The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014] See more...

Aliases for ZNF2 Gene

Aliases for ZNF2 Gene

  • Zinc Finger Protein 2 2 3 4 5
  • Zinc Finger Protein 2.2 3 4
  • Zinc Finger Protein 661 3 4
  • ZNF661 3 4
  • Zinc Finger Protein 2 (A1-5) 2
  • Zfp661 3
  • A1-5 3

External Ids for ZNF2 Gene

Previous GeneCards Identifiers for ZNF2 Gene

  • GC02P093728
  • GC02P094264
  • GC02P095299
  • GC02P095315
  • GC02P095162
  • GC02P095253
  • GC02P095194
  • GC02P095831
  • GC02P089859

Summaries for ZNF2 Gene

Entrez Gene Summary for ZNF2 Gene

  • The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for ZNF2 Gene

ZNF2 (Zinc Finger Protein 2) is a Protein Coding gene. Diseases associated with ZNF2 include Hypoparathyroidism, Sensorineural Deafness, And Renal Disease and Cryptococcosis. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZFP28.

UniProtKB/Swiss-Prot Summary for ZNF2 Gene

Additional gene information for ZNF2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF2 Gene

Genomics for ZNF2 Gene

GeneHancer (GH) Regulatory Elements for ZNF2 Gene

Promoters and enhancers for ZNF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J095164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.1 84 3 EP300 HNRNPK ZBTB40 ZNF217 SIN3A NRF1 MYC TCF12 USF1 POLR2G ZNF514 ZNF2 lnc-ZNF514-1 PROM2 lnc-ZNF514-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF2

Top Transcription factor binding sites by QIAGEN in the ZNF2 gene promoter:
  • c-Myb
  • FAC1
  • HTF
  • Ik-2
  • p300
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT3
  • STAT5A

Genomic Locations for ZNF2 Gene

Genomic Locations for ZNF2 Gene
chr2:95,165,417-95,184,317
(GRCh38/hg38)
Size:
18,901 bases
Orientation:
Plus strand
chr2:95,831,177-95,850,065
(GRCh37/hg19)
Size:
18,889 bases
Orientation:
Plus strand

Genomic View for ZNF2 Gene

Genes around ZNF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF2 Gene

Proteins for ZNF2 Gene

  • Protein details for ZNF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSG1-ZNF2_HUMAN
    Recommended name:
    Zinc finger protein 2
    Protein Accession:
    Q9BSG1
    Secondary Accessions:
    • A8MWV7
    • B0AZN8
    • B4DIR4
    • Q4ZFY6
    • Q96G44
    • Q9UMC5

    Protein attributes for ZNF2 Gene

    Size:
    425 amino acids
    Molecular mass:
    48707 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX88982.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF2 Gene

Post-translational modifications for ZNF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF2 Gene

Domains & Families for ZNF2 Gene

Gene Families for ZNF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF2 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79478, highly similar to Homo sapiens zinc finger protein 2 (ZNF2), transcript variant 1, mRNA (B0AZN8_HUMAN)
  • cDNA FLJ56636, highly similar to Homo sapiens zinc finger protein 2 (ZNF2), transcript variant 1, mRNA (B4DIR4_HUMAN)
  • Zinc finger protein 661 (ZNF2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BSG1

UniProtKB/Swiss-Prot:

ZNF2_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF2: view

Function for ZNF2 Gene

Molecular function for ZNF2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 2 (A1-5) with Kruppel type C2H2 finger motif,ubiquitously expressed

Gene Ontology (GO) - Molecular Function for ZNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 1945843
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF2: view
genes like me logo Genes that share phenotypes with ZNF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF2 Gene

Localization for ZNF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF2 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF2: view

Pathways & Interactions for ZNF2 Gene

genes like me logo Genes that share pathways with ZNF2: view

Pathways by source for ZNF2 Gene

2 Reactome pathways for ZNF2 Gene
1 KEGG pathway for ZNF2 Gene

Gene Ontology (GO) - Biological Process for ZNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS,IEA 1945843
genes like me logo Genes that share ontologies with ZNF2: view

No data available for SIGNOR curated interactions for ZNF2 Gene

Drugs & Compounds for ZNF2 Gene

No Compound Related Data Available

Transcripts for ZNF2 Gene

mRNA/cDNA for ZNF2 Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF2

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF2 Gene

No ASD Table

Relevant External Links for ZNF2 Gene

GeneLoc Exon Structure for
ZNF2

Expression for ZNF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF2 Gene

Protein differential expression in normal tissues from HIPED for ZNF2 Gene

This gene is overexpressed in Heart (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF2 Gene



Protein tissue co-expression partners for ZNF2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF2

SOURCE GeneReport for Unigene cluster for ZNF2 Gene:

Hs.590916

Evidence on tissue expression from TISSUES for ZNF2 Gene

  • Nervous system(4.3)
  • Muscle(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZNF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF2 Gene

Orthologs for ZNF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF2 30
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia ZNF2 30
  • 85.93 (n)
dog
(Canis familiaris)
Mammalia LOC100856076 30
  • 85.33 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909998 30
  • 80.52 (n)
mouse
(Mus musculus)
Mammalia Zfp661 17 30
  • 79.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18555 32
  • 44 (a)
CG17803 32
  • 36 (a)
Species where no ortholog for ZNF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF2 Gene

ENSEMBL:
Gene Tree for ZNF2 (if available)
TreeFam:
Gene Tree for ZNF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF2: view image

Paralogs for ZNF2 Gene

Paralogs for ZNF2 Gene

(527) SIMAP similar genes for ZNF2 Gene using alignment to 5 proteins:

  • ZNF2_HUMAN
  • B0AZN8_HUMAN
  • B4DIR4_HUMAN
  • E9PCG2_HUMAN
  • E9PGF4_HUMAN

Pseudogenes.org Pseudogenes for ZNF2 Gene

genes like me logo Genes that share paralogs with ZNF2: view

Variants for ZNF2 Gene

Additional dbSNP identifiers (rs#s) for ZNF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF2 Gene

Variant ID Type Subtype PubMed ID
dgv4007n100 CNV gain 25217958
esv3591652 OTHER inversion 21293372
nsv1160825 CNV duplication 26073780

Variation tolerance for ZNF2 Gene

Residual Variation Intolerance Score: 47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF2 Gene

Disorders for ZNF2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypoparathyroidism, sensorineural deafness, and renal disease
  • hdr
cryptococcosis
  • busse-buschke's disease
fungal meningitis
  • meningitis, fungal
- elite association - COSMIC cancer census association via MalaCards
Search ZNF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNF2

genes like me logo Genes that share disorders with ZNF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF2 Gene

Publications for ZNF2 Gene

  1. Members of the zinc finger protein gene family sharing a conserved N-terminal module. (PMID: 1945843) Rosati M … Grimaldi G (Nucleic acids research 1991) 2 3 4 54
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. (PMID: 8183940) Witzgall R … Bonventre JV (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 54

Products for ZNF2 Gene

Sources for ZNF2 Gene