Aliases for ZNF169 Gene

Aliases for ZNF169 Gene

  • Zinc Finger Protein 169 2 3 4 5
  • EC 2.1.1.43 51
  • MGC51961 2
  • ZNF169 5

External Ids for ZNF169 Gene

Previous GeneCards Identifiers for ZNF169 Gene

  • GC09U990077
  • GC09M088768
  • GC09P090320
  • GC09P092363
  • GC09P092382
  • GC09P094101
  • GC09P096061
  • GC09P097021
  • GC09P066701

Summaries for ZNF169 Gene

GeneCards Summary for ZNF169 Gene

ZNF169 (Zinc Finger Protein 169) is a Protein Coding gene. Diseases associated with ZNF169 include Malignant Essential Hypertension and Multiple Self-Healing Squamous Epithelioma. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF875.

UniProtKB/Swiss-Prot Summary for ZNF169 Gene

Additional gene information for ZNF169 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF169 Gene

Genomics for ZNF169 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF169 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF169 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF169

Top Transcription factor binding sites by QIAGEN in the ZNF169 gene promoter:
  • Cdc5
  • CP2
  • Elk-1
  • HNF-3beta
  • LUN-1
  • MAZR
  • MZF-1
  • NF-kappaB
  • NF-kappaB1
  • RREB-1

Genomic Locations for ZNF169 Gene

Genomic Locations for ZNF169 Gene
chr9:94,259,266-94,303,967
(GRCh38/hg38)
Size:
44,702 bases
Orientation:
Plus strand
chr9:97,021,578-97,065,291
(GRCh37/hg19)
Size:
43,714 bases
Orientation:
Plus strand

Genomic View for ZNF169 Gene

Genes around ZNF169 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF169 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF169 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF169 Gene

Proteins for ZNF169 Gene

  • Protein details for ZNF169 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14929-ZN169_HUMAN
    Recommended name:
    Zinc finger protein 169
    Protein Accession:
    Q14929
    Secondary Accessions:
    • A2AGP5
    • A8K127
    • Q6PI28

    Protein attributes for ZNF169 Gene

    Size:
    603 amino acids
    Molecular mass:
    68488 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47702.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF82431.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF169 Gene

Selected DME Specific Peptides for ZNF169 Gene

Q14929:
  • HQRTHTGEKPY
  • CRECGRGF

Post-translational modifications for ZNF169 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF169 Gene

Domains & Families for ZNF169 Gene

Gene Families for ZNF169 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF169 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF169 Gene

GenScript: Design optimal peptide antigens:
  • Krueppel-type zinc finger protein (Q14928_HUMAN)
  • Zinc finger protein 169, isoform CRA_e (Q5SR55_HUMAN)
  • ZNF169 protein (Q6PIG1_HUMAN)
  • Zinc finger protein 169, isoform CRA_d (Q6PJ92_HUMAN)
  • ZNF169 protein (Q7Z761_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14929

UniProtKB/Swiss-Prot:

ZN169_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF169: view

Function for ZNF169 Gene

Molecular function for ZNF169 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 169 (C2H2,Kruppel-like)

Enzyme Numbers (IUBMB) for ZNF169 Gene

Phenotypes From GWAS Catalog for ZNF169 Gene

Gene Ontology (GO) - Molecular Function for ZNF169 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF169: view
genes like me logo Genes that share phenotypes with ZNF169: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF169

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF169 Gene

Localization for ZNF169 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF169 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF169 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF169 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF169: view

Pathways & Interactions for ZNF169 Gene

genes like me logo Genes that share pathways with ZNF169: view

Pathways by source for ZNF169 Gene

2 Reactome pathways for ZNF169 Gene
1 KEGG pathway for ZNF169 Gene

Gene Ontology (GO) - Biological Process for ZNF169 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF169: view

No data available for SIGNOR curated interactions for ZNF169 Gene

Drugs & Compounds for ZNF169 Gene

No Compound Related Data Available

Transcripts for ZNF169 Gene

mRNA/cDNA for ZNF169 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF169

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF169 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for ZNF169 Gene

GeneLoc Exon Structure for
ZNF169

Expression for ZNF169 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF169 Gene

Protein differential expression in normal tissues from HIPED for ZNF169 Gene

This gene is overexpressed in Platelet (43.5), Plasma (11.8), and Lung (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF169 Gene



Protein tissue co-expression partners for ZNF169 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF169

SOURCE GeneReport for Unigene cluster for ZNF169 Gene:

Hs.387623

mRNA Expression by UniProt/SwissProt for ZNF169 Gene:

Q14929-ZN169_HUMAN
Tissue specificity: Highly expressed in kidney, weakly expressed in heart, liver, spleen, and small intestine. Not expressed in adult brain or spinal cord.

Evidence on tissue expression from TISSUES for ZNF169 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF169: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF169 Gene

Orthologs for ZNF169 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF169 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF169 30 31
  • 99.23 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF169 30 31
  • 81.38 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF169 30
  • 81.1 (n)
Rat
(Rattus norvegicus)
Mammalia Zfp169 30
  • 72.28 (n)
Mouse
(Mus musculus)
Mammalia Zfp169 30 17 31
  • 72.26 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSF2 33
Species where no ortholog for ZNF169 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF169 Gene

ENSEMBL:
Gene Tree for ZNF169 (if available)
TreeFam:
Gene Tree for ZNF169 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF169: view image

Paralogs for ZNF169 Gene

(533) SIMAP similar genes for ZNF169 Gene using alignment to 7 proteins:

  • ZN169_HUMAN
  • Q14928_HUMAN
  • Q5SR55_HUMAN
  • Q6PIG1_HUMAN
  • Q6PJ92_HUMAN
  • Q7Z761_HUMAN
  • S4R440_HUMAN
genes like me logo Genes that share paralogs with ZNF169: view

Variants for ZNF169 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF169 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs12236219 - p.Arg381Cys
rs12350212 - p.Gln596His
rs1536690 - p.Pro72Leu
rs34433105 - p.Ser152Leu
rs35177967 - p.Glu78Lys

Additional dbSNP identifiers (rs#s) for ZNF169 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF169 Gene

Variant ID Type Subtype PubMed ID
dgv1491e214 CNV gain 21293372
esv1152524 CNV insertion 17803354
esv2761545 CNV gain 21179565
esv3621113 CNV gain 21293372
esv3621119 CNV gain 21293372
nsv1046906 CNV gain 25217958
nsv1112196 CNV deletion 24896259
nsv1135294 CNV deletion 24896259
nsv831655 CNV gain 17160897
nsv968732 CNV duplication 23825009

Variation tolerance for ZNF169 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.47; 88.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF169 Gene

Human Gene Mutation Database (HGMD)
ZNF169
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF169

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF169 Gene

Disorders for ZNF169 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF169 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
malignant essential hypertension
  • accelerated essential hypertension
multiple self-healing squamous epithelioma
  • multiple self-healing squamous epithelioma, susceptibility to
hereditary sensory neuropathy
  • familial dysautonomia, type ii
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF169

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF169: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF169 Gene

Publications for ZNF169 Gene

  1. Characterization of a YAC contig containing the NBCCS locus and a novel Kruppel-type zinc finger sequence on chromosome segment 9q22.3. (PMID: 9071574) Chidambaram A … Dean M (Genes, chromosomes & cancer 1997) 2 3 4
  2. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. (PMID: 22344221) Okada Y … Tanaka T (Nature genetics 2012) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: placement of a novel zinc finger gene within the NBCCS and ESS1 region. (PMID: 9186526) Levanat S … Bale AE (Cytogenetics and cell genetics 1997) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF169 Gene

Sources for ZNF169 Gene