External Ids for ZNF189 Gene
Previous GeneCards Identifiers for ZNF189 Gene
Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]
GeneCards Summary for ZNF189 Gene
ZNF189 (Zinc Finger Protein 189) is a Protein Coding gene. Diseases associated with ZNF189 include Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3 and Cleft Palate, Isolated. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF135.
UniProtKB/Swiss-Prot Summary for ZNF189 Gene
May be involved in transcriptional regulation.