Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB do... See more...

Aliases for ZNF189 Gene

Aliases for ZNF189 Gene

  • Zinc Finger Protein 189 2 3 4 5

External Ids for ZNF189 Gene

Previous GeneCards Identifiers for ZNF189 Gene

  • GC09P094961
  • GC09P095904
  • GC09P097618
  • GC09P099541
  • GC09P101240
  • GC09P103200
  • GC09P104161
  • GC09P073760

Summaries for ZNF189 Gene

Entrez Gene Summary for ZNF189 Gene

  • Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]

GeneCards Summary for ZNF189 Gene

ZNF189 (Zinc Finger Protein 189) is a Protein Coding gene. Diseases associated with ZNF189 include Cleft Palate, Isolated. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF7.

UniProtKB/Swiss-Prot Summary for ZNF189 Gene

Additional gene information for ZNF189 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF189 Gene

Genomics for ZNF189 Gene

GeneHancer (GH) Regulatory Elements for ZNF189 Gene

Promoters and enhancers for ZNF189 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J101397 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 760 +0.6 573 4.8 SIN3A ZNF24 SP1 ZBTB40 SIX5 FOXA1 RBPJ POLR2A NR2F6 ATF1 ZNF189 MRPL50 TMEFF1 ENSG00000230328 RF00017-7775
GH09J101430 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 16.4 +42.6 42580 20.9 ZNF785 CTCF LCORL FOXA1 MLX RBPJ NR2F1 NR2F6 ATF1 CREB1 ALDOB LOC105376184 ZNF189 RNF20 TMEM246 MRPL50 TMEM246-AS1 BAAT ENSG00000270982 piR-60146-194
GH09J101452 Enhancer 0.7 Ensembl ENCODE dbSUPER 10.8 +54.9 54853 1.8 ZNF644 ATF2 TMEM246 RNF20 ZNF189 MRPL50 ALDOB ENSG00000270982 RF00017-7776 LOC105376184
GH09J101421 Enhancer 0.8 ENCODE 8.7 +23.1 23063 0.9 RBPJ NR2F1 NR2F6 CREB1 MIXL1 ELF3 SP1 PPARG HNF1A KAT8 ALDOB ZNF189 NONHSAG053057.2 LOC105376184
GH09J101427 Enhancer 0.9 Ensembl ENCODE dbSUPER 6.8 +29.5 29458 1.4 ZNF24 MIXL1 RELA ZNF687 CEBPG ZNF644 RCOR2 ELF1 RUNX3 ZBTB33 ZNF189 NONHSAG053057.2 LOC105376184 ALDOB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF189 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF189 gene promoter:
  • CP2
  • CREB
  • deltaCREB
  • POU2F1
  • POU2F1a
  • POU3F1

Genomic Locations for ZNF189 Gene

Genomic Locations for ZNF189 Gene
chr9:101,398,808-101,410,660
(GRCh38/hg38)
Size:
11,853 bases
Orientation:
Plus strand
chr9:104,161,155-104,172,942
(GRCh37/hg19)
Size:
11,788 bases
Orientation:
Plus strand

Genomic View for ZNF189 Gene

Genes around ZNF189 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF189 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF189 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF189 Gene

Proteins for ZNF189 Gene

  • Protein details for ZNF189 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75820-ZN189_HUMAN
    Recommended name:
    Zinc finger protein 189
    Protein Accession:
    O75820
    Secondary Accessions:
    • O75802
    • Q5T7D7
    • Q5T7D8
    • Q5T7D9
    • Q9UBL4
    • Q9UPE9
    • Q9UPF0
    • Q9UPF1

    Protein attributes for ZNF189 Gene

    Size:
    626 amino acids
    Molecular mass:
    72976 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF189 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF189 Gene

Post-translational modifications for ZNF189 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF189 Gene

Domains & Families for ZNF189 Gene

Gene Families for ZNF189 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF189 Gene

Suggested Antigen Peptide Sequences for ZNF189 Gene

GenScript: Design optimal peptide antigens:
  • ZNF189 protein (B7ZLK9_HUMAN)
  • Zinc finger protein 189, isoform CRA_a (Q5T7D8_HUMAN)
  • Zinc finger protein 189 (ZN189_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75820

UniProtKB/Swiss-Prot:

ZN189_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF189: view

Function for ZNF189 Gene

Molecular function for ZNF189 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 189,Kruppel-like,KRAB group,ubiquitously expressed,with tissue or cell type restricted expression pattern for the splice variants four

Phenotypes From GWAS Catalog for ZNF189 Gene

Gene Ontology (GO) - Molecular Function for ZNF189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS 9653648
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF189: view
genes like me logo Genes that share phenotypes with ZNF189: view

Animal Model Products

CRISPR Products

miRNA for ZNF189 Gene

Targeted motifs for ZNF189 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF189
  • Consensus sequence: TGGAACAGMA Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF189 Gene

Localization for ZNF189 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF189 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF189 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF189: view

Pathways & Interactions for ZNF189 Gene

genes like me logo Genes that share pathways with ZNF189: view

Pathways by source for ZNF189 Gene

2 Reactome pathways for ZNF189 Gene
1 KEGG pathway for ZNF189 Gene

Gene Ontology (GO) - Biological Process for ZNF189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 9653648
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF189: view

No data available for SIGNOR curated interactions for ZNF189 Gene

Drugs & Compounds for ZNF189 Gene

No Compound Related Data Available

Transcripts for ZNF189 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF189 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - -

Relevant External Links for ZNF189 Gene

GeneLoc Exon Structure for
ZNF189
ECgene alternative splicing isoforms for
ZNF189

Expression for ZNF189 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF189 Gene

Protein differential expression in normal tissues from HIPED for ZNF189 Gene

This gene is overexpressed in Neutrophil (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF189 Gene



Protein tissue co-expression partners for ZNF189 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF189 Gene:

ZNF189

SOURCE GeneReport for Unigene cluster for ZNF189 Gene:

Hs.50123

mRNA Expression by UniProt/SwissProt for ZNF189 Gene:

O75820-ZN189_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ZNF189 Gene

  • Nervous system(4.5)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with ZNF189: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF189 Gene

Orthologs for ZNF189 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF189 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF189 33 32
  • 99.95 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF189 33 32
  • 94.92 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF189 33 32
  • 93.79 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp189 32
  • 89.8 (n)
mouse
(Mus musculus)
Mammalia Zfp189 17 33 32
  • 88.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 50 (a)
OneToMany
-- 33
  • 46 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 43 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489897 32
  • 58.58 (n)
Species where no ortholog for ZNF189 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF189 Gene

ENSEMBL:
Gene Tree for ZNF189 (if available)
TreeFam:
Gene Tree for ZNF189 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF189: view image

Paralogs for ZNF189 Gene

Paralogs for ZNF189 Gene

(507) SIMAP similar genes for ZNF189 Gene using alignment to 2 proteins:

  • ZN189_HUMAN
  • B7ZLK9_HUMAN
genes like me logo Genes that share paralogs with ZNF189: view

Variants for ZNF189 Gene

Sequence variations from dbSNP and Humsavar for ZNF189 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000028563 -- 101,397,664(+) T/A upstream_transcript_variant
rs1000189078 -- 101,403,253(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000289701 -- 101,397,402(+) T/C upstream_transcript_variant
rs1000489863 -- 101,402,796(+) A/C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000658529 -- 101,407,451(+) ACACA/ACA coding_sequence_variant, frameshift, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF189 Gene

Variant ID Type Subtype PubMed ID
esv2738839 CNV deletion 23290073
nsv478694 CNV novel sequence insertion 20440878

Variation tolerance for ZNF189 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 38.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF189 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF189

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF189 Gene

Disorders for ZNF189 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF189 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cleft palate, isolated
  • cpi
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF189

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF189: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF189 Gene

Publications for ZNF189 Gene

  1. Cloning and characterization of ZNF189, a novel human Krüppel-like zinc finger gene localized to chromosome 9q22-q31. (PMID: 9653648) Odeberg J … Lundeberg J (Genomics 1998) 2 3 4 56
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 43 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 56
  5. Context-dependent Taq-polymerase-mediated nucleotide alterations, as revealed by direct sequencing of the ZNF189 gene: implications for mutation detection. (PMID: 10415338) Odeberg J … Lundeberg J (Gene 1999) 3 4 56

Products for ZNF189 Gene

Sources for ZNF189 Gene