Aliases for ZNF175 Gene

Aliases for ZNF175 Gene

  • Zinc Finger Protein 175 2 3 4 5
  • Zinc Finger Protein OTK18 3 4
  • OTK18 2 3
  • ZNF175 5

External Ids for ZNF175 Gene

Previous GeneCards Identifiers for ZNF175 Gene

  • GC19P052705
  • GC19P052435
  • GC19P056750
  • GC19P056766
  • GC19P052074
  • GC19P048406

Summaries for ZNF175 Gene

GeneCards Summary for ZNF175 Gene

ZNF175 (Zinc Finger Protein 175) is a Protein Coding gene. Diseases associated with ZNF175 include Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF585B.

UniProtKB/Swiss-Prot Summary for ZNF175 Gene

  • Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF175 Gene

Genomics for ZNF175 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF175 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF175 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the ZNF175 gene promoter:
  • AP-2rep
  • AREB6
  • CP2
  • GATA-1
  • IRF-1
  • ISGF-3
  • Msx-1
  • Spz1
  • ZID

Genomic Locations for ZNF175 Gene

Genomic Locations for ZNF175 Gene
chr19:51,571,283-51,592,510
(GRCh38/hg38)
Size:
21,228 bases
Orientation:
Plus strand
chr19:52,074,531-52,092,991
(GRCh37/hg19)
Size:
18,461 bases
Orientation:
Plus strand

Genomic View for ZNF175 Gene

Genes around ZNF175 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF175 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF175 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF175 Gene

Proteins for ZNF175 Gene

  • Protein details for ZNF175 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y473-ZN175_HUMAN
    Recommended name:
    Zinc finger protein 175
    Protein Accession:
    Q9Y473
    Secondary Accessions:
    • A8K9H2

    Protein attributes for ZNF175 Gene

    Size:
    711 amino acids
    Molecular mass:
    81609 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF175 Gene

Post-translational modifications for ZNF175 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF175 Gene

No data available for DME Specific Peptides for ZNF175 Gene

Domains & Families for ZNF175 Gene

Gene Families for ZNF175 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF175 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF175 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein OTK18 (ZN175_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y473

UniProtKB/Swiss-Prot:

ZN175_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF175: view

Function for ZNF175 Gene

Molecular function for ZNF175 Gene

UniProtKB/Swiss-Prot Function:
Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.
UniProtKB/Swiss-Prot Induction:
By HIV-1 infection.
GENATLAS Biochemistry:
zinc finger protein 175,C2H2 type,ubiquitously expressed

Phenotypes From GWAS Catalog for ZNF175 Gene

Gene Ontology (GO) - Molecular Function for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 17170456
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 17170456
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 17170456
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZNF175: view
genes like me logo Genes that share phenotypes with ZNF175: view

Animal Models for ZNF175 Gene

MGI Knock Outs for ZNF175:
  • Zfp715 Zfp715<tm1a(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF175

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF175 Gene

Localization for ZNF175 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF175 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF175 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with ZNF175: view

Pathways & Interactions for ZNF175 Gene

genes like me logo Genes that share pathways with ZNF175: view

Pathways by source for ZNF175 Gene

2 Reactome pathways for ZNF175 Gene
1 KEGG pathway for ZNF175 Gene

Gene Ontology (GO) - Biological Process for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 17170456
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 17170456
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with ZNF175: view

No data available for SIGNOR curated interactions for ZNF175 Gene

Drugs & Compounds for ZNF175 Gene

(1) Drugs for ZNF175 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF175: view

Transcripts for ZNF175 Gene

mRNA/cDNA for ZNF175 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF175

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF175 Gene

No ASD Table

Relevant External Links for ZNF175 Gene

GeneLoc Exon Structure for
ZNF175

Expression for ZNF175 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF175 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF175 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF175

SOURCE GeneReport for Unigene cluster for ZNF175 Gene:

Hs.119014

mRNA Expression by UniProt/SwissProt for ZNF175 Gene:

Q9Y473-ZN175_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ZNF175 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF175: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF175 Gene

Orthologs for ZNF175 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF175 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF175 30 31
  • 98.83 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF175 30 31
  • 83.83 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC100686614 30
  • 81.26 (n)
ZNF175 31
  • 73 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp715 30 17
  • 63.19 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta D19A 32
  • 35 (a)
CG6792 32
  • 34 (a)
CG2129 32
  • 29 (a)
Species where no ortholog for ZNF175 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF175 Gene

ENSEMBL:
Gene Tree for ZNF175 (if available)
TreeFam:
Gene Tree for ZNF175 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF175: view image

Paralogs for ZNF175 Gene

Paralogs for ZNF175 Gene

(449) SIMAP similar genes for ZNF175 Gene using alignment to 5 proteins:

  • ZN175_HUMAN
  • F5GZI7_HUMAN
  • G3V1K8_HUMAN
  • L8E9H5_HUMAN
  • M0R013_HUMAN
genes like me logo Genes that share paralogs with ZNF175: view

Variants for ZNF175 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF175 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs3764548 - p.Cys505Arg
rs60097262 - p.Tyr363Asn
VAR_083478 - p.Lys622Arg

Additional dbSNP identifiers (rs#s) for ZNF175 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF175 Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
esv3304500 CNV mobile element insertion 20981092
esv3451949 CNV insertion 20981092
esv3644673 CNV loss 21293372
nsv1140251 OTHER inversion 24896259
nsv469584 CNV loss 16826518
nsv579966 CNV loss 21841781

Variation tolerance for ZNF175 Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.35; 81.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF175 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF175

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF175 Gene

Disorders for ZNF175 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF175 Gene - From: DISEASES

Disorder Aliases PubMed IDs
non-syndromic x-linked intellectual disability
  • non-specific x-linked mental retardation
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF175

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF175: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF175 Gene

Publications for ZNF175 Gene

  1. Molecular characterization of a putative antiretroviral transcriptional factor, OTK18. (PMID: 14688346) Carlson KA … Ikezu T (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 23
  2. Isolation and mapping of a novel human gene encoding a protein containing zinc-finger structures. (PMID: 8838321) Saito H … Nakamura Y (Genomics 1996) 2 3 4
  3. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J … Platt A (The pharmacogenomics journal 2013) 3 41
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET. (PMID: 19034669) Martinez LB … Ikezu T (Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2009) 3 23

Products for ZNF175 Gene

  • Signalway Proteins for ZNF175

Sources for ZNF175 Gene