Aliases for ZNF20 Gene

Aliases for ZNF20 Gene

  • Zinc Finger Protein 20 2 3 4 5
  • Zinc Finger Protein KOX13 3 4
  • KOX13 3 4
  • Zinc Finger Protein 20 (KOX 13) 2

External Ids for ZNF20 Gene

Previous GeneCards Identifiers for ZNF20 Gene

  • GC19M012374
  • GC19M012465
  • GC19M012089
  • GC19M012241
  • GC19M011818

Summaries for ZNF20 Gene

GeneCards Summary for ZNF20 Gene

ZNF20 (Zinc Finger Protein 20) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF440.

UniProtKB/Swiss-Prot Summary for ZNF20 Gene

Additional gene information for ZNF20 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF20 Gene

Genomics for ZNF20 Gene

GeneHancer (GH) Regulatory Elements for ZNF20 Gene

Promoters and enhancers for ZNF20 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF20 gene promoter:
  • p300
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)

Genomic Locations for ZNF20 Gene

Genomic Locations for ZNF20 Gene
chr19:12,092,843-12,140,407
(GRCh38/hg38)
Size:
47,565 bases
Orientation:
Minus strand
chr19:12,203,658-12,251,222
(GRCh37/hg19)
Size:
47,565 bases
Orientation:
Minus strand

Genomic View for ZNF20 Gene

Genes around ZNF20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF20 Gene

Proteins for ZNF20 Gene

  • Protein details for ZNF20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17024-ZNF20_HUMAN
    Recommended name:
    Zinc finger protein 20
    Protein Accession:
    P17024
    Secondary Accessions:
    • Q8N457
    • Q9UG41

    Protein attributes for ZNF20 Gene

    Size:
    532 amino acids
    Molecular mass:
    61567 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF20 Gene

Post-translational modifications for ZNF20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF20 Gene

No data available for DME Specific Peptides for ZNF20 Gene

Domains & Families for ZNF20 Gene

Gene Families for ZNF20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF20 Gene

Suggested Antigen Peptide Sequences for ZNF20 Gene

GenScript: Design optimal peptide antigens:
  • ZNF20 protein (Q86XA2_HUMAN)
  • Zinc finger protein KOX13 (ZNF20_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17024

UniProtKB/Swiss-Prot:

ZNF20_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF20: view

Function for ZNF20 Gene

Molecular function for ZNF20 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 20 (KOX13) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF20 Gene

Gene Ontology (GO) - Molecular Function for ZNF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF20: view
genes like me logo Genes that share phenotypes with ZNF20: view

Animal Model Products

CRISPR Products

miRNA for ZNF20 Gene

miRTarBase miRNAs that target ZNF20

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF20

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF20 Gene

Localization for ZNF20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF20 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF20 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF20: view

Pathways & Interactions for ZNF20 Gene

genes like me logo Genes that share pathways with ZNF20: view

Pathways by source for ZNF20 Gene

2 Reactome pathways for ZNF20 Gene
1 KEGG pathway for ZNF20 Gene

Gene Ontology (GO) - Biological Process for ZNF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF20: view

No data available for SIGNOR curated interactions for ZNF20 Gene

Drugs & Compounds for ZNF20 Gene

No Compound Related Data Available

Transcripts for ZNF20 Gene

mRNA/cDNA for ZNF20 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF20

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF20 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6:
SP7: - -
SP8: -
SP9: - - - -

Relevant External Links for ZNF20 Gene

GeneLoc Exon Structure for
ZNF20
ECgene alternative splicing isoforms for
ZNF20

Expression for ZNF20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF20 Gene

This gene is overexpressed in Testis (x13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF20 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF20 Gene:

ZNF20

SOURCE GeneReport for Unigene cluster for ZNF20 Gene:

Hs.512823

Evidence on tissue expression from TISSUES for ZNF20 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF20: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF20 Gene

Orthologs for ZNF20 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF20 32
  • 99.75 (n)
cow
(Bos Taurus)
Mammalia -- 33
  • 50 (a)
ManyToMany
Species where no ortholog for ZNF20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF20 Gene

ENSEMBL:
Gene Tree for ZNF20 (if available)
TreeFam:
Gene Tree for ZNF20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF20: view image

Paralogs for ZNF20 Gene

(521) SIMAP similar genes for ZNF20 Gene using alignment to 5 proteins:

  • ZNF20_HUMAN
  • C9JIP4_HUMAN
  • F8WDZ5_HUMAN
  • M0QYR3_HUMAN
  • Q86XA2_HUMAN

Pseudogenes.org Pseudogenes for ZNF20 Gene

genes like me logo Genes that share paralogs with ZNF20: view

Variants for ZNF20 Gene

Sequence variations from dbSNP and Humsavar for ZNF20 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000003116 -- 12,131,343(-) C/A downstream_transcript_variant
rs1000557516 -- 12,142,062(-) C/T upstream_transcript_variant
rs1000749406 -- 12,136,439(-) T/G intron_variant
rs1000951901 -- 12,134,614(-) G/A/T intron_variant
rs1001159276 -- 12,140,640(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF20 Gene

Variant ID Type Subtype PubMed ID
esv2665806 CNV deletion 23128226
nsv578619 CNV loss 21841781
nsv833753 CNV loss 17160897
nsv961178 CNV duplication 23825009

Variation tolerance for ZNF20 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF20

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF20 Gene

Disorders for ZNF20 Gene

Additional Disease Information for ZNF20

No disorders were found for ZNF20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF20 Gene

Publications for ZNF20 Gene

  1. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 56
  2. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart AE … Wells CM (The Journal of cell biology 2015) 3 56
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 56

Products for ZNF20 Gene

Sources for ZNF20 Gene