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Aliases for ZNF169 Gene

Aliases for ZNF169 Gene

  • Zinc Finger Protein 169 2 3 5
  • EC 56

External Ids for ZNF169 Gene

Previous GeneCards Identifiers for ZNF169 Gene

  • GC09U990077
  • GC09M088768
  • GC09P090320
  • GC09P092363
  • GC09P092382
  • GC09P094101
  • GC09P096061
  • GC09P097021
  • GC09P066701

Summaries for ZNF169 Gene

GeneCards Summary for ZNF169 Gene

ZNF169 (Zinc Finger Protein 169) is a Protein Coding gene. Diseases associated with ZNF169 include Multiple Self-Healing Squamous Epithelioma. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is HKR1.

UniProtKB/Swiss-Prot for ZNF169 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF169 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF169 Gene

Genomics for ZNF169 Gene

GeneHancer (GH) Regulatory Elements for ZNF169 Gene

Promoters and enhancers for ZNF169 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I094258 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 174 1.5 HDGF SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 POLR2B ZNF169 MFSD14B LOC100132077 GC09P094279 PIR44325
GH09I094373 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 4.8 +115.6 115635 2.2 HDGF ATF1 ARID4B SIN3A ZNF2 ZNF48 GLIS2 ZNF213 E2F8 ZNF207 MFSD14B LOC100132077 ZNF169 YRDCP1 NUTM2F
GH09I094911 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.9 +661.5 661536 19.6 PKNOX1 FOXA2 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 YY1 ZNF143 ZNF548 ERCC6L2 MIR2278 ENSG00000271155 LOC100132077 FBP1 ZNF169 FANCC C9orf3 LOC101928119 ENSG00000236095
GH09I094693 Enhancer 0.9 ENCODE 9.9 +435.0 435019 1.2 FOXA2 NFIB ZSCAN4 ZNF133 MZF1 ZNF76 FEZF1 RCOR1 KLF13 ZNF680 ENSG00000271155 LOC100132077 RPS26P37 ENSG00000271659 FBP1 ZNF169 PIR42796
GH09I094277 Enhancer 1.2 Ensembl ENCODE 7.3 +19.6 19635 1.9 PKNOX1 ATF1 FOXA2 ARNT SIN3A NCOA2 TCF12 ZNF766 ATF7 FOS GC09P094279 PIR44325 MFSD14B LOC100132077 ZNF169 PIR48739
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF169 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF169 gene promoter:

Genomic Locations for ZNF169 Gene

Genomic Locations for ZNF169 Gene
43,743 bases
Plus strand

Genomic View for ZNF169 Gene

Genes around ZNF169 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF169 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF169 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF169 Gene

Proteins for ZNF169 Gene

  • Protein details for ZNF169 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 169
    Protein Accession:
    Secondary Accessions:
    • A2AGP5
    • A8K127
    • Q6PI28

    Protein attributes for ZNF169 Gene

    603 amino acids
    Molecular mass:
    68488 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH47702.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF82431.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF169 Gene

Selected DME Specific Peptides for ZNF169 Gene


Post-translational modifications for ZNF169 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ZNF169 Gene

Gene Families for ZNF169 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF169: view

Function for ZNF169 Gene

Molecular function for ZNF169 Gene

GENATLAS Biochemistry:
zinc finger protein 169 (C2H2,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Enzyme Numbers (IUBMB) for ZNF169 Gene

Phenotypes From GWAS Catalog for ZNF169 Gene

Gene Ontology (GO) - Molecular Function for ZNF169 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF169: view

Phenotypes for ZNF169 Gene

genes like me logo Genes that share phenotypes with ZNF169: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF169 Gene

Localization for ZNF169 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF169 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF169 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF169 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF169: view

Pathways & Interactions for ZNF169 Gene

SuperPathways for ZNF169 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF169: view

Pathways by source for ZNF169 Gene

2 Reactome pathways for ZNF169 Gene

Gene Ontology (GO) - Biological Process for ZNF169 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF169: view

No data available for SIGNOR curated interactions for ZNF169 Gene

Drugs & Compounds for ZNF169 Gene

No Compound Related Data Available

Transcripts for ZNF169 Gene

Unigene Clusters for ZNF169 Gene

Zinc finger protein 169:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF169 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for ZNF169 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF169 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF169 Gene

Protein differential expression in normal tissues from HIPED for ZNF169 Gene

This gene is overexpressed in Platelet (43.5), Plasma (11.8), and Lung (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF169 Gene

Protein tissue co-expression partners for ZNF169 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF169 Gene:


SOURCE GeneReport for Unigene cluster for ZNF169 Gene:


mRNA Expression by UniProt/SwissProt for ZNF169 Gene:

Tissue specificity: Highly expressed in kidney, weakly expressed in heart, liver, spleen, and small intestine. Not expressed in adult brain or spinal cord.

Evidence on tissue expression from TISSUES for ZNF169 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF169: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF169 Gene

Orthologs for ZNF169 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF169 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF169 33 34
  • 99.23 (n)
(Bos Taurus)
Mammalia ZNF169 33 34
  • 81.38 (n)
(Canis familiaris)
Mammalia ZNF169 33
  • 81.1 (n)
(Rattus norvegicus)
Mammalia Zfp169 33
  • 72.28 (n)
(Mus musculus)
Mammalia Zfp169 33 16 34
  • 72.26 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSF2 36
Species where no ortholog for ZNF169 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF169 Gene

Gene Tree for ZNF169 (if available)
Gene Tree for ZNF169 (if available)

Paralogs for ZNF169 Gene

Paralogs for ZNF169 Gene

(533) SIMAP similar genes for ZNF169 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF169: view

Variants for ZNF169 Gene

Sequence variations from dbSNP and Humsavar for ZNF169 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000223284 -- 94,269,146(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000264404 -- 94,260,982(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000273346 -- 94,276,580(+) A/G intron_variant
rs1000488597 -- 94,282,226(+) T/G intron_variant
rs1000506612 -- 94,268,206(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF169 Gene

Variant ID Type Subtype PubMed ID
dgv1491e214 CNV gain 21293372
esv1152524 CNV insertion 17803354
esv2761545 CNV gain 21179565
esv3621113 CNV gain 21293372
esv3621119 CNV gain 21293372
nsv1046906 CNV gain 25217958
nsv1112196 CNV deletion 24896259
nsv1135294 CNV deletion 24896259
nsv831655 CNV gain 17160897
nsv968732 CNV duplication 23825009

Variation tolerance for ZNF169 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.47; 88.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF169 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF169 Gene

Disorders for ZNF169 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF169 Gene - From: GeneCards

Disorder Aliases PubMed IDs
multiple self-healing squamous epithelioma
  • multiple self-healing squamous epithelioma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF169

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF169: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF169 Gene

Publications for ZNF169 Gene

  1. Characterization of a YAC contig containing the NBCCS locus and a novel Kruppel-type zinc finger sequence on chromosome segment 9q22.3. (PMID: 9071574) Chidambaram A … Dean M (Genes, chromosomes & cancer 1997) 2 3 4 58
  2. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. (PMID: 22344221) Okada Y … Tanaka T (Nature genetics 2012) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: placement of a novel zinc finger gene within the NBCCS and ESS1 region. (PMID: 9186526) Levanat S … Bale AE (Cytogenetics and cell genetics 1997) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF169 Gene

Sources for ZNF169 Gene

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