Aliases for ZNF177 Gene

Aliases for ZNF177 Gene

  • Zinc Finger Protein 177 2 3 4 5
  • PIGX 3

External Ids for ZNF177 Gene

Previous GeneCards Identifiers for ZNF177 Gene

  • GC19P009595
  • GC19P009696
  • GC19P009097
  • GC19P009114
  • GC19P009334
  • GC19P009475
  • GC19P009437

Summaries for ZNF177 Gene

GeneCards Summary for ZNF177 Gene

ZNF177 (Zinc Finger Protein 177) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF559-ZNF177.

UniProtKB/Swiss-Prot Summary for ZNF177 Gene

Additional gene information for ZNF177 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF177 Gene

Genomics for ZNF177 Gene

GeneHancer (GH) Regulatory Elements for ZNF177 Gene

Promoters and enhancers for ZNF177 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009323 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.3 -38.7 -38719 3 EP300 CTCF NRF1 SP1 PHF8 POLR2A ZBTB26 KLF7 ZNF740 MYC ZNF559 NONHSAG024732.2 ZNF559-ZNF177 piR-39487 piR-49398 ZNF177 ZNF266 lnc-ZNF177-2
GH19J009362 Promoter 1.5 EPDnew Ensembl CraniofacialAtlas 500.7 +0.0 43 1.1 ZBTB40 ZBTB11 KDM4B GABPA POLR2G NRF1 VEZF1 DIDO1 HMGN3 GABPB1 ZNF177 ZNF266 ZNF559 piR-43105-316 ZNF559-ZNF177
GH19J009366 Promoter 0.3 EPDnew 500.7 +3.1 3129 0.1 ZNF177 ZNF699 piR-43105-316 ZNF559-ZNF177
GH19J010100 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 37 +741.4 741367 8.3 RXRA ZBTB40 ZNF217 EP300 SIN3A NRF1 MYC POLR2G USF1 SP1 PPAN ANGPTL6 PPAN-P2RY11 ZNF699 LOC100419831 FBXL12 ZNF561 ILF3 ZNF317 ZNF559
GH19J008608 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas 23.8 -752.4 -752353 4.9 EP300 TCF12 ZNF639 ZIC2 ZBTB10 ZBTB26 SAP30 KLF7 ZNF740 ZKSCAN8 ADAMTS10 lnc-OR2Z1-4 ZNF266 ZNF699 ZNF317 XAB2 ZNF558 ZNF559 ELAVL1 ZNF414
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF177 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF177

Top Transcription factor binding sites by QIAGEN in the ZNF177 gene promoter:
  • AREB6
  • C/EBPbeta
  • Evi-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Pbx1a

Genomic Locations for ZNF177 Gene

Genomic Locations for ZNF177 Gene
chr19:9,363,020-9,382,617
(GRCh38/hg38)
Size:
19,598 bases
Orientation:
Plus strand
chr19:9,435,021-9,493,293
(GRCh37/hg19)
Size:
58,273 bases
Orientation:
Plus strand

Genomic View for ZNF177 Gene

Genes around ZNF177 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF177 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF177 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF177 Gene

Proteins for ZNF177 Gene

  • Protein details for ZNF177 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13360-ZN177_HUMAN
    Recommended name:
    Zinc finger protein 177
    Protein Accession:
    Q13360
    Secondary Accessions:
    • B4DY57
    • E9PDG0
    • I3L0I4
    • Q96ER2

    Protein attributes for ZNF177 Gene

    Size:
    481 amino acids
    Molecular mass:
    54782 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF177 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF177 Gene

Post-translational modifications for ZNF177 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF177 Gene

No data available for DME Specific Peptides for ZNF177 Gene

Domains & Families for ZNF177 Gene

Gene Families for ZNF177 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF177 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF177 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 177 (ZN177_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13360

UniProtKB/Swiss-Prot:

ZN177_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF177: view

Function for ZNF177 Gene

Molecular function for ZNF177 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF177 Gene

Gene Ontology (GO) - Molecular Function for ZNF177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF177: view
genes like me logo Genes that share phenotypes with ZNF177: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF177 Gene

Localization for ZNF177 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF177 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF177 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with ZNF177: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF177 Gene

Pathways & Interactions for ZNF177 Gene

PathCards logo

SuperPathways for ZNF177 Gene

genes like me logo Genes that share pathways with ZNF177: view

Pathways by source for ZNF177 Gene

1 KEGG pathway for ZNF177 Gene

Gene Ontology (GO) - Biological Process for ZNF177 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 8661005
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF177: view

No data available for SIGNOR curated interactions for ZNF177 Gene

Drugs & Compounds for ZNF177 Gene

No Compound Related Data Available

Transcripts for ZNF177 Gene

mRNA/cDNA for ZNF177 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF177 Gene

No ASD Table

Relevant External Links for ZNF177 Gene

GeneLoc Exon Structure for
ZNF177

Expression for ZNF177 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF177 Gene

Protein differential expression in normal tissues from HIPED for ZNF177 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF177 Gene



Protein tissue co-expression partners for ZNF177 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF177

SOURCE GeneReport for Unigene cluster for ZNF177 Gene:

Hs.728944

Evidence on tissue expression from TISSUES for ZNF177 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with ZNF177: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF177 Gene

Orthologs for ZNF177 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF177 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF177 30
  • 99.51 (n)
-- 31
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZNF177 30
  • 83.86 (n)
-- 31
  • 48 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF177 30
  • 83.02 (n)
-- 31
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 29 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 5730507C01Rik 31
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 27 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF557 31
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3407 32
  • 40 (a)
BG:DS02740.8 32
  • 37 (a)
Species where no ortholog for ZNF177 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF177 Gene

ENSEMBL:
Gene Tree for ZNF177 (if available)
TreeFam:
Gene Tree for ZNF177 (if available)

Paralogs for ZNF177 Gene

(504) SIMAP similar genes for ZNF177 Gene using alignment to 14 proteins:

  • ZN177_HUMAN
  • K7EK36_HUMAN
  • K7EQU1_HUMAN
  • S4R342_HUMAN
  • S4R365_HUMAN
  • S4R367_HUMAN
  • S4R3A1_HUMAN
  • S4R3B1_HUMAN
  • S4R3H7_HUMAN
  • S4R3Q2_HUMAN
  • S4R3T9_HUMAN
  • S4R401_HUMAN
  • S4R422_HUMAN
  • V9H066_HUMAN
genes like me logo Genes that share paralogs with ZNF177: view

Variants for ZNF177 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF177 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2217652 - p.Thr112Met
rs2230750 - p.Asp94Gly
rs2230752 - p.Ile455Phe

Additional dbSNP identifiers (rs#s) for ZNF177 Gene

Variation tolerance for ZNF177 Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF177 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF177

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF177 Gene

Disorders for ZNF177 Gene

Additional Disease Information for ZNF177

No disorders were found for ZNF177 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF177 Gene

Publications for ZNF177 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Repetitive elements in the 5' untranslated region of a human zinc-finger gene modulate transcription and translation efficiency. (PMID: 11549323) Landry JR … Mager DL (Genomics 2001) 3 4 54
  3. Transcripts from a novel human KRAB zinc finger gene contain spliced Alu and endogenous retroviral segments. (PMID: 8661005) Baban S … Mager DL (Genomics 1996) 3 4 54
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54
  5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart AE … Wells CM (The Journal of cell biology 2015) 3 54

Products for ZNF177 Gene

Sources for ZNF177 Gene