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Aliases for ZNF197 Gene

Aliases for ZNF197 Gene

  • Zinc Finger Protein 197 2 3 5
  • Zinc Finger Protein With KRAB And SCAN Domains 9 3 4
  • PVHL-Associated KRAB Domain-Containing Protein 3 4
  • Zinc Finger Protein 166 2 3
  • ZKSCAN9 3 4
  • ZNF166 3 4
  • ZNF20 3 4
  • VHL-Associated KRAB-A Domain-Containing Protein 3
  • Zinc Finger Protein 20 3
  • D3S1363E 3
  • ZSCAN41 3
  • VHLaK 3
  • P18 3

External Ids for ZNF197 Gene

Previous HGNC Symbols for ZNF197 Gene

  • ZNF166

Previous GeneCards Identifiers for ZNF197 Gene

  • GC03P044135
  • GC03P043850
  • GC03P044416
  • GC03P044631
  • GC03P044558
  • GC03P044645
  • GC03P044674
  • GC03P044688
  • GC03P044716
  • GC03P044783
  • GC03P044676
  • GC03P044800
  • GC03P044827
  • GC03P044871
  • GC03P044935
  • GC03P044974
  • GC03P045014

Summaries for ZNF197 Gene

Entrez Gene Summary for ZNF197 Gene

  • This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. Naturally-occurring readthrough transcription is observed between this gene and the upstream zinc finger protein 660 gene and is represented by GeneID:110354863. [provided by RefSeq, May 2017]

GeneCards Summary for ZNF197 Gene

ZNF197 (Zinc Finger Protein 197) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF850.

UniProtKB/Swiss-Prot for ZNF197 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF197 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF197 Gene

Genomics for ZNF197 Gene

GeneHancer (GH) Regulatory Elements for ZNF197 Gene

Promoters and enhancers for ZNF197 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I044624 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 584.8 +40.4 40409 2.2 PKNOX1 ARNT ARID4B SIN3A YY1 POLR2B ZNF766 CBX5 E2F8 ZNF143 ZNF197 ZNF197-AS1 ZNF35 ZNF852 KIAA1143 ZNF660 ZDHHC3 ZNF502 ZNF445 ENSG00000236869
GH03I044584 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 564.5 +0.1 99 1.7 MXI1 FOXA2 SAP130 ARID4B SIN3A KLF5 ETS1 POLR2A VEZF1 ZNF207 ZNF197 ZNF660 ZNF197-AS1 ZKSCAN7 ZNF501 ZNF35 PIR39553 ENSG00000236869
GH03I044438 Enhancer 1.5 Ensembl ENCODE dbSUPER 25.3 -144.7 -144701 3.5 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 LINC00694 ZNF660 ZNF197 ZNF852 ZNF502 ZNF445 ZNF35 GC03M044441
GH03I044509 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.8 -74.2 -74189 2.6 HDGF ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 YY1 TCF12 POLR2B ZNF852 ZNF660 ZNF197 ZNF35 ZDHHC3 ZNF502 EI24P3
GH03I044685 Promoter/Enhancer 1.3 Ensembl ENCODE 24.2 +100.7 100712 1.2 HDGF PKNOX1 RB1 BMI1 ZBTB40 E4F1 ETS1 POLR2A PHF20 ZNF207 LOC101928592 ENSG00000236869 ZNF197 ZNF35 KIAA1143 ZNF852 KIF15 ZNF501 ZNF660 ZNF502
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF197 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF197 gene promoter:

Genomic Locations for ZNF197 Gene

Genomic Locations for ZNF197 Gene
chr3:44,584,888-44,648,471
(GRCh38/hg38)
Size:
63,584 bases
Orientation:
Plus strand
chr3:44,626,380-44,689,963
(GRCh37/hg19)

Genomic View for ZNF197 Gene

Genes around ZNF197 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF197 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF197 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF197 Gene

Proteins for ZNF197 Gene

  • Protein details for ZNF197 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14709-ZN197_HUMAN
    Recommended name:
    Zinc finger protein 197
    Protein Accession:
    O14709
    Secondary Accessions:
    • B2RAH8
    • Q86VG0

    Protein attributes for ZNF197 Gene

    Size:
    1029 amino acids
    Molecular mass:
    118847 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF197 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF197 Gene

Post-translational modifications for ZNF197 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF197 Gene

Domains & Families for ZNF197 Gene

Gene Families for ZNF197 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF197 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14709

UniProtKB/Swiss-Prot:

ZN197_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF197: view

Function for ZNF197 Gene

Molecular function for ZNF197 Gene

GENATLAS Biochemistry:
zinc finger protein 197
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF197 Gene

Gene Ontology (GO) - Molecular Function for ZNF197 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS,IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF197: view
genes like me logo Genes that share phenotypes with ZNF197: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF197 Gene

Localization for ZNF197 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF197 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF197 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF197 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF197: view

Pathways & Interactions for ZNF197 Gene

SuperPathways for ZNF197 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF197: view

Pathways by source for ZNF197 Gene

2 Reactome pathways for ZNF197 Gene

Gene Ontology (GO) - Biological Process for ZNF197 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF197: view

No data available for SIGNOR curated interactions for ZNF197 Gene

Drugs & Compounds for ZNF197 Gene

No Compound Related Data Available

Transcripts for ZNF197 Gene

Unigene Clusters for ZNF197 Gene

Zinc finger protein 197:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF197 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:
SP2: -

Relevant External Links for ZNF197 Gene

GeneLoc Exon Structure for
ZNF197
ECgene alternative splicing isoforms for
ZNF197

Expression for ZNF197 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF197 Gene

Protein differential expression in normal tissues from HIPED for ZNF197 Gene

This gene is overexpressed in Breast (39.9) and Cerebrospinal fluid (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF197 Gene



Protein tissue co-expression partners for ZNF197 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF197 Gene:

ZNF197

SOURCE GeneReport for Unigene cluster for ZNF197 Gene:

Hs.157035
genes like me logo Genes that share expression patterns with ZNF197: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF197 Gene

Orthologs for ZNF197 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF197 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF197 33 34
  • 91.05 (n)
mouse
(Mus musculus)
Mammalia Zfp616 34
  • 32 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4900 33
fruit fly
(Drosophila melanogaster)
Insecta CG6654 35
  • 39 (a)
CG10959 35
  • 37 (a)
CG6689 35
  • 33 (a)
zf30C 35
  • 33 (a)
CG11902 35
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
CSA.1668 34
  • 32 (a)
ManyToMany
Species where no ortholog for ZNF197 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF197 Gene

ENSEMBL:
Gene Tree for ZNF197 (if available)
TreeFam:
Gene Tree for ZNF197 (if available)

Paralogs for ZNF197 Gene

(306) SIMAP similar genes for ZNF197 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF197: view

Variants for ZNF197 Gene

Sequence variations from dbSNP and Humsavar for ZNF197 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000221208 -- 44,639,006(+) G/A/C intron_variant
rs1000233234 -- 44,639,392(+) C/A intron_variant
rs1000343534 -- 44,631,946(+) C/A intron_variant
rs1000597474 -- 44,625,127(+) C/T 5_prime_UTR_variant
rs1000826160 -- 44,631,808(+) C/T intron_variant

Variation tolerance for ZNF197 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF197 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF197

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF197 Gene

Disorders for ZNF197 Gene

Additional Disease Information for ZNF197

No disorders were found for ZNF197 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF197 Gene

Publications for ZNF197 Gene

  1. Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets. (PMID: 9380504) Gonsky R … Fagin JA (Nucleic acids research 1997) 2 3 4 22 58
  2. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. (PMID: 12682018) Li Z … Wu G (The EMBO journal 2003) 3 4 22 58
  3. YAC-assisted cloning of transcribed sequences from the human chromosome 3p21 region. (PMID: 8353497) Pengue G … D'Urso M (Human molecular genetics 1993) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ZNF197 Gene

Sources for ZNF197 Gene

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