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Aliases for ZNF215 Gene

Aliases for ZNF215 Gene

  • Zinc Finger Protein 215 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 11 3 4
  • BWSCR2-Associated Zinc Finger Protein 2 3 4
  • ZKSCAN11 3 4
  • BAZ-2 3 4
  • BAZ2 3 4
  • ZSCAN43 3

External Ids for ZNF215 Gene

Previous GeneCards Identifiers for ZNF215 Gene

  • GC11P007690
  • GC11P007408
  • GC11P006906
  • GC11P006911
  • GC11P006904
  • GC11P006606

Summaries for ZNF215 Gene

Entrez Gene Summary for ZNF215 Gene

  • This gene is imprinted in a tissue-specific manner with preferential expression in the testis, and encodes a zinc finger protein that belongs to a family of zinc finger transcription factors. The encoded protein contains an N-terminal SRE-ZBP, Ctfin51, AW-1, and Number 18 (SCAN) domain, a kruppel-associated box A (KRABA) domain, and four C-terminal zinc finger domains. This gene is located within one of three regions on chromosome 11p15 associated with Beckwith-Wiedemann syndrome, called Beckwith-Wiedemann syndrome chromosome region-2 (BWSCR2), and is thought to play a role in the etiology of this disease. [provided by RefSeq, Aug 2017]

GeneCards Summary for ZNF215 Gene

ZNF215 (Zinc Finger Protein 215) is a Protein Coding gene. Diseases associated with ZNF215 include Beckwith-Wiedemann Syndrome and Cryptorchidism, Unilateral Or Bilateral. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF483.

UniProtKB/Swiss-Prot for ZNF215 Gene

  • May be involved in transcriptional regulation.

Tocris Summary for ZNF215 Gene

  • Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.

Additional gene information for ZNF215 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF215 Gene

Genomics for ZNF215 Gene

GeneHancer (GH) Regulatory Elements for ZNF215 Gene

Promoters and enhancers for ZNF215 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I006925 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 584.8 +0.3 318 2.3 HDGF PKNOX1 ATF1 ARNT ZNF2 ETS1 POLR2B GLIS2 E2F8 ARID2 ZNF215 ENSG00000283415 OR2AG2 LOC644169
GH11I006991 Enhancer 0.8 Ensembl ENCODE 6.2 +66.0 66001 2.5 PKNOX1 ZNF792 ZIC2 ZNF843 ZNF335 PRDM6 ZFP3 ZXDB TRIM28 ZBTB20 LOC102724711 NLRP14 ZNF214 GVINP1 ZNF215 GC11M006969 GC11P006959 GC11M006985
GH11I007004 Enhancer 0.7 Ensembl ENCODE 0.2 +78.3 78314 0.5 MEIS2 PKNOX1 CEBPB CEBPG LOC102724711 PIR41527 ZNF214 GC11P006959 GC11M006985 ZNF215
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF215 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF215 gene promoter:

Genomic Locations for ZNF215 Gene

Genomic Locations for ZNF215 Gene
78,951 bases
Plus strand

Genomic View for ZNF215 Gene

Genes around ZNF215 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF215 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF215 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF215 Gene

Proteins for ZNF215 Gene

  • Protein details for ZNF215 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 215
    Protein Accession:
    Secondary Accessions:
    • Q96C84

    Protein attributes for ZNF215 Gene

    517 amino acids
    Molecular mass:
    60034 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF215 Gene


neXtProt entry for ZNF215 Gene

Post-translational modifications for ZNF215 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF215 Gene

Domains & Families for ZNF215 Gene

Gene Families for ZNF215 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF215 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF215: view

Function for ZNF215 Gene

Molecular function for ZNF215 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF215 Gene

Gene Ontology (GO) - Molecular Function for ZNF215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 10762538
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF215: view

Phenotypes for ZNF215 Gene

genes like me logo Genes that share phenotypes with ZNF215: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF215 Gene

Localization for ZNF215 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF215 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF215 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF215: view

Pathways & Interactions for ZNF215 Gene

SuperPathways for ZNF215 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF215: view

Pathways by source for ZNF215 Gene

2 Reactome pathways for ZNF215 Gene

Gene Ontology (GO) - Biological Process for ZNF215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF215: view

No data available for SIGNOR curated interactions for ZNF215 Gene

Drugs & Compounds for ZNF215 Gene

No Compound Related Data Available

Transcripts for ZNF215 Gene

Unigene Clusters for ZNF215 Gene

Zinc finger protein 215:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF215 Gene

No ASD Table

Relevant External Links for ZNF215 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF215 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF215 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF215 Gene:


SOURCE GeneReport for Unigene cluster for ZNF215 Gene:


Evidence on tissue expression from TISSUES for ZNF215 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with ZNF215: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF215 Gene

Orthologs for ZNF215 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF215 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF215 33 34
  • 99.23 (n)
(Bos Taurus)
Mammalia ZNF215 33 34
  • 85.12 (n)
(Canis familiaris)
Mammalia ZNF215 33 34
  • 84.6 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
Species where no ortholog for ZNF215 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF215 Gene

Gene Tree for ZNF215 (if available)
Gene Tree for ZNF215 (if available)

Paralogs for ZNF215 Gene

Variants for ZNF215 Gene

Sequence variations from dbSNP and Humsavar for ZNF215 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000008184 -- 6,946,108(+) A/G intron_variant
rs1000053896 -- 6,957,757(+) T/C 3_prime_UTR_variant
rs1000090265 -- 6,951,761(+) C/A intron_variant
rs1000255677 -- 6,927,388(+) G/A intron_variant
rs1000406771 -- 6,933,768(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF215 Gene

Variant ID Type Subtype PubMed ID
esv2557168 CNV deletion 19546169
nsv1035138 CNV gain 25217958
nsv1046129 CNV loss 25217958
nsv1046864 CNV loss 25217958
nsv832061 CNV loss 17160897

Variation tolerance for ZNF215 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.50; 64.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF215 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF215 Gene

Disorders for ZNF215 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF215 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • bws
cryptorchidism, unilateral or bilateral
  • undescended testis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF215

genes like me logo Genes that share disorders with ZNF215: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF215 Gene

Publications for ZNF215 Gene

  1. Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. (PMID: 10762538) Alders M … Mannens M (American journal of human genetics 2000) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. (PMID: 24483146) Li L … Wang L (BMC genomics 2014) 3 58
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58

Products for ZNF215 Gene

Sources for ZNF215 Gene

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