Aliases for ZNF18 Gene

Aliases for ZNF18 Gene

  • Zinc Finger Protein 18 2 3 4 5
  • ZKSCAN6 2 3 4
  • ZNF535 2 3 4
  • HDSG1 2 3 4
  • KOX11 2 3 4
  • Zinc Finger Protein With KRAB And SCAN Domains 6 3 4
  • Heart Development-Specific Gene 1 Protein 3 4
  • Zinc Finger Protein 18 (KOX 11) 2 3
  • Zinc Finger Protein 535 3 4
  • ZSCAN38 2 3
  • Zfp535 2 3
  • Zinc Finger Protein KOX11 4
  • ZNF18 5

External Ids for ZNF18 Gene

Previous GeneCards Identifiers for ZNF18 Gene

  • GC17M012223
  • GC17M012995
  • GC17M011823
  • GC17M012081
  • GC17M011821
  • GC17M011884
  • GC17M011977

Summaries for ZNF18 Gene

GeneCards Summary for ZNF18 Gene

ZNF18 (Zinc Finger Protein 18) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ZSCAN29.

UniProtKB/Swiss-Prot Summary for ZNF18 Gene

Additional gene information for ZNF18 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF18 Gene

Genomics for ZNF18 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J011996 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.4 +24.3 24321 2.8 SP1 HNRNPL CREB1 TEAD4 PRDM10 ZNF629 POLR2A BACH1 TARDBP ZHX2 ZNF18 MAP2K4 piR-61687-015 ENSG00000266368 lnc-ZNF18-3 RPL21P122 DNAH9
GH17J012020 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -0.1 -81 2.8 SP1 ZNF629 ZNF692 POLR2A BACH1 LARP7 ZNF143 ZIC2 RBFOX2 TCF12 MAP2K4 ZNF18 RPL21P122 lnc-ZNF18-3 RNU11-2P MYOCD
GH17J011992 Promoter 0.3 EPDnew 600.3 +28.5 28514 0.1 ZNF18 MAP2K4 ENSG00000266368 piR-61687-015 DNAH9
GH17J012023 Enhancer 0.6 ENCODE 0.7 -3.1 -3079 2.4 SCRT2 CEBPB SP1 JUND ZSCAN5C FOXA2 JUN EP300 FOSL2 DPF2 MIR744 MAP2K4 ZNF18 RNU11-2P MYOCD
GH17J011987 Enhancer 0.8 Ensembl ENCODE 0.3 +34.1 34113 2.4 CTCF PRDM1 REST SP1 CEBPA SOX13 RAD21 TCF7 FOXA2 KDM6A MAP2K4 ENSG00000266368 piR-61687-015 ZNF18 DNAH9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF18 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF18

Top Transcription factor binding sites by QIAGEN in the ZNF18 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • CUTL1
  • GR
  • GR-alpha
  • p53
  • POU3F2

Genomic Locations for ZNF18 Gene

Genomic Locations for ZNF18 Gene
64,090 bases
Minus strand
20,072 bases
Minus strand

Genomic View for ZNF18 Gene

Genes around ZNF18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF18 Gene

Proteins for ZNF18 Gene

  • Protein details for ZNF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 18
    Protein Accession:
    Secondary Accessions:
    • Q5QHQ3
    • Q8IYC4
    • Q8NAH6

    Protein attributes for ZNF18 Gene

    549 amino acids
    Molecular mass:
    62288 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF18 Gene


neXtProt entry for ZNF18 Gene

Post-translational modifications for ZNF18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF18 Gene

Domains & Families for ZNF18 Gene

Gene Families for ZNF18 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF18 Gene

  • KRAB box
  • Transcriptional regulator SCAN

Suggested Antigen Peptide Sequences for ZNF18 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein with KRAB and SCAN domains 6 (ZNF18_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF18: view

Function for ZNF18 Gene

Molecular function for ZNF18 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 18 (KOX11) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF18 Gene

Gene Ontology (GO) - Molecular Function for ZNF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF18: view
genes like me logo Genes that share phenotypes with ZNF18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF18

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF18 Gene

Localization for ZNF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF18 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF18 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2
plasma membrane 1
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF18: view

Pathways & Interactions for ZNF18 Gene

PathCards logo

SuperPathways for ZNF18 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF18: view

Pathways by source for ZNF18 Gene

2 Reactome pathways for ZNF18 Gene

Gene Ontology (GO) - Biological Process for ZNF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042552 myelination IBA --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF18: view

No data available for SIGNOR curated interactions for ZNF18 Gene

Drugs & Compounds for ZNF18 Gene

No Compound Related Data Available

Transcripts for ZNF18 Gene

mRNA/cDNA for ZNF18 Gene

8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF18

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF18 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - -
SP2: - - - - -
SP3: -
SP5: -
SP6: - - -

Relevant External Links for ZNF18 Gene

GeneLoc Exon Structure for

Expression for ZNF18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF18

SOURCE GeneReport for Unigene cluster for ZNF18 Gene:


Evidence on tissue expression from TISSUES for ZNF18 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF18: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF18 Gene

Orthologs for ZNF18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF18 30 31
  • 99.39 (n)
(Canis familiaris)
Mammalia ZNF18 30 31
  • 85.05 (n)
(Rattus norvegicus)
Mammalia Zfp18 30
  • 82.54 (n)
(Mus musculus)
Mammalia Zkscan6 30 17 31
  • 82.05 (n)
(Bos Taurus)
Mammalia ZNF18 30 31
  • 78.37 (n)
(Monodelphis domestica)
Mammalia ZNF18 31
  • 51 (a)
Species where no ortholog for ZNF18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF18 Gene

Gene Tree for ZNF18 (if available)
Gene Tree for ZNF18 (if available)
Evolutionary constrained regions (ECRs) for ZNF18: view image

Paralogs for ZNF18 Gene

genes like me logo Genes that share paralogs with ZNF18: view

Variants for ZNF18 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF18 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs1990236 Benign: not specified 11,962,145(-) G/A MISSENSE_VARIANT
rs17853545 - p.Met240Ile
rs17857095 - p.Gln210Arg

Additional dbSNP identifiers (rs#s) for ZNF18 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF18 Gene

Variant ID Type Subtype PubMed ID
esv3639961 CNV loss 21293372
esv3639962 CNV gain 21293372

Variation tolerance for ZNF18 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF18 Gene

Disorders for ZNF18 Gene

Additional Disease Information for ZNF18

No disorders were found for ZNF18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF18 Gene

Publications for ZNF18 Gene

  1. [Molecular cloning and expression analysis of a novel human gene ZNF18]. (PMID: 16120570) Guo LL … Li YP (Yi chuan = Hereditas 2005) 3 4
  2. Identification and characterization of human ZNF18 gene in silico. (PMID: 15702252) Yoshida K (International journal of molecular medicine 2005) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4

Products for ZNF18 Gene

Sources for ZNF18 Gene