Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for... See more...

Aliases for ZNF208 Gene

Aliases for ZNF208 Gene

  • Zinc Finger Protein 208 2 3 4 5
  • Zinc Finger Protein 95 2 3
  • Zinc Finger Protein 91-Like 4
  • ZNF91L 4
  • PMIDP 3
  • ZNF95 3

External Ids for ZNF208 Gene

Previous GeneCards Identifiers for ZNF208 Gene

  • GC19M022601
  • GC19M022483
  • GC19M021683
  • GC19M021782
  • GC19M021945
  • GC19M022148
  • GC19M021686
  • GC19M022115
  • GC19M022588
  • GC19M022797
  • GC19M022846
  • GC19M021950
  • GC19M022077
  • GC19M022112
  • GC19M022300
  • GC19M022469

Summaries for ZNF208 Gene

Entrez Gene Summary for ZNF208 Gene

  • Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug 2009]

GeneCards Summary for ZNF208 Gene

ZNF208 (Zinc Finger Protein 208) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF729.

UniProtKB/Swiss-Prot Summary for ZNF208 Gene

Additional gene information for ZNF208 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF208 Gene

Genomics for ZNF208 Gene

GeneHancer (GH) Regulatory Elements for ZNF208 Gene

Promoters and enhancers for ZNF208 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J022010 Promoter 0.9 EPDnew Ensembl 507.8 +0.7 748 2 PRDM10 GABPB1 PKNOX1 ZNF208 ZNF257 BNIP3P29 ZNF676 BNIP3P28 lnc-ZNF257-2
GH19J022051 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 5.9 -41.8 -41752 2.2 ZFX TAF9B SIN3A POLR2A SP2 PBX2 POLR2G TBP ELF1 SUPT5H ZNF257 ENSG00000269504 BNIP3P29 ZNF208 piR-43105-335
GH19J022429 Enhancer 0.2 FANTOM5 15.5 -416.7 -416654 0.3 ZNF208 ZNF98 ZNF257 ZNF492 ZNF676 ENSG00000269796 piR-48209-340 lnc-ZNF492-2 NONHSAG045689.2-002
GH19J021699 Enhancer 0.7 FANTOM5 ENCODE 3.1 +311.6 311550 0.3 USF1 RFX1 YY1 SIN3A MNT EGR1 POU5F1 USF2 MAX RF02002-019 piR-35674-253 ZNF100 ZNF208 ZNF676 piR-50308-315 lnc-ZNF429-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF208 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF208

Genomic Locations for ZNF208 Gene

Genomic Locations for ZNF208 Gene
chr19:21,932,958-22,010,949
(GRCh38/hg38)
Size:
77,992 bases
Orientation:
Minus strand
chr19:22,115,760-22,193,751
(GRCh37/hg19)
Size:
77,992 bases
Orientation:
Minus strand

Genomic View for ZNF208 Gene

Genes around ZNF208 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF208 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF208 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF208 Gene

Proteins for ZNF208 Gene

  • Protein details for ZNF208 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43345-ZN208_HUMAN
    Recommended name:
    Zinc finger protein 208
    Protein Accession:
    O43345

    Protein attributes for ZNF208 Gene

    Size:
    1280 amino acids
    Molecular mass:
    147487 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF208 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF208 Gene

Post-translational modifications for ZNF208 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF208 Gene

Domains & Families for ZNF208 Gene

Gene Families for ZNF208 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF208 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF208 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 91-like (ZN208_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43345

UniProtKB/Swiss-Prot:

ZN208_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF208: view

Function for ZNF208 Gene

Molecular function for ZNF208 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 208,ubiquitously expressed,located in a cluster of Kruppel associated box zinc finger

Phenotypes From GWAS Catalog for ZNF208 Gene

Gene Ontology (GO) - Molecular Function for ZNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA 21873635
GO:0008270 zinc ion binding NAS 9724325
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF208: view
genes like me logo Genes that share phenotypes with ZNF208: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF208

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF208 Gene

Localization for ZNF208 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF208 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF208 gene
Compartment Confidence
nucleus 4
cytosol 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for ZNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF208: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF208 Gene

Pathways & Interactions for ZNF208 Gene

genes like me logo Genes that share pathways with ZNF208: view

Pathways by source for ZNF208 Gene

2 Reactome pathways for ZNF208 Gene
1 KEGG pathway for ZNF208 Gene

Interacting Proteins for ZNF208 Gene

;

Gene Ontology (GO) - Biological Process for ZNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF208: view

No data available for SIGNOR curated interactions for ZNF208 Gene

Drugs & Compounds for ZNF208 Gene

No Compound Related Data Available

Transcripts for ZNF208 Gene

mRNA/cDNA for ZNF208 Gene

5 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF208

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF208 Gene

No ASD Table

Relevant External Links for ZNF208 Gene

GeneLoc Exon Structure for
ZNF208

Expression for ZNF208 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF208 Gene

Protein differential expression in normal tissues from HIPED for ZNF208 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF208 Gene



Protein tissue co-expression partners for ZNF208 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF208

SOURCE GeneReport for Unigene cluster for ZNF208 Gene:

Hs.732975

mRNA Expression by UniProt/SwissProt for ZNF208 Gene:

O43345-ZN208_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ZNF208: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF208 Gene

Orthologs for ZNF208 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF208 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF208 31
  • 99 (a)
OneToOne
ZNF493 30
  • 80.87 (n)
rat
(Rattus norvegicus)
Mammalia LOC102548231 30
  • 55.29 (n)
mouse
(Mus musculus)
Mammalia Zfp619 17 30
  • 55.26 (n)
cow
(Bos Taurus)
Mammalia -- 31
  • 55 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia ZNF208 30
  • 54.54 (n)
-- 31
  • 17 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 53 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 56 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 53 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC101884857 30
  • 62.65 (n)
zgc:171418 31
  • 51 (a)
ManyToMany
si:dkey-14o6.6 31
  • 51 (a)
ManyToMany
zgc:113100 31
  • 50 (a)
ManyToMany
si:ch211-209p16.3 31
  • 50 (a)
ManyToMany
BX005085.3 31
  • 50 (a)
ManyToMany
BX942815.1 31
  • 50 (a)
ManyToMany
si:ch211-245n8.1 31
  • 49 (a)
ManyToMany
BX321873.2 31
  • 49 (a)
ManyToMany
CR927215.1 31
  • 49 (a)
ManyToMany
si:dkey-111k8.1 31
  • 48 (a)
ManyToMany
si:dkey-92c21.3 31
  • 48 (a)
ManyToMany
si:ch211-208f21.5 31
  • 48 (a)
ManyToMany
BX571760.1 31
  • 47 (a)
ManyToMany
BX510909.3 31
  • 47 (a)
ManyToMany
AL935044.2 31
  • 46 (a)
ManyToMany
si:dkey-196n19.7 31
  • 46 (a)
ManyToMany
si:dkey-240n22.7 31
  • 45 (a)
ManyToMany
CR847941.1 31
  • 45 (a)
ManyToMany
si:dkey-15h8.4 31
  • 45 (a)
ManyToMany
BX510909.2 31
  • 45 (a)
ManyToMany
CU467646.2 31
  • 45 (a)
ManyToMany
CU929391.1 31
  • 45 (a)
ManyToMany
CR356223.5 31
  • 45 (a)
ManyToMany
zgc:171570 31
  • 44 (a)
ManyToMany
CABZ01084613.2 31
  • 44 (a)
ManyToMany
BX321887.1 31
  • 44 (a)
ManyToMany
zgc:174234 31
  • 44 (a)
ManyToMany
CABZ01021450.1 31
  • 43 (a)
ManyToMany
BX324216.1 31
  • 43 (a)
ManyToMany
zgc:113381 31
  • 41 (a)
ManyToMany
si:ch73-40a17.5 31
  • 39 (a)
ManyToMany
si:dkey-77f5.7 31
  • 20 (a)
ManyToMany
znf770 31
  • 18 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10147 32
  • 36 (a)
l(2)35Ea 32
  • 36 (a)
CG3032 32
  • 31 (a)
Oaz 31
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
ManyToMany
-- 31
  • 46 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
CSA.11281 31
  • 39 (a)
ManyToMany
Species where no ortholog for ZNF208 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF208 Gene

ENSEMBL:
Gene Tree for ZNF208 (if available)
TreeFam:
Gene Tree for ZNF208 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF208: view image

Paralogs for ZNF208 Gene

(382) SIMAP similar genes for ZNF208 Gene using alignment to 6 proteins:

  • ZN208_HUMAN
  • M0QXL7_HUMAN
  • M0QYK4_HUMAN
  • M0R1F2_HUMAN
  • M0R293_HUMAN
  • M0R370_HUMAN

Pseudogenes.org Pseudogenes for ZNF208 Gene

genes like me logo Genes that share paralogs with ZNF208: view

Variants for ZNF208 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF208 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs747779872 Not Provided: CIC-DUX Sarcoma 21,971,191(-) C/G STOP_LOST,INTRON_VARIANT
rs10425763 - p.Lys640Glu
rs12462668 - p.Ser298Leu
rs2007506 - p.Glu282Lys
rs7255075 - p.Glu456Gln

Additional dbSNP identifiers (rs#s) for ZNF208 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF208 Gene

Variant ID Type Subtype PubMed ID
dgv3471n100 CNV gain 25217958
dgv511e201 CNV deletion 23290073
dgv512e201 CNV deletion 23290073
dgv513e201 CNV deletion 23290073
dgv633e199 CNV deletion 23128226
esv2718335 CNV deletion 23290073
esv2758750 CNV gain+loss 17122850
esv34340 CNV loss 17911159
esv3556184 CNV deletion 23714750
esv4924 OTHER complex 18987735
nsv1061327 CNV gain 25217958
nsv1063115 CNV gain 25217958
nsv1112317 CNV deletion 24896259
nsv1153943 CNV deletion 26484159
nsv436253 CNV deletion 17901297
nsv436853 CNV insertion 17901297
nsv469674 CNV loss 16826518
nsv7306 OTHER inversion 18451855
nsv833785 CNV gain 17160897
nsv961196 CNV duplication 23825009

Variation tolerance for ZNF208 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.93; 93.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF208 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF208

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF208 Gene

Disorders for ZNF208 Gene

Additional Disease Information for ZNF208

No disorders were found for ZNF208 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF208 Gene

Publications for ZNF208 Gene

  1. Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12. (PMID: 9724325) Eichler EE … Mohrenweiser HW (Genome research 1998) 2 3 4 54
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 54
  3. ZNF208 polymorphisms associated with ischemic stroke in a southern Chinese Han population. (PMID: 27936511) Yu J … Yu D (The journal of gene medicine 2017) 3 54
  4. Genetic variants in the ZNF208 gene are associated with esophageal cancer in a Chinese Han population. (PMID: 27907911) Wang H … Wang Z (Oncotarget 2016) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for ZNF208 Gene

Sources for ZNF208 Gene