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Aliases for ZNF175 Gene

Aliases for ZNF175 Gene

  • Zinc Finger Protein 175 2 3 5
  • Zinc Finger Protein OTK18 3 4
  • OTK18 3

External Ids for ZNF175 Gene

Previous GeneCards Identifiers for ZNF175 Gene

  • GC19P052705
  • GC19P052435
  • GC19P056750
  • GC19P056766
  • GC19P052074
  • GC19P048406

Summaries for ZNF175 Gene

GeneCards Summary for ZNF175 Gene

ZNF175 (Zinc Finger Protein 175) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF81.

UniProtKB/Swiss-Prot for ZNF175 Gene

  • Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.

Additional gene information for ZNF175 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF175 Gene

Genomics for ZNF175 Gene

GeneHancer (GH) Regulatory Elements for ZNF175 Gene

Promoters and enhancers for ZNF175 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I051570 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 573.4 +0.9 949 3.6 HDGF PKNOX1 SMAD1 ARNT ARID4B ZNF2 IRF4 YY1 POLR2B ZNF766 ZNF175 ZNF766 ZNF701 ZNF350 ZNF616 ZNF808 ZNF841 SIGLEC14 SIGLEC5 RPL7P51
GH19I051687 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 72.3 +119.2 119213 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 ZNF137P ZNF808 ZNF841 ZNF616 ZNF766 ZNF577 ENSG00000268970 ZNF836 ENSG00000269825 ZNF175
GH19I051393 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 78.2 -176.2 -176231 2.8 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A IRF4 YY1 POLR2B ENSG00000268889 LOC105372446 ZNF841 ZNF766 ZNF577 ZNF616 ZNF175 ZNF836 ZNF432 ZNF614
GH19I050802 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 38.6 -767.0 -766995 4.2 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 C19orf48 GC19M050829 GC19M050838 SNORD88C POLD1 PTOV1-AS2 NUP62 PNKP ZNF175 CTU1
GH19I050657 Promoter/Enhancer 1.6 Ensembl ENCODE 40.3 -912.3 -912317 2.9 HDGF PKNOX1 SMAD1 ARNT SIN3A YBX1 ZNF2 ZBTB7B POLR2B FOS SYT3 POLD1 NUP62 PTOV1-AS2 IRF3 ZNF175 PNKP ENSG00000268047 ZNF473 CTU1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF175 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF175 gene promoter:

Genomic Locations for ZNF175 Gene

Genomic Locations for ZNF175 Gene
chr19:51,571,278-51,592,510
(GRCh38/hg38)
Size:
21,233 bases
Orientation:
Plus strand
chr19:52,074,531-52,092,991
(GRCh37/hg19)

Genomic View for ZNF175 Gene

Genes around ZNF175 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF175 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF175 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF175 Gene

Proteins for ZNF175 Gene

  • Protein details for ZNF175 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y473-ZN175_HUMAN
    Recommended name:
    Zinc finger protein 175
    Protein Accession:
    Q9Y473
    Secondary Accessions:
    • A8K9H2

    Protein attributes for ZNF175 Gene

    Size:
    711 amino acids
    Molecular mass:
    81609 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF175 Gene

Post-translational modifications for ZNF175 Gene

No Post-translational modifications

Other Protein References for ZNF175 Gene

No data available for DME Specific Peptides for ZNF175 Gene

Domains & Families for ZNF175 Gene

Gene Families for ZNF175 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF175 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y473

UniProtKB/Swiss-Prot:

ZN175_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF175: view

Function for ZNF175 Gene

Molecular function for ZNF175 Gene

GENATLAS Biochemistry:
zinc finger protein 175,C2H2 type,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.
UniProtKB/Swiss-Prot Induction:
By HIV-1 infection.

Phenotypes From GWAS Catalog for ZNF175 Gene

Gene Ontology (GO) - Molecular Function for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 17170456
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 17170456
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 17170456
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZNF175: view

Phenotypes for ZNF175 Gene

genes like me logo Genes that share phenotypes with ZNF175: view

Animal Models for ZNF175 Gene

MGI Knock Outs for ZNF175:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF175 Gene

Localization for ZNF175 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF175 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF175 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF175: view

Pathways & Interactions for ZNF175 Gene

SuperPathways for ZNF175 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF175: view

Pathways by source for ZNF175 Gene

2 Reactome pathways for ZNF175 Gene

Gene Ontology (GO) - Biological Process for ZNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 17170456
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 17170456
genes like me logo Genes that share ontologies with ZNF175: view

No data available for SIGNOR curated interactions for ZNF175 Gene

Drugs & Compounds for ZNF175 Gene

(1) Drugs for ZNF175 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF175: view

Transcripts for ZNF175 Gene

Unigene Clusters for ZNF175 Gene

Zinc finger protein 175:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF175 Gene

No ASD Table

Relevant External Links for ZNF175 Gene

GeneLoc Exon Structure for
ZNF175
ECgene alternative splicing isoforms for
ZNF175

Expression for ZNF175 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF175 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF175 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF175 Gene:

ZNF175

SOURCE GeneReport for Unigene cluster for ZNF175 Gene:

Hs.119014

mRNA Expression by UniProt/SwissProt for ZNF175 Gene:

Q9Y473-ZN175_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ZNF175 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF175: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF175 Gene

Orthologs for ZNF175 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF175 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF175 33 34
  • 98.83 (n)
cow
(Bos Taurus)
Mammalia ZNF175 33 34
  • 83.83 (n)
dog
(Canis familiaris)
Mammalia LOC100686614 33
  • 81.26 (n)
ZNF175 34
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp715 33 16
  • 63.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta D19A 35
  • 35 (a)
CG6792 35
  • 34 (a)
CG2129 35
  • 29 (a)
Species where no ortholog for ZNF175 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF175 Gene

ENSEMBL:
Gene Tree for ZNF175 (if available)
TreeFam:
Gene Tree for ZNF175 (if available)

Paralogs for ZNF175 Gene

Paralogs for ZNF175 Gene

(449) SIMAP similar genes for ZNF175 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF175: view

Variants for ZNF175 Gene

Sequence variations from dbSNP and Humsavar for ZNF175 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000070484 -- 51,577,836(+) T/A/C genic_downstream_transcript_variant, intron_variant
rs1000087142 -- 51,583,932(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000455032 -- 51,573,443(+) G/A intron_variant, non_coding_transcript_variant
rs1000865976 -- 51,586,616(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000923440 -- 51,585,737(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF175 Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
esv3304500 CNV mobile element insertion 20981092
esv3451949 CNV insertion 20981092
esv3644673 CNV loss 21293372
nsv1140251 OTHER inversion 24896259
nsv469584 CNV loss 16826518
nsv579966 CNV loss 21841781

Variation tolerance for ZNF175 Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.35; 81.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF175 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF175

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF175 Gene

Disorders for ZNF175 Gene

Additional Disease Information for ZNF175

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF175 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF175 Gene

Publications for ZNF175 Gene

  1. Molecular characterization of a putative antiretroviral transcriptional factor, OTK18. (PMID: 14688346) Carlson KA … Ikezu T (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 22 58
  2. Isolation and mapping of a novel human gene encoding a protein containing zinc-finger structures. (PMID: 8838321) Saito H … Nakamura Y (Genomics 1996) 2 3 4 58
  3. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J … Platt A (The pharmacogenomics journal 2013) 3 44 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection. (PMID: 19034670) Buescher JL … Ikezu T (Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2009) 3 22 58

Products for ZNF175 Gene

Sources for ZNF175 Gene

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