This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded protein may play a role in spermatogenesis. [provided by RefSeq, Jul 2008] See more...

Aliases for ZNF165 Gene

Aliases for ZNF165 Gene

  • Zinc Finger Protein 165 2 3 4 5
  • Cancer/Testis Antigen 53 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 7 3 4
  • ZSCAN7 3 4
  • CT53 3 4
  • LD65 3 4
  • ZPF165 4

External Ids for ZNF165 Gene

Previous GeneCards Identifiers for ZNF165 Gene

  • GC06P028106
  • GC06P028155
  • GC06P028159
  • GC06P028164
  • GC06P028165
  • GC06P028046
  • GC06P027856

Summaries for ZNF165 Gene

Entrez Gene Summary for ZNF165 Gene

  • This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded protein may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF165 Gene

ZNF165 (Zinc Finger Protein 165) is a Protein Coding gene. Diseases associated with ZNF165 include Suppurative Thyroiditis. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZSCAN30.

UniProtKB/Swiss-Prot Summary for ZNF165 Gene

Gene Wiki entry for ZNF165 Gene

Additional gene information for ZNF165 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF165 Gene

Genomics for ZNF165 Gene

GeneHancer (GH) Regulatory Elements for ZNF165 Gene

Promoters and enhancers for ZNF165 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF165 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF165

Top Transcription factor binding sites by QIAGEN in the ZNF165 gene promoter:
  • AML1a
  • En-1
  • HSF1 (long)
  • HSF1short
  • MyoD
  • p53
  • Sox5
  • TBP
  • TFIID

Genomic Locations for ZNF165 Gene

Genomic Locations for ZNF165 Gene
chr6:28,080,568-28,089,563
(GRCh38/hg38)
Size:
8,996 bases
Orientation:
Plus strand
chr6:28,048,482-28,057,341
(GRCh37/hg19)
Size:
8,860 bases
Orientation:
Plus strand

Genomic View for ZNF165 Gene

Genes around ZNF165 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF165 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF165 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF165 Gene

Proteins for ZNF165 Gene

  • Protein details for ZNF165 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49910-ZN165_HUMAN
    Recommended name:
    Zinc finger protein 165
    Protein Accession:
    P49910

    Protein attributes for ZNF165 Gene

    Size:
    485 amino acids
    Molecular mass:
    55771 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF165 Gene

Post-translational modifications for ZNF165 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF165 Gene

No data available for DME Specific Peptides for ZNF165 Gene

Domains & Families for ZNF165 Gene

Gene Families for ZNF165 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF165 Gene

Blocks:
  • C2H2-type zinc finger signature
  • Transcriptional regulator SCAN
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF165 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 165 (Q53Z40_HUMAN)
  • ZNF165 protein (Q8IY56_HUMAN)
  • Zinc finger and SCAN domain-containing protein 7 (ZN165_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49910

UniProtKB/Swiss-Prot:

ZN165_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF165: view

Function for ZNF165 Gene

Molecular function for ZNF165 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 165,C2H2 type,Kruppel-like,specifically expressed in testis

Phenotypes From GWAS Catalog for ZNF165 Gene

Gene Ontology (GO) - Molecular Function for ZNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF165: view
genes like me logo Genes that share phenotypes with ZNF165: view

Animal Model Products

CRISPR Products

miRNA for ZNF165 Gene

miRTarBase miRNAs that target ZNF165
Targeted motifs for ZNF165 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF165
  • Consensus sequence: AAGGKGRCGCAGGCA Submotif: canonical Cell Type: WHIM12 GEO ID: GSE65937

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF165 Gene

Localization for ZNF165 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF165 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF165 gene
Compartment Confidence
nucleus 4
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF165: view

Pathways & Interactions for ZNF165 Gene

PathCards logo

SuperPathways for ZNF165 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042552 myelination IBA 21873635
GO:0045892 negative regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with ZNF165: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF165 Gene

Drugs & Compounds for ZNF165 Gene

No Compound Related Data Available

Transcripts for ZNF165 Gene

mRNA/cDNA for ZNF165 Gene

5 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF165 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: - -
SP3: -
SP4: - - - -

Relevant External Links for ZNF165 Gene

GeneLoc Exon Structure for
ZNF165

Expression for ZNF165 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF165 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF165 Gene

This gene is overexpressed in Testis (x11.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF165

SOURCE GeneReport for Unigene cluster for ZNF165 Gene:

Hs.55481

mRNA Expression by UniProt/SwissProt for ZNF165 Gene:

P49910-ZN165_HUMAN
Tissue specificity: Expressed specifically in testis.
genes like me logo Genes that share expression patterns with ZNF165: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF165 Gene

Orthologs for ZNF165 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF165 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF165 31 30
  • 99.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF165 31 30
  • 86.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF165 30
  • 84.24 (n)
Species where no ortholog for ZNF165 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF165 Gene

ENSEMBL:
Gene Tree for ZNF165 (if available)
TreeFam:
Gene Tree for ZNF165 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF165: view image

Paralogs for ZNF165 Gene

(390) SIMAP similar genes for ZNF165 Gene using alignment to 3 proteins:

  • ZN165_HUMAN
  • Q53Z40_HUMAN
  • Q8IY56_HUMAN
genes like me logo Genes that share paralogs with ZNF165: view

Variants for ZNF165 Gene

Additional dbSNP identifiers (rs#s) for ZNF165 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF165 Gene

Variant ID Type Subtype PubMed ID
dgv1005n67 CNV gain 20364138
esv33436 CNV gain 17666407
nsv830619 CNV loss 17160897

Variation tolerance for ZNF165 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF165 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF165

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF165 Gene

Disorders for ZNF165 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF165 Gene - From: DISEASES

Disorder Aliases PubMed IDs
suppurative thyroiditis
  • acute suppurative thyroiditis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF165

genes like me logo Genes that share disorders with ZNF165: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF165 Gene

Publications for ZNF165 Gene

  1. Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis. (PMID: 7490084) Tirosvoutis KN … Affara NA (Genomics 1995) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 54
  4. Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain. (PMID: 9244436) Lee PL … Beutler E (Genomics 1997) 3 4 54
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 54

Products for ZNF165 Gene