This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. This protein may play a role in developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] See more...

Aliases for ZNF211 Gene

Aliases for ZNF211 Gene

  • Zinc Finger Protein 211 2 3 4 5
  • Zinc Finger Protein C2H2-25 3 4
  • CH2H2-25 3
  • C2H2-25 3
  • ZNF-25 3

External Ids for ZNF211 Gene

Previous GeneCards Identifiers for ZNF211 Gene

  • GC19P059043
  • GC19P058598
  • GC19P062820
  • GC19P062836
  • GC19P058141
  • GC19P054456

Summaries for ZNF211 Gene

Entrez Gene Summary for ZNF211 Gene

  • This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. This protein may play a role in developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for ZNF211 Gene

ZNF211 (Zinc Finger Protein 211) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF786.

UniProtKB/Swiss-Prot Summary for ZNF211 Gene

Additional gene information for ZNF211 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF211 Gene

Genomics for ZNF211 Gene

GeneHancer (GH) Regulatory Elements for ZNF211 Gene

Promoters and enhancers for ZNF211 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J057632 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 518.4 +3.2 3162 2.1 ZBTB40 ZNF217 SIN3A TCF12 POLR2G SP1 NCOR1 PHF8 SIX5 ZIC2 ZNF211 HSALNG0127871 ZNF548 ZNF264 ZNF550 TRIM28 ZNF134 ZNF805 ZNF417 ZNF551
GH19J057630 Promoter 0.3 EPDnew 506.6 -0.1 -93 0.1 ZNF211 ENSG00000268392
GH19J057599 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 33.5 -30.2 -30194 2.4 ZBTB40 ZNF217 SIN3A NRF1 TCF12 ZNF300 SP1 SIX5 ZBTB5 ZBTB11 ZNF530 NONHSAG026674.2 lnc-ZNF416-1 ZNF606 ZNF549 ZNF135 ZNF417 ZNF132 ZNF418 ENSG00000176593
GH19J058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 12.3 +696.5 696476 3.6 EP300 ZBTB40 ZNF217 ZSCAN5C NRF1 TCF12 POLR2G NCOR1 RBAK GTF2E2 ZSCAN22 ENSG00000283103 LOC105372480 piR-50425 ZNF134 ZNF135 ZNF549 ZNF446 TRIM28 ZNF324B
GH19J058450 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.3 +821.3 821306 2.6 ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 PHF8 SIX5 ZFX ZNF324B ZNF134 TRIM28 ZNF550 ZNF274 ZNF417 ENSG00000176593 ZNF256 ZNF773 ZNF584
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF211 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF211

Top Transcription factor binding sites by QIAGEN in the ZNF211 gene promoter:
  • CUTL1
  • Pax-6
  • POU2F1
  • POU2F1a

Genomic Locations for ZNF211 Gene

Genomic Locations for ZNF211 Gene
chr19:57,630,395-57,644,041
(GRCh38/hg38)
Size:
13,647 bases
Orientation:
Plus strand
chr19:58,141,761-58,154,147
(GRCh37/hg19)
Size:
12,387 bases
Orientation:
Plus strand

Genomic View for ZNF211 Gene

Genes around ZNF211 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF211 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF211 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF211 Gene

Proteins for ZNF211 Gene

  • Protein details for ZNF211 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13398-ZN211_HUMAN
    Recommended name:
    Zinc finger protein 211
    Protein Accession:
    Q13398
    Secondary Accessions:
    • B4DH10
    • B4DLC9
    • B4E3C9
    • B9ZVS7
    • B9ZVW1
    • F8WDV2
    • Q05BQ7
    • Q2TAL7
    • Q59EG4
    • Q59G36
    • Q5EBL6

    Protein attributes for ZNF211 Gene

    Size:
    564 amino acids
    Molecular mass:
    64535 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA93261.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH34351.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAD93084.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF211 Gene

neXtProt entry for ZNF211 Gene

Post-translational modifications for ZNF211 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF211 Gene

Domains & Families for ZNF211 Gene

Gene Families for ZNF211 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF211 Gene

Blocks:
  • C2H2-type zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF211 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein C2H2-25 (ZN211_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13398

UniProtKB/Swiss-Prot:

ZN211_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF211: view

Function for ZNF211 Gene

Molecular function for ZNF211 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 211,C2H2 type,expressed in the brain

Phenotypes From GWAS Catalog for ZNF211 Gene

Gene Ontology (GO) - Molecular Function for ZNF211 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF211: view
genes like me logo Genes that share phenotypes with ZNF211: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF211

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF211 Gene

Localization for ZNF211 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF211 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF211 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Rods & Rings (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF211 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF211: view

Pathways & Interactions for ZNF211 Gene

genes like me logo Genes that share pathways with ZNF211: view

Pathways by source for ZNF211 Gene

2 Reactome pathways for ZNF211 Gene
1 KEGG pathway for ZNF211 Gene

Gene Ontology (GO) - Biological Process for ZNF211 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF211: view

No data available for SIGNOR curated interactions for ZNF211 Gene

Drugs & Compounds for ZNF211 Gene

(1) Drugs for ZNF211 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methylphenidate Approved, Investigational Pharma 418
genes like me logo Genes that share compounds with ZNF211: view

Transcripts for ZNF211 Gene

mRNA/cDNA for ZNF211 Gene

8 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF211

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF211 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - -
SP2: -
SP3: - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - -
SP6: - -
SP7:
SP8: - -

Relevant External Links for ZNF211 Gene

GeneLoc Exon Structure for
ZNF211

Expression for ZNF211 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF211 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF211

SOURCE GeneReport for Unigene cluster for ZNF211 Gene:

Hs.590977

Evidence on tissue expression from TISSUES for ZNF211 Gene

  • Heart(4.2)
  • Skin(4.2)
  • Nervous system(4.2)
  • Blood(4)
genes like me logo Genes that share expression patterns with ZNF211: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF211 Gene

Orthologs for ZNF211 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF211 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF211 31 30
  • 98.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF211 31 30
  • 84.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC789996 30
  • 83.48 (n)
ZNF211 31
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cf2 32
  • 48 (a)
CG3407 32
  • 40 (a)
CG8319 32
  • 36 (a)
CG6689 32
  • 30 (a)
Species where no ortholog for ZNF211 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF211 Gene

ENSEMBL:
Gene Tree for ZNF211 (if available)
TreeFam:
Gene Tree for ZNF211 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF211: view image

Paralogs for ZNF211 Gene

Paralogs for ZNF211 Gene

(551) SIMAP similar genes for ZNF211 Gene using alignment to 4 proteins:

  • ZN211_HUMAN
  • F5GY70_HUMAN
  • F5H771_HUMAN
  • H0Y3T8_HUMAN

Pseudogenes.org Pseudogenes for ZNF211 Gene

genes like me logo Genes that share paralogs with ZNF211: view

Variants for ZNF211 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF211 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs11879465 - p.Ala314Val
rs34897843 - p.Asp110Asn

Additional dbSNP identifiers (rs#s) for ZNF211 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF211 Gene

Variant ID Type Subtype PubMed ID
dgv3685n100 CNV gain 25217958
esv3575120 CNV gain 25503493
nsv580402 CNV gain 21841781

Variation tolerance for ZNF211 Gene

Residual Variation Intolerance Score: 63.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.02; 87.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF211 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF211

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF211 Gene

Disorders for ZNF211 Gene

Additional Disease Information for ZNF211

No disorders were found for ZNF211 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF211 Gene

Publications for ZNF211 Gene

  1. Molecular cloning and mapping of a novel developmentally regulated human C2H2-type zinc finger. (PMID: 9096115) Becker KG … Drew PD (Mammalian genome : official journal of the International Mammalian Genome Society 1997) 2 3 4 54
  2. Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain. (PMID: 7633419) Becker KG … Drew PD (Human molecular genetics 1995) 2 3 4 54
  3. OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer. (PMID: 30662561) Li J … Yao M (Theranostics 2019) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S … Beisel C (Cell reports 2016) 3 54

Products for ZNF211 Gene

Sources for ZNF211 Gene