This gene is imprinted in a tissue-specific manner with preferential expression in the testis, and encodes a zinc finger protein that belongs to a family of zinc finger transcription factors. The encoded protein contains an N-terminal SRE-ZBP, Ctfin51, AW-1, and Number 18 (SCAN) domain, a kruppel-associated box A (KRABA) domain, and four C-terminal zinc finger domains. This gen... See more...

Aliases for ZNF215 Gene

Aliases for ZNF215 Gene

  • Zinc Finger Protein 215 2 3 4 5
  • ZKSCAN11 2 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 11 3 4
  • BWSCR2-Associated Zinc Finger Protein 2 3 4
  • ZSCAN43 2 3
  • BAZ-2 3 4
  • BAZ2 3 4
  • ZNF215 5

External Ids for ZNF215 Gene

Previous GeneCards Identifiers for ZNF215 Gene

  • GC11P007690
  • GC11P007408
  • GC11P006906
  • GC11P006911
  • GC11P006904
  • GC11P006606

Summaries for ZNF215 Gene

Entrez Gene Summary for ZNF215 Gene

  • This gene is imprinted in a tissue-specific manner with preferential expression in the testis, and encodes a zinc finger protein that belongs to a family of zinc finger transcription factors. The encoded protein contains an N-terminal SRE-ZBP, Ctfin51, AW-1, and Number 18 (SCAN) domain, a kruppel-associated box A (KRABA) domain, and four C-terminal zinc finger domains. This gene is located within one of three regions on chromosome 11p15 associated with Beckwith-Wiedemann syndrome, called Beckwith-Wiedemann syndrome chromosome region-2 (BWSCR2), and is thought to play a role in the etiology of this disease. [provided by RefSeq, Aug 2017]

GeneCards Summary for ZNF215 Gene

ZNF215 (Zinc Finger Protein 215) is a Protein Coding gene. Diseases associated with ZNF215 include Beckwith-Wiedemann Syndrome. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZSCAN31.

UniProtKB/Swiss-Prot Summary for ZNF215 Gene

Tocris Summary for ZNF215 Gene

  • Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.

Additional gene information for ZNF215 Gene

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF215 Gene

Genomics for ZNF215 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF215 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006925 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 634.6 +0.6 571 2.9 ZNF221 PRDM10 IKZF1 JUND PRDM1 MTA2 PKNOX1 PATZ1 ZNF24 TCF12 ZNF215 ENSG00000283415 LOC107984019 ENSG00000254595 piR-48209-091 ZNF214
GH11J006991 Enhancer 0.8 Ensembl ENCODE 6.2 +66.0 66001 2.5 FOXA1 ZIC2 ZNF792 ZBTB20 ZXDB CEBPB ZNF335 BHLHE40 MAFK ZFP3 NLRP14 ZNF214 GVINP1 ZNF215 lnc-ZNF214-1 piR-61580-072
GH11J007019 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 +93.9 93905 2.5 TEAD4 RFX1 KDM1A PKNOX1 POLR2A ZNF24 REST SP1 ZNF501 GABPA ZNF214 NLRP14 lnc-OR2D2-2 piR-48528 DNHD1 ENSG00000254641 C11orf42 CYB5R2 ARFIP2 ZNF215
GH11J007004 Enhancer 0.6 Ensembl ENCODE 0.2 +78.2 78214 0.8 PKNOX1 CEBPG CEBPB MEIS2 SPI1 lnc-ZNF214-1 FJ601684-057 ZNF214 ZNF215
GH11J007013 Enhancer 0.3 Ensembl 0.2 +87.0 86997 0.4 ZNF407 MEIS2 FJ601684-057 ZNF214 lnc-ZNF214-1 ZNF215
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF215 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF215

Top Transcription factor binding sites by QIAGEN in the ZNF215 gene promoter:
  • AREB6
  • Elk-1
  • En-1
  • GATA-1
  • MIF-1
  • Nkx6-1
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha1
  • TBP

Genomic Locations for ZNF215 Gene

Genomic Locations for ZNF215 Gene
chr11:6,926,404-7,001,004
(GRCh38/hg38)
Size:
74,601 bases
Orientation:
Plus strand
chr11:6,947,635-7,005,863
(GRCh37/hg19)
Size:
58,229 bases
Orientation:
Plus strand

Genomic View for ZNF215 Gene

Genes around ZNF215 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF215 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF215 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF215 Gene

Proteins for ZNF215 Gene

  • Protein details for ZNF215 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL58-ZN215_HUMAN
    Recommended name:
    Zinc finger protein 215
    Protein Accession:
    Q9UL58
    Secondary Accessions:
    • Q96C84

    Protein attributes for ZNF215 Gene

    Size:
    517 amino acids
    Molecular mass:
    60034 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF215 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF215 Gene

Post-translational modifications for ZNF215 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF215 Gene

Domains & Families for ZNF215 Gene

Gene Families for ZNF215 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF215 Gene

InterPro:
Blocks:
  • KRAB box
  • Transcriptional regulator SCAN
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF215 Gene

GenScript: Design optimal peptide antigens:
  • ZNF215 protein (Q96C84_HUMAN)
  • Zinc finger protein with KRAB and SCAN domains 11 (ZN215_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UL58

UniProtKB/Swiss-Prot:

ZN215_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF215: view

Function for ZNF215 Gene

Molecular function for ZNF215 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF215 Gene

Gene Ontology (GO) - Molecular Function for ZNF215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS 10762538
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF215: view
genes like me logo Genes that share phenotypes with ZNF215: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF215

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF215 Gene

Localization for ZNF215 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF215 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF215 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF215: view

Pathways & Interactions for ZNF215 Gene

PathCards logo

SuperPathways for ZNF215 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF215: view

Pathways by source for ZNF215 Gene

2 Reactome pathways for ZNF215 Gene

Gene Ontology (GO) - Biological Process for ZNF215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042552 myelination IBA --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF215: view

No data available for SIGNOR curated interactions for ZNF215 Gene

Drugs & Compounds for ZNF215 Gene

No Compound Related Data Available

Transcripts for ZNF215 Gene

mRNA/cDNA for ZNF215 Gene

9 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF215

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF215 Gene

No ASD Table

Relevant External Links for ZNF215 Gene

GeneLoc Exon Structure for
ZNF215

Expression for ZNF215 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF215 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF215

SOURCE GeneReport for Unigene cluster for ZNF215 Gene:

Hs.523457

Evidence on tissue expression from TISSUES for ZNF215 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with ZNF215: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF215 Gene

Orthologs for ZNF215 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF215 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF215 30 31
  • 99.23 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF215 30 31
  • 85.12 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF215 30 31
  • 84.6 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 44 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 31 (a)
OneToMany
Species where no ortholog for ZNF215 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF215 Gene

ENSEMBL:
Gene Tree for ZNF215 (if available)
TreeFam:
Gene Tree for ZNF215 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF215: view image

Paralogs for ZNF215 Gene

Pseudogenes.org Pseudogenes for ZNF215 Gene

genes like me logo Genes that share paralogs with ZNF215: view

Variants for ZNF215 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF215 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
709933 Likely Benign: not provided 6,956,094(+) C/A MISSENSE_VARIANT,INTRON_VARIANT
710353 Likely Benign: not provided 6,955,753(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
726100 Likely Benign: not provided 6,943,642(+) G/A SPLICE_DONOR_VARIANT,INTRON_VARIANT
782124 Benign: not provided 6,955,878(+) T/C MISSENSE_VARIANT,INTRON_VARIANT
787901 Benign: not provided 6,932,384(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF215 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF215 Gene

Variant ID Type Subtype PubMed ID
esv2557168 CNV deletion 19546169
nsv1035138 CNV gain 25217958
nsv1046129 CNV loss 25217958
nsv1046864 CNV loss 25217958
nsv832061 CNV loss 17160897

Variation tolerance for ZNF215 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF215 Gene

Human Gene Mutation Database (HGMD)
ZNF215
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF215

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF215 Gene

Disorders for ZNF215 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF215 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • bws
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF215: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF215 Gene

Publications for ZNF215 Gene

  1. Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. (PMID: 10762538) Alders M … Mannens M (American journal of human genetics 2000) 3 4
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  5. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. (PMID: 24483146) Li L … Wang L (BMC genomics 2014) 3

Products for ZNF215 Gene

Sources for ZNF215 Gene