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Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2010]
ZNF182 (Zinc Finger Protein 182) is a Protein Coding gene. Diseases associated with ZNF182 include Atrial Septal Defect 4 and Aland Island Eye Disease. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF33B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Herpes simplex virus 1 infection |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 |
---|---|---|---|---|---|---|---|
SP1: | - | ||||||
SP2: | - | ||||||
SP3: |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNF182 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ZNF182 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZNF182 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zfp182 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Zfp182 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs146965366 | - | p.Asn62Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv17n29 | CNV | gain+loss | 16826518 |
esv25781 | CNV | gain | 19812545 |
esv2752324 | CNV | gain | 17911159 |
esv2758866 | CNV | gain+loss | 17122850 |
esv32909 | CNV | gain+loss | 17666407 |
esv8782 | OTHER | inversion | 19470904 |
nsv471601 | CNV | gain | 15918152 |
nsv522886 | CNV | gain | 19592680 |
nsv6890 | CNV | deletion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
atrial septal defect 4 |
|
|
aland island eye disease |
|
|
congenital stationary night blindness |
|
|