Aliases for ZNF207 Gene
External Ids for ZNF207 Gene
Previous GeneCards Identifiers for ZNF207 Gene
GeneCards Summary for ZNF207 Gene
ZNF207 (Zinc Finger Protein 207) is a Protein Coding gene. Diseases associated with ZNF207 include Chromosome 15Q26-Qter Deletion Syndrome and Hypophosphatasia, Infantile. Gene Ontology (GO) annotations related to this gene include microtubule binding.
UniProtKB/Swiss-Prot Summary for ZNF207 Gene
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).