ZNF143 Gene (Protein Coding)

Zinc Finger Protein 143

GC11P009483
GIFtS:
40

Aliases for ZNF143 Gene

Aliases for ZNF143 Gene

  • Zinc Finger Protein 143 2 3 4 5
  • Selenocysteine TRNA Gene Transcription-Activating Factor 3 4
  • SPH-Binding Factor 3 4
  • HStaf 3 4
  • STAF 3 4
  • SBF 3 4
  • Zinc Finger Protein 143 (Clone PHZ-1) 2
  • Transcriptional Activator Staf 3
  • PHZ-1 3

External Ids for ZNF143 Gene

Previous GeneCards Identifiers for ZNF143 Gene

  • GC11P010122
  • GC11P009522
  • GC11P009446
  • GC11P009439
  • GC11P009153

Summaries for ZNF143 Gene

GeneCards Summary for ZNF143 Gene

ZNF143 (Zinc Finger Protein 143) is a Protein Coding gene. Diseases associated with ZNF143 include Disorders Of Intracellular Cobalamin Metabolism and Basilar Artery Insufficiency. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and RNA Polymerase III Transcription Initiation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF76.

UniProtKB/Swiss-Prot Summary for ZNF143 Gene

  • Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8.

Gene Wiki entry for ZNF143 Gene

Additional gene information for ZNF143 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF143 Gene

Genomics for ZNF143 Gene

GeneHancer (GH) Regulatory Elements for ZNF143 Gene

Promoters and enhancers for ZNF143 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF143 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF143

Top Transcription factor binding sites by QIAGEN in the ZNF143 gene promoter:
  • aMEF-2
  • AML1a
  • AP-1
  • ATF-2
  • Brachyury
  • c-Jun
  • HFH-1
  • MEF-2A

Genomic Locations for ZNF143 Gene

Genomic Locations for ZNF143 Gene
chr11:9,460,319-9,528,524
(GRCh38/hg38)
Size:
68,206 bases
Orientation:
Plus strand
chr11:9,481,866-9,550,071
(GRCh37/hg19)
Size:
68,206 bases
Orientation:
Plus strand

Genomic View for ZNF143 Gene

Genes around ZNF143 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF143 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF143 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF143 Gene

Proteins for ZNF143 Gene

Products:

  1. Antibody
  2. Protein
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  • Protein details for ZNF143 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52747-ZN143_HUMAN
    Recommended name:
    Zinc finger protein 143
    Protein Accession:
    P52747
    Secondary Accessions:
    • A8K518
    • B4DLY5
    • E7ER34
    • O75559
    • Q8WUK9

    Protein attributes for ZNF143 Gene

    Size:
    638 amino acids
    Molecular mass:
    68896 Da
    Quaternary structure:
    • Interacts with CHD8.
    SequenceCaution:
    • Sequence=AAC50266.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH20219.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF83822.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF143 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF143 Gene

Protein Expression for ZNF143 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF143 Gene

  • Ubiquitination at Lys375
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF143 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF143 Gene

Domains & Families for ZNF143 Gene

Gene Families for ZNF143 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF143 Gene

Blocks:
  • C2H2-type zinc finger signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF143 Gene

GenScript: Design optimal peptide antigens:
  • ZNF143 protein (Q9H176_HUMAN)
  • ZNF143 protein (Q9H4D4_HUMAN)
  • Selenocysteine tRNA gene transcription-activating factor (ZN143_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P52747

UniProtKB/Swiss-Prot:

ZN143_HUMAN :
  • Belongs to the GLI C2H2-type zinc-finger protein family.
Family:
  • Belongs to the GLI C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF143: view

Function for ZNF143 Gene

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  2. CRISPR
  3. miRNA
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  5. Clone
  6. Cell Line

Molecular function for ZNF143 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8.
GENATLAS Biochemistry:
zinc finger protein 143,GLI-Kruppel family member,homolog of Xenopus laevis STAF transcriptional activator ortholog

Phenotypes From GWAS Catalog for ZNF143 Gene

Gene Ontology (GO) - Molecular Function for ZNF143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10893243
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 10893243
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF143: view
genes like me logo Genes that share phenotypes with ZNF143: view

Animal Model Products

CRISPR Products

miRNA for ZNF143 Gene

miRTarBase miRNAs that target ZNF143
Targeted motifs for ZNF143 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF143
  • Consensus sequence: ATTTCCCAGVAKSCY Submotif: canonical Cell Type: CUTLL GEO ID: GSE29600

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF143

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF143 Gene

Localization for ZNF143 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF143 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF143 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZNF143: view

Pathways & Interactions for ZNF143 Gene

genes like me logo Genes that share pathways with ZNF143: view

Gene Ontology (GO) - Biological Process for ZNF143 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II TAS 9566884
GO:0006359 regulation of transcription by RNA polymerase III TAS 9566884
GO:0006366 transcription by RNA polymerase II TAS 9009278
GO:0006383 transcription by RNA polymerase III TAS 9009278
genes like me logo Genes that share ontologies with ZNF143: view

No data available for SIGNOR curated interactions for ZNF143 Gene

Drugs & Compounds for ZNF143 Gene

Products:

  1. Drug

(1) Drugs for ZNF143 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF143: view

Transcripts for ZNF143 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZNF143 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF143

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF143 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17
SP1: - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for ZNF143 Gene

GeneLoc Exon Structure for
ZNF143

Expression for ZNF143 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF143 Gene

mRNA expression in normal human tissues for ZNF143 Gene
mRNA expression by GTEx for ZNF143 GenemRNA expression by BioGPS for ZNF143 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF143 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.4), CD8 Tcells (10.6), Retina (7.6), Fetal Liver (7.3), and NK cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF143 Gene



Protein tissue co-expression partners for ZNF143 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF143

SOURCE GeneReport for Unigene cluster for ZNF143 Gene:

Hs.523471

mRNA Expression by UniProt/SwissProt for ZNF143 Gene:

P52747-ZN143_HUMAN
Tissue specificity: Expressed in all tissues tested, with the strongest expression in ovary.

Evidence on tissue expression from TISSUES for ZNF143 Gene

  • Nervous system(4.6)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with ZNF143: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF143 Gene

Orthologs for ZNF143 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF143 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZNF143 31 30
  • 99.42 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia ZNF143 31
  • 96 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia ZNF143 31 30
  • 93.5 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia ZNF143 31 30
  • 93.14 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Zfp143 17 31 30
  • 90.63 (n)
rat
(Rattus norvegicus)
 Mammalia Zfp143 30
  • 90.4 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia ZNF143 31
  • 90 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ZNF143 31 30
  • 82.26 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ZNF143 31
  • 92 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia znf143 30
  • 73.03 (n)
Str.3450 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.23822 30
zebrafish
(Danio rerio)
 Actinopterygii wee1 31
  • 74 (a)
 OneToMany
znf143b 31 30
  • 70.1 (n)
 OneToMany
znf143a 31
  • 64 (a)
 OneToMany
zgc66276 30
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.13634 30
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 53 (a)
 OneToMany
Species where no ortholog for ZNF143 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF143 Gene

ENSEMBL:
Gene Tree for ZNF143 (if available)
TreeFam:
Gene Tree for ZNF143 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF143: view image

Paralogs for ZNF143 Gene

Paralogs for ZNF143 Gene

(150) SIMAP similar genes for ZNF143 Gene using alignment to 16 proteins:

  • ZN143_HUMAN
  • C9J2G7_HUMAN
  • C9JCG1_HUMAN
  • C9JRS3_HUMAN
  • C9JTC5_HUMAN
  • E7EN86_HUMAN
  • E7ER34_HUMAN
  • E9PJF2_HUMAN
  • E9PLN4_HUMAN
  • E9PLS7_HUMAN
  • E9PMY8_HUMAN
  • E9PPB0_HUMAN
  • E9PS81_HUMAN
  • H7C1P6_HUMAN
  • Q9H176_HUMAN
  • Q9H4D4_HUMAN
genes like me logo Genes that share paralogs with ZNF143: view

Variants for ZNF143 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF143 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
768424 Benign: not provided 9,478,591(+) A/G INTRON_VARIANT
768425 Benign: not provided 9,512,454(+) G/A MISSENSE_VARIANT
787374 Benign: not provided 9,497,751(+) A/G SYNONYMOUS_VARIANT
rs10743108 - p.Glu561Gln
rs34972213 - p.Gly461Asp

Additional dbSNP identifiers (rs#s) for ZNF143 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF143 Gene

Variant ID Type Subtype PubMed ID
dgv584n106 CNV deletion 24896259
esv24739 CNV loss 19812545
esv2486941 CNV deletion 19546169
esv2675320 CNV deletion 23128226
esv2744093 CNV deletion 23290073
esv3547301 CNV deletion 23714750
esv3625334 CNV loss 21293372
esv3625335 CNV loss 21293372
esv3625336 CNV loss 21293372
nsv1039537 CNV gain 25217958
nsv1055078 CNV gain 25217958
nsv1069561 CNV deletion 25765185
nsv1119859 CNV deletion 24896259
nsv1122583 CNV deletion 24896259
nsv1148850 CNV deletion 26484159
nsv499766 OTHER inversion 21111241
nsv512209 CNV loss 21212237
nsv553467 CNV loss 21841781
nsv7215 OTHER inversion 18451855
nsv7670 CNV deletion 18451855
nsv7671 CNV insertion 18451855
nsv957161 CNV deletion 24416366

Variation tolerance for ZNF143 Gene

Residual Variation Intolerance Score: 4.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF143 Gene

Human Gene Mutation Database (HGMD)
ZNF143
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF143

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF143 Gene

Disorders for ZNF143 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF143 Gene - From: GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
disorders of intracellular cobalamin metabolism
basilar artery insufficiency
  • basilar artery syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF143

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF143: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF143 Gene

Publications for ZNF143 Gene

  1. CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription. (PMID: 17938208) Yuan CC … Hernandez N (Molecular and cellular biology 2007) 3 4 23 54
  2. Molecular cloning of a cDNA encoding human SPH-binding factor, a conserved protein that binds to the enhancer-like region of the U6 small nuclear RNA gene promoter. (PMID: 9776743) Rincon JC … Kunkel GR (Nucleic acids research 1998) 3 4 23 54
  3. Transcriptional regulation of the human establishment of cohesion 1 homolog 2 gene. (PMID: 20116366) Nishihara M … Yanagihara I (Biochemical and biophysical research communications 2010) 3 23 54
  4. ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes. (PMID: 17297437) Wakasugi T … Kohno K (Oncogene 2007) 3 23 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

ExternalLinks

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