Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF146 Gene

Aliases for ZNF146 Gene

  • Zinc Finger Protein 146 2 3 4 5
  • Only Zinc Finger Protein 3 4
  • OZF 3 4
  • Zinc Finger Protein OZF 3

External Ids for ZNF146 Gene

Previous GeneCards Identifiers for ZNF146 Gene

  • GC19P037373
  • GC19P037154
  • GC19P041382
  • GC19P041411
  • GC19P036705
  • GC19P033211
  • GC19P036215
  • GC19P036374
  • GC19P036436

Summaries for ZNF146 Gene

GeneCards Summary for ZNF146 Gene

ZNF146 (Zinc Finger Protein 146) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and heparin binding. An important paralog of this gene is ZNF260.

Gene Wiki entry for ZNF146 Gene

Additional gene information for ZNF146 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF146 Gene

Genomics for ZNF146 Gene

GeneHancer (GH) Regulatory Elements for ZNF146 Gene

Promoters and enhancers for ZNF146 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I036213 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 602 +0.7 707 3.3 MLX YBX1 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC ZNF146 ZNF565 ZNF345 ZNF567 TMEM147-AS1 ZNF850 HAUS5 ZNF790 ZNF260 ZNF529
GH19I036836 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 52.7 +623.5 623467 2.7 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF213 ZNF790 ZNF383 ZNF345 ZNF850 ZNF567 ZNF527 ZNF585B ZNF571 ZNF573 HKR1
GH19I036849 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 50 +635.6 635581 3.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF416 ZNF207 ZNF345 ZNF790 ZNF527 ZNF567 ZNF383 ZNF585B HKR1 ZNF850 ZFP30 ZNF571
GH19I035296 Enhancer 1 dbSUPER 102.1 -916.4 -916376 3.2 HDGF ZNF493 ZNF133 SIN3A ZNF2 TCF12 ZNF121 ZNF302 ZNF416 ZNF207 ZNF599 TMEM147-AS1 HAUS5 ZNF146 ZNF181 KMT2B PROSER3 ENSG00000267219 ZNF792 ZNF30
GH19I035946 Enhancer 1.5 FANTOM5 Ensembl ENCODE 67.4 -267.2 -267209 0.8 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 ZNF213 ZNF302 E2F8 LOC105372383 ZNF567 ZNF345 TMEM147-AS1 ZNF850 HAUS5 PROSER3 ZNF790 KMT2B ZNF529
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF146 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF146 gene promoter:

Genomic Locations for ZNF146 Gene

Genomic Locations for ZNF146 Gene
chr19:36,214,602-36,238,774
(GRCh38/hg38)
Size:
24,173 bases
Orientation:
Plus strand
chr19:36,705,504-36,729,676
(GRCh37/hg19)

Genomic View for ZNF146 Gene

Genes around ZNF146 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF146 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF146 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF146 Gene

Proteins for ZNF146 Gene

  • Protein details for ZNF146 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15072-OZF_HUMAN
    Recommended name:
    Zinc finger protein OZF
    Protein Accession:
    Q15072
    Secondary Accessions:
    • Q2TB94

    Protein attributes for ZNF146 Gene

    Size:
    292 amino acids
    Molecular mass:
    33308 Da
    Quaternary structure:
    • Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP.

neXtProt entry for ZNF146 Gene

Post-translational modifications for ZNF146 Gene

  • Sumoylated.
  • Ubiquitination at posLast=1919, isoforms=84, posLast=112112, and isoforms=247
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF146 Gene

Domains & Families for ZNF146 Gene

Gene Families for ZNF146 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF146 Gene

Suggested Antigen Peptide Sequences for ZNF146 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15072

UniProtKB/Swiss-Prot:

OZF_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF146: view

Function for ZNF146 Gene

Molecular function for ZNF146 Gene

GENATLAS Biochemistry:
only zinc finger protein 145,(C2H2 type),Kruppel-like,expressed in liver,skeletal muscle,mammary cells,amplified or overexpressed in pancreatic carcinoma and contributing to the progression of tumour

Phenotypes From GWAS Catalog for ZNF146 Gene

Gene Ontology (GO) - Molecular Function for ZNF146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,TAS --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0008201 heparin binding TAS 8665923
GO:0008270 zinc ion binding TAS 8665923
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF146: view
genes like me logo Genes that share phenotypes with ZNF146: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF146 Gene

Localization for ZNF146 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF146 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF146 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8665923
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF146: view

Pathways & Interactions for ZNF146 Gene

SuperPathways for ZNF146 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 8107129
genes like me logo Genes that share ontologies with ZNF146: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF146 Gene

Drugs & Compounds for ZNF146 Gene

(1) Drugs for ZNF146 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2430
genes like me logo Genes that share compounds with ZNF146: view

Transcripts for ZNF146 Gene

Unigene Clusters for ZNF146 Gene

Zinc finger protein 146:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF146 Gene

No ASD Table

Relevant External Links for ZNF146 Gene

GeneLoc Exon Structure for
ZNF146
ECgene alternative splicing isoforms for
ZNF146

Expression for ZNF146 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF146 Gene

Protein differential expression in normal tissues from HIPED for ZNF146 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (50.8), Blymphocyte (10.8), and Fetal testis (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF146 Gene



Protein tissue co-expression partners for ZNF146 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF146 Gene:

ZNF146

SOURCE GeneReport for Unigene cluster for ZNF146 Gene:

Hs.643436

mRNA Expression by UniProt/SwissProt for ZNF146 Gene:

Q15072-OZF_HUMAN
Tissue specificity: Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers.

Evidence on tissue expression from TISSUES for ZNF146 Gene

  • Nervous system(3.7)
  • Heart(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with ZNF146: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF146 Gene

Orthologs for ZNF146 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF146 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF146 33 34
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 98 (a)
OneToMany
-- 34
  • 97 (a)
OneToMany
ZNF146 33
  • 93.15 (n)
dog
(Canis familiaris)
Mammalia ZNF146 33 34
  • 93.49 (n)
rat
(Rattus norvegicus)
Mammalia LOC102555183 33
  • 87.56 (n)
mouse
(Mus musculus)
Mammalia Zfp146 33 16 34
  • 85.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 45 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF146 34
  • 29 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11398 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F35H8.3 35
  • 35 (a)
Species where no ortholog for ZNF146 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF146 Gene

ENSEMBL:
Gene Tree for ZNF146 (if available)
TreeFam:
Gene Tree for ZNF146 (if available)

Paralogs for ZNF146 Gene

Paralogs for ZNF146 Gene

(546) SIMAP similar genes for ZNF146 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF146 Gene

genes like me logo Genes that share paralogs with ZNF146: view

Variants for ZNF146 Gene

Sequence variations from dbSNP and Humsavar for ZNF146 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000053811 -- 36,213,760(+) G/A upstream_transcript_variant
rs1000108253 -- 36,237,342(+) G/A 3_prime_UTR_variant
rs1000224228 -- 36,224,305(+) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000228624 -- 36,212,630(+) A/C upstream_transcript_variant
rs1000247245 -- 36,229,971(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF146 Gene

Variant ID Type Subtype PubMed ID
esv3644249 CNV loss 21293372
nsv509739 CNV insertion 20534489
nsv520020 CNV loss 19592680

Variation tolerance for ZNF146 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.20; 87.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF146 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF146

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF146 Gene

Disorders for ZNF146 Gene

Additional Disease Information for ZNF146

No disorders were found for ZNF146 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF146 Gene

Publications for ZNF146 Gene

  1. Genomic organization and promoter identification of ZNF146, a gene encoding a protein consisting solely of zinc finger domains. (PMID: 11306801) Pibouin L … Goubin G (Cytogenetics and cell genetics 2001) 3 4 22 58
  2. Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene. (PMID: 10449921) Blottière L … Goubin G (Cytogenetics and cell genetics 1999) 2 3 22 58
  3. Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1. (PMID: 15838871) Antoine K … Goubin G (Journal of cellular biochemistry 2005) 3 4 58
  4. A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo. (PMID: 15881673) Antoine K … Goubin G (Molecular and cellular biochemistry 2005) 3 4 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58

Products for ZNF146 Gene

Sources for ZNF146 Gene

Content
Loading form....