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Aliases for ZNF2 Gene

Aliases for ZNF2 Gene

  • Zinc Finger Protein 2 2 3 3 5
  • Zinc Finger Protein 2.2 3 4
  • Zinc Finger Protein 661 3 4
  • ZNF661 3 4
  • Zinc Finger Protein 2 (A1-5) 2
  • Zfp661 3
  • A1-5 3

External Ids for ZNF2 Gene

Previous GeneCards Identifiers for ZNF2 Gene

  • GC02P093728
  • GC02P094264
  • GC02P095299
  • GC02P095315
  • GC02P095162
  • GC02P095253
  • GC02P095194
  • GC02P095831
  • GC02P089859

Summaries for ZNF2 Gene

Entrez Gene Summary for ZNF2 Gene

  • The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for ZNF2 Gene

ZNF2 (Zinc Finger Protein 2) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF37A.

UniProtKB/Swiss-Prot for ZNF2 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF2 Gene

Genomics for ZNF2 Gene

GeneHancer (GH) Regulatory Elements for ZNF2 Gene

Promoters and enhancers for ZNF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J095164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.2 245 2.1 HDGF SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF514 ZNF2 GC02M095163 PROM2 GC02M095170
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF2 gene promoter:
  • STAT1beta
  • STAT1alpha
  • STAT1
  • c-Myb
  • STAT5A
  • Ik-2
  • FAC1
  • p300
  • STAT3
  • HTF

Genomic Locations for ZNF2 Gene

Genomic Locations for ZNF2 Gene
18,901 bases
Plus strand
18,889 bases
Plus strand

Genomic View for ZNF2 Gene

Genes around ZNF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF2 Gene

Proteins for ZNF2 Gene

  • Protein details for ZNF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 2
    Protein Accession:
    Secondary Accessions:
    • A8MWV7
    • B4DIR4
    • Q4ZFY6
    • Q96G44
    • Q9UMC5

    Protein attributes for ZNF2 Gene

    426 amino acids
    Molecular mass:
    48863 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAX88982.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF2 Gene


neXtProt entry for ZNF2 Gene

Post-translational modifications for ZNF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF2 Gene

Domains & Families for ZNF2 Gene

Gene Families for ZNF2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF2: view

Function for ZNF2 Gene

Molecular function for ZNF2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 2 (A1-5) with Kruppel type C2H2 finger motif,ubiquitously expressed

Gene Ontology (GO) - Molecular Function for ZNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0008270 zinc ion binding NAS 1945843
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF2: view
genes like me logo Genes that share phenotypes with ZNF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF2 Gene

Localization for ZNF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF2 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF2: view

Pathways & Interactions for ZNF2 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF2: view

Pathways by source for ZNF2 Gene

2 Reactome pathways for ZNF2 Gene

Gene Ontology (GO) - Biological Process for ZNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 1945843
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF2: view

No data available for SIGNOR curated interactions for ZNF2 Gene

Drugs & Compounds for ZNF2 Gene

No Compound Related Data Available

Transcripts for ZNF2 Gene

Unigene Clusters for ZNF2 Gene

Zinc finger protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF2

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF2 Gene

No ASD Table

Relevant External Links for ZNF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF2 Gene

Protein differential expression in normal tissues from HIPED for ZNF2 Gene

This gene is overexpressed in Heart (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF2 Gene

Protein tissue co-expression partners for ZNF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF2 Gene:


SOURCE GeneReport for Unigene cluster for ZNF2 Gene:


Evidence on tissue expression from TISSUES for ZNF2 Gene

  • Nervous system(4.3)
  • Muscle(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZNF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF2 Gene

Orthologs for ZNF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF2 33
  • 99.45 (n)
(Bos Taurus)
Mammalia ZNF2 33
  • 85.93 (n)
(Canis familiaris)
Mammalia LOC100856076 33
  • 85.33 (n)
(Rattus norvegicus)
Mammalia LOC100909998 33
  • 80.52 (n)
(Mus musculus)
Mammalia Zfp661 16 33
  • 79.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18555 35
  • 44 (a)
CG17803 35
  • 36 (a)
Species where no ortholog for ZNF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF2 Gene

Gene Tree for ZNF2 (if available)
Gene Tree for ZNF2 (if available)
Evolutionary constrained regions (ECRs) for ZNF2: view image

Paralogs for ZNF2 Gene

Paralogs for ZNF2 Gene

(527) SIMAP similar genes for ZNF2 Gene using alignment to 5 proteins:

  • E9PGF4_HUMAN Pseudogenes for ZNF2 Gene

genes like me logo Genes that share paralogs with ZNF2: view

Variants for ZNF2 Gene

Sequence variations from dbSNP and Humsavar for ZNF2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000000009 -- 95,169,763(+) A/G intron_variant
rs1000272010 -- 95,163,484(+) A/G upstream_transcript_variant
rs1000276023 -- 95,183,192(+) G/A 3_prime_UTR_variant
rs1000562308 -- 95,170,049(+) C/T intron_variant
rs1000983508 -- 95,175,552(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF2 Gene

Variant ID Type Subtype PubMed ID
dgv4007n100 CNV gain 25217958
esv3591652 OTHER inversion 21293372
nsv1160825 CNV duplication 26073780

Variation tolerance for ZNF2 Gene

Residual Variation Intolerance Score: 47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF2 Gene

Disorders for ZNF2 Gene

Additional Disease Information for ZNF2

No disorders were found for ZNF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF2 Gene

Publications for ZNF2 Gene

  1. Members of the zinc finger protein gene family sharing a conserved N-terminal module. (PMID: 1945843) Rosati M … Grimaldi G (Nucleic acids research 1991) 2 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. (PMID: 8183940) Witzgall R … Bonventre JV (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 58

Products for ZNF2 Gene

Sources for ZNF2 Gene

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