Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc... See more...

Aliases for ZNF180 Gene

Aliases for ZNF180 Gene

  • Zinc Finger Protein 180 2 3 4 5
  • HHZ168 2 3 4
  • Zinc Finger Protein 180 (HHZ168) 2
  • ZNF180 5

External Ids for ZNF180 Gene

Previous GeneCards Identifiers for ZNF180 Gene

  • GC19M045625
  • GC19M045371
  • GC19M049655
  • GC19M049671
  • GC19M044979
  • GC19M041412

Summaries for ZNF180 Gene

Entrez Gene Summary for ZNF180 Gene

  • Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]

GeneCards Summary for ZNF180 Gene

ZNF180 (Zinc Finger Protein 180) is a Protein Coding gene. Diseases associated with ZNF180 include Clear Cell Renal Cell Carcinoma. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZFP37.

UniProtKB/Swiss-Prot Summary for ZNF180 Gene

Additional gene information for ZNF180 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF180 Gene

Genomics for ZNF180 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF180 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF180 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF180

Top Transcription factor binding sites by QIAGEN in the ZNF180 gene promoter:
  • AREB6
  • ARP-1
  • c-Myc
  • FOXC1
  • LCR-F1
  • Max1
  • MRF-2
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT5A

Genomic Locations for ZNF180 Gene

Genomic Locations for ZNF180 Gene
chr19:44,474,428-44,500,524
(GRCh38/hg38)
Size:
26,097 bases
Orientation:
Minus strand
chr19:44,979,854-45,004,576
(GRCh37/hg19)
Size:
24,723 bases
Orientation:
Minus strand

Genomic View for ZNF180 Gene

Genes around ZNF180 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF180 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF180 Gene

Proteins for ZNF180 Gene

  • Protein details for ZNF180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJW8-ZN180_HUMAN
    Recommended name:
    Zinc finger protein 180
    Protein Accession:
    Q9UJW8
    Secondary Accessions:
    • B2RCN6
    • B3KV56
    • K7EQX9
    • Q58F03
    • Q9P1U2

    Protein attributes for ZNF180 Gene

    Size:
    692 amino acids
    Molecular mass:
    79111 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF180 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF180 Gene

Post-translational modifications for ZNF180 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF180 Gene

Domains & Families for ZNF180 Gene

Gene Families for ZNF180 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF180 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF180 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 180 (HHZ168), isoform CRA_c (Q58F03_HUMAN)
  • HHZ168 (ZN180_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJW8

UniProtKB/Swiss-Prot:

ZN180_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF180: view

Function for ZNF180 Gene

Molecular function for ZNF180 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger 180,human heart 168,C2H2 type,involved in DNA repair deficiencies and cellular malignancies

Phenotypes From GWAS Catalog for ZNF180 Gene

Gene Ontology (GO) - Molecular Function for ZNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF180: view
genes like me logo Genes that share phenotypes with ZNF180: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF180

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF180 Gene

Localization for ZNF180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF180 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF180 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF180: view

Pathways & Interactions for ZNF180 Gene

genes like me logo Genes that share pathways with ZNF180: view

Pathways by source for ZNF180 Gene

2 Reactome pathways for ZNF180 Gene
1 KEGG pathway for ZNF180 Gene

Gene Ontology (GO) - Biological Process for ZNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF180: view

No data available for SIGNOR curated interactions for ZNF180 Gene

Drugs & Compounds for ZNF180 Gene

No Compound Related Data Available

Transcripts for ZNF180 Gene

mRNA/cDNA for ZNF180 Gene

8 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF180

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF180 Gene

No ASD Table

Relevant External Links for ZNF180 Gene

GeneLoc Exon Structure for
ZNF180

Expression for ZNF180 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF180 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF180 Gene



Protein tissue co-expression partners for ZNF180 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF180

SOURCE GeneReport for Unigene cluster for ZNF180 Gene:

Hs.22305

Evidence on tissue expression from TISSUES for ZNF180 Gene

  • Nervous system(4.4)
  • Skin(4.2)
  • Spleen(4.2)
  • Kidney(2.4)
genes like me logo Genes that share expression patterns with ZNF180: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF180 Gene

Orthologs for ZNF180 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF180 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF180 30 31
  • 98.14 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF180 30 31
  • 88.56 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF180 30 31
  • 88.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp180 30
  • 74.81 (n)
Mouse
(Mus musculus)
Mammalia Zfp180 30 17 31
  • 74.14 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 61 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG2202 32
  • 54 (a)
Meics 32
  • 39 (a)
Kr-h1 32
  • 38 (a)
Neu2 32
  • 37 (a)
Species where no ortholog for ZNF180 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF180 Gene

ENSEMBL:
Gene Tree for ZNF180 (if available)
TreeFam:
Gene Tree for ZNF180 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF180: view image

Paralogs for ZNF180 Gene

(559) SIMAP similar genes for ZNF180 Gene using alignment to 8 proteins:

  • ZN180_HUMAN
  • G5E9B8_HUMAN
  • K7EMI5_HUMAN
  • K7EN00_HUMAN
  • K7EQP0_HUMAN
  • K7EQX9_HUMAN
  • K7ES30_HUMAN
  • Q58F03_HUMAN

Pseudogenes.org Pseudogenes for ZNF180 Gene

genes like me logo Genes that share paralogs with ZNF180: view

Variants for ZNF180 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF180 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1897820 - p.Cys272Ser
rs2253563 - p.Trp89Cys
rs2571108 - p.Ala41Val

Additional dbSNP identifiers (rs#s) for ZNF180 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF180 Gene

Variant ID Type Subtype PubMed ID
esv3306608 CNV mobile element insertion 20981092
esv3412314 CNV insertion 20981092
nsv1061350 CNV loss 25217958
nsv1125674 CNV tandem duplication 24896259
nsv521513 CNV loss 19592680
nsv960853 CNV duplication 23825009

Variation tolerance for ZNF180 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.74; 97.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF180 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF180

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF180 Gene

Disorders for ZNF180 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF180 Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
clear cell renal cell carcinoma
  • clear cell carcinoma of kidney
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF180

genes like me logo Genes that share disorders with ZNF180: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF180 Gene

Publications for ZNF180 Gene

  1. Genome-wide association scan for five major dimensions of personality. (PMID: 18957941) Terracciano A … Costa PT (Molecular psychiatry 2010) 3 41
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF180 Gene

Sources for ZNF180 Gene