Aliases for ZNF202 Gene

Aliases for ZNF202 Gene

  • Zinc Finger Protein 202 2 3 4 5
  • ZKSCAN10 2 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 10 3 4
  • ZSCAN42 2 3
  • ZNF202 5

External Ids for ZNF202 Gene

Previous GeneCards Identifiers for ZNF202 Gene

  • GC11M125595
  • GC11M125107
  • GC11M123628
  • GC11M123132
  • GC11M123099
  • GC11M123594
  • GC11M119536

Summaries for ZNF202 Gene

GeneCards Summary for ZNF202 Gene

ZNF202 (Zinc Finger Protein 202) is a Protein Coding gene. Diseases associated with ZNF202 include Muscular Dystrophy-Dystroglycanopathy , Type C, 3 and Central Hypoventilation Syndrome, Congenital. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZSCAN29.

UniProtKB/Swiss-Prot Summary for ZNF202 Gene

  • Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.

Gene Wiki entry for ZNF202 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF202 Gene

Genomics for ZNF202 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF202 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J123740 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 316.1 -0.1 -121 4.4 BCLAF1 ZNF207 ZNF600 MYC NCOR1 POLR2A NFIC YY1 MXD4 REST ZNF202 lnc-ZNF202-1 lnc-GRAMD1B-6 VWA5A CLMP OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P
GH11J123055 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 55.4 +680.6 680563 10.9 BCLAF1 SP1 ZNF207 MYC ZNF600 SSRP1 JUND POLR2A CEBPA ZNF10 ENSG00000288061 LOC101929289 HSPA8 lnc-CLMP-3 SNORD14C piR-59038 piR-61486 ZNF202 CLMP SCN3B
GH11J124622 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 18 -881.3 -881326 3.2 BCLAF1 IKZF1 ZNF600 ZNF580 ATF2 POLR2A CEBPA YY1 MXD4 CEBPB TBRG1 STT3A ZNF202 TMEM218 MSANTD2 ROBO3 HSALNG0087895 HSALNG0087896 SPA17
GH11J124642 Enhancer 1.1 FANTOM5 ENCODE 33.2 -902.3 -902330 2.4 ZNF654 NCOR1 MYC IKZF1 ZNF10 ZIC2 ZBTB10 YY1 CTCF CEBPB ZNF202 MSANTD2 TMEM218 STT3A ENSG00000254509 SPA17 OR8A1 OR8B4 OR8D1 OR8G1
GH11J122841 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 17.1 +897.7 897717 4.6 ZNF10 ZIC2 SIN3A FEZF1 ZNF639 HOMEZ THAP11 FOXA2 SMAD4 SAP130 ZNF202 JHY CRTAM ENSG00000285909
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF202 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF202

Top Transcription factor binding sites by QIAGEN in the ZNF202 gene promoter:
  • aMEF-2
  • Evi-1
  • FAC1
  • GR
  • GR-alpha
  • MEF-2
  • MEF-2A
  • SREBP-1a
  • TBP
  • YY1

Genomic Locations for ZNF202 Gene

Latest Assembly
chr11:123,723,914-123,741,675
(GRCh38/hg38)
Size:
17,762 bases
Orientation:
Minus strand

Previous Assembly
chr11:123,594,622-123,612,368
(GRCh37/hg19 by Entrez Gene)
Size:
17,747 bases
Orientation:
Minus strand

chr11:123,594,885-123,612,383
(GRCh37/hg19 by Ensembl)
Size:
17,499 bases
Orientation:
Minus strand

Genomic View for ZNF202 Gene

Genes around ZNF202 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF202 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF202 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF202 Gene

Proteins for ZNF202 Gene

  • Protein details for ZNF202 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95125-ZN202_HUMAN
    Recommended name:
    Zinc finger protein 202
    Protein Accession:
    O95125
    Secondary Accessions:
    • B0LPH9
    • Q4JG21
    • Q9H1B9
    • Q9NSM4

    Protein attributes for ZNF202 Gene

    Size:
    648 amino acids
    Molecular mass:
    74720 Da
    Quaternary structure:
    • Interacts with SDP1.

    Alternative splice isoforms for ZNF202 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF202 Gene

Post-translational modifications for ZNF202 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Boster Bio Antibodies for ZNF202
  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF202

No data available for DME Specific Peptides for ZNF202 Gene

Domains & Families for ZNF202 Gene

Gene Families for ZNF202 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF202 Gene

InterPro:
Blocks:
  • KRAB box
  • Transcriptional regulator SCAN

Suggested Antigen Peptide Sequences for ZNF202 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein with KRAB and SCAN domains 10 (ZN202_HUMAN)
genes like me logo Genes that share domains with ZNF202: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF202 Gene

Function for ZNF202 Gene

Molecular function for ZNF202 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.
GENATLAS Biochemistry:
zinc finger protein C2H2 type,specifically expressed in testis with two alternatively spliced isoforms alpha and beta

Phenotypes From GWAS Catalog for ZNF202 Gene

Gene Ontology (GO) - Molecular Function for ZNF202 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10748193
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 10748193
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZNF202: view
genes like me logo Genes that share phenotypes with ZNF202: view

Animal Models for ZNF202 Gene

MGI Knock Outs for ZNF202:
  • Zfp202 Zfp202<tm1(NCOM)Cmhd>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF202

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF202 Gene

Localization for ZNF202 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF202 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF202 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitotic chromosome (2)
  • Nuclear bodies (2)
  • Nucleoli rim (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF202 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IDA --
GO:0005730 nucleolus IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with ZNF202: view

Pathways & Interactions for ZNF202 Gene

PathCards logo

SuperPathways for ZNF202 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF202: view

Pathways by source for ZNF202 Gene

2 Reactome pathways for ZNF202 Gene

SIGNOR curated interactions for ZNF202 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for ZNF202 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 10748193
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006629 lipid metabolic process TAS 10748193
genes like me logo Genes that share ontologies with ZNF202: view

Drugs & Compounds for ZNF202 Gene

(3) Drugs for ZNF202 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for ZNF202 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZNF202: view

Transcripts for ZNF202 Gene

mRNA/cDNA for ZNF202 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF202

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF202 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - - -
SP2: - - - - - -
SP3:
SP4: - - -
SP5: - - - -
SP6: - -
SP7: - -
SP8: - - - - -
SP9:

Relevant External Links for ZNF202 Gene

GeneLoc Exon Structure for
ZNF202

Expression for ZNF202 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF202 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF202 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF202

SOURCE GeneReport for Unigene cluster for ZNF202 Gene:

Hs.112556

mRNA Expression by UniProt/SwissProt for ZNF202 Gene:

O95125-ZN202_HUMAN
Tissue specificity: Highly expressed in testis. Also expressed in breast carcinoma cell lines.

Evidence on tissue expression from TISSUES for ZNF202 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ZNF202: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF202 Gene

Orthologs for ZNF202 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF202 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF202 29 30
  • 99.18 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF202 29 30
  • 89.04 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF202 29 30
  • 85.39 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp202 29
  • 81.74 (n)
Mouse
(Mus musculus)
Mammalia Zfp202 29 16 30
  • 81.59 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF202 30
  • 73 (a)
OneToOne
Species where no ortholog for ZNF202 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF202 Gene

ENSEMBL:
Gene Tree for ZNF202 (if available)
TreeFam:
Gene Tree for ZNF202 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF202: view image
Alliance of Genome Resources:
Additional Orthologs for ZNF202

Paralogs for ZNF202 Gene

genes like me logo Genes that share paralogs with ZNF202: view

Variants for ZNF202 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF202 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs143645376 Benign: not provided 123,729,766(-) C/T
NM_003455.4(ZNF202):c.462G>A (p.Val154=)
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR
rs35781146 Benign: not provided 123,726,486(-) G/A
NM_003455.4(ZNF202):c.1458C>T (p.Cys486=)
SYNONYMOUS
rs1144507 -- p.Val154Ala
rs34111365 -- p.Gly533Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF202 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF202 Gene

Variant ID Type Subtype PubMed ID
esv3627962 CNV gain 21293372

Variation tolerance for ZNF202 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF202 Gene

Human Gene Mutation Database (HGMD)
ZNF202
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF202
Leiden Open Variation Database (LOVD)
ZNF202

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF202 Gene

Disorders for ZNF202 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF202 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF202

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ZNF202: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF202 Gene

Publications for ZNF202 Gene

  1. Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease. (PMID: 18652945) Stene MC … Tybjaerg-Hansen A (Journal of the American College of Cardiology 2008) 3 22 40
  2. Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population. (PMID: 16467280) Stene MC … Tybjaerg-Hansen A (Journal of lipid research 2006) 3 22 40
  3. Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study. (PMID: 16289551) Stene MC … Tybjaerg-Hansen A (Atherosclerosis 2006) 3 22 40
  4. The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux. (PMID: 11279031) Porsch-Ozcurumez M … Schmitz G (The Journal of biological chemistry 2001) 3 4 22
  5. A broad role for the zinc finger protein ZNF202 in human lipid metabolism. (PMID: 10748193) Wagner S … Bowen BR (The Journal of biological chemistry 2000) 3 4 22

Products for ZNF202 Gene

Sources for ZNF202 Gene