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Aliases for ZNF207 Gene

Aliases for ZNF207 Gene

  • Zinc Finger Protein 207 2 3 4 5
  • HBuGZ 3 4
  • BuGZ 3 4
  • BUB3-Interacting And GLEBS Motif-Containing Protein ZNF207 3
  • BUGZ 4

External Ids for ZNF207 Gene

Previous GeneCards Identifiers for ZNF207 Gene

  • GC17P030443
  • GC17P032712
  • GC17P030525
  • GC17P030822
  • GC17P027636
  • GC17P027414
  • GC17P030678
  • GC17P026863
  • GC17P030679
  • GC17P030681
  • GC17P030683
  • GC17P032351
  • GC17P032353
  • GC17P032354
  • GC17P032355
  • GC17P032356
  • GC17P032357

Summaries for ZNF207 Gene

GeneCards Summary for ZNF207 Gene

ZNF207 (Zinc Finger Protein 207) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for ZNF207 Gene

  • Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

Additional gene information for ZNF207 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF207 Gene

Genomics for ZNF207 Gene

GeneHancer (GH) Regulatory Elements for ZNF207 Gene

Promoters and enhancers for ZNF207 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J032348 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 723.8 +0.5 513 4.1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC MEF2D ZNF207 C17orf75 PIR54391 GC17M032350 GC17P032359 MIR632 UTP6 SUZ12 PSMD11 LRRC37B
GH17J032340 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 85.7 -8.0 -8047 2.2 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC C17orf75 ZNF207 UTP6 SUZ12 ENSG00000266599 ENSG00000265337 ENSG00000264497 ENSG00000264300 ENSG00000265046 ENSG00000263567
GH17J032927 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 77.3 +578.4 578368 3 HDGF FOXA2 MLX ARNT ZFP64 ARID4B YBX1 DMAP1 ZNF766 NFYC TMEM98 ZNF207 SUZ12 SH3GL1P1 LRRC37B PIR43668
GH17J031936 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 42.5 -412.5 -412538 2.8 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 SUZ12 ZNF207 UTP6 ENSG00000264456 RNF135 COPRS DPRXP4 LOC105371722 LRRC37B RHOT1
GH17J031858 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 32.7 -491.0 -491030 1.9 HDAC1 FOXA2 RB1 ARID4B SIN3A ZBTB40 RAD21 ZNF335 EGR1 SCRT2 COPRS ZNF207 UTP6 SUZ12 TEFM ENSG00000264456 RNF135 DPRXP4 PIR57755
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF207 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF207 gene promoter:
  • LCR-F1
  • Sox5
  • AP-4
  • Pbx1a
  • CREB
  • Pax-2b
  • Pax-2
  • Pax-2a
  • Nkx2-2
  • Nkx3-1 v2

Genomic Locations for ZNF207 Gene

Genomic Locations for ZNF207 Gene
chr17:32,350,117-32,408,085
(GRCh38/hg38)
Size:
57,969 bases
Orientation:
Plus strand
chr17:30,677,136-30,708,905
(GRCh37/hg19)
Size:
31,770 bases
Orientation:
Plus strand

Genomic View for ZNF207 Gene

Genes around ZNF207 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF207 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF207 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF207 Gene

Proteins for ZNF207 Gene

  • Protein details for ZNF207 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43670-ZN207_HUMAN
    Recommended name:
    BUB3-interacting and GLEBS motif-containing protein ZNF207
    Protein Accession:
    O43670
    Secondary Accessions:
    • A8K6Y6
    • E1P660
    • E1P661
    • E1P662
    • Q53XS9
    • Q96HW5
    • Q9BUQ7

    Protein attributes for ZNF207 Gene

    Size:
    478 amino acids
    Molecular mass:
    50751 Da
    Quaternary structure:
    • Interacts (via GLEBS region) with BUB3.

    Alternative splice isoforms for ZNF207 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF207 Gene

Post-translational modifications for ZNF207 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ZNF207
  • Boster Bio Antibodies for ZNF207

No data available for DME Specific Peptides for ZNF207 Gene

Domains & Families for ZNF207 Gene

Gene Families for ZNF207 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ZNF207 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF207 Gene

Graphical View of Domain Structure for InterPro Entry

O43670

UniProtKB/Swiss-Prot:

ZN207_HUMAN :
  • The GLEBS region mediates interaction with BUB3 (PubMed:24462186, PubMed:24462187).
Domain:
  • The GLEBS region mediates interaction with BUB3 (PubMed:24462186, PubMed:24462187).
  • The microtubule-binding region is required for efficient loading of BUB3 onto kinetochores and proper mitosis.
  • Mainly composed of disordered low-complexity regions outside of the C2H2-type zinc fingers. Coacervation depends on hydrophobic and aromatic Phe and Tyr in the disordered low-complexity region, that may promote coacervation by forming intermolecular hydrophobic interactions.
genes like me logo Genes that share domains with ZNF207: view

Function for ZNF207 Gene

Molecular function for ZNF207 Gene

UniProtKB/Swiss-Prot Function:
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).
GENATLAS Biochemistry:
zinc finger protein 207 (C2H2 type Kruppel like),ubiquitously expressed

Phenotypes From GWAS Catalog for ZNF207 Gene

Gene Ontology (GO) - Molecular Function for ZNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 9799612
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI 24462186
genes like me logo Genes that share ontologies with ZNF207: view
genes like me logo Genes that share phenotypes with ZNF207: view

Animal Models for ZNF207 Gene

MGI Knock Outs for ZNF207:
  • Zfp207 Zfp207<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for ZNF207 Gene

miRTarBase miRNAs that target ZNF207

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF207

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF207 Gene

Localization for ZNF207 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF207 Gene

Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding. {ECO:0000269 PubMed:24462186, ECO:0000269 PubMed:24462187}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF207 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IMP 24462186
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus NAS,IDA 9799612
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF207: view

Pathways & Interactions for ZNF207 Gene

SuperPathways for ZNF207 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IMP 24462186
GO:0001578 microtubule bundle formation ISS --
GO:0006355 regulation of transcription, DNA-templated NAS 9799612
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IEA --
genes like me logo Genes that share ontologies with ZNF207: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF207 Gene

Drugs & Compounds for ZNF207 Gene

No Compound Related Data Available

Transcripts for ZNF207 Gene

mRNA/cDNA for ZNF207 Gene

Unigene Clusters for ZNF207 Gene

Zinc finger protein 207:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF207

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF207 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ·
SP1: - - - - - - - - - - -
SP2:
SP3: -
SP4:
SP5:
SP6: - - -
SP7: -
SP8: -
SP9: - - -
SP10: - - -
SP11: -
SP12: - -
SP13:
SP14:

ExUns: 13d ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:

Relevant External Links for ZNF207 Gene

GeneLoc Exon Structure for
ZNF207
ECgene alternative splicing isoforms for
ZNF207

Expression for ZNF207 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF207 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF207 Gene

This gene is overexpressed in Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF207 Gene



Protein tissue co-expression partners for ZNF207 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF207 Gene:

ZNF207

SOURCE GeneReport for Unigene cluster for ZNF207 Gene:

Hs.500775

mRNA Expression by UniProt/SwissProt for ZNF207 Gene:

O43670-ZN207_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ZNF207 Gene

  • Eye(2.1)
  • Lymph node(2.1)
  • Heart(2)
  • Nervous system(5)
  • Lung(4.8)
  • Kidney(4.3)
  • Skin(4.3)
  • Intestine(4)
  • Liver(3.4)
  • Blood(3.1)
  • Spleen(2.9)
  • Adrenal gland(2.8)
  • Bone marrow(2.8)
  • Gall bladder(2.8)
  • Pancreas(2.8)
  • Stomach(2.8)
  • Thyroid gland(2.8)
genes like me logo Genes that share expression patterns with ZNF207: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF207 Gene

Orthologs for ZNF207 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF207 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToMany
-- 34
  • 93 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF207 34 33
  • 99.8 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF207 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF207 34
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF207 34
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp207 16 34 33
  • 93.95 (n)
rat
(Rattus norvegicus)
Mammalia Zfp207 33
  • 93.74 (n)
chicken
(Gallus gallus)
Aves ZNF207 34 33
  • 83.3 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF207 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75627 33
African clawed frog
(Xenopus laevis)
Amphibia 4m77-prov 33
zebrafish
(Danio rerio)
Actinopterygii znf207a 34
  • 70 (a)
OneToMany
znf207b 34
  • 69 (a)
OneToMany
znf207 33
fruit fly
(Drosophila melanogaster)
Insecta CG17912 34 35
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0035.1a 35
  • 68 (a)
B0035.1b 35
  • 68 (a)
B0035.1 34
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10678 34
  • 47 (a)
OneToOne
Cin.237 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.237 33
Species where no ortholog for ZNF207 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF207 Gene

ENSEMBL:
Gene Tree for ZNF207 (if available)
TreeFam:
Gene Tree for ZNF207 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF207: view image

Paralogs for ZNF207 Gene

(1) SIMAP similar genes for ZNF207 Gene using alignment to 8 proteins:

  • ZN207_HUMAN
  • H0Y3M2_HUMAN
  • J3KRB6_HUMAN
  • J3KRW6_HUMAN
  • J3KS31_HUMAN
  • J3KTL1_HUMAN
  • J3QRS9_HUMAN
  • J3QS27_HUMAN

Pseudogenes.org Pseudogenes for ZNF207 Gene

genes like me logo Genes that share paralogs with ZNF207: view

No data available for Paralogs for ZNF207 Gene

Variants for ZNF207 Gene

Sequence variations from dbSNP and Humsavar for ZNF207 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000097005 -- 32,378,629(+) C/G genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000121677 -- 32,357,358(+) T/A intron_variant
rs1000181486 -- 32,376,901(+) CT/ genic_downstream_transcript_variant, intron_variant
rs1000200727 -- 32,373,857(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000210740 -- 32,370,654(+) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF207 Gene

Variant ID Type Subtype PubMed ID
esv3640380 CNV loss 21293372

Variation tolerance for ZNF207 Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF207 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF207

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF207 Gene

Disorders for ZNF207 Gene

Additional Disease Information for ZNF207

No disorders were found for ZNF207 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF207 Gene

Publications for ZNF207 Gene

  1. A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting. (PMID: 24462186) Jiang H … Zheng Y (Developmental cell 2014) 2 3 4 58
  2. ZNF207, a ubiquitously expressed zinc finger gene on chromosome 6p21.3. (PMID: 9799612) Pahl PM … Horwitz LD (Genomics 1998) 2 3 4 58
  3. Phase transition of spindle-associated protein regulate spindle apparatus assembly. (PMID: 26388440) Jiang H … Zheng Y (Cell 2015) 3 4 58
  4. BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment. (PMID: 24462187) Toledo CM … Paddison PJ (Developmental cell 2014) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ZNF207 Gene

Sources for ZNF207 Gene

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