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Aliases for ZNF214 Gene

Aliases for ZNF214 Gene

  • Zinc Finger Protein 214 2 3 5
  • BWSCR2-Associated Zinc Finger Protein 1 3 4
  • BAZ-1 3 4
  • BAZ1 3 4

External Ids for ZNF214 Gene

Previous GeneCards Identifiers for ZNF214 Gene

  • GC11M007763
  • GC11M007481
  • GC11M006979
  • GC11M006984
  • GC11M006977
  • GC11M006679

Summaries for ZNF214 Gene

Entrez Gene Summary for ZNF214 Gene

  • This gene is expressed predominantly in the testis and encodes a zinc finger protein that contains an N-terminal kruppel-associated box A (KRABA) domain and twelve zinc finger domains. This gene is located within one of three regions on chromosome 11p15 associated with Beckwith-Wiedemann syndrome, called Beckwith-Wiedemann syndrome chromosome region-2 (BWSCR2), and is thought to play a role in the etiology of this disease. [provided by RefSeq, Aug 2017]

GeneCards Summary for ZNF214 Gene

ZNF214 (Zinc Finger Protein 214) is a Protein Coding gene. Diseases associated with ZNF214 include Beckwith-Wiedemann Syndrome and Cryptorchidism, Unilateral Or Bilateral. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF112.

UniProtKB/Swiss-Prot for ZNF214 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF214 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF214 Gene

Genomics for ZNF214 Gene

GeneHancer (GH) Regulatory Elements for ZNF214 Gene

Promoters and enhancers for ZNF214 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I007019 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 556.1 +0.1 67 2.5 PKNOX1 ZFP64 ARID4B SIN3A YY1 ETS1 ZNF143 SP3 RXRA SP5 ZNF214 PIR41527 NLRP14 DNHD1 ENSG00000254641 C11orf42 CYB5R2 ARFIP2 GC11P006959 GC11M006985
GH11I007985 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 24.6 -966.8 -966813 2.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 EIF3F SNORA3B OLFML1 TMEM9B-AS1 ZNF214 RPL27A ST5 CASC23 TUB COX6CP5
GH11I006991 Enhancer 0.8 Ensembl ENCODE 11.3 +28.0 27971 2.5 PKNOX1 ZNF792 ZIC2 ZNF843 ZNF335 PRDM6 ZFP3 ZXDB TRIM28 ZBTB20 LOC102724711 ZNF214 NLRP14 GVINP1 ZNF215 GC11M006969 GC11P006959 GC11M006985
GH11I007071 Enhancer 0.4 ENCODE 10.9 -52.8 -52813 3.3 CBFA2T3 ZEB2 NLRP14 ZNF214 OVCH2 OLFML1 GC11M006985 GC11P007052 GC11P007045
GH11I006654 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 1.6 +364.6 364617 3 HDAC1 FOXA2 MLX SIN3A ZNF48 RARA ZNF366 EGR2 HMG20B SP5 DCHS1 RRP8 FAM160A2 ENSG00000254641 LOC100506258 LOC644169 ILK APBB1 OR2D2 TRIM3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF214 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF214 gene promoter:

Genomic Locations for ZNF214 Gene

Genomic Locations for ZNF214 Gene
23,764 bases
Minus strand

Genomic View for ZNF214 Gene

Genes around ZNF214 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF214 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF214 Gene

Proteins for ZNF214 Gene

  • Protein details for ZNF214 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 214
    Protein Accession:
    Secondary Accessions:
    • B2R8Q1

    Protein attributes for ZNF214 Gene

    606 amino acids
    Molecular mass:
    70992 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF214 Gene

Post-translational modifications for ZNF214 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF214 Gene

Domains & Families for ZNF214 Gene

Gene Families for ZNF214 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF214 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF214: view

Function for ZNF214 Gene

Molecular function for ZNF214 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 10762538
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF214: view
genes like me logo Genes that share phenotypes with ZNF214: view

Animal Model Products

CRISPR Products

miRNA for ZNF214 Gene

miRTarBase miRNAs that target ZNF214

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF214 Gene

Localization for ZNF214 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF214 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF214 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF214: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF214 Gene

Pathways & Interactions for ZNF214 Gene

SuperPathways for ZNF214 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF214: view

Pathways by source for ZNF214 Gene

2 Reactome pathways for ZNF214 Gene

Interacting Proteins for ZNF214 Gene

Gene Ontology (GO) - Biological Process for ZNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF214: view

No data available for SIGNOR curated interactions for ZNF214 Gene

Drugs & Compounds for ZNF214 Gene

No Compound Related Data Available

Transcripts for ZNF214 Gene

mRNA/cDNA for ZNF214 Gene

Unigene Clusters for ZNF214 Gene

Zinc finger protein 214:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF214 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: - -
SP5: - -

Relevant External Links for ZNF214 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF214 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF214 Gene

Protein differential expression in normal tissues from HIPED for ZNF214 Gene

This gene is overexpressed in Monocytes (40.4), Pancreatic juice (11.8), Fetal Brain (7.5), and CD4 Tcells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF214 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF214 Gene:


SOURCE GeneReport for Unigene cluster for ZNF214 Gene:


Evidence on tissue expression from TISSUES for ZNF214 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF214: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF214 Gene

Orthologs for ZNF214 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF214 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF214 33 34
  • 99.34 (n)
(Canis familiaris)
Mammalia ZNF214 33 34
  • 88.5 (n)
(Bos Taurus)
Mammalia ZNF214 33 34
  • 86.67 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
-- 34
  • 47 (a)
-- 34
  • 37 (a)
-- 34
  • 35 (a)
-- 34
  • 34 (a)
-- 34
  • 30 (a)
-- 34
  • 29 (a)
-- 34
  • 28 (a)
(Mus musculus)
Mammalia Gm14443 34
  • 38 (a)
Zfp109 34
  • 35 (a)
Zfp53 34
  • 35 (a)
Zfp677 34
  • 35 (a)
Gm13242 34
  • 33 (a)
Zfp760 34
  • 33 (a)
Zfp229 34
  • 32 (a)
Zfp54 34
  • 32 (a)
Rex2 34
  • 32 (a)
Zfp948 34
  • 30 (a)
Gm26919 34
  • 27 (a)
(Gallus gallus)
Aves -- 34
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
(Danio rerio)
Actinopterygii ZNF214 34
  • 11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2120 35
  • 35 (a)
CG5245 34
  • 32 (a)
CG11695 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea tag-146 34
  • 21 (a)
C27A12.2 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
-- 34
  • 23 (a)
Species where no ortholog for ZNF214 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF214 Gene

Gene Tree for ZNF214 (if available)
Gene Tree for ZNF214 (if available)

Paralogs for ZNF214 Gene

(497) SIMAP similar genes for ZNF214 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF214: view

Variants for ZNF214 Gene

Sequence variations from dbSNP and Humsavar for ZNF214 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000107318 -- 6,998,252(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000174724 -- 7,001,550(-) A/G coding_sequence_variant, missense_variant
rs1000204526 -- 7,005,153(-) C/A intron_variant
rs1000480590 -- 7,017,994(-) T/G intron_variant
rs1000521678 -- 6,997,955(-) G/T 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF214 Gene

Variant ID Type Subtype PubMed ID
esv3417932 CNV insertion 20981092
nsv832061 CNV loss 17160897

Variation tolerance for ZNF214 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.41; 77.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF214 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF214 Gene

Disorders for ZNF214 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF214 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • bws
cryptorchidism, unilateral or bilateral
  • undescended testis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF214

genes like me logo Genes that share disorders with ZNF214: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF214 Gene

Publications for ZNF214 Gene

  1. Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. (PMID: 10762538) Alders M … Mannens M (American journal of human genetics 2000) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. A novel familial 11p15.4 microduplication associated with intellectual disability, dysmorphic features, and obesity with involvement of the ZNF214 gene. (PMID: 22052655) Sofos E … Shur N (American journal of medical genetics. Part A 2012) 3 58
  4. Reduced transcript expression of genes affected by inherited and de novo CNVs in autism. (PMID: 21448237) Nord AS … McClellan JM (European journal of human genetics : EJHG 2011) 3 58
  5. Morphogenetic targets and genetics of undescended testis. (PMID: 20980787) Massart F … Saggese G (Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2010) 3 58

Products for ZNF214 Gene

Sources for ZNF214 Gene

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