Free for academic non-profit institutions. Other users need a Commercial license
Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB do... See more...
Aliases for ZNF189 Gene
External Ids for ZNF189 Gene
- HGNC: 12980
- Entrez Gene: 7743
- Ensembl: ENSG00000136870
- OMIM: 603132
- UniProtKB: O75820
Previous GeneCards Identifiers for ZNF189 Gene
- GC09P094961
- GC09P095904
- GC09P097618
- GC09P099541
- GC09P101240
- GC09P103200
- GC09P104161
- GC09P073760
Summaries for ZNF189 Gene
-
Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]
GeneCards Summary for ZNF189 Gene
ZNF189 (Zinc Finger Protein 189) is a Protein Coding gene. Diseases associated with ZNF189 include Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3 and Cleft Palate, Isolated. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF135.
UniProtKB/Swiss-Prot Summary for ZNF189 Gene
-
May be involved in transcriptional regulation.
Additional gene information for ZNF189 Gene
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF189 Gene
Genomics for ZNF189 Gene
GeneHancer (GH) Regulatory Elements for ZNF189 Gene
Promoters and enhancers for ZNF189 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF189 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF189
- Top Transcription factor binding sites by QIAGEN in the ZNF189 gene promoter:
-
- CP2
- CREB
- deltaCREB
- POU2F1
- POU2F1a
- POU3F1
Genomic Locations for ZNF189 Gene
Genomic Locations for ZNF189 Gene
- chr9:101,398,808-101,410,660
- (GRCh38/hg38)
- Size:
- 11,853 bases
- Orientation:
- Plus strand
- chr9:104,161,155-104,172,942
- (GRCh37/hg19)
- Size:
- 11,788 bases
- Orientation:
- Plus strand
Genomic View for ZNF189 Gene
Genes around ZNF189 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q31.1 by HGNC
- 9q31.1 by Entrez Gene
- 9q31.1 by Ensembl
ZNF189 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF189 Gene
Proteins for ZNF189 Gene
-
Protein details for ZNF189 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75820-ZN189_HUMAN
- Recommended name:
- Zinc finger protein 189
- Protein Accession:
- O75820
- O75802
- Q5T7D7
- Q5T7D8
- Q5T7D9
- Q9UBL4
- Q9UPE9
- Q9UPF0
- Q9UPF1
Protein attributes for ZNF189 Gene
- Size:
- 626 amino acids
- Molecular mass:
- 72976 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZNF189 Gene
Post-translational modifications for ZNF189 Gene
Other Protein References for ZNF189 Gene
Antibody Products
- Creative Diagnostics Anti-ZNF189 monoclonal antibody
- Creative Biolabs Mouse Anti-ZNF189 Recombinant Antibody (3C5)
- Novus Biologicals Antibodies for ZNF189
- Invitrogen Antibodies for ZNF189 (AFLGC-ZNF189)
- antibodies-online: Show 8 available ZNF189 Antibodies ranked by validation data
- Compare Top ZNF189 Antibodies
-
Quality Products:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZNF189
- Origene Custom Protein Services for ZNF189
- antibodies-online: Show 2 available ZNF189 Proteins ranked by validation data
- Compare Top ZNF189 Proteins
-
Quality Products:
-
Abcam proteins for ZNF189
No data available for DME Specific Peptides for ZNF189 Gene
Domains & Families for ZNF189 Gene
Gene Families for ZNF189 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF189 Gene
- Blocks:
-
- C2H2-type zinc finger signature
- KRAB box
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF189 Gene
- GenScript: Design optimal peptide antigens:
-
- ZNF189 protein (B7ZLK9_HUMAN)
- Zinc finger protein 189, isoform CRA_a (Q5T7D8_HUMAN)
- Zinc finger protein 189 (ZN189_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O75820- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF189 Gene
Molecular function for ZNF189 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
- GENATLAS Biochemistry:
- zinc finger protein 189,Kruppel-like,KRAB group,ubiquitously expressed,with tissue or cell type restricted expression pattern for the splice variants four
Phenotypes From GWAS Catalog for ZNF189 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | TAS | 9653648 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF189 Gene
- GenomeRNAi human phenotypes for ZNF189:
-
- Dynamic nuclei (hole, folded or small irregular)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability
- no effect
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Decreased homologous recombination repair frequency
- Decreased hepcidin::fluc mRNA expression
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF189 - Select products 50% OFF >
- * ZNF189 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF189
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF189
- genomics-online: gRNA clones - Search for available ZNF189 gRNA products
- Overview of 113 available ZNF189 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF189
miRNA for ZNF189 Gene
- miRTarBase miRNAs that target ZNF189
Targeted motifs for ZNF189 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF189
- Consensus sequence: TGGAACAGMA Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF189
- Browse OriGene Inhibitory RNA Products For ZNF189
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF189
- genomics-online: shRNA clones - Search for available ZNF189 shRNA products
- Overview of 113 available ZNF189 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ZNF189 - Select products 50% OFF >
- * ZNF189 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF189
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF189
Cell Line Products
-
Horizon Cell Lines for ZNF189
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF189 Gene
Localization for ZNF189 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF189 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytoskeleton | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
- Intermediate filaments (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for ZNF189 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | Herpes simplex virus 1 infection | ||
Pathways by source for ZNF189 Gene
2 Reactome pathways for ZNF189 Gene
1 KEGG pathway for ZNF189 Gene
Interacting Proteins for ZNF189 Gene
GPS-Prot Interaction Network for ZNF189
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | 9653648 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for ZNF189 Gene
Transcripts for ZNF189 Gene
mRNA/cDNA for ZNF189 Gene
- 5 REFSEQ mRNAs :
- 23 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000259395 3115 bps (ENST00000259395.4)
- ENST00000339664 3021 bps (ENST00000339664.6)
- ENST00000374861 3134 bps (ENST00000374861.7)
- ENST00000615466 2316 bps (ENST00000615466.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ZNF189 - Select products 50% OFF >
- * ZNF189 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ZNF189
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF189
- genomics-online: gRNA clones - Search for available ZNF189 gRNA products
- Overview of 113 available ZNF189 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF189
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF189
- Browse OriGene Inhibitory RNA Products For ZNF189
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF189
- genomics-online: shRNA clones - Search for available ZNF189 shRNA products
- Overview of 113 available ZNF189 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ZNF189 - Select products 50% OFF >
- * ZNF189 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ZNF189
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF189
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - |
Relevant External Links for ZNF189 Gene
- GeneLoc Exon Structure for
- ZNF189
Expression for ZNF189 Gene
This gene is overexpressed in Neutrophil (68.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF189 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF189
SOURCE GeneReport for Unigene cluster for ZNF189 Gene:
Hs.50123mRNA Expression by UniProt/SwissProt for ZNF189 Gene:
O75820-ZN189_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for ZNF189 Gene
- Nervous system(4.5)
- Bone marrow(4.1)
Primer Products
-
OriGene qPCR primer pairs for ZNF189
- genomics-online: primer clones - Search for available ZNF189 Primer products
- Overview of 113 available ZNF189 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF189 Gene
Orthologs for ZNF189 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF189 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ZNF189 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ZNF189 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Zfp189 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Zfp189 17 31 30 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100489897 30 |
|
- Species where no ortholog for ZNF189 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for ZNF189 Gene
- ENSEMBL:
- Gene Tree for ZNF189 (if available)
- TreeFam:
- Gene Tree for ZNF189 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF189: view image
Paralogs for ZNF189 Gene
Paralogs for ZNF189 Gene
- ZNF135 5
- ZNF605 5
- ZNF470 5
- ZNF41 5
- ZNF250 5
- ZNF484 5
- ZNF780B 5
- ZNF658 5
- ZNF33B 5
- ZNF132 5
- ZNF585A 5
- ZNF585B 5
- ZNF571 5
- ZNF606 5
- ZNF528 5
- ZNF33A 5
- ZNF229 5
- ZNF568 5
- ZNF616 5
- ZNF836 5
- ZNF283 5
- ZNF197 5
- ZFP28 5
- ZNF226 5
- ZNF234 5
- ZNF624 5
- ZNF7 5
- ZNF227 5
- ZNF235 5
- ZNF23 5
- ZNF502 5
- ZNF354B 5
- ZNF615 5
- ZNF471 5
- ZNF45 5
- RBAK 5
- ZNF345 5
- ZNF12 5
- ZNF112 5
- ZNF30 5
- ZNF354A 5
- ZNF544 5
- ZNF726 5
- ZNF546 5
- ZNF224 5
- ZNF43 5
- ZNF630 5
- ZNF432 5
- ZNF879 5
- ZNF268 5
- ZNF543 5
- ZNF254 5
- ZNF267 5
- ZNF93 5
- ZNF573 5
- ZNF175 5
- ZNF780A 5
- ZNF26 5
- ZNF300 5
- ZFP14 5
- ZNF607 5
- ZNF790 5
- ZFP30 5
- ZNF595 5
- ZNF814 5
- ZNF225 5
- ZNF429 5
- ZNF708 5
- ZNF37A 5
- ZNF724 5
- ZNF493 5
- ZNF16 5
- ZNF677 5
- ZNF74 5
- ZNF81 5
- ZNF540 5
- ZNF436 5
- ZNF782 5
- ZNF311 5
- ZNF732 5
- ZNF85 5
- ZNF681 5
- ZNF699 5
- ZNF383 5
- ZNF251 5
- ZNF483 5
- ZNF415 5
- ZNF728 5
- ZNF534 5
- ZNF28 5
- ZNF880 5
- ZNF182 5
- ZNF354C 5
- ZNF331 5
- ZNF454 5
- ZNF611 5
- ZNF510 5
- ZFP82 5
- ZNF565 5
- ZFP3 5
- ZNF623 5
- ZNF157 5
- ZNF90 5
- ENSG00000255104 5
- ZNF317 5
- ZNF286A 5
- ZNF835 5
- ZNF629 5
- ZFP2 5
- ZNF461 5
- ZNF83 5
- ZNF284 5
- ZNF678 5
- ZNF320 5
- ZNF71 5
- ZNF519 5
- ZNF717 5
- ZNF600 5
- ZNF334 5
- ZNF140 5
- ZNF460 5
- ZNF260 5
- ZNF676 5
- ZNF221 5
- ZNF695 5
- ZNF490 5
- ZNF3 5
- ZNF682 5
- ENSG00000285447 5
- ZNF841 5
- ZNF718 5
- ZNF195 5
- ZNF492 5
- ZKSCAN5 5
- ZSCAN10 5
- ZNF727 5
- ZNF117 5
- ZNF2 5
- ZNF577 5
- ENSG00000233757 5
- ZNF829 5
- ZNF716 5
- ZNF714 5
- ZNF628 5
- ZIM3 5
- ZNF517 5
- ZFP1 5
- ZNF713 5
- ZNF322 5
- ZNF391 5
- MZF1 5
- ZNF141 5
- ZNF679 5
- ZNF736 5
- ZNF672 5
- ZNF486 5
- ZNF121 5
- ZNF735 5
- ZNF775 5
- ZNF655 5
- ZNF146 5
- ZNF514 5
- ZNF621 5
- ENSG00000241149 5
- ZNF789 5
- ZNF501 5
- ZNF506 5
- ZNF696 5
- ZNF239 5
- GLI4 5
- ZNF32 5
- ZIM2 5
- ZNF138 5
- ENSG00000269693 5
- ENSG00000285978 5
- ENSG00000283930 5
- ENSG00000267360 5
- RBAK-RBAKDN 5
- ENSG00000267552 5
- ENSG00000283515 5
- ENSG00000267173 5
(507) SIMAP similar genes for ZNF189 Gene using alignment to 2 proteins:
- ZN189_HUMAN
- B7ZLK9_HUMAN
- kr-znf3
- ZNF78L1
- HZF36
- ZFS-4
- DKFZp666C237
- ZNF283
- ZNF501
- ZNF24
- ZSCAN16
- ZNF702P
- ZNF22
- ZNF204
- zf30
- ZNF345
- ZNF286B
- ZNF146
- HZF30
- ZFS-5
- ZFS-2
- ZSCAN23
- ZNF696
- ZNF282
- ZNF232
- ZNF213
- ZNF91
- ZNF84
- ZNF708
- ZNF271
- ZNF
- ZFS-6
- DKFZp686M04222
- ZNF664
- ZNF420
- ZNF845
- ZNF768
- ZNF347
- HZF41
- DKFZp762K012
- ZNF138
- ZNF594
- ZNF55
- ZNF323
- ZSCAN30
- ZNF721
- ZNF665
- ZNF268
- ZNF107
- DKFZp686B16128
- DKFZp313M0722
- ZNF697
- ZNF418
- ZNF485
- DKFZp686N14223
- ZSCAN12
- ZNF818P
- ZNF410
- ZNF83
- ZNF814
- ZNF808
- ZNF658B
- ZNF658
- ZNF493
- ZNF3
- ZNF226
- ZFS-1
- DKFZp686D2168
- GLI4
- ZNF331
- ZNF550
- smap-7
- ZSCAN25
- ZNF833P
- ZNF498
- ZNF85
- ZNF660
- ZNF623
- ZNF600
- ZNF572
- ZNF497
- ZNF484
- ZNF33A
- ZNF229
- Nbla00121
- ZFP41
- HZF40
- DKFZp434J0650
- ZNF566
- ZNF506
- ZSCAN29
- ZNF500
- ZNF449
- ZNF32
- ZNF883
- ZNF829
- ZNF774
- ZNF729
- ZNF648
- ZNF502
- ZNF41
- ZNF263
- ZNF23
- ZNF227
- ZNF112
- DKFZp686O111
- DKFZp686H20223
- DKFZp571N1833
- DKFZp434G1930
- ZNF137P
- PRMD9
- ZNF569
- ZNF239
- ZNF154
- ZNF28
- ZNF626
- ZNF780B
- ZSCAN21
- ZNF80
- ZNF691
- ZNF852
- ZNF678
- ZNF616
- ZNF578
- ZNF397
- ZNF391
- ZNF260
- ZNF135
- ZFP2
- ZKSCAN8
- HZF17
- ZNF782
- ZNF585B
- ZFP1
- ZNF571
- ZNF35
- ZNF208
- ZNF234
- ZNF160
- ZNF558
- PRDM9
- ZNF876P
- ZNF197
- ZSCAN20
- ZNF93
- ZNF835
- ZNF79
- ZNF662
- ZNF473
- ZNF436
- ZNF43
- ZNF429
- ZNF329
- ZNF30
- ZNF117
- MST154
- HZF14
- DKFZp686K03205
- DKFZp686J1732
- DKFZp666M039
- HZF28
- ZNF761
- ZNF286A
- ZNF850
- ZNF324B
- ZNF19
- ZNF254
- ZNF619
- ZSCAN31
- ZNF72
- ZNF250
- ZSCAN2
- ZNF844
- ZNF780A
- ZNF724P
- ZNF71
- ZNF605
- ZNF586
- ZNF546
- ZNF355P
- ZNF322
- ZNF304
- ZNF16
- ZFP62
- DKFZp686G16228
- DKFZp547L155
- ZFS-3
- HZF16
- ZNF813
- ZNF728
- ZNF709
- ZNF676
- ZNF354B
- ZKSCAN7
- DKFZp686L0787
- ZNF7
- ZNF99
- ZNF98
- ZNF92
- ZNF805
- ZNF736
- ZNF720
- ZNF680
- ZNF675
- ZNF624
- ZNF595
- ZNF567
- ZNF530
- ZNF415
- ZNF235
- ZNF184
- ZNF157
- ZFP3
- DKFZp572F2170
- DKFZp547H249
- ZNF324
- ZNF681
- ZNF841
- ZNF791
- ZNF684
- ZNF66
- ZNF471
- ZNF2
- ZNF589
- ZNF33B
- ZNF726
- ZNF354A
- ZNF257
- ZNF880
- ZNF879
- ZNF799
- ZNF790
- ZNF73
- ZNF629
- ZNF585A
- ZNF584
- ZNF551
- ZNF492
- ZNF470
- ZNF454
- ZNF34
- ZNF333
- ZFP112
- DKFZp686C13142
- ZNF544
- ZNF416
- ZNF606
- ZNF555
- ZNF528
- ZNF480
- ZNF337
- ZNF205
- ZNF182
- ZNF140
- ZNF132
- ZFP92
- ZNF667
- ZNF570
- ZNF417
- ZNF141
- ZNF568
- ZNF581
- ZNF90
- ZNF823
- ZNF816
- ZNF778
- ZNF737
- ZNF732
- ZNF649
- ZNF625
- ZNF621
- ZNF573
- ZNF565
- ZNF479
- ZNF266
- ZNF211
- ZNF14
- ZKSCAN1
- ZFP90
- RhitH
- HKR1
- GFI1
- DKFZp686O1631
- ZFP28
- ZNF557
- ZNF404
- ZNF394
- ZNF765
- ZNF701
- ZNF679
- ZNF630
- ZNF529
- ZNF383
- ZNF334
- ZNF320
- ZNF287
- ZNF175
- ZFP14
- ZKSCAN4
- ZKSCAN3
- ZNF468
- ZNF26
- ZNF514
- ZNF888
- ZNF735
- ZNF716
- ZNF70
- ZNF695
- ZNF674
- ZNF613
- ZNF607
- ZNF599
- ZNF583
- ZNF582
- ZNF549
- ZNF547
- ZNF534
- ZNF432
- ZNF431
- ZNF267
- ZNF256
- ZNF251
- ZNF225
- ZNF17
- ZNF121
- ZFP69
- MZF1
- ZNF167
- OSR2
- MYNN
- GFI1B
- DKFZp570I0164
- ZNF430
- ZNF10
- ZNF527
- ZNF74
- ZNF620
- ZNF614
- ZNF460
- ZNF442
- ZNF354C
- ZNF343
- ZNF311
- ZNF300
- ZNF181
- GD
- ZNF180
- ZNF20
- ZNF726P1
- ZSCAN26
- ZNF860
- ZNF730
- ZNF727
- ZNF615
- ZNF543
- ZNF540
- ZNF491
- ZNF483
- ZNF467
- ZNF45
- ZNF350
- ZNF25
- RBAK
- KIAA1829
- GZF1
- DKFZp686N0199
- ZNF44
- ZNF517
- ZNF165
- ZNF461
- ZNF275
- ZSCAN22
- ZNF789
- ZNF677
- ZNF670
- ZNF560
- ZNF519
- ZNF273
- ZNF224
- ZKSCAN5
- ZIM3
- ZFP95
- ZFP30
- ZNF682
- ZNF766
- ZNF587
- ZNF707
- ZNF749
- ZNF718
- ZNF714
- ZNF559
- ZNF486
- ZNF358
- ZNF264
- ZFP82
- PLAGL1
- A-328A3.4
- ZNF776
- ZNF793
- ZNF846
- ZNF836
- ZNF699
- ZNF548
- ZNF510
- ZNF441
- ZNF221
- ZNF202
- ZNF134
- ZNF124
- ZFP37
- ZNF419
- ZNF57
- ZNF382
- ZNF787
- ZNF786
- ZNF75A
- ZNF669
- ZNF878
- ZNF788
- ZNF771
- ZNF713
- ZNF611
- ZNF577
- ZNF564
- ZNF443
- ZNF37A
- ZNF319
- ZNF253
- ZNF133
- ZNF12
- ZIK1
- DKFZp434G1621
- ZNF655
- ZNF214
- ZNF561
- ZNF773
- ZNF763
- ZNF643
- ZNF554
- ZNF285A
- ZFP69B
- ZNF169
- ZNF136
- ZNF284
- ZNF81
- ZNF792
- ZNF317
- ZNF195
- ZNF100
- ZBTB47
- DKFZp686H10254
- ZNF587B
- ZNFN1A2
- ZNF155
- ZNF302
- ZNF233
- ZNF248
- ZNF562
- ZNF705A
- ZNF840
- ZNF837
- CTCFL
- ZNF671
- PRDM5
- ZNF812
- ZNF700
- ZNF596
- ZNF552
- ZNF490
- ZNF426
- ZNF425
- ZBTB41
- LOC126295
- ZSCAN9
- ZNF740
- ZNF705D
- ZNF772
- ZNF717
- ZNF672
- ZNF610
- ZNF563
- ZNF439
- ZNF285
- ZNF177
- HZF11
- ZFP64
- PLZF
- ZNF77
- ZNF525
- ZNF8
- ZNF114
- ZNF433
- REPIN1
- ZNF891
- ZF6
- ZNF101
- ZNF440
- ZSCAN10
- ZNF69
- ZNF689
- ZNF627
- ZNF230
- ZNF223
- TIPUH1
- ZNF597
- ZNF806
- ZNF764
- ZNF668
- ZNF48
Variants for ZNF189 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF189 Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs10989492 | - | p.Arg221Lys |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2738839 | CNV | deletion | 23290073 |
| nsv478694 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.15;
38.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF189 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF189
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF189 Gene
Disorders for ZNF189 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 |
|
|
| cleft palate, isolated |
|
|
| miller-dieker lissencephaly syndrome |
|
|
Search ZNF189 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ZNF189
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF189 Gene
Publications for ZNF189 Gene
- Cloning and characterization of ZNF189, a novel human Krüppel-like zinc finger gene localized to chromosome 9q22-q31. (PMID: 9653648) Odeberg J … Lundeberg J (Genomics 1998) 2 3 4 54
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41 54
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 54
- Context-dependent Taq-polymerase-mediated nucleotide alterations, as revealed by direct sequencing of the ZNF189 gene: implications for mutation detection. (PMID: 10415338) Odeberg J … Lundeberg J (Gene 1999) 3 4 54
ExternalLinks
Products for ZNF189 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZNF189
- Origene Custom Protein Services for ZNF189
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF189
- Browse OriGene Inhibitory RNA Products For ZNF189
- OriGene qPCR primer pairs for ZNF189
- OriGene CRISPR knockouts for ZNF189
- OriGene ORF clones in human for ZNF189
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ZNF189
- Sino Biological Human cDNA Clone for ZNF189
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ZNF189
- Novus Biologicals proteins and lysates for ZNF189
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for ZNF189
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for ZNF189 (AFLGC-ZNF189)
- VectorBuilder Custom and pre-made DNA vectors for ZNF189 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ZNF189 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ZNF189 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ZNF189 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ZNF189
- antibodies-online: Show 8 available ZNF189 Antibodies ranked by validation data
- Compare Top ZNF189 Antibodies
- Quality Products:
- antibodies-online: Search results for available ZNF189 related products ranked by validation data
- antibodies-online: Show 2 available ZNF189 Proteins ranked by validation data
- Compare Top ZNF189 Proteins
- Quality Products:
- Horizon Cell Lines for ZNF189
- genomics-online: cdna clones - Search for available ZNF189 CDNA products
- Overview of 113 available ZNF189 gene related products
- orf clones - Search for available ZNF189 ORF products
- Overview of 113 available ZNF189 gene related products
- genomics-online: gRNA clones - Search for available ZNF189 gRNA products
- Overview of 113 available ZNF189 gene related products
- genomics-online: primer clones - Search for available ZNF189 Primer products
- Overview of 113 available ZNF189 gene related products
- genomics-online: shRNA clones - Search for available ZNF189 shRNA products
- Overview of 113 available ZNF189 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF189
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF189
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ZNF189
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF189
Sources for ZNF189 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody