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Aliases for ZNF182 Gene

Aliases for ZNF182 Gene

  • Zinc Finger Protein 182 2 3 5
  • Zinc Finger Protein 21 (KOX 14) 2 3
  • Zinc Finger Protein KOX14 3 4
  • ZNF21 3 4
  • KOX14 3 4
  • Zinc Finger Protein 182 (HHZ150) 2
  • Zinc Finger Protein 21 4
  • HHZ150 3
  • Zfp182 3

External Ids for ZNF182 Gene

Previous HGNC Symbols for ZNF182 Gene

  • ZNF21

Previous GeneCards Identifiers for ZNF182 Gene

  • GC00U990427
  • GC0XM047719
  • GC0XM047834
  • GC0XM045547

Summaries for ZNF182 Gene

Entrez Gene Summary for ZNF182 Gene

  • Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2010]

GeneCards Summary for ZNF182 Gene

ZNF182 (Zinc Finger Protein 182) is a Protein Coding gene. Diseases associated with ZNF182 include Aland Island Eye Disease and Congenital Stationary Night Blindness. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF33B.

UniProtKB/Swiss-Prot for ZNF182 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF182 Gene

Additional gene information for ZNF182 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF182 Gene

Genomics for ZNF182 Gene

GeneHancer (GH) Regulatory Elements for ZNF182 Gene

Promoters and enhancers for ZNF182 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI048002 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 329 2.3 ATF1 FOXA2 ZNF133 ARID4B FEZF1 ZNF2 BRCA1 YY1 ETS1 POLR2B SPACA5 ZNF182 ENSG00000228343 PIR34840 ZNF630 ZNF81
GH0XI048573 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30 -571.0 -570991 3.4 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 ENSG00000204620 RBM3 ZNF182 ENSG00000228343 FTSJ1 ZNF81 PRICKLE3 PQBP1 ENSG00000270012 HDAC6
GH0XI047216 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 25 +785.5 785476 5 HDGF PKNOX1 CLOCK ARNT SIN3A FEZF1 ZNF2 IRF4 YY1 POLR2B CDK16 LOC105373194 ZNF81 LOC100113397 INE1 ZNF182 ZNF674-AS1 LINC01560 USP11 ZNF674
GH0XI048896 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 15.9 -894.0 -894033 3.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B PQBP1 TIMM17B FTSJ1 ENSG00000204620 ENSG00000270012 ZNF182 HDAC6 RBM3 CCDC22 PLP2
GH0XI048916 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 -915.8 -915770 5.6 HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A ZNF2 ZBTB7B POLR2B ZNF213 PIM2 ENSG00000204620 FTSJ1 ENSG00000270012 RBM3 PQBP1 CCDC22 ZNF182 PLP2 OTUD5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF182 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF182 gene promoter:

Genomic Locations for ZNF182 Gene

Genomic Locations for ZNF182 Gene
chrX:47,974,851-48,003,995
(GRCh38/hg38)
Size:
29,145 bases
Orientation:
Minus strand
chrX:47,834,250-47,863,394
(GRCh37/hg19)

Genomic View for ZNF182 Gene

Genes around ZNF182 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF182 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF182 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF182 Gene

Proteins for ZNF182 Gene

  • Protein details for ZNF182 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17025-ZN182_HUMAN
    Recommended name:
    Zinc finger protein 182
    Protein Accession:
    P17025
    Secondary Accessions:
    • A2IDD7
    • Q3KP67
    • Q96QH7

    Protein attributes for ZNF182 Gene

    Size:
    639 amino acids
    Molecular mass:
    73646 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF182 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF182 Gene

Post-translational modifications for ZNF182 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF182 Gene

No data available for DME Specific Peptides for ZNF182 Gene

Domains & Families for ZNF182 Gene

Gene Families for ZNF182 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF182 Gene

Suggested Antigen Peptide Sequences for ZNF182 Gene

Graphical View of Domain Structure for InterPro Entry

P17025

UniProtKB/Swiss-Prot:

ZN182_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF182: view

Function for ZNF182 Gene

Molecular function for ZNF182 Gene

GENATLAS Biochemistry:
zinc finger 182,C2H2 type,Kruppel-like,Krab subfamily,involved in differentiation and development of heart
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF182: view
genes like me logo Genes that share phenotypes with ZNF182: view

Animal Models for ZNF182 Gene

MGI Knock Outs for ZNF182:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF182 Gene

Localization for ZNF182 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF182 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF182 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF182: view

Pathways & Interactions for ZNF182 Gene

SuperPathways for ZNF182 Gene

No Data Available

Interacting Proteins for ZNF182 Gene

Gene Ontology (GO) - Biological Process for ZNF182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF182: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF182 Gene

Drugs & Compounds for ZNF182 Gene

No Compound Related Data Available

Transcripts for ZNF182 Gene

mRNA/cDNA for ZNF182 Gene

Unigene Clusters for ZNF182 Gene

Zinc finger protein 182:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF182 Gene

ExUns: 1 ^ 2a · 2b ^ 3
SP1: -
SP2: -
SP3:

Relevant External Links for ZNF182 Gene

GeneLoc Exon Structure for
ZNF182
ECgene alternative splicing isoforms for
ZNF182

Expression for ZNF182 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF182 Gene

Protein differential expression in normal tissues from HIPED for ZNF182 Gene

This gene is overexpressed in Uterus (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF182 Gene



Protein tissue co-expression partners for ZNF182 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF182 Gene:

ZNF182

SOURCE GeneReport for Unigene cluster for ZNF182 Gene:

Hs.189690
genes like me logo Genes that share expression patterns with ZNF182: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF182 Gene

Orthologs for ZNF182 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF182 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF182 33 34
  • 98.32 (n)
cow
(Bos Taurus)
Mammalia ZNF182 33 34
  • 91.87 (n)
dog
(Canis familiaris)
Mammalia ZNF182 33 34
  • 90.36 (n)
rat
(Rattus norvegicus)
Mammalia Zfp182 33
  • 85.8 (n)
mouse
(Mus musculus)
Mammalia Zfp182 33 16 34
  • 85.7 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 53 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 41 (a)
OneToMany
Species where no ortholog for ZNF182 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF182 Gene

ENSEMBL:
Gene Tree for ZNF182 (if available)
TreeFam:
Gene Tree for ZNF182 (if available)

Paralogs for ZNF182 Gene

(506) SIMAP similar genes for ZNF182 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF182 Gene

genes like me logo Genes that share paralogs with ZNF182: view

Variants for ZNF182 Gene

Sequence variations from dbSNP and Humsavar for ZNF182 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000073254 -- 47,994,559(-) T/A intron_variant
rs1000119540 -- 47,986,985(-) C/T intron_variant
rs1000209631 -- 47,975,562(-) T/C 3_prime_UTR_variant
rs1000475562 -- 47,975,880(-) T/C/G 3_prime_UTR_variant
rs1000683804 -- 47,997,146(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF182 Gene

Variant ID Type Subtype PubMed ID
dgv17n29 CNV gain+loss 16826518
esv25781 CNV gain 19812545
esv2752324 CNV gain 17911159
esv2758866 CNV gain+loss 17122850
esv32909 CNV gain+loss 17666407
esv8782 OTHER inversion 19470904
nsv471601 CNV gain 15918152
nsv522886 CNV gain 19592680
nsv6890 CNV deletion 18451855

Variation tolerance for ZNF182 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF182 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF182

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF182 Gene

Disorders for ZNF182 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF182 Gene - From: DISEASES

Disorder Aliases PubMed IDs
aland island eye disease
  • aied
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF182

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF182: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF182 Gene

Publications for ZNF182 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Localization of a novel zinc finger gene to the human chromosome 7p11.2-p12 by fluorescence in situ hybridization. (PMID: 8914609) Wang R … Liew CC (Somatic cell and molecular genetics 1996) 2 3 58
  4. Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1. (PMID: 8088786) Knight JC … Coleman MP (Genomics 1994) 2 3 58
  5. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K … Thiesen HJ (American journal of human genetics 1991) 2 3 58

Products for ZNF182 Gene

Sources for ZNF182 Gene

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