Aliases for ZNF17 Gene

Aliases for ZNF17 Gene

  • Zinc Finger Protein 17 2 3 4 5
  • Zinc Finger Protein 17 (HPF3, KOX 10) 2 3
  • Zinc Finger Protein KOX10 3 4
  • Zinc Finger Protein HPF3 3 4
  • KOX10 3 4
  • KIAA1947 4
  • HPF3 3

External Ids for ZNF17 Gene

Previous GeneCards Identifiers for ZNF17 Gene

  • GC19P058829
  • GC19P058376
  • GC19P062539
  • GC19P062615
  • GC19P062616
  • GC19P062617
  • GC19P057922
  • GC19P054235

Summaries for ZNF17 Gene

GeneCards Summary for ZNF17 Gene

ZNF17 (Zinc Finger Protein 17) is a Protein Coding gene. Diseases associated with ZNF17 include Parainfluenza Virus Type 3 and Croup. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF530.

UniProtKB/Swiss-Prot Summary for ZNF17 Gene

Additional gene information for ZNF17 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF17 Gene

Genomics for ZNF17 Gene

GeneHancer (GH) Regulatory Elements for ZNF17 Gene

Promoters and enhancers for ZNF17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF17 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF17

Top Transcription factor binding sites by QIAGEN in the ZNF17 gene promoter:
  • HTF
  • XBP-1

Genomic Locations for ZNF17 Gene

Genomic Locations for ZNF17 Gene
chr19:57,411,161-57,421,953
(GRCh38/hg38)
Size:
10,793 bases
Orientation:
Plus strand
chr19:57,922,529-57,933,307
(GRCh37/hg19)
Size:
10,779 bases
Orientation:
Plus strand

Genomic View for ZNF17 Gene

Genes around ZNF17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF17 Gene

Proteins for ZNF17 Gene

  • Protein details for ZNF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17021-ZNF17_HUMAN
    Recommended name:
    Zinc finger protein 17
    Protein Accession:
    P17021
    Secondary Accessions:
    • B3KXU2
    • B3KY20
    • Q8N7M1
    • Q8N893
    • Q8TF54

    Protein attributes for ZNF17 Gene

    Size:
    662 amino acids
    Molecular mass:
    77204 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04956.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05252.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF17 Gene

Post-translational modifications for ZNF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF17 Gene

No data available for DME Specific Peptides for ZNF17 Gene

Domains & Families for ZNF17 Gene

Gene Families for ZNF17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF17 Gene

Blocks:
  • C2H2-type zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF17 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein KOX10 (ZNF17_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17021

UniProtKB/Swiss-Prot:

ZNF17_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF17: view

Function for ZNF17 Gene

Molecular function for ZNF17 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 17 (KOX10) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF17 Gene

Gene Ontology (GO) - Molecular Function for ZNF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF17: view
genes like me logo Genes that share phenotypes with ZNF17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF17 Gene

Localization for ZNF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF17 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ZNF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF17 Gene

Pathways & Interactions for ZNF17 Gene

genes like me logo Genes that share pathways with ZNF17: view

Pathways by source for ZNF17 Gene

2 Reactome pathways for ZNF17 Gene
1 KEGG pathway for ZNF17 Gene

Interacting Proteins for ZNF17 Gene

;

Gene Ontology (GO) - Biological Process for ZNF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF17: view

No data available for SIGNOR curated interactions for ZNF17 Gene

Drugs & Compounds for ZNF17 Gene

(1) Drugs for ZNF17 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ZNF17 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZNF17: view

Transcripts for ZNF17 Gene

mRNA/cDNA for ZNF17 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF17

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF17 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2: -
SP3: -
SP4: - -

Relevant External Links for ZNF17 Gene

GeneLoc Exon Structure for
ZNF17

Expression for ZNF17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF17 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF17 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF17

SOURCE GeneReport for Unigene cluster for ZNF17 Gene:

Hs.729403

Evidence on tissue expression from TISSUES for ZNF17 Gene

  • Spleen(4.2)
  • Nervous system(4.2)
  • Liver(4)
genes like me logo Genes that share expression patterns with ZNF17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF17 Gene

Orthologs for ZNF17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF17 30
  • 99.3 (n)
cow
(Bos Taurus)
Mammalia ZNF17 30
  • 71.81 (n)
-- 31
  • 49 (a)
ManyToMany
Species where no ortholog for ZNF17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF17 Gene

ENSEMBL:
Gene Tree for ZNF17 (if available)
TreeFam:
Gene Tree for ZNF17 (if available)

Paralogs for ZNF17 Gene

(494) SIMAP similar genes for ZNF17 Gene using alignment to 3 proteins:

  • ZNF17_HUMAN
  • M0QZR3_HUMAN
  • M0R2T2_HUMAN
genes like me logo Genes that share paralogs with ZNF17: view

Variants for ZNF17 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF17 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2014827 - p.Thr148Lys

Additional dbSNP identifiers (rs#s) for ZNF17 Gene

Variation tolerance for ZNF17 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF17 Gene

Human Gene Mutation Database (HGMD)
ZNF17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF17

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF17 Gene

Disorders for ZNF17 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF17 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
parainfluenza virus type 3
  • human parainfluenza virus type 3
croup
  • acute laryngotracheobronchitis
- elite association - COSMIC cancer census association via MalaCards
Search ZNF17 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNF17

genes like me logo Genes that share disorders with ZNF17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF17 Gene

Publications for ZNF17 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 54
  4. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K … Thiesen HJ (American journal of human genetics 1991) 2 3 54
  5. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel. (PMID: 2115127) Kato N … Cohen M (Molecular and cellular biology 1990) 2 3 54

Products for ZNF17 Gene

Sources for ZNF17 Gene