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Aliases for ZNF181 Gene

Aliases for ZNF181 Gene

  • Zinc Finger Protein 181 2 3 5
  • HHZ181 3 4
  • Zinc Finger Protein 181 (HHZ181) 2

External Ids for ZNF181 Gene

Previous GeneCards Identifiers for ZNF181 Gene

  • GC00U990426
  • GC19P039901
  • GC19P039916
  • GC19P039914
  • GC19P035225
  • GC19P031732

Summaries for ZNF181 Gene

Entrez Gene Summary for ZNF181 Gene

  • Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2003]

GeneCards Summary for ZNF181 Gene

ZNF181 (Zinc Finger Protein 181) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF302.

UniProtKB/Swiss-Prot for ZNF181 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF181 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF181 Gene

Genomics for ZNF181 Gene

GeneHancer (GH) Regulatory Elements for ZNF181 Gene

Promoters and enhancers for ZNF181 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I034732 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 607.6 +0.7 695 2.8 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 ZNF610 ZNF181 ENSG00000274104 ZNF599 TMEM147-AS1 ZNF302 HAUS5 ZNF30 LSM14A KIAA0355 ENSG00000267219
GH19I034731 Enhancer 0.7 ENCODE 560.8 -1.6 -1565 1 HDAC1 HDGF ZNF23 ZNF316 FOXK2 TRIM24 NFE2 MAFK SMARCE1 ZNF639 ZNF181 ZNF302 ZNF30 ZNF599 ENSG00000267219 ENSG00000270281 GC19M034703
GH19I034676 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 62.6 -55.6 -55628 2.5 PKNOX1 SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF213 ZNF302 ZNF416 ZNF207 ZNF302 ENSG00000279329 GC19P034675 GC19M034683 PIR50277 PIR41849 SCGB2B2 TMEM147-AS1 ZNF599 HAUS5
GH19I034994 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 45.2 +267.6 267616 13.5 CLOCK MLX YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF548 GRAMD1A ENSG00000269303 TMEM147-AS1 ZNF599 HAUS5 LSM14A KMT2B ZNF792 KIAA0355 ZNF302
GH19I034972 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 68.4 +240.7 240746 2.5 HDGF PKNOX1 ARID4B SIN3A ZNF2 IRF4 YY1 SLC30A9 ZNF302 ZNF416 TMEM147-AS1 ZNF599 HAUS5 ZNF181 ENSG00000267049 PROSER3 LSM14A KMT2B KIAA0355 ZNF30
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF181 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF181 Gene

Genomic Locations for ZNF181 Gene
12,063 bases
Plus strand

Genomic View for ZNF181 Gene

Genes around ZNF181 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF181 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF181 Gene

Proteins for ZNF181 Gene

  • Protein details for ZNF181 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 181
    Protein Accession:
    Secondary Accessions:
    • B7ZKX3
    • Q49A75

    Protein attributes for ZNF181 Gene

    571 amino acids
    Molecular mass:
    65842 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF181 Gene


neXtProt entry for ZNF181 Gene

Post-translational modifications for ZNF181 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF181 Gene

Domains & Families for ZNF181 Gene

Gene Families for ZNF181 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF181 Gene

Suggested Antigen Peptide Sequences for ZNF181 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF181: view

Function for ZNF181 Gene

Molecular function for ZNF181 Gene

GENATLAS Biochemistry:
zinc finger 181,human heart 181,C2H2 type,involved in DNA repair deficiencies and cellular malignancies
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF181 Gene

Gene Ontology (GO) - Molecular Function for ZNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF181: view
genes like me logo Genes that share phenotypes with ZNF181: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF181 Gene

Localization for ZNF181 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF181 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF181 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF181: view

Pathways & Interactions for ZNF181 Gene

SuperPathways for ZNF181 Gene

No Data Available

Interacting Proteins for ZNF181 Gene

Gene Ontology (GO) - Biological Process for ZNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF181: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF181 Gene

Drugs & Compounds for ZNF181 Gene

No Compound Related Data Available

Transcripts for ZNF181 Gene

mRNA/cDNA for ZNF181 Gene

Unigene Clusters for ZNF181 Gene

Zinc finger protein 181:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF181 Gene

No ASD Table

Relevant External Links for ZNF181 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF181 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF181 Gene

Protein differential expression in normal tissues from HIPED for ZNF181 Gene

This gene is overexpressed in Urinary Bladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF181 Gene

Protein tissue co-expression partners for ZNF181 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF181 Gene:


SOURCE GeneReport for Unigene cluster for ZNF181 Gene:


Evidence on tissue expression from TISSUES for ZNF181 Gene

  • Lung(4.2)
  • Nervous system(2.6)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ZNF181: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF181 Gene

Orthologs for ZNF181 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF181 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF181 33 34
  • 99.36 (n)
(Canis familiaris)
Mammalia ZNF181 33 34
  • 89.03 (n)
(Bos Taurus)
Mammalia ZNF181 33 34
  • 88.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6654 34
  • 23 (a)
Species where no ortholog for ZNF181 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF181 Gene

Gene Tree for ZNF181 (if available)
Gene Tree for ZNF181 (if available)

Paralogs for ZNF181 Gene

Paralogs for ZNF181 Gene

(516) SIMAP similar genes for ZNF181 Gene using alignment to 5 proteins: Pseudogenes for ZNF181 Gene

genes like me logo Genes that share paralogs with ZNF181: view

Variants for ZNF181 Gene

Sequence variations from dbSNP and Humsavar for ZNF181 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1001169493 -- 34,743,707(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1001219030 -- 34,732,931(+) CCCTC/CCCTCCCTC upstream_transcript_variant
rs1001326344 -- 34,743,471(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1001470769 -- 34,732,124(+) G/C upstream_transcript_variant
rs1001542785 -- 34,731,967(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF181 Gene

Variant ID Type Subtype PubMed ID
esv2718487 CNV deletion 23290073
esv2758756 CNV gain 17122850
esv3329051 OTHER inversion 20981092
nsv963039 CNV duplication 23825009

Variation tolerance for ZNF181 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF181 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF181 Gene

Disorders for ZNF181 Gene

Additional Disease Information for ZNF181

No disorders were found for ZNF181 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF181 Gene

Publications for ZNF181 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  3. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks IA … Vertegaal AC (Nature structural & molecular biology 2014) 4 58
  4. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. (PMID: 24104479) Vizeacoumar FJ … Moffat J (Molecular systems biology 2013) 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ZNF181 Gene

Sources for ZNF181 Gene

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