The protein encoded by this gene is predicted to be a Kruppel C2H2-type zinc-finger protein family member. Sequence analysis predicts that the protein contains two Kruppel associated box (KRAB) boxes in the N-terminus and highly conserved zinc finger motifs at the C-terminus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016] See more...

Aliases for ZNF184 Gene

Aliases for ZNF184 Gene

  • Zinc Finger Protein 184 2 3 4 5
  • Zinc Finger Protein 184 (Kruppel-Like) 2 3
  • Kr-ZNF3 3
  • ZNF184 5

External Ids for ZNF184 Gene

Previous GeneCards Identifiers for ZNF184 Gene

  • GC06M027476
  • GC06M027389
  • GC06M027435
  • GC06M027436
  • GC06M027526
  • GC06M027226
  • GC06M027450

Summaries for ZNF184 Gene

Entrez Gene Summary for ZNF184 Gene

  • The protein encoded by this gene is predicted to be a Kruppel C2H2-type zinc-finger protein family member. Sequence analysis predicts that the protein contains two Kruppel associated box (KRAB) boxes in the N-terminus and highly conserved zinc finger motifs at the C-terminus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]

GeneCards Summary for ZNF184 Gene

ZNF184 (Zinc Finger Protein 184) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF420.

UniProtKB/Swiss-Prot Summary for ZNF184 Gene

Gene Wiki entry for ZNF184 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF184 Gene

Genomics for ZNF184 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF184 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF184 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF184

Top Transcription factor binding sites by QIAGEN in the ZNF184 gene promoter:
  • CREB
  • deltaCREB
  • E2F
  • E2F-1
  • En-1
  • p300
  • Pax-3
  • POU2F1
  • POU2F1a
  • Sox9

Genomic Locations for ZNF184 Gene

Genomic Locations for ZNF184 Gene
chr6:27,404,006-27,473,118
(GRCh38/hg38)
Size:
69,113 bases
Orientation:
Minus strand
chr6:27,418,521-27,440,897
(GRCh37/hg19)
Size:
22,377 bases
Orientation:
Minus strand

Genomic View for ZNF184 Gene

Genes around ZNF184 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF184 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF184 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF184 Gene

Proteins for ZNF184 Gene

  • Protein details for ZNF184 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99676-ZN184_HUMAN
    Recommended name:
    Zinc finger protein 184
    Protein Accession:
    Q99676
    Secondary Accessions:
    • B2R715
    • O60792
    • Q8TBA9

    Protein attributes for ZNF184 Gene

    Size:
    751 amino acids
    Molecular mass:
    86174 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF184 Gene

Post-translational modifications for ZNF184 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF184 Gene

No data available for DME Specific Peptides for ZNF184 Gene

Domains & Families for ZNF184 Gene

Gene Families for ZNF184 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF184 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF184 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ16197 fis, clone CTONG1000113, highly similar to ZINC FINGER PROTEIN 184 (Q6ZND3_HUMAN)
  • Zinc finger protein 184 (ZN184_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99676

UniProtKB/Swiss-Prot:

ZN184_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF184: view

Function for ZNF184 Gene

Molecular function for ZNF184 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger 184,C2H2 type,Kruppel-like,Krab subfamily,predominantly but not exclusively expressed in testis

Phenotypes From GWAS Catalog for ZNF184 Gene

Gene Ontology (GO) - Molecular Function for ZNF184 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding NAS 9073517
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF184: view
genes like me logo Genes that share phenotypes with ZNF184: view

Animal Models for ZNF184 Gene

MGI Knock Outs for ZNF184:
  • Zfp184 Zfp184<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ZNF184 Gene

miRTarBase miRNAs that target ZNF184

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF184

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF184 Gene

Localization for ZNF184 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF184 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF184 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF184 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF184: view

Pathways & Interactions for ZNF184 Gene

genes like me logo Genes that share pathways with ZNF184: view

Pathways by source for ZNF184 Gene

2 Reactome pathways for ZNF184 Gene
1 KEGG pathway for ZNF184 Gene

Gene Ontology (GO) - Biological Process for ZNF184 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF184: view

No data available for SIGNOR curated interactions for ZNF184 Gene

Drugs & Compounds for ZNF184 Gene

No Compound Related Data Available

Transcripts for ZNF184 Gene

mRNA/cDNA for ZNF184 Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF184

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF184 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for ZNF184 Gene

GeneLoc Exon Structure for
ZNF184

Expression for ZNF184 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF184 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF184 Gene

This gene is overexpressed in Plasma (65.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF184 Gene



Protein tissue co-expression partners for ZNF184 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF184

SOURCE GeneReport for Unigene cluster for ZNF184 Gene:

Hs.158174

mRNA Expression by UniProt/SwissProt for ZNF184 Gene:

Q99676-ZN184_HUMAN
Tissue specificity: Predominant expression in testis.

Evidence on tissue expression from TISSUES for ZNF184 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with ZNF184: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF184 Gene

Orthologs for ZNF184 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF184 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF184 30 31
  • 99.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF184 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC515674 30
  • 91.43 (n)
ZNF184 31
  • 91 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp184 30
  • 85.19 (n)
Mouse
(Mus musculus)
Mammalia Zfp184 30 17 31
  • 84.94 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 58 (a)
OneToMany
-- 31
  • 57 (a)
OneToMany
-- 31
  • 57 (a)
OneToMany
-- 31
  • 56 (a)
OneToMany
-- 31
  • 55 (a)
OneToMany
-- 31
  • 54 (a)
OneToMany
-- 31
  • 54 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
-- 31
  • 49 (a)
OneToMany
-- 31
  • 49 (a)
OneToMany
-- 31
  • 49 (a)
OneToMany
-- 31
  • 48 (a)
OneToMany
-- 31
  • 48 (a)
OneToMany
-- 31
  • 48 (a)
OneToMany
-- 31
  • 48 (a)
OneToMany
-- 31
  • 47 (a)
OneToMany
-- 31
  • 47 (a)
OneToMany
-- 31
  • 47 (a)
OneToMany
-- 31
  • 47 (a)
OneToMany
-- 31
  • 47 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
-- 31
  • 44 (a)
OneToMany
-- 31
  • 44 (a)
OneToMany
-- 31
  • 44 (a)
OneToMany
-- 31
  • 44 (a)
OneToMany
-- 31
  • 44 (a)
OneToMany
-- 31
  • 43 (a)
OneToMany
-- 31
  • 43 (a)
OneToMany
-- 31
  • 43 (a)
OneToMany
-- 31
  • 43 (a)
OneToMany
-- 31
  • 43 (a)
OneToMany
-- 31
  • 42 (a)
OneToMany
-- 31
  • 42 (a)
OneToMany
-- 31
  • 41 (a)
OneToMany
-- 31
  • 38 (a)
OneToMany
-- 31
  • 35 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 48 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Kr 32
  • 44 (a)
Meics 32
  • 40 (a)
crol 32
  • 39 (a)
wdn 32
  • 39 (a)
CG6254 32
  • 36 (a)
Neu2 32
  • 34 (a)
CG6689 32
  • 34 (a)
CG7987 32
  • 33 (a)
CG4707 32
  • 31 (a)
CG9609 32
  • 31 (a)
zf30C 32
  • 30 (a)
CG4282 32
  • 29 (a)
CG8484 32
  • 27 (a)
CG18476 32
  • 26 (a)
CG11902 32
  • 26 (a)
Species where no ortholog for ZNF184 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF184 Gene

ENSEMBL:
Gene Tree for ZNF184 (if available)
TreeFam:
Gene Tree for ZNF184 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF184: view image

Paralogs for ZNF184 Gene

(461) SIMAP similar genes for ZNF184 Gene using alignment to 1 proteins:

  • ZN184_HUMAN

Pseudogenes.org Pseudogenes for ZNF184 Gene

genes like me logo Genes that share paralogs with ZNF184: view

Variants for ZNF184 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF184 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
790032 Benign: not provided 27,451,555(-) C/T SYNONYMOUS_VARIANT
rs193921063 Uncertain Significance: Malignant tumor of prostate 27,457,372(-) G/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT
rs1883216 - p.Ala27Ser

Additional dbSNP identifiers (rs#s) for ZNF184 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF184 Gene

Variant ID Type Subtype PubMed ID
esv3570827 CNV loss 25503493
nsv1131951 CNV deletion 24896259
nsv830617 CNV loss 17160897

Variation tolerance for ZNF184 Gene

Residual Variation Intolerance Score: 8.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF184 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF184

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF184 Gene

Disorders for ZNF184 Gene

Additional Disease Information for ZNF184

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ZNF184 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF184 Gene

Publications for ZNF184 Gene

  1. Common variants on chromosome 6p22.1 are associated with schizophrenia. (PMID: 19571809) Shi J … Gejman PV (Nature 2009) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Identification of a novel Krueppel-related zinc finger gene (ZNF184) mapping to 6p21.3. (PMID: 9073517) Goldwurm S … Jazwinska EC (Genomics 1997) 3 4
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3

Products for ZNF184 Gene