This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefS... See more...

Aliases for ZNF212 Gene

Aliases for ZNF212 Gene

  • Zinc Finger Protein 212 2 3 4 5
  • Zinc Finger Protein C2H2-150 3 4
  • C2H2-150 2 3
  • ZNFC150 3 4
  • ZNF182 3
  • ZNF212 5

External Ids for ZNF212 Gene

Previous GeneCards Identifiers for ZNF212 Gene

  • GC07P147194
  • GC07P148251
  • GC07P148328
  • GC07P148374
  • GC07P148567
  • GC07P148936
  • GC07P143014

Summaries for ZNF212 Gene

Entrez Gene Summary for ZNF212 Gene

  • This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF212 Gene

ZNF212 (Zinc Finger Protein 212) is a Protein Coding gene. Diseases associated with ZNF212 include Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription coregulator activity. An important paralog of this gene is ZNF783.

UniProtKB/Swiss-Prot Summary for ZNF212 Gene

Additional gene information for ZNF212 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF212 Gene

Genomics for ZNF212 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF212 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF212 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF212

Top Transcription factor binding sites by QIAGEN in the ZNF212 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • Lmo2
  • Nkx2-5
  • STAT3

Genomic Locations for ZNF212 Gene

Genomic Locations for ZNF212 Gene
chr7:149,239,651-149,255,606
(GRCh38/hg38)
Size:
15,956 bases
Orientation:
Plus strand
chr7:148,936,742-148,952,700
(GRCh37/hg19)
Size:
15,959 bases
Orientation:
Plus strand

Genomic View for ZNF212 Gene

Genes around ZNF212 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF212 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF212 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF212 Gene

Proteins for ZNF212 Gene

  • Protein details for ZNF212 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UDV6-ZN212_HUMAN
    Recommended name:
    Zinc finger protein 212
    Protein Accession:
    Q9UDV6
    Secondary Accessions:
    • B2RCF4
    • Q13396
    • Q8N664

    Protein attributes for ZNF212 Gene

    Size:
    495 amino acids
    Molecular mass:
    55447 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC51296.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD45826.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF212 Gene

Post-translational modifications for ZNF212 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF212 Gene

No data available for DME Specific Peptides for ZNF212 Gene

Domains & Families for ZNF212 Gene

Gene Families for ZNF212 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF212 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF212 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein C2H2-150 (ZN212_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UDV6

UniProtKB/Swiss-Prot:

ZN212_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF212: view

Function for ZNF212 Gene

Molecular function for ZNF212 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 122,KRAB subfamily (C2H2 Kruppel-like)

Phenotypes From GWAS Catalog for ZNF212 Gene

Gene Ontology (GO) - Molecular Function for ZNF212 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 18255255
GO:0008270 zinc ion binding NAS 7633419
GO:0042802 identical protein binding IPI 18255255
genes like me logo Genes that share ontologies with ZNF212: view
genes like me logo Genes that share phenotypes with ZNF212: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF212

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF212 Gene

Localization for ZNF212 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF212 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF212 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF212 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF212: view

Pathways & Interactions for ZNF212 Gene

genes like me logo Genes that share pathways with ZNF212: view

Pathways by source for ZNF212 Gene

2 Reactome pathways for ZNF212 Gene
1 KEGG pathway for ZNF212 Gene

Gene Ontology (GO) - Biological Process for ZNF212 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 7633419
genes like me logo Genes that share ontologies with ZNF212: view

No data available for SIGNOR curated interactions for ZNF212 Gene

Drugs & Compounds for ZNF212 Gene

No Compound Related Data Available

Transcripts for ZNF212 Gene

mRNA/cDNA for ZNF212 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF212

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF212 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - - -
SP6:
SP7: - - -
SP8: - - - -
SP9: - - -

Relevant External Links for ZNF212 Gene

GeneLoc Exon Structure for
ZNF212

Expression for ZNF212 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF212 Gene

Protein differential expression in normal tissues from HIPED for ZNF212 Gene

This gene is overexpressed in Liver, secretome (57.2) and Peripheral blood mononuclear cells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF212 Gene



Protein tissue co-expression partners for ZNF212 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF212

SOURCE GeneReport for Unigene cluster for ZNF212 Gene:

Hs.490510

Evidence on tissue expression from TISSUES for ZNF212 Gene

  • Nervous system(4.7)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ZNF212: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF212 Gene

Orthologs for ZNF212 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF212 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF212 30 31
  • 99.19 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF212 30
  • 87.07 (n)
Cow
(Bos Taurus)
Mammalia ZNF212 30 31
  • 83.19 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp212 30 17 31
  • 82.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp212 30
  • 81.33 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZNF212 31
  • 72 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF212 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 24 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia ZNF212 31
  • 29 (a)
OneToOne
Species where no ortholog for ZNF212 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF212 Gene

ENSEMBL:
Gene Tree for ZNF212 (if available)
TreeFam:
Gene Tree for ZNF212 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF212: view image

Paralogs for ZNF212 Gene

Paralogs for ZNF212 Gene

genes like me logo Genes that share paralogs with ZNF212: view

Variants for ZNF212 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF212 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs34185245 - p.His293Tyr

Additional dbSNP identifiers (rs#s) for ZNF212 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF212 Gene

Variant ID Type Subtype PubMed ID
dgv11712n54 CNV loss 21841781
nsv465196 CNV loss 19166990
nsv819456 CNV gain 19587683

Variation tolerance for ZNF212 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.77; 73.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF212 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF212

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF212 Gene

Disorders for ZNF212 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF212 Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-syndromic x-linked intellectual disability
  • non-specific x-linked mental retardation
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF212

genes like me logo Genes that share disorders with ZNF212: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF212 Gene

Publications for ZNF212 Gene

  1. Molecular cloning and mapping of a novel human KRAB domain-containing C2H2-type zinc finger to chromosome 7q36.1. (PMID: 9169157) Becker KG … Drew PD (Genomics 1997) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
  4. Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain. (PMID: 7633419) Becker KG … Drew PD (Human molecular genetics 1995) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF212 Gene

  • Signalway Proteins for ZNF212

Sources for ZNF212 Gene