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Aliases for ZNF16 Gene

Aliases for ZNF16 Gene

  • Zinc Finger Protein 16 2 3 3 5
  • Zinc Finger Protein KOX9 3 4
  • HZF1 3 4
  • KOX9 3 4
  • Zinc Finger Protein Kruppel Type 9 3
  • Zinc Finger Protein 16 (KOX 9) 2

External Ids for ZNF16 Gene

Previous GeneCards Identifiers for ZNF16 Gene

  • GC08M143762
  • GC08M146192
  • GC08M145603
  • GC08M146004
  • GC08M146006
  • GC08M146126
  • GC08M141271
  • GC08M146155

Summaries for ZNF16 Gene

Entrez Gene Summary for ZNF16 Gene

  • The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in the differentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes on chromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

GeneCards Summary for ZNF16 Gene

ZNF16 (Zinc Finger Protein 16) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZNF569.

UniProtKB/Swiss-Prot for ZNF16 Gene

  • Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis.

Gene Wiki entry for ZNF16 Gene

Additional gene information for ZNF16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF16 Gene

Genomics for ZNF16 Gene

GeneHancer (GH) Regulatory Elements for ZNF16 Gene

Promoters and enhancers for ZNF16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J144948 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 662.1 +0.7 689 2.6 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZBTB7B ZNF48 YY1 ETS1 SLC30A9 ZNF16 ZNF7 CPSF1 VPS28 ADCK5 SLC52A2 COMMD5 LRRC14 GPAA1 ZNF252P
GH08J144101 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 69 +847.0 846977 4 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 NFYC SHARPIN MAF1 ZNF623 ZNF7 ZNF16 ZNF251 ZNF250 ZNF517 CPSF1 ZNF696
GH08J144455 Enhancer 1.3 Ensembl ENCODE 89.2 +494.4 494442 1.6 HDGF HNRNPUL1 PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF2 YY1 POLR2B ZNF251 ZNF7 ZNF623 LRRC14 ZNF250 CPSF1 ZNF16 VPS28 ZNF517 GPAA1
GH08J144899 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 28.2 +49.3 49297 3.6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 ZNF250 ZNF7 CPSF1 VPS28 RPL8 SLC52A2 GPAA1 COMMD5 LRRC14 ZNF16
GH08J143968 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 24.5 +976.6 976648 11 HDGF CLOCK FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 PLEC ZNF623 ZNF7 ZNF251 LRRC14 ZNF16 CPSF1 GPAA1 WDR97 ZNF707
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF16 gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2
  • GATA-1

Genomic Locations for ZNF16 Gene

Genomic Locations for ZNF16 Gene
chr8:144,930,358-144,950,888
(GRCh38/hg38)
Size:
20,531 bases
Orientation:
Minus strand
chr8:146,155,744-146,176,274
(GRCh37/hg19)
Size:
20,531 bases
Orientation:
Minus strand

Genomic View for ZNF16 Gene

Genes around ZNF16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF16 Gene

Proteins for ZNF16 Gene

  • Protein details for ZNF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17020-ZNF16_HUMAN
    Recommended name:
    Zinc finger protein 16
    Protein Accession:
    P17020
    Secondary Accessions:
    • B3KXM4
    • D3DWP2
    • Q45SH7
    • Q96FG0
    • Q9NRA4

    Protein attributes for ZNF16 Gene

    Size:
    682 amino acids
    Molecular mass:
    76472 Da
    Quaternary structure:
    • Interacts with INCA1; the interaction inhibits INCA1 activity and induces the cell cycle process.
    SequenceCaution:
    • Sequence=AAF75235.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAZ20773.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF16 Gene

Post-translational modifications for ZNF16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF16 Gene

Domains & Families for ZNF16 Gene

Gene Families for ZNF16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF16 Gene

Suggested Antigen Peptide Sequences for ZNF16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17020

UniProtKB/Swiss-Prot:

ZNF16_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF16: view

Function for ZNF16 Gene

Molecular function for ZNF16 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by hemin during erythroid differentiation. Up-regulated by phorbol myristate acetate (PMA) during megakaryocytic differentiation. Up-regulated by the transcriptional activator MEF2A.
GENATLAS Biochemistry:
zinc finger protein 16 (KOX9) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF16 Gene

Gene Ontology (GO) - Molecular Function for ZNF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 21874239
genes like me logo Genes that share ontologies with ZNF16: view
genes like me logo Genes that share phenotypes with ZNF16: view

Animal Model Products

Targeted motifs for ZNF16 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF16
  • Consensus sequence: MACCTTCYATGGCTCCCTAKTGCCY Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA and Transcription Factor Targets for ZNF16 Gene

Localization for ZNF16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF16 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 16628192
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZNF16: view

Pathways & Interactions for ZNF16 Gene

SuperPathways for ZNF16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007049 cell cycle IEA --
GO:0008284 positive regulation of cell proliferation IDA 21874239
genes like me logo Genes that share ontologies with ZNF16: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF16 Gene

Drugs & Compounds for ZNF16 Gene

No Compound Related Data Available

Transcripts for ZNF16 Gene

Unigene Clusters for ZNF16 Gene

Zinc finger protein 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF16 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - -

Relevant External Links for ZNF16 Gene

GeneLoc Exon Structure for
ZNF16
ECgene alternative splicing isoforms for
ZNF16

Expression for ZNF16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF16 Gene

Protein differential expression in normal tissues from HIPED for ZNF16 Gene

This gene is overexpressed in Lung (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF16 Gene



Protein tissue co-expression partners for ZNF16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF16 Gene:

ZNF16

SOURCE GeneReport for Unigene cluster for ZNF16 Gene:

Hs.493225

mRNA Expression by UniProt/SwissProt for ZNF16 Gene:

P17020-ZNF16_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ZNF16 Gene

  • Bone marrow(4)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with ZNF16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF16 Gene

Orthologs for ZNF16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF16 34 33
  • 99.07 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF16 33
  • 85.69 (n)
cow
(Bos Taurus)
Mammalia ZNF16 34 33
  • 78.24 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF16 34
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 46 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489533 33
  • 56.55 (n)
zebrafish
(Danio rerio)
Actinopterygii BX927130.1 34
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14711 35
  • 47 (a)
dwg 35
  • 43 (a)
CG17385 35
  • 41 (a)
CG4936 35
  • 41 (a)
BG:DS02740.8 35
  • 37 (a)
CG7987 35
  • 31 (a)
CG2129 35
  • 29 (a)
CG2052 35
  • 29 (a)
CG8301 35
  • 29 (a)
Species where no ortholog for ZNF16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF16 Gene

ENSEMBL:
Gene Tree for ZNF16 (if available)
TreeFam:
Gene Tree for ZNF16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF16: view image

Paralogs for ZNF16 Gene

(505) SIMAP similar genes for ZNF16 Gene using alignment to 4 proteins:

  • ZNF16_HUMAN
  • E9PNT9_HUMAN
  • E9PQV1_HUMAN
  • L8EAK2_HUMAN
genes like me logo Genes that share paralogs with ZNF16: view

Variants for ZNF16 Gene

Sequence variations from dbSNP and Humsavar for ZNF16 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000144827 -- 144,936,076(-) C/G intron_variant
rs1000276905 -- 144,950,844(-) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000299480 -- 144,941,977(-) TTTTTTTTTTTTTTTTTTT/TTTTTTTTTTT/TTTTTTTTTTTT/TTTTTTTTTTTTTTTTTT intron_variant
rs1000537313 -- 144,939,405(-) G/A intron_variant
rs1000860790 -- 144,948,684(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF16 Gene

Variant ID Type Subtype PubMed ID
nsv1016357 CNV gain 25217958
nsv1031737 CNV gain 25217958
nsv1032588 CNV loss 25217958
nsv1149224 CNV deletion 26484159
nsv469809 CNV loss 16826518
nsv519737 CNV loss 19592680
nsv524560 CNV gain 19592680
nsv612970 CNV gain 21841781
nsv612971 CNV loss 21841781
nsv612972 CNV gain 21841781
esv990431 CNV insertion 20482838
esv3619144 CNV loss 21293372
esv28548 CNV gain+loss 19812545
esv2761199 CNV gain+loss 21179565
esv2759653 CNV loss 17122850
esv2669134 CNV deletion 23128226
esv2664252 CNV deletion 23128226
esv2080072 CNV deletion 18987734
esv1750274 CNV insertion 17803354
esv1592346 CNV insertion 17803354
esv1336384 CNV insertion 17803354
dgv7338n100 CNV gain 25217958
dgv7337n100 CNV loss 25217958

Variation tolerance for ZNF16 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.27; 52.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF16

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF16 Gene

Disorders for ZNF16 Gene

Additional Disease Information for ZNF16

No disorders were found for ZNF16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF16 Gene

Publications for ZNF16 Gene

  1. Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1. (PMID: 21874239) Li XB … Zhang JW (Molecular medicine reports 2011) 3 4 58
  2. Identification of HZF1 as a novel target gene of the MEF2 transcription factor. (PMID: 21468593) Liu X … Li XQ (Molecular medicine reports 2011) 3 4 58
  3. Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16). (PMID: 19763908) Deng MJ … Zhang JW (Molecular biotechnology 2010) 3 4 58
  4. Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells. (PMID: 16628192) Peng H … Zhang JW (Leukemia 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ZNF16 Gene

Sources for ZNF16 Gene

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