This gene encodes a protein that belongs to the zinc finger Kruppel family of transcriptional regulators, whose members are thought to function in normal and abnormal cell growth and differentiation. Hypermethylation of this gene is associated with the recurrence of non muscle invasive bladder cancer. Alternative splicing results in multiple transcript variants. [provided by Re... See more...

Aliases for ZNF154 Gene

Aliases for ZNF154 Gene

  • Zinc Finger Protein 154 2 3 4 5
  • PHZ-92 2 3
  • Zinc Finger Protein 154 (PHZ-92) 2
  • KIAA2003 4
  • ZNF154 5

External Ids for ZNF154 Gene

Previous GeneCards Identifiers for ZNF154 Gene

  • GC19M059111
  • GC19M058662
  • GC19M062888
  • GC19M062900
  • GC19M058208
  • GC19M054524

Summaries for ZNF154 Gene

Entrez Gene Summary for ZNF154 Gene

  • This gene encodes a protein that belongs to the zinc finger Kruppel family of transcriptional regulators, whose members are thought to function in normal and abnormal cell growth and differentiation. Hypermethylation of this gene is associated with the recurrence of non muscle invasive bladder cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for ZNF154 Gene

ZNF154 (Zinc Finger Protein 154) is a Protein Coding gene. Diseases associated with ZNF154 include Bladder Cancer. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF256.

UniProtKB/Swiss-Prot Summary for ZNF154 Gene

Additional gene information for ZNF154 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF154 Gene

Genomics for ZNF154 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF154 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF154 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF154

Genomic Locations for ZNF154 Gene

Genomic Locations for ZNF154 Gene
chr19:57,696,275-57,709,204
(GRCh38/hg38)
Size:
12,930 bases
Orientation:
Minus strand
chr19:58,208,735-58,220,579
(GRCh37/hg19)
Size:
11,845 bases
Orientation:
Minus strand

Genomic View for ZNF154 Gene

Genes around ZNF154 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF154 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF154 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF154 Gene

Proteins for ZNF154 Gene

  • Protein details for ZNF154 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13106-ZN154_HUMAN
    Recommended name:
    Zinc finger protein 154
    Protein Accession:
    Q13106
    Secondary Accessions:
    • A7MCY3
    • Q8IVG7
    • Q8NAR0

    Protein attributes for ZNF154 Gene

    Size:
    437 amino acids
    Molecular mass:
    49865 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC23100.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF154 Gene

Post-translational modifications for ZNF154 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF154 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF154 Gene

Domains & Families for ZNF154 Gene

Gene Families for ZNF154 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF154 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF154 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 154 (ZN154_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13106

UniProtKB/Swiss-Prot:

ZN154_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF154: view

Function for ZNF154 Gene

Molecular function for ZNF154 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 154 (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF154 Gene

Gene Ontology (GO) - Molecular Function for ZNF154 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF154: view
genes like me logo Genes that share phenotypes with ZNF154: view

Animal Model Products

CRISPR Products

miRNA for ZNF154 Gene

miRTarBase miRNAs that target ZNF154

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF154

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF154 Gene

Localization for ZNF154 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF154 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF154 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF154 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,IEA --
genes like me logo Genes that share ontologies with ZNF154: view

Pathways & Interactions for ZNF154 Gene

genes like me logo Genes that share pathways with ZNF154: view

Pathways by source for ZNF154 Gene

2 Reactome pathways for ZNF154 Gene
1 KEGG pathway for ZNF154 Gene

Interacting Proteins for ZNF154 Gene

Gene Ontology (GO) - Biological Process for ZNF154 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS --
GO:0045892 negative regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF154: view

No data available for SIGNOR curated interactions for ZNF154 Gene

Drugs & Compounds for ZNF154 Gene

No Compound Related Data Available

Transcripts for ZNF154 Gene

mRNA/cDNA for ZNF154 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF154

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF154 Gene

No ASD Table

Relevant External Links for ZNF154 Gene

GeneLoc Exon Structure for
ZNF154

Expression for ZNF154 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF154 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF154

SOURCE GeneReport for Unigene cluster for ZNF154 Gene:

Hs.646378

Evidence on tissue expression from TISSUES for ZNF154 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF154: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF154 Gene

Orthologs for ZNF154 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF154 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF154 30 31
  • 99.62 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC789374 30
  • 82.19 (n)
Dog
(Canis familiaris)
Mammalia ZNF154 30 31
  • 80.07 (n)
OneToOne
Species where no ortholog for ZNF154 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF154 Gene

ENSEMBL:
Gene Tree for ZNF154 (if available)
TreeFam:
Gene Tree for ZNF154 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF154: view image

Paralogs for ZNF154 Gene

(495) SIMAP similar genes for ZNF154 Gene using alignment to 2 proteins:

  • ZN154_HUMAN
  • L8E8L7_HUMAN
genes like me logo Genes that share paralogs with ZNF154: view

Variants for ZNF154 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF154 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2074078 - p.Gly122Val
rs2188736 - p.Leu182Val
rs34282745 - p.His57Arg
rs34746514 - p.Pro384Leu

Additional dbSNP identifiers (rs#s) for ZNF154 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF154 Gene

Variant ID Type Subtype PubMed ID
esv3644907 CNV gain 21293372
nsv1066059 CNV gain 25217958
nsv580402 CNV gain 21841781

Variation tolerance for ZNF154 Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF154 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF154

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF154 Gene

Disorders for ZNF154 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF154 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bladder cancer
  • bladder cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF154: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF154 Gene

Publications for ZNF154 Gene

  1. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PMID: 7557990) Tommerup N … Vissing H (Genomics 1995) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Silenced ZNF154 Is Associated with Longer Survival in Resectable Pancreatic Cancer. (PMID: 31683647) Wiesmueller F … Grützmann R (International journal of molecular sciences 2019) 3
  4. ZNF154 is a promising diagnosis biomarker and predicts biochemical recurrence in prostate cancer. (PMID: 29966681) Zhang W … Ran L (Gene 2018) 3
  5. Recurrent patterns of DNA methylation in the ZNF154, CASP8, and VHL promoters across a wide spectrum of human solid epithelial tumors and cancer cell lines. (PMID: 24149212) Sánchez-Vega F … Elnitski L (Epigenetics 2013) 3

Products for ZNF154 Gene

Sources for ZNF154 Gene