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Aliases for ZNF200 Gene

Aliases for ZNF200 Gene

  • Zinc Finger Protein 200 2 3 5
  • ZNFMF 4

External Ids for ZNF200 Gene

Previous GeneCards Identifiers for ZNF200 Gene

  • GC16M003292
  • GC16M003272
  • GC16M003212

Summaries for ZNF200 Gene

GeneCards Summary for ZNF200 Gene

ZNF200 (Zinc Finger Protein 200) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF597.

UniProtKB/Swiss-Prot for ZNF200 Gene

  • Could have a role in spermatogenesis.

Additional gene information for ZNF200 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF200 Gene

Genomics for ZNF200 Gene

GeneHancer (GH) Regulatory Elements for ZNF200 Gene

Promoters and enhancers for ZNF200 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I003233 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 563.4 +1.2 1187 2.2 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF200 CREBBP ZNF263 LOC105371055 ENSG00000261938 ZNF597 SRRM2 AMDHD2 ZNF205 ERVK13-1
GH16I003003 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 23.9 +228.4 228405 8.4 HDGF HNRNPUL1 PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A LOC107984895 LOC105371056 CREBBP ZNF597 MMP25 AMDHD2 SRRM2 ZNF598 ZNF263 ZNF200
GH16I003400 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.4 -165.0 -164998 2.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF174 ZSCAN32 ZNF597 TIGD7 CREBBP ZNF75A CLUAP1 ZNF200 MTCO1P28 SRRM2
GH16I002266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.2 +968.0 968009 3.2 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 RNPS1 LOC106660606 GC16M002267 GC16M002266 ZNF263 ENSG00000260051 ENSG00000261505 E4F1 AMDHD2 TSC2
GH16I003442 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 23.4 -207.5 -207505 2.2 ATF1 ZFP64 SIN3A YY1 ETS1 ELK1 FOS RUNX3 SP3 CEBPZ ZNF597 NAA60 ZNF200 CREBBP AMDHD2 ENSG00000261938 MEFV ZNF75A TIGD7 ZNF263
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF200 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF200 gene promoter:

Genomic Locations for ZNF200 Gene

Genomic Locations for ZNF200 Gene
chr16:3,222,325-3,236,221
(GRCh38/hg38)
Size:
13,897 bases
Orientation:
Minus strand
chr16:3,272,325-3,286,221
(GRCh37/hg19)

Genomic View for ZNF200 Gene

Genes around ZNF200 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF200 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF200 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF200 Gene

Proteins for ZNF200 Gene

  • Protein details for ZNF200 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98182-ZN200_HUMAN
    Recommended name:
    Zinc finger protein 200
    Protein Accession:
    P98182
    Secondary Accessions:
    • D3DUB7
    • D3DUB8
    • O15361
    • Q5XKM5
    • Q7Z5V1

    Protein attributes for ZNF200 Gene

    Size:
    395 amino acids
    Molecular mass:
    45534 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC70008.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH54005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF200 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF200 Gene

Post-translational modifications for ZNF200 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF200 Gene

Domains & Families for ZNF200 Gene

Gene Families for ZNF200 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF200 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF200: view

No data available for UniProtKB/Swiss-Prot for ZNF200 Gene

Function for ZNF200 Gene

Molecular function for ZNF200 Gene

GENATLAS Biochemistry:
zinc finger protein 200,C2H2 type,predominantly expressed in testis
UniProtKB/Swiss-Prot Function:
Could have a role in spermatogenesis.

Phenotypes From GWAS Catalog for ZNF200 Gene

Gene Ontology (GO) - Molecular Function for ZNF200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF200: view
genes like me logo Genes that share phenotypes with ZNF200: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF200 Gene

Localization for ZNF200 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF200 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF200 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with ZNF200: view

Pathways & Interactions for ZNF200 Gene

SuperPathways for ZNF200 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF200: view

Pathways by source for ZNF200 Gene

2 Reactome pathways for ZNF200 Gene

Gene Ontology (GO) - Biological Process for ZNF200 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF200: view

No data available for SIGNOR curated interactions for ZNF200 Gene

Drugs & Compounds for ZNF200 Gene

No Compound Related Data Available

Transcripts for ZNF200 Gene

Unigene Clusters for ZNF200 Gene

Zinc finger protein 200:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF200 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - - -
SP3: -
SP4: -
SP5: - -
SP6: - - - -
SP7:

Relevant External Links for ZNF200 Gene

GeneLoc Exon Structure for
ZNF200
ECgene alternative splicing isoforms for
ZNF200

Expression for ZNF200 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF200 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF200 Gene

This gene is overexpressed in Testis (x5.1) and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for ZNF200 Gene

This gene is overexpressed in Esophagus (47.8) and Saliva (21.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF200 Gene



Protein tissue co-expression partners for ZNF200 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF200 Gene:

ZNF200

SOURCE GeneReport for Unigene cluster for ZNF200 Gene:

Hs.632222

mRNA Expression by UniProt/SwissProt for ZNF200 Gene:

P98182-ZN200_HUMAN
Tissue specificity: Highly expressed in testis, weakly expressed in spleen, thymus, prostate, ovary, small intestine colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for ZNF200 Gene

  • Liver(4.1)
  • Skin(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZNF200: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF200 Gene

Orthologs for ZNF200 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF200 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF200 33 34
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia ZNF200 33 34
  • 88.01 (n)
dog
(Canis familiaris)
Mammalia ZNF200 33 34
  • 87.44 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF200 34
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR352258.1 34
  • 35 (a)
OneToMany
Species where no ortholog for ZNF200 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF200 Gene

ENSEMBL:
Gene Tree for ZNF200 (if available)
TreeFam:
Gene Tree for ZNF200 (if available)

Paralogs for ZNF200 Gene

Paralogs for ZNF200 Gene

genes like me logo Genes that share paralogs with ZNF200: view

Variants for ZNF200 Gene

Sequence variations from dbSNP and Humsavar for ZNF200 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000144535 -- 3,229,527(-) C/A intron_variant
rs1000326461 -- 3,225,056(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000502312 -- 3,234,448(-) G/A intron_variant
rs1001046331 -- 3,226,130(-) G/A genic_downstream_transcript_variant, intron_variant
rs1001072170 -- 3,236,807(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF200 Gene

Variant ID Type Subtype PubMed ID
nsv1036149 CNV gain 25217958
nsv1044147 CNV loss 25217958
nsv1070737 CNV deletion 25765185
nsv457355 CNV gain 19166990
nsv471074 CNV gain 18288195
nsv509592 CNV insertion 20534489
nsv516280 CNV gain 19592680
nsv571249 CNV gain 21841781
nsv833127 CNV gain+loss 17160897

Variation tolerance for ZNF200 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF200 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF200

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF200 Gene

Disorders for ZNF200 Gene

Additional Disease Information for ZNF200

No disorders were found for ZNF200 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF200 Gene

Publications for ZNF200 Gene

  1. Identification of two Krüppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3. (PMID: 9787081) Deng Z … Kastner DL (Genomics 1998) 2 3 4 58
  2. A candidate gene for familial Mediterranean fever. (PMID: 9288094) French FMF Consortium (Nature genetics 1997) 2 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58

Products for ZNF200 Gene

Sources for ZNF200 Gene

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