This gene encodes a protein with three Cys2-His2-type zinc fingers in the carboxy-terminus, a putative nuclear localization signal, and an amino-terminus SCAN box which forms homodimers. This protein is believed to function as a transcriptional repressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016] See more...

Aliases for ZNF174 Gene

Aliases for ZNF174 Gene

  • Zinc Finger Protein 174 2 3 4 5
  • ZSCAN8 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 8 3 4
  • AW-1 3 4
  • ZNF174 5

External Ids for ZNF174 Gene

Previous GeneCards Identifiers for ZNF174 Gene

  • GC16P003480
  • GC16P003451
  • GC16P003391
  • GC16P003420

Summaries for ZNF174 Gene

Entrez Gene Summary for ZNF174 Gene

  • This gene encodes a protein with three Cys2-His2-type zinc fingers in the carboxy-terminus, a putative nuclear localization signal, and an amino-terminus SCAN box which forms homodimers. This protein is believed to function as a transcriptional repressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]

GeneCards Summary for ZNF174 Gene

ZNF174 (Zinc Finger Protein 174) is a Protein Coding gene. Diseases associated with ZNF174 include Central Nervous System Sarcoma and Febrile Seizures, Familial, 5. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is ZSCAN29.

UniProtKB/Swiss-Prot Summary for ZNF174 Gene

Additional gene information for ZNF174 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF174 Gene

Genomics for ZNF174 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF174 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF174 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF174

Top Transcription factor binding sites by QIAGEN in the ZNF174 gene promoter:
  • AP-1
  • AP-4
  • AREB6
  • c-Fos
  • c-Jun
  • CUTL1
  • Ik-1
  • RSRFC4
  • Sp1
  • YY1

Genomic Locations for ZNF174 Gene

Genomic Locations for ZNF174 Gene
chr16:3,401,190-3,409,364
(GRCh38/hg38)
Size:
8,175 bases
Orientation:
Plus strand
chr16:3,451,190-3,459,370
(GRCh37/hg19)
Size:
8,181 bases
Orientation:
Plus strand

Genomic View for ZNF174 Gene

Genes around ZNF174 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF174 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF174 Gene

Proteins for ZNF174 Gene

  • Protein details for ZNF174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15697-ZN174_HUMAN
    Recommended name:
    Zinc finger protein 174
    Protein Accession:
    Q15697
    Secondary Accessions:
    • Q53Y68
    • Q9BQ34

    Protein attributes for ZNF174 Gene

    Size:
    407 amino acids
    Molecular mass:
    46455 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for ZNF174 Gene

    Alternative splice isoforms for ZNF174 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF174 Gene

Post-translational modifications for ZNF174 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF174 Gene

Domains & Families for ZNF174 Gene

Gene Families for ZNF174 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF174 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • Transcriptional regulator SCAN
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF174 Gene

GenScript: Design optimal peptide antigens:
  • Truncated zinc finger protein isoform (Q8IZN5_HUMAN)
  • Zinc finger and SCAN domain-containing protein 8 (ZN174_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15697

UniProtKB/Swiss-Prot:

ZN174_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF174: view

Function for ZNF174 Gene

Molecular function for ZNF174 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.
GENATLAS Biochemistry:
zinc finger 174 (C2H2 type,Kruppel-like),most strongly expressed in adult testis and ovary,potential transcriptional repressor

Phenotypes From GWAS Catalog for ZNF174 Gene

Gene Ontology (GO) - Molecular Function for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA, IBA 7673192
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,IDA 7673192
genes like me logo Genes that share ontologies with ZNF174: view
genes like me logo Genes that share phenotypes with ZNF174: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF174

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF174 Gene

Localization for ZNF174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF174 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF174 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
cytoskeleton 4
extracellular 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,NAS 7673192
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ZNF174: view

Pathways & Interactions for ZNF174 Gene

PathCards logo

SuperPathways for ZNF174 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA,IDA 7673192
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 7673192
genes like me logo Genes that share ontologies with ZNF174: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF174 Gene

Drugs & Compounds for ZNF174 Gene

No Compound Related Data Available

Transcripts for ZNF174 Gene

mRNA/cDNA for ZNF174 Gene

5 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF174

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF174 Gene

No ASD Table

Relevant External Links for ZNF174 Gene

GeneLoc Exon Structure for
ZNF174

Expression for ZNF174 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF174 Gene

Protein differential expression in normal tissues from HIPED for ZNF174 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.0) and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF174 Gene



Protein tissue co-expression partners for ZNF174 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF174

SOURCE GeneReport for Unigene cluster for ZNF174 Gene:

Hs.155204

mRNA Expression by UniProt/SwissProt for ZNF174 Gene:

Q15697-ZN174_HUMAN
Tissue specificity: Expressed in a variety of organs, but most strongly in adult testis and ovary followed by small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain and kidney. Also expressed in umbilical vein endothelial cells, foreskin fibroblast and Hep-G2 cells.

Evidence on tissue expression from TISSUES for ZNF174 Gene

  • Lung(4.3)
  • Skin(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with ZNF174: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF174 Gene

Orthologs for ZNF174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF174 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF174 30 31
  • 99.26 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF174 30 31
  • 87.55 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF174 31
  • 82 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC102551846 30
  • 80.58 (n)
Mouse
(Mus musculus)
Mammalia Zfp174 30 17 31
  • 80.41 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 28 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 28 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves ZFP92 31
  • 22 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia ZNF174 31
  • 28 (a)
OneToOne
Species where no ortholog for ZNF174 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF174 Gene

ENSEMBL:
Gene Tree for ZNF174 (if available)
TreeFam:
Gene Tree for ZNF174 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF174: view image

Paralogs for ZNF174 Gene

genes like me logo Genes that share paralogs with ZNF174: view

Variants for ZNF174 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF174 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs761098156 Likely Benign: Long QT syndrome 3,408,899(+) C/T NONSENSE

Additional dbSNP identifiers (rs#s) for ZNF174 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF174 Gene

Variant ID Type Subtype PubMed ID
dgv2695n100 CNV gain 25217958

Variation tolerance for ZNF174 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF174 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF174

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF174 Gene

Disorders for ZNF174 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ZNF174 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF174: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF174 Gene

Publications for ZNF174 Gene

  1. Isolation and characterization of a novel zinc-finger protein with transcription repressor activity. (PMID: 7673192) Williams AJ … Collins T (The Journal of biological chemistry 1995) 3 4 23
  2. Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain. (PMID: 15629724) Ivanov D … Wagner G (Molecular cell 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1. (PMID: 29871923) Chen S … Xu G (The Journal of biological chemistry 2018) 3

Products for ZNF174 Gene

Sources for ZNF174 Gene