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Aliases for ZNF165 Gene

Aliases for ZNF165 Gene

  • Zinc Finger Protein 165 2 3 5
  • Cancer/Testis Antigen 53 2 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 7 3 4
  • ZSCAN7 3 4
  • CT53 3 4
  • LD65 3 4
  • ZPF165 4

External Ids for ZNF165 Gene

Previous GeneCards Identifiers for ZNF165 Gene

  • GC06P028106
  • GC06P028155
  • GC06P028159
  • GC06P028164
  • GC06P028165
  • GC06P028046
  • GC06P027856

Summaries for ZNF165 Gene

Entrez Gene Summary for ZNF165 Gene

  • This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded protein may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF165 Gene

ZNF165 (Zinc Finger Protein 165) is a Protein Coding gene. Diseases associated with ZNF165 include Suppurative Thyroiditis. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZSCAN30.

UniProtKB/Swiss-Prot for ZNF165 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF165 Gene

Additional gene information for ZNF165 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF165 Gene

Genomics for ZNF165 Gene

GeneHancer (GH) Regulatory Elements for ZNF165 Gene

Promoters and enhancers for ZNF165 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I028079 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 560.9 0.0 -38 3.1 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF165 LOC102724889 ZNF603P ZKSCAN8 ZKSCAN3 ZSCAN12 ZSCAN9 ZKSCAN4 PGBD1 OR2B8P
GH06I027834 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 -243.4 -243411 6.4 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 SP3 NFYC MEF2D HIST1H2BN HIST1H2AK GC06M027849 ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN9 ZSCAN12 HIST1H3J GUSBP2
GH06I028266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.7 +186.8 186782 2.4 HDGF SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ENSG00000276302 ZSCAN26 ZSCAN12 ZKSCAN3 ZKSCAN8 ZSCAN31 ZKSCAN4 ZNF603P PGBD1 ZNF391
GH06I028135 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 10.2 +56.5 56494 3.6 ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZKSCAN8 ENSG00000261839 ZSCAN16-AS1 ZKSCAN3 ZKSCAN4 ZSCAN12 ZNF603P ZSCAN9 TRIM27 ZSCAN31
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF165 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF165 gene promoter:

Genomic Locations for ZNF165 Gene

Genomic Locations for ZNF165 Gene
8,860 bases
Plus strand

Genomic View for ZNF165 Gene

Genes around ZNF165 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF165 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF165 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF165 Gene

Proteins for ZNF165 Gene

  • Protein details for ZNF165 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 165
    Protein Accession:

    Protein attributes for ZNF165 Gene

    485 amino acids
    Molecular mass:
    55771 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF165 Gene

Post-translational modifications for ZNF165 Gene

No Post-translational modifications

Other Protein References for ZNF165 Gene

No data available for DME Specific Peptides for ZNF165 Gene

Domains & Families for ZNF165 Gene

Gene Families for ZNF165 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF165 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF165: view

Function for ZNF165 Gene

Molecular function for ZNF165 Gene

GENATLAS Biochemistry:
zinc finger protein 165,C2H2 type,Kruppel-like,specifically expressed in testis
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF165 Gene

Gene Ontology (GO) - Molecular Function for ZNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF165: view
genes like me logo Genes that share phenotypes with ZNF165: view

miRNA for ZNF165 Gene

miRTarBase miRNAs that target ZNF165
Targeted motifs for ZNF165 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF165
  • Consensus sequence: AAGGKGRCGCAGGCA Submotif: canonical Cell Type: WHIM12 GEO ID: GSE65937

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF165 Gene

Localization for ZNF165 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF165 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF165 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF165: view

Pathways & Interactions for ZNF165 Gene

SuperPathways for ZNF165 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF165: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF165 Gene

Drugs & Compounds for ZNF165 Gene

No Compound Related Data Available

Transcripts for ZNF165 Gene

mRNA/cDNA for ZNF165 Gene

(6) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF165 Gene

Zinc finger protein 165:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF165 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5
SP2: - -
SP3: -
SP4: - - - -

Relevant External Links for ZNF165 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF165 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF165 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF165 Gene

This gene is overexpressed in Testis (x11.7).

NURSA nuclear receptor signaling pathways regulating expression of ZNF165 Gene:


SOURCE GeneReport for Unigene cluster for ZNF165 Gene:


mRNA Expression by UniProt/SwissProt for ZNF165 Gene:

Tissue specificity: Expressed specifically in testis.
genes like me logo Genes that share expression patterns with ZNF165: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF165 Gene

Orthologs for ZNF165 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF165 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF165 33 34
  • 99.59 (n)
(Bos Taurus)
Mammalia ZNF165 33 34
  • 86.19 (n)
(Canis familiaris)
Mammalia ZNF165 33
  • 84.24 (n)
Species where no ortholog for ZNF165 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF165 Gene

Gene Tree for ZNF165 (if available)
Gene Tree for ZNF165 (if available)

Paralogs for ZNF165 Gene

(390) SIMAP similar genes for ZNF165 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF165: view

Variants for ZNF165 Gene

Sequence variations from dbSNP and Humsavar for ZNF165 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000085812 -- 28,092,467(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000403003 -- 28,084,892(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000604228 -- 28,084,546(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000940371 -- 28,099,648(+) A/C genic_downstream_transcript_variant, intron_variant
rs1001106057 -- 28,079,072(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF165 Gene

Variant ID Type Subtype PubMed ID
nsv830619 CNV loss 17160897
esv33436 CNV gain 17666407
dgv1005n67 CNV gain 20364138

Variation tolerance for ZNF165 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF165 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF165 Gene

Disorders for ZNF165 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF165 Gene - From: DISEASES

Disorder Aliases PubMed IDs
suppurative thyroiditis
  • acute suppurative thyroiditis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF165

genes like me logo Genes that share disorders with ZNF165: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF165 Gene

Publications for ZNF165 Gene

  1. Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis. (PMID: 7490084) Tirosvoutis KN … Affara NA (Genomics 1995) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  4. Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain. (PMID: 9244436) Lee PL … Beutler E (Genomics 1997) 3 4 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF165 Gene

Sources for ZNF165 Gene

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