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Aliases for ZNF213 Gene

Aliases for ZNF213 Gene

  • Zinc Finger Protein 213 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 21 3 4
  • Putative Transcription Factor CR53 3 4
  • ZKSCAN21 3 4
  • ZSCAN53 3
  • CR53 3

External Ids for ZNF213 Gene

Previous GeneCards Identifiers for ZNF213 Gene

  • GC16P003205
  • GC16P003185
  • GC16P003124
  • GC16P003126
  • GC16P003156
  • GC16P003179
  • GC16P003182
  • GC16P003231
  • GC16P003234
  • GC16P003287
  • GC16P003324
  • GC16P003378
  • GC16P003413

Summaries for ZNF213 Gene

Entrez Gene Summary for ZNF213 Gene

  • C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the other modulates target gene expression.[supplied by OMIM, Apr 2004]

GeneCards Summary for ZNF213 Gene

ZNF213 (Zinc Finger Protein 213) is a Protein Coding gene. Diseases associated with ZNF213 include Patent Ductus Arteriosus 1. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF500.

UniProtKB/Swiss-Prot for ZNF213 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF213 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF213 Gene

Genomics for ZNF213 Gene

GeneHancer (GH) Regulatory Elements for ZNF213 Gene

Promoters and enhancers for ZNF213 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I003133 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 555.2 +5.2 5209 2.8 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 ZNF213-AS1 ZNF213 ZNF205 ERVK13-1 CASP16P
GH16I003128 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 550.8 -0.2 -211 1.8 PKNOX1 ATF1 ARID4B SIN3A ZNF2 YY1 E2F8 ARID2 ZNF143 ATF7 PIR58259 ZNF213 GC16M003129 RNU1-125P IL32 MMP25 BICDL2 LOC100128770 CLDN6 HCFC1R1
GH16I003127 Enhancer 0.4 ENCODE 550.8 -1.9 -1919 0.7 ZNF664 POLR2A GC16M003129 PIR58259 ZNF213 ERVK13-1 ZNF213-AS1 ZNF205-AS1
GH16I003156 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 7.6 +29.0 29017 3.8 DMAP1 YY1 ZNF213 E2F8 SP3 MEF2D SSRP1 ZNF610 GLIS1 NBN GC16M003157 TRK-CTT3-1 TRP-TGG3-3 ZNF75A ZNF213-AS1 ZNF205 E4F1 RNPS1 PDPK2P LOC652276
GH16I003069 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7.1 -55.4 -55397 9.8 HDGF PKNOX1 YBX1 IRF4 ZNF207 ZNF143 ATF7 RUNX3 PAF1 ATF4 GC16P003518 ZNF205 LOC105371058 MMP25 IL32 FLYWCH2 BICDL2 LOC100128770 CLDN6 HCFC1R1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF213 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF213 gene promoter:

Genomic Locations for ZNF213 Gene

Genomic Locations for ZNF213 Gene
13,029 bases
Plus strand

Genomic View for ZNF213 Gene

Genes around ZNF213 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF213 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF213 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF213 Gene

Proteins for ZNF213 Gene

  • Protein details for ZNF213 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 213
    Protein Accession:
    Secondary Accessions:
    • A8K1B9
    • B4DMG6
    • Q96IS1

    Protein attributes for ZNF213 Gene

    459 amino acids
    Molecular mass:
    51263 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB70531.1; Type=Frameshift; Positions=400, 405, 457; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF213 Gene


neXtProt entry for ZNF213 Gene

Post-translational modifications for ZNF213 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF213 Gene

Domains & Families for ZNF213 Gene

Gene Families for ZNF213 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF213 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF213: view

Function for ZNF213 Gene

Molecular function for ZNF213 Gene

GENATLAS Biochemistry:
zinc finger protein 213 (C2H2 type,Kruppel-like),ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF213 Gene

Gene Ontology (GO) - Molecular Function for ZNF213 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF213: view
genes like me logo Genes that share phenotypes with ZNF213: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF213 Gene

Localization for ZNF213 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF213 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF213 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF213 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF213: view

Pathways & Interactions for ZNF213 Gene

SuperPathways for ZNF213 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF213: view

Pathways by source for ZNF213 Gene

2 Reactome pathways for ZNF213 Gene

Gene Ontology (GO) - Biological Process for ZNF213 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF213: view

No data available for SIGNOR curated interactions for ZNF213 Gene

Drugs & Compounds for ZNF213 Gene

No Compound Related Data Available

Transcripts for ZNF213 Gene

Unigene Clusters for ZNF213 Gene

Zinc finger protein 213:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF213 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP4: - -

Relevant External Links for ZNF213 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF213 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF213 Gene

Protein differential expression in normal tissues from HIPED for ZNF213 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF213 Gene

Protein tissue co-expression partners for ZNF213 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF213 Gene:


SOURCE GeneReport for Unigene cluster for ZNF213 Gene:


mRNA Expression by UniProt/SwissProt for ZNF213 Gene:

Tissue specificity: Widely expressed with highest levels in testis.

Evidence on tissue expression from TISSUES for ZNF213 Gene

  • Nervous system(4.5)
  • Kidney(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with ZNF213: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF213 Gene

Orthologs for ZNF213 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF213 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF213 33 34
  • 99.35 (n)
(Bos Taurus)
Mammalia ZNF213 33 34
  • 85.89 (n)
(Canis familiaris)
Mammalia ZNF213 33
  • 85.01 (n)
(Mus musculus)
Mammalia Zfp213 33 16 34
  • 80.24 (n)
(Ornithorhynchus anatinus)
Mammalia ZNF213 34
  • 69 (a)
(Monodelphis domestica)
Mammalia ZNF213 34
  • 68 (a)
Species where no ortholog for ZNF213 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF213 Gene

Gene Tree for ZNF213 (if available)
Gene Tree for ZNF213 (if available)

Paralogs for ZNF213 Gene

(297) SIMAP similar genes for ZNF213 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF213: view

Variants for ZNF213 Gene

Sequence variations from dbSNP and Humsavar for ZNF213 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000267260 -- 3,139,962(+) C/T intron_variant
rs1000445393 -- 3,133,235(+) G/C upstream_transcript_variant
rs1000486670 -- 3,134,851(+) C/T upstream_transcript_variant
rs1000570780 -- 3,134,575(+) T/C upstream_transcript_variant
rs1000773259 -- 3,143,024(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF213 Gene

Variant ID Type Subtype PubMed ID
esv1496729 CNV insertion 17803354
nsv103291 CNV insertion 16902084
nsv1117154 CNV tandem duplication 24896259
nsv1148275 CNV insertion 26484159
nsv457355 CNV gain 19166990
nsv509589 CNV insertion 20534489
nsv571248 CNV loss 21841781
nsv571249 CNV gain 21841781

Variation tolerance for ZNF213 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF213 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF213 Gene

Disorders for ZNF213 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF213 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
patent ductus arteriosus 1
  • pda1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF213

genes like me logo Genes that share disorders with ZNF213: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF213 Gene

Publications for ZNF213 Gene

  1. Identification and characterization of a zinc finger gene (ZNF213) from 16p13.3. (PMID: 10023065) Chen X … Fischel-Ghodsian N (Biochimica et biophysica acta 1999) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A transcriptional Map of the FMF region. (PMID: 9653642) Bernot A … Weissenbach J (Genomics 1998) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF213 Gene

Sources for ZNF213 Gene

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