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Aliases for ZNF180 Gene

Aliases for ZNF180 Gene

  • Zinc Finger Protein 180 2 3 5
  • HHZ168 3 4
  • Zinc Finger Protein 180 (HHZ168) 2

External Ids for ZNF180 Gene

Previous GeneCards Identifiers for ZNF180 Gene

  • GC19M045625
  • GC19M045371
  • GC19M049655
  • GC19M049671
  • GC19M044979
  • GC19M041412

Summaries for ZNF180 Gene

Entrez Gene Summary for ZNF180 Gene

  • Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]

GeneCards Summary for ZNF180 Gene

ZNF180 (Zinc Finger Protein 180) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF606.

UniProtKB/Swiss-Prot for ZNF180 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF180 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF180 Gene

Genomics for ZNF180 Gene

GeneHancer (GH) Regulatory Elements for ZNF180 Gene

Promoters and enhancers for ZNF180 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I044499 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 640.7 +1.3 1282 1.9 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF180 ZNF45 ZNF224 ZNF155 ZNF234 CLASRP ZNF225 ZNF112 ZNF284 XRCC1
GH19I043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 246 +721.8 721848 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF224 ZNF284 ZNF227 ZNF283 ZNF223 ZNF576
GH19I044844 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 150.4 -346.3 -346264 7.3 YBX1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 MCM3 SP3 ZNF610 NECTIN2 GC19P044850 ZNF180 ZNF45 ZNF225 CLASRP ZNF224 ZNF234 ZNF284 FBXO46
GH19I044164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 191.7 +336.5 336500 1.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF226 ZNF45 ZNF180 ZNF225 ZNF155 ZNF224 ZNF227 ZNF284 ZNF234 ZNF112
GH19I044259 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 177.1 +241.7 241718 1.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ZBTB7B ZNF233 ZNF45 ZNF180 ZNF225 ZNF224 ZNF284 ZNF227 ZNF234 ZNF235 CLASRP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF180 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF180 gene promoter:

Genomic Locations for ZNF180 Gene

Genomic Locations for ZNF180 Gene
27,323 bases
Minus strand

Genomic View for ZNF180 Gene

Genes around ZNF180 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF180 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF180 Gene

Proteins for ZNF180 Gene

  • Protein details for ZNF180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 180
    Protein Accession:
    Secondary Accessions:
    • B2RCN6
    • B3KV56
    • K7EQX9
    • Q58F03
    • Q9P1U2

    Protein attributes for ZNF180 Gene

    692 amino acids
    Molecular mass:
    79111 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF180 Gene


neXtProt entry for ZNF180 Gene

Post-translational modifications for ZNF180 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF180 Gene

Domains & Families for ZNF180 Gene

Gene Families for ZNF180 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF180 Gene

Suggested Antigen Peptide Sequences for ZNF180 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF180: view

Function for ZNF180 Gene

Molecular function for ZNF180 Gene

GENATLAS Biochemistry:
zinc finger 180,human heart 168,C2H2 type,involved in DNA repair deficiencies and cellular malignancies
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF180 Gene

Gene Ontology (GO) - Molecular Function for ZNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF180: view

Phenotypes for ZNF180 Gene

genes like me logo Genes that share phenotypes with ZNF180: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF180 Gene

Localization for ZNF180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF180 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF180 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF180: view

Pathways & Interactions for ZNF180 Gene

SuperPathways for ZNF180 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF180: view

Pathways by source for ZNF180 Gene

2 Reactome pathways for ZNF180 Gene

Gene Ontology (GO) - Biological Process for ZNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF180: view

No data available for SIGNOR curated interactions for ZNF180 Gene

Drugs & Compounds for ZNF180 Gene

No Compound Related Data Available

Transcripts for ZNF180 Gene

Unigene Clusters for ZNF180 Gene

Zinc finger protein 180:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF180 Gene

No ASD Table

Relevant External Links for ZNF180 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF180 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF180 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF180 Gene

Protein tissue co-expression partners for ZNF180 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF180 Gene:


SOURCE GeneReport for Unigene cluster for ZNF180 Gene:


Evidence on tissue expression from TISSUES for ZNF180 Gene

  • Nervous system(4.4)
  • Spleen(4.2)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with ZNF180: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF180 Gene

Orthologs for ZNF180 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF180 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF180 33 34
  • 98.14 (n)
(Canis familiaris)
Mammalia ZNF180 33 34
  • 88.56 (n)
(Bos Taurus)
Mammalia ZNF180 33 34
  • 88.29 (n)
(Rattus norvegicus)
Mammalia Zfp180 33
  • 74.81 (n)
(Mus musculus)
Mammalia Zfp180 33 16 34
  • 74.14 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2202 35
  • 54 (a)
Meics 35
  • 39 (a)
Kr-h1 35
  • 38 (a)
Neu2 35
  • 37 (a)
Species where no ortholog for ZNF180 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF180 Gene

Gene Tree for ZNF180 (if available)
Gene Tree for ZNF180 (if available)

Paralogs for ZNF180 Gene

Paralogs for ZNF180 Gene

(559) SIMAP similar genes for ZNF180 Gene using alignment to 8 proteins: Pseudogenes for ZNF180 Gene

genes like me logo Genes that share paralogs with ZNF180: view

Variants for ZNF180 Gene

Sequence variations from dbSNP and Humsavar for ZNF180 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000089418 -- 44,474,625(-) G/A 3_prime_UTR_variant
rs1000177809 -- 44,498,282(-) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000331205 -- 44,492,489(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000606991 -- 44,486,240(-) A/G intron_variant
rs1000712287 -- 44,479,948(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF180 Gene

Variant ID Type Subtype PubMed ID
esv3306608 CNV mobile element insertion 20981092
esv3412314 CNV insertion 20981092
nsv1061350 CNV loss 25217958
nsv1125674 CNV tandem duplication 24896259
nsv521513 CNV loss 19592680
nsv960853 CNV duplication 23825009

Variation tolerance for ZNF180 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.74; 97.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF180 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF180 Gene

Disorders for ZNF180 Gene

Additional Disease Information for ZNF180

No disorders were found for ZNF180 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF180 Gene

Publications for ZNF180 Gene

  1. Genome-wide association scan for five major dimensions of personality. (PMID: 18957941) Terracciano A … Costa PT (Molecular psychiatry 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  4. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. (PMID: 12743021) Shannon M … Stubbs L (Genome research 2003) 3 4 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF180 Gene

Sources for ZNF180 Gene

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