF1 ZNF2 IRF4 YY1 GC20M053610 ZNF217 PFDN4 RNU7-14P ENSG00000236352 LOC105372672
GH20I053921 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.1 -314.8 -314829 6.3 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B IRF4 ETS1 TCF12 SLC30A9 ZNF217 ENSG00000236352 GC20P053902
GH20I053651 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21 -45.6 -45620 7.6 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 IRF4 ZNF217 ENSG00000236352 GC20M053669 GC20M053610
GH20I053913 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.3 -306.1 -306072 5.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 IRF4 YY1 ZNF766 ZNF217 ENSG00000236352 GC20P053902
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF217 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF217 gene promoter:

Genomic Locations for ZNF217 Gene

Genomic Locations for ZNF217 Gene
chr20:53,567,065-53,609,907
(GRCh38/hg38)
Size:
42,843 bases
Orientation:
Minus strand
chr20:52,183,604-52,226,446
(GRCh37/hg19)

Genomic View for ZNF217 Gene

Genes around ZNF217 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF217 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF217 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF217 Gene

Proteins for ZNF217 Gene

  • Protein details for ZNF217 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75362-ZN217_HUMAN
    Recommended name:
    Zinc finger protein 217
    Protein Accession:
    O75362
    Secondary Accessions:
    • E1P5Y6
    • Q14DB8

    Protein attributes for ZNF217 Gene

    Size:
    1048 amino acids
    Molecular mass:
    115272 Da
    Quaternary structure:
    • Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2.

    Three dimensional structures from OCA and Proteopedia for ZNF217 Gene

neXtProt entry for ZNF217 Gene

Post-translational modifications for ZNF217 Gene

No Post-translational modifications

Other Protein References for ZNF217 Gene

No data available for DME Specific Peptides for ZNF217 Gene

Domains & Families for ZNF217 Gene

Gene Families for ZNF217 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF217 Gene

Graphical View of Domain Structure for InterPro Entry

O75362

UniProtKB/Swiss-Prot:

ZN217_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF217: view

Function for ZNF217 Gene

Molecular function for ZNF217 Gene

GENATLAS Biochemistry:
zinc finger protein 217 (C2H2 type Kruppel-like) with two alternatively spliced isoforms amplified and overexpressed in breast carcinoma
UniProtKB/Swiss-Prot Function:
Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at Ser-473.

Phenotypes From GWAS Catalog for ZNF217 Gene

Gene Ontology (GO) - Molecular Function for ZNF217 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 17130829
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 17130829
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 9671742
genes like me logo Genes that share ontologies with ZNF217: view
genes like me logo Genes that share phenotypes with ZNF217: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF217 Gene

Localization for ZNF217 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF217 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF217 gene
Compartment Confidence
nucleus 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF217 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 18625718
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA 18625718
GO:0005739 mitochondrion IDA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with ZNF217: view

Pathways & Interactions for ZNF217 Gene

SuperPathways for ZNF217 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF217 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 17130829
GO:0006351 transcription, DNA-templated IEA,TAS --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 18625718
GO:0007165 signal transduction IBA --
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with ZNF217: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF217 Gene

Drugs & Compounds for ZNF217 Gene

(1) Drugs for ZNF217 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF217: view

Transcripts for ZNF217 Gene

Unigene Clusters for ZNF217 Gene

Zinc finger protein 217:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF217 Gene

No ASD Table

Relevant External Links for ZNF217 Gene

GeneLoc Exon Structure for
ZNF217
ECgene alternative splicing isoforms for
ZNF217

Expression for ZNF217 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF217 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF217 Gene

This gene is overexpressed in Breast (48.9) and CD8 Tcells (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF217 Gene



Protein tissue co-expression partners for ZNF217 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF217 Gene:

ZNF217

SOURCE GeneReport for Unigene cluster for ZNF217 Gene:

Hs.155040

Evidence on tissue expression from TISSUES for ZNF217 Gene

  • Intestine(4.5)
genes like me logo Genes that share expression patterns with ZNF217: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF217 Gene

Orthologs for ZNF217 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF217 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF217 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia ZNF217 33 34
  • 76.71 (n)
rat
(Rattus norvegicus)
Mammalia Zfp217 33
  • 75.07 (n)
mouse
(Mus musculus)
Mammalia Zfp217 33 16 34
  • 75.03 (n)
cow
(Bos Taurus)
Mammalia ZNF217 33 34
  • 70.13 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF217 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF217 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF217 33 34
  • 66.04 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF217 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf217 33
  • 53.73 (n)
Str.10081 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398381 33
zebrafish
(Danio rerio)
Actinopterygii LOC100537540 33
  • 51.16 (n)
CABZ01070579.1 34
  • 39 (a)
OneToOne
Dr.26396 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4604 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3642 34
  • 27 (a)
OneToMany
Species where no ortholog for ZNF217 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF217 Gene

ENSEMBL:
Gene Tree for ZNF217 (if available)
TreeFam:
Gene Tree for ZNF217 (if available)

Paralogs for ZNF217 Gene

Paralogs for ZNF217 Gene

genes like me logo Genes that share paralogs with ZNF217: view

Variants for ZNF217 Gene

Sequence variations from dbSNP and Humsavar for ZNF217 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs767530299 A colorectal cancer sample 53,581,860(-) C/T coding_sequence_variant, missense_variant
rs1000063327 -- 53,572,034(-) A/G intron_variant
rs1000090954 -- 53,577,432(-) T/C intron_variant
rs1000146223 -- 53,568,198(-) C/A 3_prime_UTR_variant
rs1000164182 -- 53,593,012(-) ATCTTTA/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF217 Gene

Variant ID Type Subtype PubMed ID
nsv834006 CNV gain+loss 17160897
nsv954059 CNV duplication 24416366
nsv3417 CNV insertion 18451855
nsv1059236 CNV gain 25217958

Variation tolerance for ZNF217 Gene

Residual Variation Intolerance Score: 3.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF217 Gene

Human Gene Mutation Database (HGMD)
ZNF217
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF217

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF217 Gene

Disorders for ZNF217 Gene

MalaCards: The human disease database

(12) MalaCards diseases for ZNF217 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian serous cystadenocarcinoma
  • serous cystadenoma
ovarian cystadenocarcinoma
  • cystadenocarcinoma of ovary
ovarian clear cell carcinoma
  • clear-cell ovarian carcinoma
ovarian benign neoplasm
ovary serous adenocarcinoma
  • malignant ovarian serous tumor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF217

genes like me logo Genes that share disorders with ZNF217: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF217 Gene

Publications for ZNF217 Gene

  1. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. (PMID: 9671742) Collins C … Gray JW (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 58
  2. The ZNF217 oncogene is a candidate organizer of repressive histone modifiers. (PMID: 19242095) Banck MS … Walsh MJ (Epigenetics 2009) 3 22 58
  3. Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex. (PMID: 18625718) Thillainadesan G … Torchia J (Molecular and cellular biology 2008) 3 4 58
  4. Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line. (PMID: 18425333) Sun G … Zhong M (International journal of oncology 2008) 3 22 58
  5. Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad. (PMID: 17572303) Quinlan KG … Crossley M (Biochimica et biophysica acta 2007) 3 22 58

Products for ZNF217 Gene

Sources for ZNF217 Gene

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