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Aliases for ZNF160 Gene

Aliases for ZNF160 Gene

  • Zinc Finger Protein 160 2 3 3 5
  • Zinc Finger Protein HZF5 3 4
  • Zinc Finger Protein Kr18 3 4
  • HKr18 3 4
  • KRAB Zinc Finger Protein KR18 3
  • Zinc Finger Protein 5 3
  • KIAA1611 4
  • HZF5 3
  • KR18 3
  • F11 3

External Ids for ZNF160 Gene

Previous GeneCards Identifiers for ZNF160 Gene

  • GC19U990141
  • GC19M058102
  • GC19M058260
  • GC19M053569
  • GC19M049897

Summaries for ZNF160 Gene

Entrez Gene Summary for ZNF160 Gene

  • The protein encoded by this gene is a Kruppel-related zinc finger protein which is characterized by the presence of an N-terminal repressor domain, the Kruppel-associated box (KRAB). The KRAB domain is a potent repressor of transcription; thus this protein may function in transcription regulation. Multiple transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]

GeneCards Summary for ZNF160 Gene

ZNF160 (Zinc Finger Protein 160) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF347.

UniProtKB/Swiss-Prot for ZNF160 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF160 Gene

Additional gene information for ZNF160 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF160 Gene

Genomics for ZNF160 Gene

GeneHancer (GH) Regulatory Elements for ZNF160 Gene

Promoters and enhancers for ZNF160 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J053097 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 668.6 +2.6 2553 7.3 HDGF ATF1 ARNT ARID4B SIN3A DMAP1 YY1 ETS1 POLR2B GLIS2 ZNF160 ZNF415 ZNF347 TPM3P6 GC19M053068
GH19J052137 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 51.4 +963.8 963839 3.3 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF616 ZNF137P ZNF160 ZNF808 ENSG00000268970 ZNF600 ZNF350 ZNF816 ZNF836 ZNF577
GH19J053977 Promoter/Enhancer 1.7 Ensembl ENCODE 42.3 -876.5 -876491 5.8 HDGF PKNOX1 CLOCK SIN3A FEZF1 ZNF2 ZNF766 ZNF213 ZNF143 SP3 PRPF31 ZNF525 LENG8-AS1 ZNF160 ZNF845 ZNF665 ZNF761 ZNF347 LENG8 ENSG00000235681
GH19J053517 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 30.4 -416.1 -416143 4.8 PKNOX1 SMAD1 ARNT ARID4B SIN3A YY1 ZNF766 E2F8 ZNF143 KLF13 ZNF331 ZNF137P LENG8 ZNF525 LENG8-AS1 ZNF808 PRPF31 CNOT3 ZNF160 ZNF701
GH19J052733 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 21.7 +368.2 368228 2.9 HDGF SMAD1 ARID4B SIN3A ZNF48 YY1 ETS1 POLR2B E2F8 ARID2 ZNF611 ZNF83 ZNF701 ZNF137P ENSG00000268970 ENSG00000269001 ZNF845 ZNF808 ZNF160 ZNF525
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF160 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF160 gene promoter:
  • ATF6
  • Ik-1
  • HTF

Genomic Locations for ZNF160 Gene

Genomic Locations for ZNF160 Gene
chr19:53,064,882-53,103,471
(GRCh38/hg38)
Size:
38,590 bases
Orientation:
Minus strand
chr19:53,569,859-53,606,689
(GRCh37/hg19)
Size:
36,831 bases
Orientation:
Minus strand

Genomic View for ZNF160 Gene

Genes around ZNF160 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF160 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF160 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF160 Gene

Proteins for ZNF160 Gene

  • Protein details for ZNF160 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCG1-ZN160_HUMAN
    Recommended name:
    Zinc finger protein 160
    Protein Accession:
    Q9HCG1
    Secondary Accessions:
    • Q14589
    • Q504Q8
    • Q96JC5
    • Q9BVY9
    • Q9H7N6

    Protein attributes for ZNF160 Gene

    Size:
    818 amino acids
    Molecular mass:
    94112 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA55528.1; Type=Miscellaneous discrepancy; Note=Dubious alternative splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF160 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF160 Gene

Post-translational modifications for ZNF160 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF160 Gene

Domains & Families for ZNF160 Gene

Gene Families for ZNF160 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF160 Gene

Suggested Antigen Peptide Sequences for ZNF160 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCG1

UniProtKB/Swiss-Prot:

ZN160_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF160: view

Function for ZNF160 Gene

Molecular function for ZNF160 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 160 (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF160 Gene

Gene Ontology (GO) - Molecular Function for ZNF160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF160: view
genes like me logo Genes that share phenotypes with ZNF160: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF160 Gene

Localization for ZNF160 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF160 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF160 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF160: view

Pathways & Interactions for ZNF160 Gene

SuperPathways for ZNF160 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF160: view

Pathways by source for ZNF160 Gene

2 Reactome pathways for ZNF160 Gene

Gene Ontology (GO) - Biological Process for ZNF160 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0030097 hemopoiesis NAS 11410164
genes like me logo Genes that share ontologies with ZNF160: view

No data available for SIGNOR curated interactions for ZNF160 Gene

Drugs & Compounds for ZNF160 Gene

No Compound Related Data Available

Transcripts for ZNF160 Gene

Unigene Clusters for ZNF160 Gene

Zinc finger protein 160:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF160 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - -
SP4: - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - -
SP8:
SP9:
SP10: - -

Relevant External Links for ZNF160 Gene

GeneLoc Exon Structure for
ZNF160
ECgene alternative splicing isoforms for
ZNF160

Expression for ZNF160 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF160 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF160 Gene

This gene is overexpressed in Plasma (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF160 Gene



Protein tissue co-expression partners for ZNF160 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF160 Gene:

ZNF160

SOURCE GeneReport for Unigene cluster for ZNF160 Gene:

Hs.655967

mRNA Expression by UniProt/SwissProt for ZNF160 Gene:

Q9HCG1-ZN160_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ZNF160 Gene

  • Nervous system(4.5)
  • Spleen(4.4)
genes like me logo Genes that share expression patterns with ZNF160: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF160 Gene

Orthologs for ZNF160 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF160 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF160 33
  • 99.43 (n)
-- 34
  • 51 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 49 (a)
ManyToMany
-- 34
  • 49 (a)
ManyToMany
-- 34
  • 49 (a)
ManyToMany
-- 34
  • 48 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp52 34
  • 40 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
-- 34
  • 37 (a)
ManyToMany
CSA.1668 34
  • 32 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
Species where no ortholog for ZNF160 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF160 Gene

ENSEMBL:
Gene Tree for ZNF160 (if available)
TreeFam:
Gene Tree for ZNF160 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF160: view image

Paralogs for ZNF160 Gene

(548) SIMAP similar genes for ZNF160 Gene using alignment to 6 proteins:

  • ZN160_HUMAN
  • M0QXU9_HUMAN
  • M0QZ49_HUMAN
  • M0QZI7_HUMAN
  • M0R285_HUMAN
  • Q9BVY9_HUMAN

Pseudogenes.org Pseudogenes for ZNF160 Gene

genes like me logo Genes that share paralogs with ZNF160: view

Variants for ZNF160 Gene

Sequence variations from dbSNP and Humsavar for ZNF160 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000053899 -- 53,085,622(-) C/T intron_variant
rs1000054033 -- 53,075,667(-) C/T intron_variant
rs1000101948 -- 53,081,722(-) A/C intron_variant
rs1000127843 -- 53,070,693(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000245652 -- 53,077,470(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF160 Gene

Variant ID Type Subtype PubMed ID
dgv429n27 CNV gain 19166990
dgv6533n54 CNV gain 21841781
dgv6534n54 CNV loss 21841781
esv2488809 CNV deletion 19546169
esv2718787 CNV deletion 23290073
esv2718810 CNV deletion 23290073
esv2758769 CNV loss 17122850
esv3347755 CNV insertion 20981092
esv3644737 CNV loss 21293372
esv3644738 CNV gain 21293372
esv3893239 CNV gain+loss 25118596
esv8151 CNV loss 19470904
nsv1061016 CNV gain 25217958
nsv1071944 CNV deletion 25765185
nsv1078889 OTHER inversion 25765185
nsv1134808 CNV deletion 24896259
nsv1141887 OTHER inversion 24896259
nsv428370 CNV loss 18775914
nsv435700 CNV deletion 17901297
nsv470153 CNV loss 18288195
nsv515862 CNV gain+loss 19592680
nsv527053 CNV gain 19592680
nsv580068 CNV gain 21841781
nsv580071 CNV gain+loss 21841781
nsv963073 CNV duplication 23825009
nsv963074 CNV duplication 23825009
nsv9748 CNV gain 18304495
nsv978844 CNV duplication 23825009

Variation tolerance for ZNF160 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF160 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF160

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF160 Gene

Disorders for ZNF160 Gene

Additional Disease Information for ZNF160

No disorders were found for ZNF160 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF160 Gene

Publications for ZNF160 Gene

  1. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 2 3 4 58
  2. Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19. (PMID: 11410164) Mark C … Hellman L (DNA and cell biology 2001) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  4. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  5. A novel C2H2 zinc-finger protein gene (ZNF160) maps to human chromosome 19q13.3-q13.4. (PMID: 7774943) Halford S … Scambler PJ (Genomics 1995) 2 3 58

Products for ZNF160 Gene

Sources for ZNF160 Gene

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