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Aliases for ZNF174 Gene

Aliases for ZNF174 Gene

  • Zinc Finger Protein 174 2 3 4 5
  • Zinc Finger And SCAN Domain-Containing Protein 8 3 4
  • ZSCAN8 3 4
  • AW-1 3 4

External Ids for ZNF174 Gene

Previous GeneCards Identifiers for ZNF174 Gene

  • GC16P003480
  • GC16P003451
  • GC16P003391
  • GC16P003420

Summaries for ZNF174 Gene

Entrez Gene Summary for ZNF174 Gene

  • This gene encodes a protein with three Cys2-His2-type zinc fingers in the carboxy-terminus, a putative nuclear localization signal, and an amino-terminus SCAN box which forms homodimers. This protein is believed to function as a transcriptional repressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]

GeneCards Summary for ZNF174 Gene

ZNF174 (Zinc Finger Protein 174) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is ZKSCAN2.

UniProtKB/Swiss-Prot for ZNF174 Gene

Additional gene information for ZNF174 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF174 Gene

Genomics for ZNF174 Gene

GeneHancer (GH) Regulatory Elements for ZNF174 Gene

Promoters and enhancers for ZNF174 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J003400 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 600.7 +0.0 11 3.2 HDGF SP1 ELF3 ZFX SIX5 ZNF148 NKRF POLR2A ZNF121 ZNF687 ZSCAN32 ZNF174 ZNF597 ZNF75A CREBBP ZNF200 TIGD7 ZNF263 ENSG00000261938 CLUAP1
GH16J003364 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 600.3 -36.0 -35990 2.4 CTCF MNT POLR2A CEBPG ZNF687 AHR SP1 CREM MLLT1 KAT8 ENSG00000285329 LOC105371059 ZNF174 ZNF75A ENSG00000261938 ZNF263 ERVK13-1 ZNF213-AS1 ZNF597 ZSCAN32
GH16J002679 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 30.2 -719.0 -719039 5.3 MTA3 ZNF652 ZFX SP1 ELF3 MNT SIX5 NKRF POLR2A MLLT1 ENSG00000279901 KCTD5 PIR38297 PIR43814 PIR61225 ABCA3 TBL3 ENSG00000261613 ZNF597 E4F1
GH16J003017 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 29.1 -380.2 -380189 8.8 ZNF652 CC2D1A SP1 ZFX ELF3 MNT SIX5 CBFA2T2 ZNF148 NKRF THOC6 CLDN6 HCFC1R1 TNFRSF12A PKMYT1 ZNF263 ENSG00000261938 E4F1 ERVK13-1 TSC2
GH16J004182 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 23.3 +782.6 782600 2.4 SP1 ZFX CC2D1A ZNF148 NKRF POLR2A MLLT1 ZNF121 RERE GTF2F1 ENSG00000263105 GC16P004182 LOC105371062 ZNF500 CREBBP ZNF75A ZNF263 ZNF597 ANKS3 ZNF174
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF174 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF174 gene promoter:
  • AP-1
  • AP-4
  • AREB6
  • c-Fos
  • c-Jun
  • CUTL1
  • Ik-1
  • RSRFC4
  • Sp1
  • YY1

Genomic Locations for ZNF174 Gene

Genomic Locations for ZNF174 Gene
chr16:3,401,190-3,430,851
(GRCh38/hg38)
Size:
29,662 bases
Orientation:
Plus strand
chr16:3,451,190-3,459,370
(GRCh37/hg19)
Size:
8,181 bases
Orientation:
Plus strand

Genomic View for ZNF174 Gene

Genes around ZNF174 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF174 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF174 Gene

Proteins for ZNF174 Gene

  • Protein details for ZNF174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15697-ZN174_HUMAN
    Recommended name:
    Zinc finger protein 174
    Protein Accession:
    Q15697
    Secondary Accessions:
    • Q53Y68
    • Q9BQ34

    Protein attributes for ZNF174 Gene

    Size:
    407 amino acids
    Molecular mass:
    46455 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for ZNF174 Gene

    Alternative splice isoforms for ZNF174 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF174 Gene

Post-translational modifications for ZNF174 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF174 Gene

Domains & Families for ZNF174 Gene

Gene Families for ZNF174 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF174 Gene

GenScript: Design optimal peptide antigens:
  • Truncated zinc finger protein isoform (Q8IZN5_HUMAN)
  • Zinc finger and SCAN domain-containing protein 8 (ZN174_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15697

UniProtKB/Swiss-Prot:

ZN174_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF174: view

Function for ZNF174 Gene

Molecular function for ZNF174 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.
GENATLAS Biochemistry:
zinc finger 174 (C2H2 type,Kruppel-like),most strongly expressed in adult testis and ovary,potential transcriptional repressor

Phenotypes From GWAS Catalog for ZNF174 Gene

Gene Ontology (GO) - Molecular Function for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IC --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,IDA 7673192
genes like me logo Genes that share ontologies with ZNF174: view
genes like me logo Genes that share phenotypes with ZNF174: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF174

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF174 - Now 50% OFF >
  • * ZNF174 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF174 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF174 Gene

Localization for ZNF174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF174 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF174 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
cytoskeleton 4
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,IEA 7673192
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ZNF174: view

Pathways & Interactions for ZNF174 Gene

PathCards logo

SuperPathways for ZNF174 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 7673192
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 7673192
genes like me logo Genes that share ontologies with ZNF174: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF174 Gene

Drugs & Compounds for ZNF174 Gene

No Compound Related Data Available

Transcripts for ZNF174 Gene

Unigene Clusters for ZNF174 Gene

Zinc finger protein 174:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF174

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF174 - Now 50% OFF >
  • * ZNF174 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF174 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF174 Gene

No ASD Table

Relevant External Links for ZNF174 Gene

GeneLoc Exon Structure for
ZNF174
ECgene alternative splicing isoforms for
ZNF174

Expression for ZNF174 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF174 Gene

Protein differential expression in normal tissues from HIPED for ZNF174 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.0) and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF174 Gene



Protein tissue co-expression partners for ZNF174 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF174 Gene:

ZNF174

SOURCE GeneReport for Unigene cluster for ZNF174 Gene:

Hs.155204

mRNA Expression by UniProt/SwissProt for ZNF174 Gene:

Q15697-ZN174_HUMAN
Tissue specificity: Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells.

Evidence on tissue expression from TISSUES for ZNF174 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF174: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF174 Gene

Orthologs for ZNF174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF174 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF174 35 34
  • 99.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF174 35 34
  • 87.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF174 35
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102551846 34
  • 80.58 (n)
mouse
(Mus musculus)
Mammalia Zfp174 17 35 34
  • 80.41 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 28 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 28 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZFP92 35
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZNF174 35
  • 28 (a)
OneToOne
Species where no ortholog for ZNF174 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF174 Gene

ENSEMBL:
Gene Tree for ZNF174 (if available)
TreeFam:
Gene Tree for ZNF174 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF174: view image

Paralogs for ZNF174 Gene

genes like me logo Genes that share paralogs with ZNF174: view

Variants for ZNF174 Gene

Sequence variations from dbSNP and Humsavar for ZNF174 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs761098156 likely-benign, Long QT syndrome 3,408,899(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, stop_gained
rs1000169149 -- 3,404,517(+) C/T coding_sequence_variant, missense_variant
rs1000540005 -- 3,407,024(+) C/A/T genic_downstream_transcript_variant, intron_variant
rs1000541786 -- 3,405,548(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000553807 -- 3,400,130(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF174 Gene

Variant ID Type Subtype PubMed ID
dgv2695n100 CNV gain 25217958

Variation tolerance for ZNF174 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF174 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF174

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF174 Gene

Disorders for ZNF174 Gene

Additional Disease Information for ZNF174

No disorders were found for ZNF174 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF174 Gene

Publications for ZNF174 Gene

  1. Isolation and characterization of a novel zinc-finger protein with transcription repressor activity. (PMID: 7673192) Williams AJ … Collins T (The Journal of biological chemistry 1995) 3 4 23 58
  2. Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain. (PMID: 15629724) Ivanov D … Wagner G (Molecular cell 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF174 Gene

  • Boster Bio Antibodies for ZNF174
  • Boster Bio ELISA Kits for ZNF174

Sources for ZNF174 Gene

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