Aliases for ZNF200 Gene

Aliases for ZNF200 Gene

  • Zinc Finger Protein 200 2 3 4 5
  • ZNF200 5
  • ZNFMF 4

External Ids for ZNF200 Gene

Previous GeneCards Identifiers for ZNF200 Gene

  • GC16M003292
  • GC16M003272
  • GC16M003212
  • GC16M003242
  • GC16M003246
  • GC16M003260

Summaries for ZNF200 Gene

GeneCards Summary for ZNF200 Gene

ZNF200 (Zinc Finger Protein 200) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF532.

UniProtKB/Swiss-Prot Summary for ZNF200 Gene

Additional gene information for ZNF200 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF200 Gene

Genomics for ZNF200 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF200 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF200 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF200

Top Transcription factor binding sites by QIAGEN in the ZNF200 gene promoter:
  • AML1a
  • PPAR-gamma1

Genomic Locations for ZNF200 Gene

Genomic Locations for ZNF200 Gene
chr16:3,222,325-3,236,221
(GRCh38/hg38)
Size:
13,897 bases
Orientation:
Minus strand
chr16:3,272,325-3,286,221
(GRCh37/hg19)
Size:
13,897 bases
Orientation:
Minus strand

Genomic View for ZNF200 Gene

Genes around ZNF200 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF200 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF200 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF200 Gene

Proteins for ZNF200 Gene

  • Protein details for ZNF200 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98182-ZN200_HUMAN
    Recommended name:
    Zinc finger protein 200
    Protein Accession:
    P98182
    Secondary Accessions:
    • D3DUB7
    • D3DUB8
    • O15361
    • Q5XKM5
    • Q7Z5V1

    Protein attributes for ZNF200 Gene

    Size:
    395 amino acids
    Molecular mass:
    45534 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC70008.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH54005.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF200 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF200 Gene

Post-translational modifications for ZNF200 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF200 Gene

Domains & Families for ZNF200 Gene

Gene Families for ZNF200 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF200 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF200 Gene

GenScript: Design optimal peptide antigens:
  • ZNF200 protein (A0PJD1_HUMAN)
  • Zinc finger protein 200, isoform CRA_a (D3DUB7_HUMAN)
  • Zinc finger protein 200 (Q7Z5V1_HUMAN)
  • Zinc finger protein 200 (ZN200_HUMAN)
genes like me logo Genes that share domains with ZNF200: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF200 Gene

Function for ZNF200 Gene

Molecular function for ZNF200 Gene

UniProtKB/Swiss-Prot Function:
Could have a role in spermatogenesis.
GENATLAS Biochemistry:
zinc finger protein 200,C2H2 type,predominantly expressed in testis

Phenotypes From GWAS Catalog for ZNF200 Gene

Gene Ontology (GO) - Molecular Function for ZNF200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF200: view
genes like me logo Genes that share phenotypes with ZNF200: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF200

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF200 Gene

Localization for ZNF200 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF200 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF200 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF200: view

Pathways & Interactions for ZNF200 Gene

genes like me logo Genes that share pathways with ZNF200: view

Pathways by source for ZNF200 Gene

2 Reactome pathways for ZNF200 Gene
1 KEGG pathway for ZNF200 Gene

Gene Ontology (GO) - Biological Process for ZNF200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF200: view

No data available for SIGNOR curated interactions for ZNF200 Gene

Drugs & Compounds for ZNF200 Gene

No Compound Related Data Available

Transcripts for ZNF200 Gene

mRNA/cDNA for ZNF200 Gene

6 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF200

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF200 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - - -
SP3: -
SP4: -
SP5: - -
SP6: - - - -
SP7:

Relevant External Links for ZNF200 Gene

GeneLoc Exon Structure for
ZNF200

Expression for ZNF200 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF200 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF200 Gene

This gene is overexpressed in Testis (x5.1) and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for ZNF200 Gene

This gene is overexpressed in Esophagus (47.8) and Saliva (21.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF200 Gene



Protein tissue co-expression partners for ZNF200 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF200

SOURCE GeneReport for Unigene cluster for ZNF200 Gene:

Hs.632222

mRNA Expression by UniProt/SwissProt for ZNF200 Gene:

P98182-ZN200_HUMAN
Tissue specificity: Highly expressed in testis, weakly expressed in spleen, thymus, prostate, ovary, small intestine colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for ZNF200 Gene

  • Skin(4.2)
  • Liver(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZNF200: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF200 Gene

Orthologs for ZNF200 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF200 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF200 30 31
  • 99.41 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF200 30 31
  • 88.01 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF200 30 31
  • 87.44 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF200 31
  • 57 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CR352258.1 31
  • 35 (a)
OneToMany
Species where no ortholog for ZNF200 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF200 Gene

ENSEMBL:
Gene Tree for ZNF200 (if available)
TreeFam:
Gene Tree for ZNF200 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF200: view image

Paralogs for ZNF200 Gene

Paralogs for ZNF200 Gene

genes like me logo Genes that share paralogs with ZNF200: view

Variants for ZNF200 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF200 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs9302870 - p.Thr140Met

Additional dbSNP identifiers (rs#s) for ZNF200 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF200 Gene

Variant ID Type Subtype PubMed ID
nsv1036149 CNV gain 25217958
nsv1044147 CNV loss 25217958
nsv1070737 CNV deletion 25765185
nsv457355 CNV gain 19166990
nsv471074 CNV gain 18288195
nsv509592 CNV insertion 20534489
nsv516280 CNV gain 19592680
nsv571249 CNV gain 21841781
nsv833127 CNV gain+loss 17160897

Variation tolerance for ZNF200 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF200 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF200

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF200 Gene

Disorders for ZNF200 Gene

No disorders were found for ZNF200 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF200 Gene

Publications for ZNF200 Gene

  1. Identification of two Krüppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3. (PMID: 9787081) Deng Z … Kastner DL (Genomics 1998) 2 3 4
  2. A candidate gene for familial Mediterranean fever. (PMID: 9288094) French FMF Consortium (Nature genetics 1997) 2 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3

Products for ZNF200 Gene

Sources for ZNF200 Gene