This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. [provided by RefSeq, Jul 2008] See more...

Aliases for ZNF157 Gene

Aliases for ZNF157 Gene

  • Zinc Finger Protein 157 2 3 4 5
  • Zinc Finger Protein HZF22 3 4
  • Zinc Finger Protein 157 (HZF22) 2
  • Zinc Finger Protein 22 3
  • HZF22 3

External Ids for ZNF157 Gene

Previous GeneCards Identifiers for ZNF157 Gene

  • GC0XP046032
  • GC0XP045490
  • GC0XP046275
  • GC0XP046986
  • GC0XP047114
  • GC0XP047230
  • GC0XP044943

Summaries for ZNF157 Gene

Entrez Gene Summary for ZNF157 Gene

  • This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF157 Gene

ZNF157 (Zinc Finger Protein 157) is a Protein Coding gene. Diseases associated with ZNF157 include Cleft Palate With Or Without Ankyloglossia, X-Linked and Ankyloglossia With Or Without Tooth Anomalies. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF33B.

UniProtKB/Swiss-Prot Summary for ZNF157 Gene

Additional gene information for ZNF157 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF157 Gene

Genomics for ZNF157 Gene

GeneHancer (GH) Regulatory Elements for ZNF157 Gene

Promoters and enhancers for ZNF157 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ047365 Promoter/Enhancer 1.5 EPDnew ENCODE CraniofacialAtlas 500.7 -4.2 -4196 1.2 ZNF217 EP300 SP1 BCLAF1 JUND SIX5 ZNF10 ZIC2 ZBTB10 RFX1 ZNF157 piR-33804-182 RF00017-8385 RF00017-8390
GH0XJ047216 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10 -152.0 -151979 5.2 FOXK2 ZNF217 ZSCAN5C SIN3A NRF1 POLR2G SP1 BCLAF1 PHF8 JUND CDK16 LOC105373194 USP11 ZNF674 ZNF182 KRBOX4 ENSG00000232009 SNORA11C ZNF157 ZNF630
GH0XJ047803 Promoter 0.8 Ensembl 9.9 +432.6 432618 0.8 RFX1 ZNF148 SIN3A SALL2 FOXA2 ZBTB17 BDP1 TBP ATF3 POLR2H WASF4P USP11 LINC01560 FTSJ1 ZNF81 ZNF157 ENSG00000228343 piR-58915-002
GH0XJ047360 Promoter/Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas 0.4 -8.6 -8585 2.5 EP300 SP1 FOS ZIC2 TRIM28 CTCF SAP30 RFX1 MEF2C SKI ZNF182 ENSG00000224072 INE1 ZNF81 ZNF41 USP11 SYN1 ZNF157 piR-33804-182 RF00017-8385
GH0XJ047384 Enhancer 0.8 Ensembl ENCODE 0.4 +14.1 14072 0.5 CTCF REST RAD21 TRIM22 SMC3 ZNF654 KLF10 SOX5 YY1 ZNF143 RF00017-8393 ZNF157 RF00017-8385 RF00017-8390
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF157 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF157

Top Transcription factor binding sites by QIAGEN in the ZNF157 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Elk-1
  • FOXF2
  • LUN-1
  • YY1

Genomic Locations for ZNF157 Gene

Genomic Locations for ZNF157 Gene
chrX:47,370,583-47,414,305
(GRCh38/hg38)
Size:
43,723 bases
Orientation:
Plus strand
chrX:47,229,982-47,273,704
(GRCh37/hg19)
Size:
43,723 bases
Orientation:
Plus strand

Genomic View for ZNF157 Gene

Genes around ZNF157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF157 Gene

Proteins for ZNF157 Gene

  • Protein details for ZNF157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51786-ZN157_HUMAN
    Recommended name:
    Zinc finger protein 157
    Protein Accession:
    P51786
    Secondary Accessions:
    • Q96LE9

    Protein attributes for ZNF157 Gene

    Size:
    506 amino acids
    Molecular mass:
    58291 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF157 Gene

Post-translational modifications for ZNF157 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF157 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF157 Gene

Domains & Families for ZNF157 Gene

Gene Families for ZNF157 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF157 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF157 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein HZF22 (ZN157_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51786

UniProtKB/Swiss-Prot:

ZN157_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF157: view

Function for ZNF157 Gene

Molecular function for ZNF157 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger 157 (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF157 Gene

Gene Ontology (GO) - Molecular Function for ZNF157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS 8586441
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF157: view
genes like me logo Genes that share phenotypes with ZNF157: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF157

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF157 Gene

Localization for ZNF157 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF157 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF157 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF157: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF157 Gene

Pathways & Interactions for ZNF157 Gene

genes like me logo Genes that share pathways with ZNF157: view

Pathways by source for ZNF157 Gene

2 Reactome pathways for ZNF157 Gene
1 KEGG pathway for ZNF157 Gene

Gene Ontology (GO) - Biological Process for ZNF157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 8586441
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF157: view

No data available for SIGNOR curated interactions for ZNF157 Gene

Drugs & Compounds for ZNF157 Gene

No Compound Related Data Available

Transcripts for ZNF157 Gene

mRNA/cDNA for ZNF157 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF157

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF157 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1:
SP2: -
SP3: - -

Relevant External Links for ZNF157 Gene

GeneLoc Exon Structure for
ZNF157

Expression for ZNF157 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF157 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF157 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.0), Brain - Cerebellum (x4.9), and Pituitary (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF157

SOURCE GeneReport for Unigene cluster for ZNF157 Gene:

Hs.89897

Evidence on tissue expression from TISSUES for ZNF157 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF157: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF157 Gene

Orthologs for ZNF157 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF157 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF157 31 30
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF157 31 30
  • 92.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF157 31 30
  • 89.32 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911510 30
  • 83.57 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
ManyToMany
-- 31
  • 45 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta jim 32
  • 48 (a)
CG15436 32
  • 42 (a)
CG11696 32
  • 30 (a)
Species where no ortholog for ZNF157 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF157 Gene

ENSEMBL:
Gene Tree for ZNF157 (if available)
TreeFam:
Gene Tree for ZNF157 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF157: view image

Paralogs for ZNF157 Gene

Paralogs for ZNF157 Gene

(469) SIMAP similar genes for ZNF157 Gene using alignment to 1 proteins:

  • ZN157_HUMAN
genes like me logo Genes that share paralogs with ZNF157: view

Variants for ZNF157 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF157 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
714914 Benign: not provided 47,413,081(+) G/A SYNONYMOUS_VARIANT
717146 Benign: not provided 47,412,997(+) G/A SYNONYMOUS_VARIANT
734687 Likely Benign: not provided 47,412,387(+) G/C MISSENSE_VARIANT
780689 Benign: not provided 47,413,571(+) A/G MISSENSE_VARIANT
785697 Benign: not provided 47,410,281(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF157 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF157 Gene

Variant ID Type Subtype PubMed ID
esv3558854 CNV deletion 23714750

Variation tolerance for ZNF157 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF157 Gene

Human Gene Mutation Database (HGMD)
ZNF157
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF157

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF157 Gene

Disorders for ZNF157 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF157 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cleft palate with or without ankyloglossia, x-linked
  • cpx
ankyloglossia with or without tooth anomalies
  • ankg
walker-warburg syndrome
  • hydrocephalus, agyria, and retinal dysplasia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF157

genes like me logo Genes that share disorders with ZNF157: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF157 Gene

Publications for ZNF157 Gene

  1. Cloning and characterization of a novel zinc finger gene in Xp11.2. (PMID: 8586441) Derry JM … Francke U (Genomics 1995) 2 3 4 23 54
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. (PMID: 27634302) Oliviero G … Cagney G (Molecular & cellular proteomics : MCP 2016) 3 54
  5. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G … Cagney G (Scientific reports 2015) 3 54

Products for ZNF157 Gene

Sources for ZNF157 Gene