Aliases for ZNF202 Gene

Aliases for ZNF202 Gene

  • Zinc Finger Protein 202 2 3 4 5
  • Zinc Finger Protein With KRAB And SCAN Domains 10 3 4
  • ZKSCAN10 3 4
  • ZSCAN42 3

External Ids for ZNF202 Gene

Previous GeneCards Identifiers for ZNF202 Gene

  • GC11M125595
  • GC11M125107
  • GC11M123628
  • GC11M123132
  • GC11M123099
  • GC11M123594
  • GC11M119536

Summaries for ZNF202 Gene

GeneCards Summary for ZNF202 Gene

ZNF202 (Zinc Finger Protein 202) is a Protein Coding gene. Diseases associated with ZNF202 include Muscular Dystrophy-Dystroglycanopathy , Type C, 3. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZNF641.

UniProtKB/Swiss-Prot Summary for ZNF202 Gene

  • Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.

Gene Wiki entry for ZNF202 Gene

Additional gene information for ZNF202 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF202 Gene

Genomics for ZNF202 Gene

GeneHancer (GH) Regulatory Elements for ZNF202 Gene

Promoters and enhancers for ZNF202 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF202 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF202

Top Transcription factor binding sites by QIAGEN in the ZNF202 gene promoter:
  • aMEF-2
  • Evi-1
  • FAC1
  • GR
  • GR-alpha
  • MEF-2
  • MEF-2A
  • SREBP-1a
  • TBP
  • YY1

Genomic Locations for ZNF202 Gene

Genomic Locations for ZNF202 Gene
chr11:123,723,914-123,741,683
(GRCh38/hg38)
Size:
17,770 bases
Orientation:
Minus strand
chr11:123,594,885-123,612,383
(GRCh37/hg19)
Size:
17,499 bases
Orientation:
Minus strand

Genomic View for ZNF202 Gene

Genes around ZNF202 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF202 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF202 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF202 Gene

Proteins for ZNF202 Gene

  • Protein details for ZNF202 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95125-ZN202_HUMAN
    Recommended name:
    Zinc finger protein 202
    Protein Accession:
    O95125
    Secondary Accessions:
    • B0LPH9
    • Q4JG21
    • Q9H1B9
    • Q9NSM4

    Protein attributes for ZNF202 Gene

    Size:
    648 amino acids
    Molecular mass:
    74720 Da
    Quaternary structure:
    • Interacts with SDP1.

    Alternative splice isoforms for ZNF202 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF202 Gene

Post-translational modifications for ZNF202 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF202 Gene

Domains & Families for ZNF202 Gene

Gene Families for ZNF202 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF202 Gene

Blocks:
  • KRAB box
  • Transcriptional regulator SCAN
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF202 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein with KRAB and SCAN domains 10 (ZN202_HUMAN)
genes like me logo Genes that share domains with ZNF202: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF202 Gene

Function for ZNF202 Gene

Molecular function for ZNF202 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.
GENATLAS Biochemistry:
zinc finger protein C2H2 type,specifically expressed in testis with two alternatively spliced isoforms alpha and beta

Phenotypes From GWAS Catalog for ZNF202 Gene

Gene Ontology (GO) - Molecular Function for ZNF202 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10748193
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 10748193
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZNF202: view
genes like me logo Genes that share phenotypes with ZNF202: view

Animal Models for ZNF202 Gene

MGI Knock Outs for ZNF202:
  • Zfp202 Zfp202<tm1(NCOM)Cmhd>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF202

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF202 Gene

Localization for ZNF202 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF202 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF202 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF202 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with ZNF202: view

Pathways & Interactions for ZNF202 Gene

PathCards logo

SuperPathways for ZNF202 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF202: view

Pathways by source for ZNF202 Gene

2 Reactome pathways for ZNF202 Gene

SIGNOR curated interactions for ZNF202 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for ZNF202 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 10748193
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 10748193
GO:0006629 lipid metabolic process TAS 10748193
genes like me logo Genes that share ontologies with ZNF202: view

Drugs & Compounds for ZNF202 Gene

(3) Drugs for ZNF202 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for ZNF202 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZNF202: view

Transcripts for ZNF202 Gene

mRNA/cDNA for ZNF202 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF202

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF202 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - - -
SP2: - - - - - -
SP3:
SP4: - - -
SP5: - - - -
SP6: - -
SP7: - -
SP8: - - - - -
SP9:

Relevant External Links for ZNF202 Gene

GeneLoc Exon Structure for
ZNF202

Expression for ZNF202 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF202 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF202 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF202

SOURCE GeneReport for Unigene cluster for ZNF202 Gene:

Hs.112556

mRNA Expression by UniProt/SwissProt for ZNF202 Gene:

O95125-ZN202_HUMAN
Tissue specificity: Highly expressed in testis. Also expressed in breast carcinoma cell lines.

Evidence on tissue expression from TISSUES for ZNF202 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ZNF202: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF202 Gene

Orthologs for ZNF202 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF202 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF202 31 30
  • 99.18 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF202 31 30
  • 89.04 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF202 31 30
  • 85.39 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp202 30
  • 81.74 (n)
mouse
(Mus musculus)
Mammalia Zfp202 17 31 30
  • 81.59 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF202 31
  • 73 (a)
OneToOne
Species where no ortholog for ZNF202 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF202 Gene

ENSEMBL:
Gene Tree for ZNF202 (if available)
TreeFam:
Gene Tree for ZNF202 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF202: view image

Paralogs for ZNF202 Gene

genes like me logo Genes that share paralogs with ZNF202: view

Variants for ZNF202 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF202 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1144507 - p.Val154Ala
rs34111365 - p.Gly533Ala

Additional dbSNP identifiers (rs#s) for ZNF202 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF202 Gene

Variant ID Type Subtype PubMed ID
esv3627962 CNV gain 21293372

Variation tolerance for ZNF202 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF202 Gene

Human Gene Mutation Database (HGMD)
ZNF202
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF202

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF202 Gene

Disorders for ZNF202 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF202 Gene - From: DISEASES

Disorder Aliases PubMed IDs
muscular dystrophy-dystroglycanopathy , type c, 3
  • mddgc3
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF202

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF202: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF202 Gene

Publications for ZNF202 Gene

  1. Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease. (PMID: 18652945) Stene MC … Tybjaerg-Hansen A (Journal of the American College of Cardiology 2008) 3 23 41 54
  2. Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population. (PMID: 16467280) Stene MC … Tybjaerg-Hansen A (Journal of lipid research 2006) 3 23 41 54
  3. Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study. (PMID: 16289551) Stene MC … Tybjaerg-Hansen A (Atherosclerosis 2006) 3 23 41 54
  4. The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux. (PMID: 11279031) Porsch-Ozcurumez M … Schmitz G (The Journal of biological chemistry 2001) 3 4 23 54
  5. A broad role for the zinc finger protein ZNF202 in human lipid metabolism. (PMID: 10748193) Wagner S … Bowen BR (The Journal of biological chemistry 2000) 3 4 23 54

Products for ZNF202 Gene

Sources for ZNF202 Gene