Aliases for ZNF18 Gene
Aliases for ZNF18 Gene
External Ids for ZNF18 Gene
- HGNC: 12969
- Entrez Gene: 7566
- Ensembl: ENSG00000154957
- OMIM: 194524
- UniProtKB: P17022
Previous GeneCards Identifiers for ZNF18 Gene
- GC17M012223
- GC17M012995
- GC17M011823
- GC17M012081
- GC17M011821
- GC17M011884
Summaries for ZNF18 Gene
GeneCards Summary for ZNF18 Gene
ZNF18 (Zinc Finger Protein 18) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF202.
UniProtKB/Swiss-Prot for ZNF18 Gene
-
May be involved in transcriptional regulation.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF18 Gene
Genomics for ZNF18 Gene
GeneHancer (GH) Regulatory Elements for ZNF18 Gene
Promoters and enhancers for ZNF18 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17I011996 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 550.8 | +0.2 | 202 | 2 | HDGF PKNOX1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 POLR2B ZNF213 | ZNF18 MAP2K4 GC17M011978 | |
| GH17I011987 | Enhancer | 0.5 | ENCODE | 0.4 | +10.4 | 10369 | 0.1 | CTCF ZNF654 SMC3 REST RAD21 PRDM1 | MAP2K4 GC17M011978 ZNF18 | |
| GH17I011999 | Enhancer | 0.2 | ENCODE | 0.8 | -2.4 | -2424 | 0.7 | RNU11-2P MIR744 ZNF18 GC17P012021 RPL21P122 | ||
| GH17I011990 | Enhancer | 0.2 | ENCODE | 0.4 | +6.0 | 5995 | 1.1 | MAP2K4 ZNF18 GC17M011978 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZNF18 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZNF18 Gene
Genomic Locations for ZNF18 Gene
- chr17:11,977,439-11,997,510
- (GRCh38/hg38)
- Size:
- 20,072 bases
- Orientation:
- Minus strand
- chr17:11,880,756-11,900,827
- (GRCh37/hg19)
Genomic View for ZNF18 Gene
Genes around ZNF18 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p12 by Ensembl
- 17p12 by Entrez Gene
- 17p12 by HGNC
ZNF18 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF18 Gene
Proteins for ZNF18 Gene
-
Protein details for ZNF18 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17022-ZNF18_HUMAN
- Recommended name:
- Zinc finger protein 18
- Protein Accession:
- P17022
- Q5QHQ3
- Q8IYC4
- Q8NAH6
Protein attributes for ZNF18 Gene
- Size:
- 549 amino acids
- Molecular mass:
- 62288 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for ZNF18 Gene
No Post-translational modifications
Other Protein References for ZNF18 Gene
Antibody Products
- Novus Biologicals Antibodies for ZNF18
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Protein Products
-
OriGene Purified Proteins for ZNF18
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- antibodies-online: Search results for 4 available ZNF18 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for ZNF18
Assay Products
No data available for DME Specific Peptides for ZNF18 Gene
Domains & Families for ZNF18 Gene
Gene Families for ZNF18 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF18 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF18 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P17022- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF18 Gene
Molecular function for ZNF18 Gene
- GENATLAS Biochemistry:
- zinc finger protein 18 (KOX11) (C2H2 type,Kruppel-like)
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | IBA | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 21516116 |
Phenotypes for ZNF18 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNF18 gene
-
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- Search ViGene Biosciences for ZNF18
CRISPR Products
-
OriGene CRISPR knockouts for ZNF18
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF18
- GenScript: Design CRISPR guide RNA sequences for ZNF18
miRNA for ZNF18 Gene
- miRTarBase miRNAs that target ZNF18
miRNA Products
- Search ViGene Biosciences for ZNF18
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ZNF18
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- genomics-online: shRNA clones - Search results for available ZNF18 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF18 gene
Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZNF18 gene related products
- orf clones - Search results for available ZNF18 gene related products
- Applied Biological Materials Clones for ZNF18
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZNF18
-
ViGene Biosciences adenoviral particle packaged cDNA for ZNF18 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZNF18 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF18 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF18 Gene
Localization for ZNF18 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF18 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| golgi apparatus | 2 |
- Cytosol (2)
- Golgi apparatus (2)
- Nucleoplasm (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IBA | -- |
Pathways & Interactions for ZNF18 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
Pathways by source for ZNF18 Gene
2 Reactome pathways for ZNF18 Gene
Interacting Proteins for ZNF18 Gene
Selected Interacting proteins:
P17022-ZNF18_HUMAN
ENSP00000315664
for ZNF18 Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
No data available for SIGNOR curated interactions for ZNF18 Gene
Transcripts for ZNF18 Gene
mRNA/cDNA for ZNF18 Gene
- (10) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (69) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF18 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZNF18
- genomics-online: gRNA clones - Search results for available ZNF18 gene related products
- Applied Biological Materials CRISPR for ZNF18
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF18
- GenScript: Design CRISPR guide RNA sequences for ZNF18
miRNA Products
- Search ViGene Biosciences for ZNF18
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ZNF18
- Browse OriGene Inhibitory RNA Products For ZNF18
- genomics-online: shRNA clones - Search results for available ZNF18 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF18 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZNF18
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF18
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZNF18 gene related products
- orf clones - Search results for available ZNF18 gene related products
- Applied Biological Materials Clones for ZNF18
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP7: |
Expression for ZNF18 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
NURSA nuclear receptor signaling pathways regulating expression of ZNF18 Gene:
ZNF18SOURCE GeneReport for Unigene cluster for ZNF18 Gene:
Hs.370473Evidence on tissue expression from TISSUES for ZNF18 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for ZNF18
- genomics-online: primer clones - Search results for available ZNF18 gene related products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF18 Gene
Orthologs for ZNF18 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF18 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ZNF18 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zfp18 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Zkscan6 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ZNF18 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZNF18 34 |
|
OneToOne |
- Species where no ortholog for ZNF18 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for ZNF18 Gene
Paralogs for ZNF18 Gene
(72) SIMAP similar genes for ZNF18 Gene using alignment to 5 proteins:
- ZSCAN10
- ZSCAN29
- ZSCAN31
- ZNF446
- DKFZp434K202
- ZNF444
- ZSCAN18
- ZNF24
- ZSCAN23
- ZNF78L1
- ZNF625
- ZNF585B
- ZNF197
- ZNF396
- ZNF263
- ZNF720
- ZNF697
- ZNF664
- ZNF32
- KLF13
- ZSCAN5B
- SCAND1
- ZSCAN30
- ZFS-6
- ZNF323
- ZNF300
- ZNF844
- ZNF397
- ZNF
- ZNF331
- ZNF80
- ZNF581
- ZNF501
- ZKSCAN8
- LOC100128510
- GLI4
- ZNF696
- ZNF174
- ZNF81
- ZNF500
- ZNF394
- ZNF213
- kr-znf3
- ZNF202
- ZNF137P
- ZKSCAN1
- ZSCAN32
- ZNF483
- KLF1
- ZNF702P
- ZNF589
- ZSCAN5A
- ZSCAN21
- ZSCAN9
- ZNF808
- ZNF718
- ZKSCAN5
- ZNF232
- ZSCAN25
- ZNF514
- OSR2
- ZNF672
- ZNF550
- ZNF257
- ZNF793
- ZNF75D
- ZNF449
- ZKSCAN7
- DKFZp451F083
- ZNF165
- ZKSCAN4
- SNAI2
Variants for ZNF18 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1990236 | benign, not specified | 11,962,145(-) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000044359 | -- | 11,982,475(-) | G/A | intron_variant | |
| rs1000175164 | -- | 11,970,721(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000220600 | -- | 11,971,723(-) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000262156 | -- | 11,962,428(-) | C/T | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3639962 | CNV | gain | 21293372 |
| esv3639961 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.70;
46.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF18 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZNF18
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF18 Gene
Disorders for ZNF18 Gene
Additional Disease Information for ZNF18
No disorders were found for ZNF18 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF18 Gene
Publications for ZNF18 Gene
- [Molecular cloning and expression analysis of a novel human gene ZNF18]. (PMID: 16120570) Guo LL … Li YP (Yi chuan = Hereditas 2005) 3 4 58
- Identification and characterization of human ZNF18 gene in silico. (PMID: 15702252) Yoshida K (International journal of molecular medicine 2005) 2 3 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 58
Products for ZNF18 Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZNF18
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 28 available ZNF18 Antibodies ranked by validation data
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- genomics-online: cdna clones - Search results for available ZNF18 gene related products
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- genomics-online: primer clones - Search results for available ZNF18 gene related products
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Sources for ZNF18 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
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