Aliases for ZNF205 Gene

Aliases for ZNF205 Gene

  • Zinc Finger Protein 205 2 3 4 5
  • Zinc Finger Protein 210 3 4
  • ZNF210 3 4
  • Zfp13 2 3
  • Transcriptional Repressor RhitH 3
  • ZNF205 5
  • RhitH 3

External Ids for ZNF205 Gene

Previous HGNC Symbols for ZNF205 Gene

  • ZNF210

Previous GeneCards Identifiers for ZNF205 Gene

  • GC16P003183
  • GC16P003162
  • GC16P003104
  • GC16P003105
  • GC16P003133
  • GC16P003147
  • GC16P003171
  • GC16P003749
  • GC16P003834
  • GC16P003885
  • GC16P004061
  • GC16P003259
  • GC16P003294
  • GC16P003334
  • GC16P003386
  • GC16P003427
  • GC16P003470
  • GC16P003545
  • GC16P003602

Summaries for ZNF205 Gene

GeneCards Summary for ZNF205 Gene

ZNF205 (Zinc Finger Protein 205) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZKSCAN8.

UniProtKB/Swiss-Prot Summary for ZNF205 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF205 Gene

Genomics for ZNF205 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF205 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF205 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF205

Top Transcription factor binding sites by QIAGEN in the ZNF205 gene promoter:
  • HSF1 (long)
  • HSF1short
  • Ik-3
  • LCR-F1
  • Nkx2-2
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • Pax-4a

Genomic Locations for ZNF205 Gene

Genomic Locations for ZNF205 Gene
chr16:3,112,560-3,120,517
(GRCh38/hg38)
Size:
7,958 bases
Orientation:
Plus strand
chr16:3,162,561-3,170,518
(GRCh37/hg19)
Size:
7,958 bases
Orientation:
Plus strand

Genomic View for ZNF205 Gene

Genes around ZNF205 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF205 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF205 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF205 Gene

Proteins for ZNF205 Gene

  • Protein details for ZNF205 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95201-ZN205_HUMAN
    Recommended name:
    Zinc finger protein 205
    Protein Accession:
    O95201
    Secondary Accessions:
    • A8MZK0
    • D3DUB4
    • Q9BU95

    Protein attributes for ZNF205 Gene

    Size:
    554 amino acids
    Molecular mass:
    60630 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC70007.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF205 Gene

Post-translational modifications for ZNF205 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF205 Gene

Domains & Families for ZNF205 Gene

Gene Families for ZNF205 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF205 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF205 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 210 (ZN205_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95201

UniProtKB/Swiss-Prot:

ZN205_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF205: view

Function for ZNF205 Gene

Molecular function for ZNF205 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 205,C2H2 type,with an alternative transcript ZNF210,ubiquitously expressed

Phenotypes From GWAS Catalog for ZNF205 Gene

Gene Ontology (GO) - Molecular Function for ZNF205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16713569
genes like me logo Genes that share ontologies with ZNF205: view
genes like me logo Genes that share phenotypes with ZNF205: view

Animal Models for ZNF205 Gene

MGI Knock Outs for ZNF205:
  • Zfp13 Zfp13<tm1a(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF205

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF205 Gene

Localization for ZNF205 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF205 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF205 gene
Compartment Confidence
nucleus 5
mitochondrion 3
endoplasmic reticulum 1
plasma membrane 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ZNF205: view

Pathways & Interactions for ZNF205 Gene

genes like me logo Genes that share pathways with ZNF205: view

Pathways by source for ZNF205 Gene

2 Reactome pathways for ZNF205 Gene
1 KEGG pathway for ZNF205 Gene

Gene Ontology (GO) - Biological Process for ZNF205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA,IMP 22306510
GO:0006355 regulation of transcription, DNA-templated NAS 9787081
GO:0010729 positive regulation of hydrogen peroxide biosynthetic process IMP 22306510
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IMP 22306510
genes like me logo Genes that share ontologies with ZNF205: view

No data available for SIGNOR curated interactions for ZNF205 Gene

Drugs & Compounds for ZNF205 Gene

No Compound Related Data Available

Transcripts for ZNF205 Gene

mRNA/cDNA for ZNF205 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF205

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF205 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - -
SP3: -
SP4: - - -
SP5:

Relevant External Links for ZNF205 Gene

GeneLoc Exon Structure for
ZNF205

Expression for ZNF205 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF205 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF205

SOURCE GeneReport for Unigene cluster for ZNF205 Gene:

Hs.592088

mRNA Expression by UniProt/SwissProt for ZNF205 Gene:

O95201-ZN205_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, pancreas and brain. Weakly expressed in placenta, lung, liver, kidney and thymus.

Evidence on tissue expression from TISSUES for ZNF205 Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with ZNF205: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF205 Gene

Orthologs for ZNF205 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF205 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF205 30 31
  • 98.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF205 30 31
  • 84.52 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF205 30 31
  • 83.8 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp13 30
  • 81.76 (n)
Mouse
(Mus musculus)
Mammalia Zfp13 30 17 31
  • 79.39 (n)
OneToOne
Species where no ortholog for ZNF205 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF205 Gene

ENSEMBL:
Gene Tree for ZNF205 (if available)
TreeFam:
Gene Tree for ZNF205 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF205: view image

Paralogs for ZNF205 Gene

(400) SIMAP similar genes for ZNF205 Gene using alignment to 4 proteins:

  • ZN205_HUMAN
  • C9JEY6_HUMAN
  • C9JS60_HUMAN
  • I3L417_HUMAN
genes like me logo Genes that share paralogs with ZNF205: view

Variants for ZNF205 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF205 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs12445220 - p.Ala255Asp
rs909410 - p.Thr43Ala

Additional dbSNP identifiers (rs#s) for ZNF205 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF205 Gene

Variant ID Type Subtype PubMed ID
nsv457355 CNV gain 19166990
nsv509589 CNV insertion 20534489
nsv571248 CNV loss 21841781
nsv571249 CNV gain 21841781
nsv833125 CNV loss 17160897

Variation tolerance for ZNF205 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF205 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF205

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF205 Gene

Disorders for ZNF205 Gene

No disorders were found for ZNF205 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF205 Gene

Publications for ZNF205 Gene

  1. Identification of two Krüppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3. (PMID: 9787081) Deng Z … Kastner DL (Genomics 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3

Products for ZNF205 Gene

Sources for ZNF205 Gene