This gene is expressed predominantly in the testis and encodes a zinc finger protein that contains an N-terminal kruppel-associated box A (KRABA) domain and twelve zinc finger domains. This gene is located within one of three regions on chromosome 11p15 associated with Beckwith-Wiedemann syndrome, called Beckwith-Wiedemann syndrome chromosome region-2 (BWSCR2), and is thought t... See more...

Aliases for ZNF214 Gene

Aliases for ZNF214 Gene

  • Zinc Finger Protein 214 2 3 4 5
  • BWSCR2-Associated Zinc Finger Protein 1 3 4
  • BAZ-1 3 4
  • BAZ1 3 4
  • ZNF214 5

External Ids for ZNF214 Gene

Previous GeneCards Identifiers for ZNF214 Gene

  • GC11M007763
  • GC11M007481
  • GC11M006979
  • GC11M006984
  • GC11M006977
  • GC11M006679
  • GC11M007020

Summaries for ZNF214 Gene

Entrez Gene Summary for ZNF214 Gene

  • This gene is expressed predominantly in the testis and encodes a zinc finger protein that contains an N-terminal kruppel-associated box A (KRABA) domain and twelve zinc finger domains. This gene is located within one of three regions on chromosome 11p15 associated with Beckwith-Wiedemann syndrome, called Beckwith-Wiedemann syndrome chromosome region-2 (BWSCR2), and is thought to play a role in the etiology of this disease. [provided by RefSeq, Aug 2017]

GeneCards Summary for ZNF214 Gene

ZNF214 (Zinc Finger Protein 214) is a Protein Coding gene. Diseases associated with ZNF214 include Beckwith-Wiedemann Syndrome. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZKSCAN7.

UniProtKB/Swiss-Prot Summary for ZNF214 Gene

Additional gene information for ZNF214 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF214 Gene

Genomics for ZNF214 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF214 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF214 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF214

Top Transcription factor binding sites by QIAGEN in the ZNF214 gene promoter:
  • FOXO3
  • FOXO3a
  • FOXO3b
  • NRSF form 1
  • NRSF form 2

Genomic Locations for ZNF214 Gene

Genomic Locations for ZNF214 Gene
chr11:6,993,482-7,020,367
(GRCh38/hg38)
Size:
26,886 bases
Orientation:
Minus strand
chr11:7,020,549-7,041,599
(GRCh37/hg19)
Size:
21,051 bases
Orientation:
Minus strand

Genomic View for ZNF214 Gene

Genes around ZNF214 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF214 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF214 Gene

Proteins for ZNF214 Gene

  • Protein details for ZNF214 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL59-ZN214_HUMAN
    Recommended name:
    Zinc finger protein 214
    Protein Accession:
    Q9UL59
    Secondary Accessions:
    • B2R8Q1

    Protein attributes for ZNF214 Gene

    Size:
    606 amino acids
    Molecular mass:
    70992 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF214 Gene

Post-translational modifications for ZNF214 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF214 Gene

Domains & Families for ZNF214 Gene

Gene Families for ZNF214 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF214 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF214 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 214 (B7ZMB1_HUMAN)
  • BWSCR2-associated zinc finger protein 1 (ZN214_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UL59

UniProtKB/Swiss-Prot:

ZN214_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF214: view

Function for ZNF214 Gene

Molecular function for ZNF214 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 10762538
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF214: view
genes like me logo Genes that share phenotypes with ZNF214: view

Animal Model Products

CRISPR Products

miRNA for ZNF214 Gene

miRTarBase miRNAs that target ZNF214

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF214

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF214 Gene

Localization for ZNF214 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF214 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF214 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ZNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF214: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF214 Gene

Pathways & Interactions for ZNF214 Gene

genes like me logo Genes that share pathways with ZNF214: view

Pathways by source for ZNF214 Gene

2 Reactome pathways for ZNF214 Gene
1 KEGG pathway for ZNF214 Gene

Gene Ontology (GO) - Biological Process for ZNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF214: view

No data available for SIGNOR curated interactions for ZNF214 Gene

Drugs & Compounds for ZNF214 Gene

No Compound Related Data Available

Transcripts for ZNF214 Gene

mRNA/cDNA for ZNF214 Gene

5 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF214

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF214 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: - -
SP4:
SP5: - -

Relevant External Links for ZNF214 Gene

GeneLoc Exon Structure for
ZNF214

Expression for ZNF214 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF214 Gene

Protein differential expression in normal tissues from HIPED for ZNF214 Gene

This gene is overexpressed in Monocytes (40.4), Pancreatic juice (11.8), Fetal Brain (7.5), and CD4 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF214 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF214

SOURCE GeneReport for Unigene cluster for ZNF214 Gene:

Hs.733636

Evidence on tissue expression from TISSUES for ZNF214 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF214: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF214 Gene

Orthologs for ZNF214 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF214 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF214 30 31
  • 99.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF214 30 31
  • 88.5 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF214 30 31
  • 86.67 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 48 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Gm14443 31
  • 38 (a)
ManyToMany
Zfp53 31
  • 35 (a)
ManyToMany
Zfp677 31
  • 35 (a)
ManyToMany
Zfp109 31
  • 35 (a)
ManyToMany
Zfp760 31
  • 33 (a)
ManyToMany
Gm13242 31
  • 33 (a)
ManyToMany
Zfp229 31
  • 32 (a)
ManyToMany
Zfp54 31
  • 32 (a)
ManyToMany
Rex2 31
  • 32 (a)
ManyToMany
Zfp948 31
  • 30 (a)
ManyToMany
Gm26919 31
  • 27 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 43 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 36 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ZNF214 31
  • 11 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG2120 32
  • 35 (a)
CG5245 31
  • 32 (a)
ManyToMany
CG11695 32
  • 29 (a)
Worm
(Caenorhabditis elegans)
Secernentea tag-146 31
  • 21 (a)
ManyToMany
C27A12.2 31
  • 18 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 42 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
Species where no ortholog for ZNF214 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ZNF214 Gene

ENSEMBL:
Gene Tree for ZNF214 (if available)
TreeFam:
Gene Tree for ZNF214 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF214: view image

Paralogs for ZNF214 Gene

(497) SIMAP similar genes for ZNF214 Gene using alignment to 2 proteins:

  • ZN214_HUMAN
  • B7ZMB1_HUMAN
genes like me logo Genes that share paralogs with ZNF214: view

Variants for ZNF214 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF214 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1156525 - p.Leu128His
rs1156526 - p.Tyr66Cys
rs16921097 - p.His160Arg
rs2239734 - p.Ile185Arg

Additional dbSNP identifiers (rs#s) for ZNF214 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF214 Gene

Variant ID Type Subtype PubMed ID
esv3417932 CNV insertion 20981092
nsv832061 CNV loss 17160897

Variation tolerance for ZNF214 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.41; 77.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF214 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF214

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF214 Gene

Disorders for ZNF214 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF214 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • bws
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF214: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF214 Gene

Publications for ZNF214 Gene

  1. Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. (PMID: 10762538) Alders M … Mannens M (American journal of human genetics 2000) 3 4
  2. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. A novel familial 11p15.4 microduplication associated with intellectual disability, dysmorphic features, and obesity with involvement of the ZNF214 gene. (PMID: 22052655) Sofos E … Shur N (American journal of medical genetics. Part A 2012) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF214 Gene

Sources for ZNF214 Gene